LOCUS       NM_014168               1001 bp    mRNA    linear   PRI 08-DEC-2024
DEFINITION  Homo sapiens methyltransferase 5, N6-adenosine (METTL5), transcript
            variant 1, mRNA.
ACCESSION   NM_014168
VERSION     NM_014168.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1001)
  AUTHORS   Luo,M., Luo,X., Sun,J., Ao,X., Han,H. and Yang,X.
  TITLE     METTL5 enhances the mRNA stability of TPRKB through m6A
            modification to facilitate the aggressive phenotypes of
            hepatocellular carcinoma cell
  JOURNAL   Exp Cell Res 442 (1), 114219 (2024)
   PUBMED   39182664
  REMARK    GeneRIF: METTL5 enhances the mRNA stability of TPRKB through m[6]A
            modification to facilitate the aggressive phenotypes of
            hepatocellular carcinoma cell.
REFERENCE   2  (bases 1 to 1001)
  AUTHORS   Gong,S., Liu,H., Gou,H. and Sun,W.
  TITLE     METTL5: A Potential Biomarker for Nonsmall Cell Lung Cancer That
            Promotes Cancer Cell Proliferation by Interacting with IGF2BP3
  JOURNAL   Genet Test Mol Biomarkers 28 (8), 311-321 (2024)
   PUBMED   39023781
  REMARK    GeneRIF: METTL5: A Potential Biomarker for Nonsmall Cell Lung
            Cancer That Promotes Cancer Cell Proliferation by Interacting with
            IGF2BP3.
REFERENCE   3  (bases 1 to 1001)
  AUTHORS   Wu,J., Wang,L., Xi,S., Ma,C., Zou,F., Fang,G., Liu,F., Wang,X. and
            Qu,L.
  TITLE     Biological significance of METTL5 in atherosclerosis: comprehensive
            analysis of single-cell and bulk RNA sequencing data
  JOURNAL   Aging (Albany NY) 16 (8), 7267-7276 (2024)
   PUBMED   38663914
  REMARK    GeneRIF: Biological significance of METTL5 in atherosclerosis:
            comprehensive analysis of single-cell and bulk RNA sequencing data.
REFERENCE   4  (bases 1 to 1001)
  AUTHORS   Wang,Q., Huang,Y., Zhu,Y., Zhang,W., Wang,B., Du,X., Dai,Q.,
            Zhang,F. and Fang,Z.
  TITLE     The m6A methyltransferase METTL5 promotes neutrophil extracellular
            trap network release to regulate hepatocellular carcinoma
            progression
  JOURNAL   Cancer Med 13 (7), e7165 (2024)
   PUBMED   38613157
  REMARK    GeneRIF: The m6A methyltransferase METTL5 promotes neutrophil
            extracellular trap network release to regulate hepatocellular
            carcinoma progression.
REFERENCE   5  (bases 1 to 1001)
  AUTHORS   Xia,P., Zhang,H., Lu,H., Xu,K., Jiang,X., Jiang,Y., Gongye,X.,
            Chen,Z., Liu,J., Chen,X., Ma,W., Zhang,Z. and Yuan,Y.
  TITLE     METTL5 stabilizes c-Myc by facilitating USP5 translation to
            reprogram glucose metabolism and promote hepatocellular carcinoma
            progression
  JOURNAL   Cancer Commun (Lond) 43 (3), 338-364 (2023)
   PUBMED   36602428
  REMARK    GeneRIF: METTL5 stabilizes c-Myc by facilitating USP5 translation
            to reprogram glucose metabolism and promote hepatocellular
            carcinoma progression.
REFERENCE   6  (bases 1 to 1001)
  AUTHORS   Rong,B., Zhang,Q., Wan,J., Xing,S., Dai,R., Li,Y., Cai,J., Xie,J.,
            Song,Y., Chen,J., Zhang,L., Yan,G., Zhang,W., Gao,H., Han,J.J.,
            Qu,Q., Ma,H., Tian,Y. and Lan,F.
  TITLE     Ribosome 18S m6A Methyltransferase METTL5 Promotes Translation
            Initiation and Breast Cancer Cell Growth
  JOURNAL   Cell Rep 33 (12), 108544 (2020)
   PUBMED   33357433
  REMARK    GeneRIF: Ribosome 18S m(6)A Methyltransferase METTL5 Promotes
            Translation Initiation and Breast Cancer Cell Growth.
REFERENCE   7  (bases 1 to 1001)
  AUTHORS   Ignatova,V.V., Stolz,P., Kaiser,S., Gustafsson,T.H., Lastres,P.R.,
            Sanz-Moreno,A., Cho,Y.L., Amarie,O.V., Aguilar-Pimentel,A.,
            Klein-Rodewald,T., Calzada-Wack,J., Becker,L., Marschall,S.,
            Kraiger,M., Garrett,L., Seisenberger,C., Holter,S.M., Borland,K.,
            Van De Logt,E., Jansen,P.W.T.C., Baltissen,M.P., Valenta,M.,
            Vermeulen,M., Wurst,W., Gailus-Durner,V., Fuchs,H., Hrabe de
            Angelis,M., Rando,O.J., Kellner,S.M., Bultmann,S. and Schneider,R.
  TITLE     The rRNA m6A methyltransferase METTL5 is involved in pluripotency
            and developmental programs
  JOURNAL   Genes Dev 34 (9-10), 715-729 (2020)
   PUBMED   32217665
REFERENCE   8  (bases 1 to 1001)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   9  (bases 1 to 1001)
  AUTHORS   Richard,E.M., Polla,D.L., Assir,M.Z., Contreras,M., Shahzad,M.,
            Khan,A.A., Razzaq,A., Akram,J., Tarar,M.N., Blanpied,T.A.,
            Ahmed,Z.M., Abou Jamra,R., Wieczorek,D., van Bokhoven,H.,
            Riazuddin,S. and Riazuddin,S.
  TITLE     Bi-allelic Variants in METTL5 Cause Autosomal-Recessive
            Intellectual Disability and Microcephaly
  JOURNAL   Am J Hum Genet 105 (4), 869-878 (2019)
   PUBMED   31564433
REFERENCE   10 (bases 1 to 1001)
  AUTHORS   van Tran,N., Ernst,F.G.M., Hawley,B.R., Zorbas,C., Ulryck,N.,
            Hackert,P., Bohnsack,K.E., Bohnsack,M.T., Jaffrey,S.R., Graille,M.
            and Lafontaine,D.L.J.
  TITLE     The human 18S rRNA m6A methyltransferase METTL5 is stabilized by
            TRMT112
  JOURNAL   Nucleic Acids Res 47 (15), 7719-7733 (2019)
   PUBMED   31328227
  REMARK    GeneRIF: METTL5-TRMT112 partners act by extruding the adenosine to
            be modified from a double-stranded nucleic acid.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CA337169.1, AL523293.3 and BC000921.2.
            
            On Nov 23, 2018 this sequence version replaced NM_014168.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1, 2, and 3 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC000921.2, SRR1803613.201062.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03267766 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000260953.10/ ENSP00000260953.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                CA337169.1         28-39
            13-62               AL523293.3         21-70
            63-1001             BC000921.2         1-939
FEATURES             Location/Qualifiers
     source          1..1001
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q31.1"
     gene            1..1001
                     /gene="METTL5"
                     /gene_synonym="HSPC133; MRT72"
                     /note="methyltransferase 5, N6-adenosine"
                     /db_xref="GeneID:29081"
                     /db_xref="HGNC:HGNC:25006"
                     /db_xref="MIM:618628"
     exon            1..417
                     /gene="METTL5"
                     /gene_synonym="HSPC133; MRT72"
                     /inference="alignment:Splign:2.1.0"
     CDS             309..938
                     /gene="METTL5"
                     /gene_synonym="HSPC133; MRT72"
                     /note="methyltransferase-like protein 5; rRNA
                     N6-adenosine-methyltransferase METTL5; methyltransferase
                     like 5"
                     /codon_start=1
                     /product="rRNA N(6)-adenosine-methyltransferase METTL5"
                     /protein_id="NP_054887.2"
                     /db_xref="CCDS:CCDS33320.1"
                     /db_xref="GeneID:29081"
                     /db_xref="HGNC:HGNC:25006"
                     /db_xref="MIM:618628"
                     /translation="MKKVRLKELESRLQQVDGFEKPKLLLEQYPTRPHIAACMLYTIH
                     NTYDDIENKVVADLGCGCGVLSIGTAMLGAGLCVGFDIDEDALEIFNRNAEEFELTNI
                     DMVQCDVCLLSNRMSKSFDTVIMNPPFGTKNNKGTDMAFLKTALEMARTAVYSLHKSS
                     TREHVQKKAAEWKIKIDIIAELRYDLPASYKFHKKKSVDIEVDLIRFSF"
     exon            418..532
                     /gene="METTL5"
                     /gene_synonym="HSPC133; MRT72"
                     /inference="alignment:Splign:2.1.0"
     exon            533..714
                     /gene="METTL5"
                     /gene_synonym="HSPC133; MRT72"
                     /inference="alignment:Splign:2.1.0"
     exon            715..797
                     /gene="METTL5"
                     /gene_synonym="HSPC133; MRT72"
                     /inference="alignment:Splign:2.1.0"
     exon            798..849
                     /gene="METTL5"
                     /gene_synonym="HSPC133; MRT72"
                     /inference="alignment:Splign:2.1.0"
     exon            850..899
                     /gene="METTL5"
                     /gene_synonym="HSPC133; MRT72"
                     /inference="alignment:Splign:2.1.0"
     exon            900..1001
                     /gene="METTL5"
                     /gene_synonym="HSPC133; MRT72"
                     /inference="alignment:Splign:2.1.0"
     regulatory      980..985
                     /regulatory_class="polyA_signal_sequence"
                     /gene="METTL5"
                     /gene_synonym="HSPC133; MRT72"
                     /note="hexamer: AATAAA"
     polyA_site      1001
                     /gene="METTL5"
                     /gene_synonym="HSPC133; MRT72"
                     /note="major polyA site"
ORIGIN      
        1 gcttccggca ccggccgagg tgcgggtcgc ctccagaggt gcgtggtcgt ggcgcgaggg
       61 atcctgaggc tgctccagca gtgcgccgcc gccgtctcct ggggcggctt gggttagccg
      121 ggaggtgggt cagaggctcg ccccgtgccc tgcgtccggg cgtctcctta gggcgcgtct
      181 tcgggtccgg ccagcggtgc tgaaaaaggg agaaggttgg gggtagggag gaaacaagat
      241 cccagttcaa tagatttctc cgcagatcct gtgccttcaa accctacgag tccatacttt
      301 aaaacaaaat gaagaaagta aggcttaagg aactagagag tcgcctgcaa caagtggatg
      361 gatttgaaaa gcccaagcta cttctggaac agtatcctac caggccgcac attgcagcat
      421 gtatgctcta tacaatccat aacacttatg atgacattga aaataaagtc gttgcagatc
      481 taggatgtgg ttgtggagta cttagcatcg gaactgcaat gttaggagca gggttgtgtg
      541 ttggatttga catagatgaa gacgcattgg aaatatttaa taggaatgca gaagagtttg
      601 agttaacaaa tattgacatg gttcaatgtg atgtgtgctt attatctaac agaatgtcca
      661 agtcattcga tacagtaatt atgaatcctc cctttgggac caaaaataat aaagggacag
      721 atatggcttt tctaaagact gctttggaaa tggcaagaac agcagtatat tccttacaca
      781 aatcctcaac tagagaacat gttcaaaaga aagctgcaga atggaaaatc aagatagata
      841 ttatagcaga acttcgatat gacctgccag catcatacaa gtttcacaaa aagaaatcag
      901 tggacattga agtggaccta attcggtttt ccttttaaaa gccccgcaaa caaaagtcgt
      961 ttaaaaccta tttaaaatga ataaaaaatt ggtttactaa a
//
