LOCUS       NM_016626               4142 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens mex-3 RNA binding family member C (MEX3C), mRNA.
ACCESSION   NM_016626
VERSION     NM_016626.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4142)
  AUTHORS   He,Z., Zhang,H., Xiao,H., Zhang,X., Xu,H., Sun,R. and Li,S.
  TITLE     Ubiquitylation of RUNX3 by RNA-binding ubiquitin ligase MEX3C
            promotes tumorigenesis in lung adenocarcinoma
  JOURNAL   J Transl Med 22 (1), 216 (2024)
   PUBMED   38424632
  REMARK    GeneRIF: Ubiquitylation of RUNX3 by RNA-binding ubiquitin ligase
            MEX3C promotes tumorigenesis in lung adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4142)
  AUTHORS   Guo,J., Zhao,J., Xu,Q. and Huang,D.
  TITLE     MEX3C as a potential target for hepatocellular carcinoma drug and
            immunity: combined therapy with Lenvatinib
  JOURNAL   BMC Cancer 23 (1), 967 (2023)
   PUBMED   37828435
  REMARK    GeneRIF: MEX3C as a potential target for hepatocellular carcinoma
            drug and immunity: combined therapy with Lenvatinib.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4142)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   4  (bases 1 to 4142)
  AUTHORS   Xiao,Y., Li,Y., Shi,D., Wang,X., Dai,S., Yang,M., Kong,L., Chen,B.,
            Huang,X., Lin,C., Liao,W., Xu,B., Chen,X., Wang,L., Chen,X.,
            Ouyang,Y., Liu,G., Li,H. and Song,L.
  TITLE     MEX3C-Mediated Decay of SOCS3 mRNA Promotes JAK2/STAT3 Signaling to
            Facilitate Metastasis in Hepatocellular Carcinoma
  JOURNAL   Cancer Res 82 (22), 4191-4205 (2022)
   PUBMED   36112698
  REMARK    GeneRIF: MEX3C-Mediated Decay of SOCS3 mRNA Promotes JAK2/STAT3
            Signaling to Facilitate Metastasis in Hepatocellular Carcinoma.
REFERENCE   5  (bases 1 to 4142)
  AUTHORS   Huang,K., Liu,D. and Su,C.
  TITLE     Circ_0007841 accelerates ovarian cancer development through
            facilitating MEX3C expression by restraining miR-151-3p activity
  JOURNAL   Aging (Albany NY) 13 (8), 12058-12066 (2021)
   PUBMED   33896797
  REMARK    GeneRIF: Circ_0007841 accelerates ovarian cancer development
            through facilitating MEX3C expression by restraining miR-151-3p
            activity.
REFERENCE   6  (bases 1 to 4142)
  AUTHORS   Kennedy,R.B., Ovsyannikova,I.G., Pankratz,V.S., Haralambieva,I.H.,
            Vierkant,R.A. and Poland,G.A.
  TITLE     Genome-wide analysis of polymorphisms associated with cytokine
            responses in smallpox vaccine recipients
  JOURNAL   Hum Genet 131 (9), 1403-1421 (2012)
   PUBMED   22610502
REFERENCE   7  (bases 1 to 4142)
  AUTHORS   Orvedahl,A., Sumpter,R. Jr., Xiao,G., Ng,A., Zou,Z., Tang,Y.,
            Narimatsu,M., Gilpin,C., Sun,Q., Roth,M., Forst,C.V., Wrana,J.L.,
            Zhang,Y.E., Luby-Phelps,K., Xavier,R.J., Xie,Y. and Levine,B.
  TITLE     Image-based genome-wide siRNA screen identifies selective autophagy
            factors
  JOURNAL   Nature 480 (7375), 113-117 (2011)
   PUBMED   22020285
REFERENCE   8  (bases 1 to 4142)
  AUTHORS   Buchet-Poyau,K., Courchet,J., Le Hir,H., Seraphin,B., Scoazec,J.Y.,
            Duret,L., Domon-Dell,C., Freund,J.N. and Billaud,M.
  TITLE     Identification and characterization of human Mex-3 proteins, a
            novel family of evolutionarily conserved RNA-binding proteins
            differentially localized to processing bodies
  JOURNAL   Nucleic Acids Res 35 (4), 1289-1300 (2007)
   PUBMED   17267406
REFERENCE   9  (bases 1 to 4142)
  AUTHORS   Guzman,B., Cormand,B., Ribases,M., Gonzalez-Nunez,D., Botey,A. and
            Poch,E.
  TITLE     Implication of chromosome 18 in hypertension by sibling pair and
            association analyses: putative involvement of the RKHD2 gene
  JOURNAL   Hypertension 48 (5), 883-891 (2006)
   PUBMED   17015768
  REMARK    GeneRIF: In combination sibling-pair linkage analysis and
            case-control association studies of chromosome 18, RKHD2 is found
            to contribute to the genetic susceptibility of essential
            hypertension.
REFERENCE   10 (bases 1 to 4142)
  AUTHORS   Nusbaum,C., Zody,M.C., Borowsky,M.L., Kamal,M., Kodira,C.D.,
            Taylor,T.D., Whittaker,C.A., Chang,J.L., Cuomo,C.A., Dewar,K.,
            FitzGerald,M.G., Yang,X., Abouelleil,A., Allen,N.R., Anderson,S.,
            Bloom,T., Bugalter,B., Butler,J., Cook,A., DeCaprio,D., Engels,R.,
            Garber,M., Gnirke,A., Hafez,N., Hall,J.L., Norman,C.H., Itoh,T.,
            Jaffe,D.B., Kuroki,Y., Lehoczky,J., Lui,A., Macdonald,P.,
            Mauceli,E., Mikkelsen,T.S., Naylor,J.W., Nicol,R., Nguyen,C.,
            Noguchi,H., O'Leary,S.B., O'Neill,K., Piqani,B., Smith,C.L.,
            Talamas,J.A., Topham,K., Totoki,Y., Toyoda,A., Wain,H.M.,
            Young,S.K., Zeng,Q., Zimmer,A.R., Fujiyama,A., Hattori,M.,
            Birren,B.W., Sakaki,Y. and Lander,E.S.
  TITLE     DNA sequence and analysis of human chromosome 18
  JOURNAL   Nature 437 (7058), 551-555 (2005)
   PUBMED   16177791
  REMARK    Erratum:[Nature. 2005 Dec 1;438(7068):696. O'Neill, Keith [added]]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC090330.22, AY950679.1 and
            BC063244.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_016626.4.
            
            Summary: This gene encodes a member of a family of proteins with
            two K homology (KH) RNA-binding domains and a C-terminal
            RING-finger domain. The protein interacts with mRNA via the KH
            domains, and the protein shuttles between the nucleus and
            cytoplasm. Polymorphisms in this gene may contribute to
            hypertension. [provided by RefSeq, Oct 2009].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK096190.1, SRR1660809.169000.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000406189.4/ ENSP00000385610.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-835               AC090330.22        52579-53413
            836-2341            AY950679.1         475-1980
            2342-4142           BC063244.1         966-2766
FEATURES             Location/Qualifiers
     source          1..4142
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q21.2"
     gene            1..4142
                     /gene="MEX3C"
                     /gene_synonym="BM-013; MEX-3C; RKHD2; RNF194"
                     /note="mex-3 RNA binding family member C"
                     /db_xref="GeneID:51320"
                     /db_xref="HGNC:HGNC:28040"
                     /db_xref="MIM:611005"
     exon            1..1115
                     /gene="MEX3C"
                     /gene_synonym="BM-013; MEX-3C; RKHD2; RNF194"
                     /inference="alignment:Splign:2.1.0"
     CDS             362..2341
                     /gene="MEX3C"
                     /gene_synonym="BM-013; MEX-3C; RKHD2; RNF194"
                     /EC_number="2.3.2.27"
                     /note="ring finger and KH domain containing 2; RNA-binding
                     protein MEX3C; RING finger protein 194; RING finger and KH
                     domain-containing protein 2; RING-type E3 ubiquitin
                     transferase MEX3C"
                     /codon_start=1
                     /product="RNA-binding E3 ubiquitin-protein ligase MEX3C"
                     /protein_id="NP_057710.3"
                     /db_xref="CCDS:CCDS11951.2"
                     /db_xref="GeneID:51320"
                     /db_xref="HGNC:HGNC:28040"
                     /db_xref="MIM:611005"
                     /translation="MPSGSSAALALAAAPAPLPQPPPPPPPPPPPLPPPSGGPELEGD
                     GLLLRERLAALGLDDPSPAEPGAPALRAPAAAAQGQARRAAELSPEERAPPGRPGAPE
                     AAELELEEDEEEGEEAELDGDLLEEEELEEAEEEDRSSLLLLSPPAATASQTQQIPGG
                     SLGSVLLPAARFDAREAAAAAAAAGVLYGGDDAQGMMAAMLSHAYGPGGCGAAAAALN
                     GEQAALLRRKSVNTTECVPVPSSEHVAEIVGRQGCKIKALRAKTNTYIKTPVRGEEPI
                     FVVTGRKEDVAMAKREILSAAEHFSMIRASRNKNGPALGGLSCSPNLPGQTTVQVRVP
                     YRVVGLVVGPKGATIKRIQQQTHTYIVTPSRDKEPVFEVTGMPENVDRAREEIEMHIA
                     MRTGNYIELNEENDFHYNGTDVSFEGGTLGSAWLSSNPVPPSRARMISNYRNDSSSSL
                     GSGSTDSYFGSNRLADFSPTSPFSTGNFWFGDTLPSVGSEDLAVDSPAFDSLPTSAQT
                     IWTPFEPVNPLSGFGSDPSGNMKTQRRGSQPSTPRLSPTFPESIEHPLARRVRSDPPS
                     TGNHVGLPIYIPAFSNGTNSYSSSNGGSTSSSPPESRRKHDCVICFENEVIAALVPCG
                     HNLFCMECANKICEKRTPSCPVCQTAVTQAIQIHS"
     exon            1116..4142
                     /gene="MEX3C"
                     /gene_synonym="BM-013; MEX-3C; RKHD2; RNF194"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4115..4120
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MEX3C"
                     /gene_synonym="BM-013; MEX-3C; RKHD2; RNF194"
                     /note="hexamer: AATAAA"
     polyA_site      4142
                     /gene="MEX3C"
                     /gene_synonym="BM-013; MEX-3C; RKHD2; RNF194"
                     /note="major polyA site"
ORIGIN      
        1 attcggagag cggcgtgggg cgtagccgcc gccgccgcgc gcgccggggg ctggttaagg
       61 ccatgaaaca aaagaaacac tgagagggga gccgctgcca cctccaccag cccgccccgc
      121 cgccgtcccc acccacccac ctagttacct acctctgcct ccttcccctg cccctccacc
      181 ccgccctctc cggtctccgg gcggccctgg cgctcctcgg cccgggtccc cagccccgcc
      241 gcctccccag aggaaaggtg tttgcgagct gagcagggcc ctggccctgt ccgccatggg
      301 gctcgccgcc tgccgcgcct gacccggccg ccgccgccgc cattgacagc gcgccgccgc
      361 gatgcccagc ggcagctccg cggccctggc cctggcggcg gccccggccc ccctgccgca
      421 gccgcccccg ccgccgccgc cgccaccgcc gcctctgccg ccgccctcgg gcggcccgga
      481 gctcgagggg gacgggctcc tgctgaggga gcgcttggcc gcgctaggcc tcgacgaccc
      541 cagcccggcg gagcccggcg ccccggcgct tcgggccccg gcagcggcgg cgcagggcca
      601 ggcccggcgg gcggcggagc tgtctccaga ggagcgggct ccgcccggcc ggcccggggc
      661 cccggaggcg gccgagctgg agctggaaga ggacgaggag gagggggagg aagcggagct
      721 ggacggagac ctgctggagg aggaggagct ggaggaagca gaggaggagg accggtcgtc
      781 gctgctgctg ctgtcgccgc ccgcggccac cgcctctcag acccagcaga tcccgggcgg
      841 gtccctgggg tctgtgctgc tgccagccgc caggttcgat gcccgggagg cggcggccgc
      901 ggcggcggcg gcgggggtgc tgtacggagg ggacgatgcc cagggcatga tggcggcgat
      961 gctgtcccac gcctacggcc ccggcggttg tggggcggcg gcggccgccc tgaacgggga
     1021 gcaggcggcc ctgctccgga gaaagagcgt caacaccacc gagtgcgtcc cggtgcccag
     1081 ctccgagcac gtcgccgaga tcgtcggccg ccagggttgt aaaattaaag cactgagagc
     1141 caagacaaac acgtatatca agactcctgt tcgtggtgaa gagcccattt ttgttgtcac
     1201 tggaaggaaa gaagatgttg ccatggccaa aagagagatc ctctcagctg cagagcactt
     1261 ctccatgatt cgtgcatctc gaaacaaaaa tgggcctgcc ctgggaggat tatcatgtag
     1321 tcctaatctg cccggtcaaa ccaccgtcca agtcagggtc ccttatcgtg tggtaggatt
     1381 agtggttgga cccaaaggag caactattaa aagaattcag cagcagaccc acacctacat
     1441 agtaactccg agcagagata aggaacctgt ctttgaagtg acagggatgc ctgaaaatgt
     1501 tgaccgagca cgggaagaaa tagaaatgca tattgccatg cgtacaggaa actatataga
     1561 gctcaatgaa gagaatgatt tccattacaa tggtaccgat gtaagctttg aaggtggcac
     1621 tcttggctct gcgtggctct cctccaatcc tgttcctcct agccgcgcaa gaatgatatc
     1681 caattatcga aatgatagtt ccagttctct aggaagtggc tctacagatt cctactttgg
     1741 aagcaatagg ctggctgact ttagtccaac aagcccattt agcacaggaa acttctggtt
     1801 tggagataca ctaccatctg taggctcaga agacctagca gttgactctc ctgcctttga
     1861 ctctttacca acatctgctc aaactatctg gactccattt gaaccagtta acccactctc
     1921 tggctttggg agtgatcctt ctggtaacat gaagactcag cgcagaggaa gtcagccatc
     1981 tactcctcgt ctgtctccta catttcctga gagcatagaa catccacttg ctcggagggt
     2041 taggagcgac ccacctagta caggcaacca tgttggcctt ccaatatata tccctgcttt
     2101 ttctaatggt accaatagtt actcctcttc caatggtggt tccacctcta gctcacctcc
     2161 agaatcaaga cgaaagcacg actgtgtgat ttgctttgag aatgaggtta ttgctgccct
     2221 agttccatgt ggccacaacc tcttctgcat ggaatgtgcc aacaagatct gtgaaaagag
     2281 aacgccatca tgtccagttt gccagacagc tgttactcag gcaatccaaa ttcactctta
     2341 actatatata tatacataaa tactatatct ctatatggac tcgtaaaggc atgggtataa
     2401 tggtaccccc cagtaaactt cctaatgatt tcttatgact gttatcaggc tttattggga
     2461 ttaggctaaa gttgttagta aacttataaa aggctgctat ggtaacacta aacctaagtg
     2521 gtctcttgtc tattagtttg gtttgaatta ttagtactat cctgtagacc cagagacata
     2581 gtttatataa gaattgctaa agctgaagtt caacttggct gagtgaagat aatcataggt
     2641 tgtgtgagcc tatgaaaaag tgtatacgtc taagatttca aaacaatggg tcccaaagcc
     2701 taaccacttt aagagtttat ggagggtact tggcattaca gacgattcat acacttccag
     2761 tgctgccttc tttacactgc cagttttgac aaaacaggtt tgttttttat tttacaacaa
     2821 catatgccta attctgcagg attgcaagta actttttaat gcattgtgat tacttattgg
     2881 taatgatagg gctgatggca gtttactaga tcactggtta taatttggga caaaaactgc
     2941 tacatcaact ttcatctcgc ccagagtgct caaggctggt atgatcagtg gatcaggaat
     3001 gcaattgtga attcctgccc attgcctctc ttggtgaatg tggaaatggc cacctgggtt
     3061 ttcccatatc aggaagggct ttgggatggc acctatattg gctgataatt gaggatgcaa
     3121 acattccatt cattagtgtg atcgagctgt taatttttag actatagatc aaaatgtgaa
     3181 acattttatg ttcaatccat atttgtcttg cacattataa atatattttt attttttagt
     3241 aatttagggg agggaggagg gagaaaggga taatgatgcc cttggcataa ttcacaaaag
     3301 cagctgtgac aacctccaat cagtttactt catttcaaaa ctatttccaa tcacaaggaa
     3361 agatttattt aaaatatact cgtacatttc acctgtggat gtctataact tcatcctcag
     3421 tatgttccca aatctgtgct ggcattgaaa ggacaaaaca ttatactagt gggtttttct
     3481 actaattatt ttttgaagca ttattttccc aacacaaaag agcttttttc tcggtataat
     3541 gaaaattgaa atcctatgtg tattcaatag taaatagaca aattttattt tttatttcca
     3601 cttgaagagt tacatttcgt ataaaagttt acaaataacg gtttttattt tgattttttc
     3661 agtataaaaa aagttgcctt gatggcatat tatgatgtaa tgctaattgc ttgtaggata
     3721 gtaaatggtc agtattgaaa cctaatctct agctgccgtc ttgtagatat gaacgaatgt
     3781 tcaccaagca tgtattttgt attttgttgc attgtacact gcaactaata agccaaggaa
     3841 tcgacatata ttaggtgcgt gtactgtttc taaaaaccac aaactaagaa tgataaatta
     3901 tcaatatagt ttagtatttg ctaattttac tacactcttt tgttatgtat atgtagggaa
     3961 gtcataggga ttataaattc aatttgagta aaatttaaaa ccatatattt tatgataaag
     4021 ggcctttaac ttaagatggc caaagcactg atattatata tttgctgtaa agagaattat
     4081 aagagtttta tttttctgat attaaaagtt acttaataaa gacttgtttc cattaacttg
     4141 aa
//
