LOCUS       NM_032246               3405 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens mex-3 RNA binding family member B (MEX3B), mRNA.
ACCESSION   NM_032246
VERSION     NM_032246.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3405)
  AUTHORS   Yang,K., Chen,G., Yu,F., Fang,X., Zhang,J., Zhang,Z., Shi,Y. and
            Zhang,L.
  TITLE     Molecular mechanism of specific HLA-A mRNA recognition by the
            RNA-binding-protein hMEX3B to promote tumor immune escape
  JOURNAL   Commun Biol 7 (1), 158 (2024)
   PUBMED   38326406
  REMARK    GeneRIF: Molecular mechanism of specific HLA-A mRNA recognition by
            the RNA-binding-protein hMEX3B to promote tumor immune escape.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3405)
  AUTHORS   Liu,J.X., Chen,A.N., Yu,Q., Shi,K.T., Liu,Y.B., Guo,C.L.,
            Wang,Z.Z., Yao,Y., Pan,L., Lu,X., Xu,K., Wang,H., Zeng,M., Liu,C.,
            Schleimer,R.P., Wu,N., Liao,B. and Liu,Z.
  TITLE     MEX3B inhibits collagen production in eosinophilic nasal polyps by
            downregulating epithelial cell TGFBR3 mRNA stability
  JOURNAL   JCI Insight 8 (9), e159058 (2023)
   PUBMED   36976645
  REMARK    GeneRIF: MEX3B inhibits collagen production in eosinophilic nasal
            polyps by downregulating epithelial cell TGFBR3 mRNA stability.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3405)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   4  (bases 1 to 3405)
  AUTHORS   Liu,J.X., Liao,B., Yu,Q.H., Wang,H., Liu,Y.B., Guo,C.L., Wang,Z.C.,
            Li,Z.Y., Wang,Z.Z., Ruan,J.W., Pan,L., Yao,Y., Chen,C.L., Wang,H.,
            Liang,Y., Zhen,G. and Liu,Z.
  TITLE     The IL-37-Mex3B-Toll-like receptor 3 axis in epithelial cells in
            patients with eosinophilic chronic rhinosinusitis with nasal polyps
  JOURNAL   J Allergy Clin Immunol 145 (1), 160-172 (2020)
   PUBMED   31330219
  REMARK    GeneRIF: he suppressed IL-37 secretion caused by a type 2 milieu
            can enhance Mex3B-mediated TLR3 activation and subsequent TSLP
            production in nasal epithelial cells and therefore promotes
            eosinophilic inflammation in patients with eosinophilic chronic
            rhinosinusitis with nasal polyps.
REFERENCE   5  (bases 1 to 3405)
  AUTHORS   Huang,L., Malu,S., McKenzie,J.A., Andrews,M.C., Talukder,A.H.,
            Tieu,T., Karpinets,T., Haymaker,C., Forget,M.A., Williams,L.J.,
            Wang,Z., Mbofung,R.M., Wang,Z.Q., Davis,R.E., Lo,R.S., Wargo,J.A.,
            Davies,M.A., Bernatchez,C., Heffernan,T., Amaria,R.N., Korkut,A.,
            Peng,W., Roszik,J., Lizee,G., Woodman,S.E. and Hwu,P.
  TITLE     The RNA-binding Protein MEX3B Mediates Resistance to Cancer
            Immunotherapy by Downregulating HLA-A Expression
  JOURNAL   Clin Cancer Res 24 (14), 3366-3376 (2018)
   PUBMED   29496759
  REMARK    GeneRIF: MEX3B mediates resistance to cancer immunotherapy by
            binding to the 3' UTR of HLA-A to destabilize the HLA-A mRNA and
            thus downregulate HLA-A expression on the surface of tumor cells.
REFERENCE   6  (bases 1 to 3405)
  AUTHORS   Pereira,B., Sousa,S., Barros,R., Carreto,L., Oliveira,P.,
            Oliveira,C., Chartier,N.T., Plateroti,M., Rouault,J.P.,
            Freund,J.N., Billaud,M. and Almeida,R.
  TITLE     CDX2 regulation by the RNA-binding protein MEX3A: impact on
            intestinal differentiation and stemness
  JOURNAL   Nucleic Acids Res 41 (7), 3986-3999 (2013)
   PUBMED   23408853
REFERENCE   7  (bases 1 to 3405)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   8  (bases 1 to 3405)
  AUTHORS   Willer,C.J., Speliotes,E.K., Loos,R.J., Li,S., Lindgren,C.M.,
            Heid,I.M., Berndt,S.I., Elliott,A.L., Jackson,A.U., Lamina,C.,
            Lettre,G., Lim,N., Lyon,H.N., McCarroll,S.A., Papadakis,K., Qi,L.,
            Randall,J.C., Roccasecca,R.M., Sanna,S., Scheet,P., Weedon,M.N.,
            Wheeler,E., Zhao,J.H., Jacobs,L.C., Prokopenko,I., Soranzo,N.,
            Tanaka,T., Timpson,N.J., Almgren,P., Bennett,A., Bergman,R.N.,
            Bingham,S.A., Bonnycastle,L.L., Brown,M., Burtt,N.P., Chines,P.,
            Coin,L., Collins,F.S., Connell,J.M., Cooper,C., Smith,G.D.,
            Dennison,E.M., Deodhar,P., Elliott,P., Erdos,M.R., Estrada,K.,
            Evans,D.M., Gianniny,L., Gieger,C., Gillson,C.J., Guiducci,C.,
            Hackett,R., Hadley,D., Hall,A.S., Havulinna,A.S., Hebebrand,J.,
            Hofman,A., Isomaa,B., Jacobs,K.B., Johnson,T., Jousilahti,P.,
            Jovanovic,Z., Khaw,K.T., Kraft,P., Kuokkanen,M., Kuusisto,J.,
            Laitinen,J., Lakatta,E.G., Luan,J., Luben,R.N., Mangino,M.,
            McArdle,W.L., Meitinger,T., Mulas,A., Munroe,P.B., Narisu,N.,
            Ness,A.R., Northstone,K., O'Rahilly,S., Purmann,C., Rees,M.G.,
            Ridderstrale,M., Ring,S.M., Rivadeneira,F., Ruokonen,A.,
            Sandhu,M.S., Saramies,J., Scott,L.J., Scuteri,A., Silander,K.,
            Sims,M.A., Song,K., Stephens,J., Stevens,S., Stringham,H.M.,
            Tung,Y.C., Valle,T.T., Van Duijn,C.M., Vimaleswaran,K.S.,
            Vollenweider,P., Waeber,G., Wallace,C., Watanabe,R.M.,
            Waterworth,D.M., Watkins,N., Witteman,J.C., Zeggini,E., Zhai,G.,
            Zillikens,M.C., Altshuler,D., Caulfield,M.J., Chanock,S.J.,
            Farooqi,I.S., Ferrucci,L., Guralnik,J.M., Hattersley,A.T., Hu,F.B.,
            Jarvelin,M.R., Laakso,M., Mooser,V., Ong,K.K., Ouwehand,W.H.,
            Salomaa,V., Samani,N.J., Spector,T.D., Tuomi,T., Tuomilehto,J.,
            Uda,M., Uitterlinden,A.G., Wareham,N.J., Deloukas,P.,
            Frayling,T.M., Groop,L.C., Hayes,R.B., Hunter,D.J., Mohlke,K.L.,
            Peltonen,L., Schlessinger,D., Strachan,D.P., Wichmann,H.E.,
            McCarthy,M.I., Boehnke,M., Barroso,I., Abecasis,G.R. and
            Hirschhorn,J.N.
  CONSRTM   Wellcome Trust Case Control Consortium; Genetic Investigation of
            ANthropometric Traits Consortium
  TITLE     Six new loci associated with body mass index highlight a neuronal
            influence on body weight regulation
  JOURNAL   Nat Genet 41 (1), 25-34 (2009)
   PUBMED   19079261
REFERENCE   9  (bases 1 to 3405)
  AUTHORS   Courchet,J., Buchet-Poyau,K., Potemski,A., Bres,A.,
            Jariel-Encontre,I. and Billaud,M.
  TITLE     Interaction with 14-3-3 adaptors regulates the sorting of hMex-3B
            RNA-binding protein to distinct classes of RNA granules
  JOURNAL   J Biol Chem 283 (46), 32131-32142 (2008)
   PUBMED   18779327
  REMARK    GeneRIF: 14-3-3 exerts combined effects on hMex-3B and acts as a
            major regulator of the sorting between distinct classes of RNA
            granules
REFERENCE   10 (bases 1 to 3405)
  AUTHORS   Buchet-Poyau,K., Courchet,J., Le Hir,H., Seraphin,B., Scoazec,J.Y.,
            Duret,L., Domon-Dell,C., Freund,J.N. and Billaud,M.
  TITLE     Identification and characterization of human Mex-3 proteins, a
            novel family of evolutionarily conserved RNA-binding proteins
            differentially localized to processing bodies
  JOURNAL   Nucleic Acids Res 35 (4), 1289-1300 (2007)
   PUBMED   17267406
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC026956.20.
            
            On Aug 31, 2019 this sequence version replaced NM_032246.5.
            
            Summary: This gene encodes an RNA-binding phosphoprotein that is
            part of the MEX3 (muscle excess 3) family of translational
            regulators. The encoded protein contains N-terminal nuclear export
            and nuclear localization signals and is exported from the cytoplasm
            to the nucleus. The protein binds to RNA via two KH domains and
            also colocalizes with MEX3A, Dcp1A decapping factor and Argonaute
            proteins within P (processing) bodies. [provided by RefSeq, Oct
            2012].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853561.10464.1, AK131424.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000329713.5/ ENSP00000329918.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-569               AC026956.20        102817-103385       c
            570-3405            AC026956.20        99145-101980        c
FEATURES             Location/Qualifiers
     source          1..3405
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q25.2"
     gene            1..3405
                     /gene="MEX3B"
                     /gene_synonym="MEX-3B; RKHD3; RNF195"
                     /note="mex-3 RNA binding family member B"
                     /db_xref="GeneID:84206"
                     /db_xref="HGNC:HGNC:25297"
                     /db_xref="MIM:611008"
     exon            1..569
                     /gene="MEX3B"
                     /gene_synonym="MEX-3B; RKHD3; RNF195"
                     /inference="alignment:Splign:2.1.0"
     CDS             314..2023
                     /gene="MEX3B"
                     /gene_synonym="MEX-3B; RKHD3; RNF195"
                     /note="ring finger and KH domain containing 3; RING finger
                     protein 195"
                     /codon_start=1
                     /product="RNA-binding protein MEX3B"
                     /protein_id="NP_115622.2"
                     /db_xref="CCDS:CCDS10319.1"
                     /db_xref="GeneID:84206"
                     /db_xref="HGNC:HGNC:25297"
                     /db_xref="MIM:611008"
                     /translation="MPSSLFADLERNGSGGGGGGSSGGGETLDDQRALQLALDQLSLL
                     GLDSDEGASLYDSEPRKKSVNMTECVPVPSSEHVAEIVGRQGCKIKALRAKTNTYIKT
                     PVRGEEPVFVVTGRKEDVAMARREIISAAEHFSMIRASRNKNTALNGAVPGPPNLPGQ
                     TTIQVRVPYRVVGLVVGPKGATIKRIQQQTHTYIVTPSRDKEPVFEVTGMPENVDRAR
                     EEIEAHIALRTGGIIELTDENDFHANGTDVGFDLHHGSGGSGPGSLWSKPTPSITPTP
                     GRKPFSSYRNDSSSSLGSASTDSYFGGGTSSSAAATQRLADYSPPSPALSFAHNGNNN
                     NNGNGYTYTAGGEASVPSPDGCPELQPTFDPAPAPPPGAPLIWAQFERSPGGGPAAPV
                     SSSCSSSASSSASSSSVVFPGGGASAPSNANLGLLVHRRLHPGTSCPRLSPPLHMAPG
                     AGEHHLARRVRSDPGGGGLAYAAYANGLGAQLPGLQPSDTSGSSSSSSSSSSSSSSSS
                     GLRRKGSRDCSVCFESEVIAALVPCGHNLFCMECANRICEKSEPECPVCHTAVTQAIR
                     IFS"
     exon            570..3405
                     /gene="MEX3B"
                     /gene_synonym="MEX-3B; RKHD3; RNF195"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3382..3387
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MEX3B"
                     /gene_synonym="MEX-3B; RKHD3; RNF195"
                     /note="hexamer: AATAAA"
     polyA_site      3405
                     /gene="MEX3B"
                     /gene_synonym="MEX-3B; RKHD3; RNF195"
                     /note="major polyA site"
ORIGIN      
        1 gcttttcgct cggcattgcg gccagccagc cgggcactcg gggggcacgc gcggccaccg
       61 ctagagctct gcccccaccc cacccgccag caggtctggg gtggggaccc aggtgggggc
      121 tcctgcagcc actgcccggt gcggaccgca cggagcgacc cactcctccc agcaccgagg
      181 aagaagcaac ggagccctca gcaggcgacc ggcctccccg cccctgacca cccgcttccc
      241 ggctgccttt gtggccgcag cttctcgccg ccgagccgag ggccggcggg ggcgcggcgc
      301 gcacggccga gcgatgccca gctcgctgtt cgcagacctg gagcgcaacg gcagcggcgg
      361 cggcggcggc ggcagcagcg gagggggaga gaccctggat gaccaaagag ccctgcagct
      421 cgcgctcgac cagctctccc tgctggggct ggacagtgac gagggcgcct ctctgtacga
      481 cagcgagccg cgcaagaaga gcgtgaacat gaccgagtgc gtgccagtac ccagttctga
      541 gcatgtcgcc gagatcgtgg ggcggcaagg ttgtaaaatc aaagcgctgc gggcgaagac
      601 caatacttac atcaagaccc cagttcgcgg ggaggagcct gtctttgttg tgacgggcag
      661 gaaggaggat gtggccatgg ctcggaggga gatcatctct gctgccgagc acttctccat
      721 gatccgcgcc tcccggaata agaacacggc actcaacggc gcggtgcctg ggccgcccaa
      781 cctgcccggg cagaccacca tccaagtgcg ggtaccctac cgcgtggtgg ggctcgtggt
      841 ggggcccaaa ggcgccacaa tcaagcgcat ccagcagcag acgcacacgt acatcgtgac
      901 gcccagccgg gataaggagc cggtgttcga ggtgaccggc atgccagaga acgtggatcg
      961 cgctcgagag gagattgagg cgcacattgc tctgcgtacc ggcggcatca ttgagctcac
     1021 agacgagaac gacttccacg ccaacggcac cgatgtgggc ttcgatctgc atcatgggtc
     1081 cggcgggtcc ggcccaggca gcctctggag caagcccacc cccagcatca cgcccacccc
     1141 cggccgcaag cctttctcta gctaccgcaa cgacagctcc agctcgcttg gcagtgcttc
     1201 cacagactct tatttcggcg gcgggaccag cagcagcgca gcggctaccc agcgcctggc
     1261 ggactacagc ccccctagcc ccgccctgag ctttgcgcac aacggaaaca ataacaataa
     1321 cggcaatggg tacacctaca cagcgggggg agaagcctca gtgccatccc ccgacggctg
     1381 ccccgagctg cagcccactt ttgacccggc tcccgctccc ccacctgggg caccacttat
     1441 ctgggcccag ttcgagcggt ccccgggagg cggacctgca gctccggtat cttcttcctg
     1501 ctcttcttct gcatcttcgt ctgcttcttc ctcctccgtg gtcttccccg ggggtggcgc
     1561 cagtgcgccc tccaacgcca acctggggct attggtgcac cgccggctgc accctggcac
     1621 cagctgcccg cgcctgtctc cacccttgca catggccccg ggggcgggag agcaccacct
     1681 ggctcgccgg gtgcgcagcg acccgggtgg aggaggcctg gcctacgccg cttatgccaa
     1741 cgggctgggg gcacagctgc ctggcttgca gccgtcggac acgtcgggct cctcctcttc
     1801 gtccagctcc tcctccagct cttcatcctc ttcctccggg cttcggcgta aaggcagccg
     1861 cgactgctcc gtgtgcttcg agagcgaagt gattgccgcg ctggtgccct gtggccacaa
     1921 cctcttctgc atggagtgcg ccaatcgcat ctgtgagaag agcgagcccg agtgcccggt
     1981 ctgccacacc gcggtcactc aggccatccg catcttttct taaaggcagc gggcgctgct
     2041 agtgcgcacc gtgctggggg aagggggaac ccctccccac cctctttccc cagcgctcgc
     2101 ctgcctccct gggtgccccc cctctccctt ctccttcccg gccccaccaa cactctgaga
     2161 tccgagagga gcttggaaag ctgtagtatc cgctcatttt taaaatttaa tttttaagta
     2221 aaggaatttg ccaggatatc tgcatcaaga gtactgtagc ctgggaaacc tgaacacctg
     2281 aaatgcatgc tctataaata ataggaacgg cgacattcta gtaatgatag tttttacact
     2341 gtacttaata ggaagcttcc aaaagaagaa aaccccacaa gttttccatt ttcttaaagt
     2401 aggaaaaaat gaacagtaat aattatgatg aagatgatag tagtgctatg ggatgtgtgg
     2461 actgtttagt gtgttcccct ttgtgggtgg gttcctatga tacttattat agaacacagt
     2521 ggatcctttt tgaatgttcg tggaagggcc aggagttcct gtgaaaccag gatactgcag
     2581 ctttattaaa gttaaagaaa ctgtaacata tctcttatat attaaaaacg tttaaaagtt
     2641 ttaaagagaa attgcattaa tacagattga agtattttat tcttttttga cttgaaaaat
     2701 tatatttcat attgcaaaga tgtttacaag tattttaatt taagttcagt gaactttttt
     2761 gtagctgggt taaatctttt tattttagta tggccttatg gcaaagaaca ctgtattatt
     2821 ttaataatca cacaattgtg acggaattac aaccataaaa tgtgtaatgt tttgaacagt
     2881 attctgttgg gatggagatt ttataggttc agacaaatct tctagatctg cttcacccag
     2941 catattttct attcagtgat ataaagcata ttttattcta tattattaca aaaacggaaa
     3001 tgtataaaca tgtcaaaaag aactgttgat gctttctaac atttgtataa atagaattca
     3061 gtgcaagtta caaaaattct gttgcaccac tctagtttta gtatttctat tttaatacat
     3121 ttgtttacca cttgtttatg tatatgtagg tgatgttact tgagcttaaa tgtactttac
     3181 tgagcaaagt ttaaaaaaca aagtatattt tattttatga taaagggcct ttaacctcat
     3241 ggtcaaatac taatattata tttgctgaga caagatttga aattgtatca agagttttat
     3301 ttttctgaca tttaaagttc tacataataa aggtaaaact taagtaatgg tgctacttca
     3361 ttttttaagt atttctatat aaataaaata ttgaagaaaa tctta
//
