LOCUS       NM_016025               3153 bp    mRNA    linear   PRI 18-NOV-2024
DEFINITION  Homo sapiens methyltransferase 9, His-X-His N1(pi)-histidine
            (METTL9), transcript variant 1, mRNA.
ACCESSION   NM_016025
VERSION     NM_016025.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3153)
  AUTHORS   Li,M., Zhi,Z., Jiang,X., Duan,G.C., Zhu,W.N., Pang,Z., Wang,L.,
            Ge,R., Dai,X., Liu,J.M., Chen,T.Y., Jia,J.J., Li,J.M. and Sun,L.N.
  TITLE     METTL9 derived circular RNA circ-METTL9 sponges miR-551b-5p to
            accelerate colorectal cancer progression by upregulating CDK6
  JOURNAL   Carcinogenesis 44 (6), 463-475 (2023)
   PUBMED   37158456
  REMARK    GeneRIF: METTL9 derived circular RNA circ-METTL9 sponges
            miR-551b-5p to accelerate colorectal cancer progression by
            upregulating CDK6.
REFERENCE   2  (bases 1 to 3153)
  AUTHORS   Wang,X., Xie,H., Guo,Q., Cao,D., Ru,W., Zhao,S., Zhu,Z., Zhang,J.,
            Pan,W., Yao,X. and Xu,C.
  TITLE     Molecular basis for METTL9-mediated N1-histidine methylation
  JOURNAL   Cell Discov 9 (1), 38 (2023)
   PUBMED   37015930
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3153)
  AUTHORS   Zhao,W., Zhou,Y., Li,C., Bi,Y., Wang,K., Ye,M. and Li,H.
  TITLE     Molecular basis for protein histidine N1-specific methylation of
            the 'His-x-His' motifs by METTL9
  JOURNAL   Cell Insight 2 (3), 100090 (2023)
   PUBMED   37398635
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3153)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   5  (bases 1 to 3153)
  AUTHORS   Daitoku,H., Someya,M., Kako,K., Hayashi,T., Tajima,T., Haruki,H.,
            Sekiguchi,N., Uetake,T., Akimoto,Y. and Fukamizu,A.
  TITLE     siRNA screening identifies METTL9 as a histidine
            Npi-methyltransferase that targets the proinflammatory protein
            S100A9
  JOURNAL   J Biol Chem 297 (5), 101230 (2021)
   PUBMED   34562450
  REMARK    GeneRIF: siRNA screening identifies METTL9 as a histidine
            Npi-methyltransferase that targets the proinflammatory protein
            S100A9.
REFERENCE   6  (bases 1 to 3153)
  AUTHORS   Shu,K.X., Wu,L.X., Xie,Y.F., Zhao,J.F., Liang,Y.L. and Li,B.
  TITLE     Characterization of the human PAP1 gene and its homologue possible
            involvement in mouse embryonic development
  JOURNAL   Colloids Surf B Biointerfaces 52 (1), 22-30 (2006)
   PUBMED   16837177
  REMARK    GeneRIF: cloned the PAP1 gene, a p53 activated protein, from a
            U251-pTet-p53 cell line which carried a wild-type p53 transgene.
REFERENCE   7  (bases 1 to 3153)
  AUTHORS   Tsang,H.T., Connell,J.W., Brown,S.E., Thompson,A., Reid,E. and
            Sanderson,C.M.
  TITLE     A systematic analysis of human CHMP protein interactions:
            additional MIT domain-containing proteins bind to multiple
            components of the human ESCRT III complex
  JOURNAL   Genomics 88 (3), 333-346 (2006)
   PUBMED   16730941
REFERENCE   8  (bases 1 to 3153)
  AUTHORS   Shu,K.X., Li,B., Liang,Y.L., Xie,Y.F., Zhang,J.C. and Wei,J.M.
  TITLE     Effects of exogenous p53 transfection on the gene expression in the
            human brain glioma cell line U251
  JOURNAL   Colloids Surf B Biointerfaces 47 (2), 126-131 (2006)
   PUBMED   16413759
REFERENCE   9  (bases 1 to 3153)
  AUTHORS   Harrington,J.J., Sherf,B., Rundlett,S., Jackson,P.D., Perry,R.,
            Cain,S., Leventhal,C., Thornton,M., Ramachandran,R.,
            Whittington,J., Lerner,L., Costanzo,D., McElligott,K., Boozer,S.,
            Mays,R., Smith,E., Veloso,N., Klika,A., Hess,J., Cothren,K., Lo,K.,
            Offenbacher,J., Danzig,J. and Ducar,M.
  TITLE     Creation of genome-wide protein expression libraries using random
            activation of gene expression
  JOURNAL   Nat Biotechnol 19 (5), 440-445 (2001)
   PUBMED   11329013
REFERENCE   10 (bases 1 to 3153)
  AUTHORS   Bates,E.E., Kissenpfennig,A., Peronne,C., Mattei,M.G., Fossiez,F.,
            Malissen,B. and Lebecque,S.
  TITLE     The mouse and human IGSF6 (DORA) genes map to the inflammatory
            bowel disease 1 locus and are embedded in an intron of a gene of
            unknown function
  JOURNAL   Immunogenetics 52 (1-2), 112-120 (2000)
   PUBMED   11132146
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CF146931.1 and BC000195.1.
            
            On Nov 24, 2018 this sequence version replaced NM_016025.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC000195.1, SRR1803616.188373.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000358154.8/ ENSP00000350874.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                CF146931.1         108-121
            15-3153             BC000195.1         1-3139
FEATURES             Location/Qualifiers
     source          1..3153
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p12.2"
     gene            1..3153
                     /gene="METTL9"
                     /gene_synonym="CGI-81; DREV; DREV1; hMETTL9; PAP1"
                     /note="methyltransferase 9, His-X-His N1(pi)-histidine"
                     /db_xref="GeneID:51108"
                     /db_xref="HGNC:HGNC:24586"
                     /db_xref="MIM:609388"
     exon            1..322
                     /gene="METTL9"
                     /gene_synonym="CGI-81; DREV; DREV1; hMETTL9; PAP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             158..1114
                     /gene="METTL9"
                     /gene_synonym="CGI-81; DREV; DREV1; hMETTL9; PAP1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; DORA reverse strand protein 1;
                     methyltransferase-like protein 9; p53 activated protein 1;
                     CTB-31N19.3; protein-L-histidine N-pros-methyltransferase;
                     methyltransferase like 9; methyltransferase 9, His-X-His
                     N1-histidine"
                     /codon_start=1
                     /product="protein-L-histidine N-pros-methyltransferase
                     isoform 1 precursor"
                     /protein_id="NP_057109.3"
                     /db_xref="CCDS:CCDS10598.2"
                     /db_xref="GeneID:51108"
                     /db_xref="HGNC:HGNC:24586"
                     /db_xref="MIM:609388"
                     /translation="MRLLAGWLCLSLASVWLARRMWTLRSPLTRSLYVNMTSGPGGPA
                     AAAGGRKENHQWYVCNREKLCESLQAVFVQSYLDQGTQIFLNNSIEKSGWLFIQLYHS
                     FVSSVFSLFMSRTSINGLLGRGSMFVFSPDQFQRLLKINPDWKTHRLLDLGAGDGEVT
                     KIMSPHFEEIYATELSETMIWQLQKKKYRVLGINEWQNTGFQYDVISCLNLLDRCDQP
                     LTLLKDIRSVLEPTRGRVILALVLPFHPYVENVGGKWEKPSEILEIKGQNWEEQVNSL
                     PEVFRKAGFVIEAFTRLPYLCEGDMYNDYYVLDDAVFVLKPV"
     exon            323..513
                     /gene="METTL9"
                     /gene_synonym="CGI-81; DREV; DREV1; hMETTL9; PAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            514..723
                     /gene="METTL9"
                     /gene_synonym="CGI-81; DREV; DREV1; hMETTL9; PAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            724..908
                     /gene="METTL9"
                     /gene_synonym="CGI-81; DREV; DREV1; hMETTL9; PAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            909..3153
                     /gene="METTL9"
                     /gene_synonym="CGI-81; DREV; DREV1; hMETTL9; PAP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1598..1603
                     /regulatory_class="polyA_signal_sequence"
                     /gene="METTL9"
                     /gene_synonym="CGI-81; DREV; DREV1; hMETTL9; PAP1"
                     /note="hexamer: AATAAA"
     polyA_site      1618
                     /gene="METTL9"
                     /gene_synonym="CGI-81; DREV; DREV1; hMETTL9; PAP1"
     regulatory      3130..3135
                     /regulatory_class="polyA_signal_sequence"
                     /gene="METTL9"
                     /gene_synonym="CGI-81; DREV; DREV1; hMETTL9; PAP1"
                     /note="hexamer: AATAAA"
     polyA_site      3153
                     /gene="METTL9"
                     /gene_synonym="CGI-81; DREV; DREV1; hMETTL9; PAP1"
                     /note="major polyA site"
ORIGIN      
        1 ctccccaccc ccagcctttg ccctgaaggg ggctggatgg gcaaggcggc cgcgatggct
       61 cgagctcggg cggtggcggc ggtggccgga ggcggcggtg cctcctcctc ctcgccccgg
      121 cgccggcggt gatccgagcg agcggccgcg gcccccgatg agactgctgg cgggctggct
      181 gtgcctgagc ctggcgtccg tgtggctggc gcggaggatg tggacgctgc ggagcccgct
      241 cacccgctcc ctgtacgtga acatgactag cggcccgggt gggccggcgg cggccgcggg
      301 cggcaggaag gagaaccacc agtggtatgt gtgcaacaga gagaaattat gcgaatcact
      361 ccaggctgtc tttgttcaga gttaccttga tcaaggaaca cagatcttct taaacaacag
      421 cattgagaaa tcgggctggc tatttatcca attatatcat tcttttgtgt catctgtttt
      481 tagcctgttt atgtctagaa catctatcaa tgggttgcta ggaagaggct caatgtttgt
      541 gttttcacca gatcagtttc agagactgct taaaattaat ccagactgga aaacccacag
      601 acttcttgat ttaggtgctg gagatggaga agtcacaaaa atcatgagcc ctcattttga
      661 agaaatctat gccactgagc tttctgaaac tatgatatgg cagcttcaga aaaagaaata
      721 cagagtcctt ggtataaatg aatggcagaa tacggggttc cagtatgatg tcatcagctg
      781 cctgaacttg ctggaccgct gtgatcagcc cctgactttg ttaaaagata tcagaagtgt
      841 cttggagcca actagaggca gggtcatcct tgcccttgtc ctcccctttc atccctatgt
      901 ggaaaacgta ggtggcaagt gggagaaacc atcagaaatt ttggaaatca aaggacagaa
      961 ctgggaagaa caagtgaata gtctgcctga agttttcaga aaagctggtt ttgttatcga
     1021 agctttcacc agactaccat acctgtgtga aggcgacatg tataatgact actacgttct
     1081 ggatgacgct gtctttgttc tcaaaccagt ataaacacgt ggaggtcgaa gtcttcagag
     1141 tccgcaccct ccgggatgtg cccttggaag agggtctgtg ttcacaatta cgtgaaggga
     1201 ggacccttgg ggaccgccat tctaaatatc atgtaggaat ttaaaaagcc aaaatactaa
     1261 ttatttcttt gtagtgtgta aaggaatgtt tttaaaagac aaaaacccaa ctctttgtgg
     1321 atttttatca actctttact cagagccact ctccaatgca ggtcacactc caattatgat
     1381 ggaagatatt ttttatactt aattgcagta gggactcatt cccagacaaa gcaatagtca
     1441 cgacttcatg gaaccaatca atggattgtt ttttgaagac tggcaataaa gctgtccatt
     1501 caattccaaa tactggtttt aaggtatagc cactgatatt ctttcatgtt tagaaattct
     1561 ttctgttatt attcaagaaa atgtttttaa tcatgctaat aaactttttt ggagatgact
     1621 ttggcatcat gtttgaattc atataaagct cccctagcat tttttattgg tttggcttca
     1681 ggagtaccca aatagtagca ttatgagaat gacgcagaca atttgaatag gggggaagga
     1741 aggcttcaga cttgggggaa ggggagatta ttgcaaattg cagtgaacac tgagtcagta
     1801 aaaaaaaaaa acagaaacaa aaacccagcc tcattcagat acagaacttc agggacccct
     1861 ccccccaccc ccccagttaa tgctgctgtg aaaaatgcaa aataacctgg ttctgacttt
     1921 gtgatcactc atgtcccata cactgaactt tgtttttttc tggacaatct caggttctca
     1981 gaattgaaac attcagtttt gtctactgac aaaatgcaac taaaaatgtt ttaattcaac
     2041 ttcttactct acacttatat acctctctcc cagagcttgg ctcttccctg aaatccttaa
     2101 aggagtttat tatttgccaa gaatatggtt tgatgaagac cgtgtcagac tcatgcattc
     2161 tggaatccgt gagtgcctcc aaccataaac ccagaaatgc tgccatagag gaacccatta
     2221 gcaagatcaa taaccatcgt ggatattcca aagagcagag catttaaccc agaatctgaa
     2281 atctcagtaa taacagaaat gtcaatatga gattgtggtt attaacaata tgttatcctc
     2341 actactttat ttcttttttc atccaggtgt ttcattaagt attctcattt atatgctcat
     2401 agaagtcatc agatcaacac attcactcca acacctgggt ataaaggcga attaaaacct
     2461 gaagaattac tttattattc attaagaact gcattcccac atcctcacac caatatcttc
     2521 cactgttact gtgcagtcat aataagagtt gggttatgtg atttatgcaa aattgttatt
     2581 ggtgtgttct aatgattttt ttccaggaat tcaagtaagt gaagtacaaa tacttagcac
     2641 catagattgt aaaaatagaa agaggaaatg agaaaactta atgtcgttct tgtacagttg
     2701 agttttgctt ctttataaac tgtctgttaa aatcaggggt tgctgttaga ctgtcaagca
     2761 gaagtgatgg atgttcaagg aggcaggttg ccccaaagtg ttttctaact ttcaagtaga
     2821 gaactttatg ctctaataag aaaaatacaa ctcattctta accacccccc caaaacagag
     2881 aaaacacata catttatgca ttttaaagat aaaaagtagt ttctcaaaaa aatctgaagt
     2941 tctctgaaaa ccagcttatt aaaagtgctg ttttgtggtg aaaattgaaa ccaaatccac
     3001 tcacatttcc tatcgggtct tgaaattctt ggtggtgtgt caccattcca ctagatggca
     3061 gtgttgctta ctgagtgtca atggcttttt tccccgtaaa tggaatcatg tttttctccc
     3121 ccaaagtaca ataaagctgc cttgtctgca cca
//
