LOCUS       NM_001093725            6591 bp    mRNA    linear   PRI 15-JUL-2024
DEFINITION  Homo sapiens mex-3 RNA binding family member A (MEX3A), mRNA.
ACCESSION   NM_001093725 XM_044166 XM_937993
VERSION     NM_001093725.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6591)
  AUTHORS   Xu,J., Chen,S., Hao,T., Liu,G., Zhang,K., Zhang,C. and He,Y.
  TITLE     MEX3A promotes colorectal cancer migration, invasion and EMT via
            regulating the Wnt/beta-catenin signaling pathway
  JOURNAL   J Cancer Res Clin Oncol 150 (6), 319 (2024)
   PUBMED   38914858
  REMARK    GeneRIF: MEX3A promotes colorectal cancer migration, invasion and
            EMT via regulating the Wnt/beta-catenin signaling pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6591)
  AUTHORS   Chen,R.X., Xu,S.D., Deng,M.H., Hao,S.H., Chen,J.W., Ma,X.D.,
            Zhuang,W.T., Cao,J.H., Lv,Y.R., Lin,J.L., Li,S.Y., Qiao,G.B.,
            Xie,D. and Wang,F.W.
  TITLE     Mex-3 RNA binding family member A (MEX3A)/circMPP6 complex promotes
            colorectal cancer progression by inhibiting autophagy
  JOURNAL   Signal Transduct Target Ther 9 (1), 80 (2024)
   PUBMED   38565536
  REMARK    GeneRIF: Mex-3 RNA binding family member A (MEX3A)/circMPP6 complex
            promotes colorectal cancer progression by inhibiting autophagy.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6591)
  AUTHORS   Fang,S., Zheng,L., Chen,X., Guo,X., Ding,Y., Ma,J., Ding,J.,
            Chen,W., Yang,Y., Chen,M., Zhao,Z., Tu,J. and Ji,J.
  TITLE     MEX3A determines in vivo hepatocellular carcinoma progression and
            induces resistance to sorafenib in a Hippo-dependent way
  JOURNAL   Hepatol Int 17 (6), 1500-1518 (2023)
   PUBMED   37460832
  REMARK    GeneRIF: MEX3A determines in vivo hepatocellular carcinoma
            progression and induces resistance to sorafenib in a
            Hippo-dependent way.
REFERENCE   4  (bases 1 to 6591)
  AUTHORS   Feng,G., Wang,P., Zhang,H., Cheng,S., Xing,Y. and Wang,Y.
  TITLE     MEX3A induces the development of thyroid cancer via targeting CREB1
  JOURNAL   Cell Biol Int 47 (11), 1843-1853 (2023)
   PUBMED   37529875
  REMARK    GeneRIF: MEX3A induces the development of thyroid cancer via
            targeting CREB1.
REFERENCE   5  (bases 1 to 6591)
  AUTHORS   Chen,W., Hu,L., Lu,X., Wang,X., Zhao,C., Guo,C., Li,X., Ding,Y.,
            Zhao,H., Tong,D., Wang,L. and Huang,C.
  TITLE     The RNA binding protein MEX3A promotes tumor progression of breast
            cancer by post-transcriptional regulation of IGFBP4
  JOURNAL   Breast Cancer Res Treat 201 (3), 353-366 (2023)
   PUBMED   37433992
  REMARK    GeneRIF: The RNA binding protein MEX3A promotes tumor progression
            of breast cancer by post-transcriptional regulation of IGFBP4.
REFERENCE   6  (bases 1 to 6591)
  AUTHORS   Jiang,S., Meng,L., Chen,X., Liu,H., Zhang,J., Chen,F., Zheng,J.,
            Liu,H., Wang,F., Hu,J. and Li,Z.
  TITLE     MEX3A promotes triple negative breast cancer proliferation and
            migration via the PI3K/AKT signaling pathway
  JOURNAL   Exp Cell Res 395 (2), 112191 (2020)
   PUBMED   32738346
  REMARK    GeneRIF: MEX3A promotes triple negative breast cancer proliferation
            and migration via the PI3K/AKT signaling pathway.
REFERENCE   7  (bases 1 to 6591)
  AUTHORS   Liang,J., Li,H., Han,J., Jiang,J., Wang,J., Li,Y., Feng,Z.,
            Zhao,R., Sun,Z., Lv,B. and Tian,H.
  TITLE     Mex3a interacts with LAMA2 to promote lung adenocarcinoma
            metastasis via PI3K/AKT pathway
  JOURNAL   Cell Death Dis 11 (8), 614 (2020)
   PUBMED   32792503
  REMARK    GeneRIF: Mex3a interacts with LAMA2 to promote lung adenocarcinoma
            metastasis via PI3K/AKT pathway.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 6591)
  AUTHORS   Pereira,B., Sousa,S., Barros,R., Carreto,L., Oliveira,P.,
            Oliveira,C., Chartier,N.T., Plateroti,M., Rouault,J.P.,
            Freund,J.N., Billaud,M. and Almeida,R.
  TITLE     CDX2 regulation by the RNA-binding protein MEX3A: impact on
            intestinal differentiation and stemness
  JOURNAL   Nucleic Acids Res 41 (7), 3986-3999 (2013)
   PUBMED   23408853
REFERENCE   9  (bases 1 to 6591)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   10 (bases 1 to 6591)
  AUTHORS   Buchet-Poyau,K., Courchet,J., Le Hir,H., Seraphin,B., Scoazec,J.Y.,
            Duret,L., Domon-Dell,C., Freund,J.N. and Billaud,M.
  TITLE     Identification and characterization of human Mex-3 proteins, a
            novel family of evolutionarily conserved RNA-binding proteins
            differentially localized to processing bodies
  JOURNAL   Nucleic Acids Res 35 (4), 1289-1300 (2007)
   PUBMED   17267406
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL355388.30, AY950677.1, AK125482.1 and CX873216.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001093725.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY950677.1, BG473450.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000532414.3/ ENSP00000432845.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-467               AL355388.30        175679-176145       c
            468-2030            AY950677.1         1-1563
            2031-2732           AK125482.1         1066-1767
            2733-3027           CX873216.1         374-668
            3028-4182           AK125482.1         2063-3217
            4183-6591           AL355388.30        165693-168101       c
FEATURES             Location/Qualifiers
     source          1..6591
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q22"
     gene            1..6591
                     /gene="MEX3A"
                     /gene_synonym="MEX-3A; RKHD4; RNF162"
                     /note="mex-3 RNA binding family member A"
                     /db_xref="GeneID:92312"
                     /db_xref="HGNC:HGNC:33482"
                     /db_xref="MIM:611007"
     exon            1..921
                     /gene="MEX3A"
                     /gene_synonym="MEX-3A; RKHD4; RNF162"
                     /inference="alignment:Splign:2.1.0"
     CDS             468..2030
                     /gene="MEX3A"
                     /gene_synonym="MEX-3A; RKHD4; RNF162"
                     /note="ring finger and KH domain containing 4; ring finger
                     and KH domain containing protein; RING finger and KH
                     domain-containing protein 4"
                     /codon_start=1
                     /product="RNA-binding protein MEX3A"
                     /protein_id="NP_001087194.1"
                     /db_xref="CCDS:CCDS53377.1"
                     /db_xref="GeneID:92312"
                     /db_xref="HGNC:HGNC:33482"
                     /db_xref="MIM:611007"
                     /translation="MPSLVVSGIMERNGGFGELGCFGGSAKDRGLLEDERALQLALDQ
                     LCLLGLGEPPAPTAGEDGGGGGGGAPAQPAAPPQPAPPPPPAAPPAAPTAAPAAQTPQ
                     PPTAPKGASDAKLCALYKEAELRLKGSSNTTECVPVPTSEHVAEIVGRQGCKIKALRA
                     KTNTYIKTPVRGEEPVFMVTGRREDVATARREIISAAEHFSMIRASRNKSGAAFGVAP
                     ALPGQVTIRVRVPYRVVGLVVGPKGATIKRIQQQTNTYIITPSRDRDPVFEITGAPGN
                     VERAREEIETHIAVRTGKILEYNNENDFLAGSPDAAIDSRYSDAWRVHQPGCKPLSTF
                     RQNSLGCIGECGVDSGFEAPRLGEQGGDFGYGGYLFPGYGVGKQDVYYGVAETSPPLW
                     AGQENATPTSVLFSSASSSSSSSAKARAGPPGAHRSPATSAGPELAGLPRRPPGEPLQ
                     GFSKLGGGGLRSPGGGRDCMVCFESEVTAALVPCGHNLFCMECAVRICERTDPECPVC
                     HITATQAIRIFS"
     exon            922..6591
                     /gene="MEX3A"
                     /gene_synonym="MEX-3A; RKHD4; RNF162"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6571..6576
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MEX3A"
                     /gene_synonym="MEX-3A; RKHD4; RNF162"
                     /note="hexamer: ATTAAA"
     polyA_site      6591
                     /gene="MEX3A"
                     /gene_synonym="MEX-3A; RKHD4; RNF162"
                     /note="major polyA site"
ORIGIN      
        1 aaaagagttt gagcgctgga aggggctggg ctctattggg ggccactgag cgccgctccc
       61 ggactggggc tcggtgcggg agcctaacgg gggcgcctgg acagcggggg ctagagactc
      121 ccaggtccga ggcgggaggg gtgggggcag agatcctgca gccccccgcc ccccgtcacc
      181 cccggagagg agaggagatc tgctttcttg gttttgcttc tctttccccc cacccccacc
      241 ccgggggctg gggcgagggg agtcgggtta cagggtgttt ggggaggggg gcttaggggg
      301 agggtctatc tttctatctc gctttcttcc cccctcccca gttctttgtt cccccctccc
      361 cacacacccc ctcctctcct ctcccctccc ctcctctctc ctcttttccc ttccaccacc
      421 tctctctctc tctctccctc tctctctccc ccagcttttg tttcgccatg cctagtctag
      481 tggtatctgg aataatggaa agaaatgggg gctttggaga actaggatgt ttcgggggaa
      541 gcgctaagga ccgagggctg ctggaagacg agcgcgccct tcagctggct ctcgatcaac
      601 tctgcctcct gggtttgggg gagccccccg cccccacggc gggcgaggac gggggaggtg
      661 gggggggcgg cgcccccgcg cagccggccg cccccccgca gccggccccg ccgccgccgc
      721 ccgcggcgcc cccggccgcc ccgacggcgg cccccgcagc gcagacgccc cagcccccca
      781 ccgcccccaa aggggcgagc gacgccaagc tctgcgctct ctacaaagag gccgagctgc
      841 gcctgaaggg cagcagcaac accacggagt gtgttcccgt gcccacctcc gagcacgtgg
      901 ccgagatcgt gggcaggcaa ggctgcaaga ttaaggcctt gagggccaag accaacacct
      961 acatcaagac accggtgagg ggcgaggaac cagtgttcat ggtgacaggg cgacgggagg
     1021 acgtggccac agcccggcgg gaaatcatct cagcagcgga gcacttctcc atgatccgtg
     1081 cctcccgcaa caagtcaggc gccgcctttg gtgtggctcc tgctctgccc ggccaggtga
     1141 ccatccgtgt gcgggtgccc taccgcgtgg tggggctggt ggtgggcccc aaaggggcaa
     1201 ccatcaagcg catccagcag caaaccaaca catacattat cacaccaagc cgtgaccgcg
     1261 accccgtgtt cgagatcacg ggtgccccag gcaacgtgga gcgtgcgcgc gaggagatcg
     1321 agacgcacat cgcggtgcgc actggcaaga tcctcgagta caacaatgaa aacgacttcc
     1381 tggcggggag ccccgacgca gcaatcgata gccgctactc cgacgcctgg cgggtgcacc
     1441 agcccggctg caagcccctc tccaccttcc ggcagaacag cctgggctgc atcggcgagt
     1501 gcggagtgga ctctggcttt gaggccccac gcctgggtga gcagggcggg gactttggct
     1561 acggcgggta cctctttccg ggctatggcg tgggcaagca ggatgtgtac tacggcgtgg
     1621 ccgagactag ccccccgctg tgggcgggcc aggagaacgc cacgcccacc tccgtgctct
     1681 tctcctctgc ctcctcctcc tcctcctctt ccgccaaggc ccgcgctggg cccccgggcg
     1741 cacaccgctc ccctgccact tccgcgggac ccgagctggc cggactcccg aggcgccccc
     1801 cgggagagcc gctccagggc ttctctaaac ttggtggggg cggcctgcgg agccccggcg
     1861 gcgggcggga ttgcatggtc tgctttgaga gcgaagtgac tgccgccctt gtgccctgcg
     1921 gacacaacct gttctgcatg gagtgtgcag tacgcatctg cgagaggacg gacccagagt
     1981 gtcccgtctg ccacatcaca gccacgcaag ccatccgaat attctcctaa gccccgtgcc
     2041 ccatgcctcc ggggcccact ccactgggcc caccctggac ctgttttcca ctaaagcctt
     2101 ttggaaagcg gtgatttgag gggcaaggtg cttagagata ctcgctcgct ggggaagggg
     2161 ggagggaggc agtggtggct ggagggtgcg ccactttcag agcctctggt caccctgtcc
     2221 tggaaagatt gggagggggc cagactgaaa attttactag agttacaact ctgatacctc
     2281 aacacaccct taaatctgga agcagctaag agaaactttt gttttgccag aggtggccac
     2341 taaggcattc tgacgccctc tgcccacctc ccccgctgtg tgtcactcca ccccttcttc
     2401 cgaggagggg gtgggtaaaa gggagaggga gaattaccac ctgtatctag aggtgctctt
     2461 tgcaatccct aagccctctg gtcctgacct ccgacctcct aacatgaccc tttacctccc
     2521 accccacccc catatcctgt ttgggaaact gtcaccagtt tccagcagtg taagggagtt
     2581 ggagtcctat cagaagttgc atagatcttc taggggttgg ggagagaagc atgtcaatcg
     2641 tttctgtggc tgaaaggctc agaagccatc tgtccccaca aagctgggct agaggaatct
     2701 ggagaggagt cctcctctct gcccctgtcc cctgcagtgt ttcccttcac tctctccgcc
     2761 tatcttccct tcctttggga tcttcccttt cctcaactct ttcctttccc tccagctctt
     2821 tgctttgctt tcttttggtg gctgtcactc ccagctctgt cttgttcctt gtctttgtct
     2881 ttcttccctt ccccctgccc ctgcccctac cagcccagct ttggggacac catccttctg
     2941 gggagaagta gggggaggaa tatttggatg gtccctccat tcctcttcag gcatctggag
     3001 gccctctccc ccactcctcc aaagaaacat ctcaaattat tgatggaatg tatccccatt
     3061 ctcagtgaaa atgtgaggag gggactaata ctggggtaaa gggtcaaacc cccaccttca
     3121 tcactatggg cattatattt agggagtagt tcttgggctg gattttctgg ttgtggaagt
     3181 gggggcgcca gagtagtgtg tctgctattt aaaggagcag gaaagggcgt gaggcaggag
     3241 gagagactgg tggagggaag agctgctcct cccatgcagt gcccgactcc ctgcacccct
     3301 ctcaacctga cctgaacctt tattgaatcc ttattagctt gaatccttat tagcttgaat
     3361 cctccatgca aatcatggag tctgtgtccc acctgatgtg gttgaggaga agccaggtct
     3421 tcaaagaggg gtcagcctgg ggcaaagcag gactgggggg aggtgggcag cagggcctat
     3481 tctgagaatc acatattgtt acaggccttg cacccccttt gctgcttccc tcctgctcat
     3541 ttggggctgc caccagctct ccaccctcct ggttccgctg gccgggccaa gagaggatgg
     3601 agggatggga gtcccaggag atccttgtaa atagtggggt gggactgttc tgagtgatca
     3661 cccgagcact taaagctcca gagtcccatt cttcctggat ggagcaggtg gaggtgcaga
     3721 ggggatttcc tcctctcctt cctcctgtcg agaattaaca cctctccaca gccttcccct
     3781 ccagaacacc agccagggag gggtggggaa ggaggtcaca gccaagaaaa ctgccctgtg
     3841 acgacttccc tccttcccgc ctatgtgagc catcctgaga tgtctgtaca atagaaacca
     3901 aaccaaatgg gcaccctcgg ttgccggggg gcaggtgggg aggggggtgg gaagaaggga
     3961 tgtctgtctg tcgtccccct ccccctctcc actctttacc cacaaaggca gaagactgtt
     4021 acactagggg gctcagcaaa ttcaatccca cccttaccaa ttgagccaaa cctagaaaca
     4081 aacacaaaac acgaatagtg agagacaaaa tagaggagag aaagagagca tgagagggag
     4141 cgagacaggc gaccaacaca gaggagagaa aacaaaaata gcaaaaaaaa aaaaaaaaag
     4201 cagttcttta taatttaata ttctatttta ataaaggcgt ttattaccat ataaatgtag
     4261 caaagaacct gggctaatat gaaaaaaaaa gactttttat taggtaattt attatatgaa
     4321 aaggatattt tattttatga taaagtgatc cttaaaaaaa taaaaaaact ttagaaggtt
     4381 tagaatatat gtagggagag aagaagaaaa aaatacattt gtattcagag ttaaatctta
     4441 aaaaaaaaaa gtgtttttaa tatatgtttg ggtttacgtt gcttttttcc cccacttttt
     4501 ttttggggag gaatgtcatt tgcttttctt gggggagcat cccgggggtg aatggtggag
     4561 agaggagctg ggggaacccg gtccctcctg ggacccttcc agtagattgg atttcactcc
     4621 atggactcct cctcccctct ccccctcccc ctcaggggag ccggcagagc caaacaaaga
     4681 aagggattaa caagaaagga agaagctgta ggactaagga ctgaggatcc tggggtgtcc
     4741 cccaccactt tcccctgccc tgtcgcaggg gcaagtgagg agggggaatc cagaattaag
     4801 gcctagcagg cctataggaa ccctcagaga tgtgtgagat ttaagagatc tagatttttt
     4861 tttaaccaaa aacaagagag aaagagaaga aaaagagaaa ccgaggggtt taaaagaaaa
     4921 gaatactaca aaataataat tattaataat aataattcaa atttatttca tataatccta
     4981 gagagagaaa gaaacaatta ctagttactt agtagacaat attaagatag cttaaagttt
     5041 agtagcattg agggcccctg ggtccagtag aatgtataaa agttgtaagg aaaagataaa
     5101 tagaggaggg aagtggctga gtccaccctg agttgcccaa tcttcagata ccagggttgg
     5161 atcaggttgc tagtttaaga ttgggagctt ccagtctgct ggggttgatt ctgagaatcc
     5221 ttggattttt aaattgtagg acaaagaaat gaggggttca tttcccaggg tcttggaaag
     5281 gatgcacact gatcatctca ataagacagg ggctgggttg ggggcagcag aggaggccaa
     5341 gcacattcac ctgcacccct agtacctggg cagcccatac tccaatgtgg tatgtcccct
     5401 cctggggctc ccagctcaaa ccctcccatg cctgcttccc ccaggcctaa ctgaggaagt
     5461 ccttcttgaa gtgtgacctc ggtccacttc tctacagatt gatttaagag cctgggaagt
     5521 cattccacaa acagacacac atgcacacac gcttctcacc ttcagagctt caagagcact
     5581 gaggcgatca gtcccctacc cctgttccca tccagctttc cacttagctt tgacctccat
     5641 ggcagcagta gcagtaacaa tctcagtaat tgttctttaa agctgactcg ttcttcacct
     5701 acttgcaaag tgctttcttg tctcataaaa gttagattcc aagaaggact tcccacggag
     5761 tggagtggaa acactgtcct tgaaggcctg ggagaaaggc atccccatgg gcacagaggc
     5821 tggggaaagg cacagggact ttgggtgacc ctaaccctga ccctctgctc cagttcacct
     5881 ccatctatat gtgttcaggt aggggtcatc tactgtaccc tggcctggga acacattgcc
     5941 ctccccacac aaaactggag ggcttggctt ctgcgtgtga gaaatcaaca tttttaaagc
     6001 acttgccttc taccaacccc agcttgcaat cactgggcct tcccctccta tccaaggggt
     6061 tggaggggcc ccttggctct ccttttggca ggaggagcct gcttcattac accaatgact
     6121 ctgccatccc cctccctggc cctagacccc aaacacatct ccctctaccc aatttactct
     6181 tctcgcccca cctagggaca gattccccct gctctttttg tcctagaaac cccgctagtt
     6241 tgggatggta gcgtctgggg tggggagggc ttccccttcc ccactcgagg gtgcgggtgg
     6301 ggaagggggg gtgggtggag acagccctgg ggcagggagg atggtctctc cactgtagaa
     6361 agtagagtag gattgtggtc agacttaatt tgaggcatct agtgaagaca cgtacaaatc
     6421 caccaaggaa aaagatttca aaagcaaaat aaaagcggga aataaaacag acccaagaat
     6481 aatcaagtca aagtgatgtt gcacaaaatg cagagaaacc aagaaggggg agggttaatg
     6541 tattaaatgt gctattaaga acttaatttt attaaaagta ctattactta a
//
