LOCUS       NP_073751                472 aa            linear   PRI 28-APR-2025
DEFINITION  N(6)-adenine-specific methyltransferase METTL4 isoform 1 [Homo
            sapiens].
ACCESSION   NP_073751
VERSION     NP_073751.3
DBSOURCE    REFSEQ: accession NM_022840.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 472)
  AUTHORS   Liu,J., Zhang,N., Zeng,J., Wang,T., Shen,Y., Ma,C. and Yang,M.
  TITLE     N6 -methyladenosine-modified lncRNA ARHGAP5-AS1 stabilises CSDE1
            and coordinates oncogenic RNA regulons in hepatocellular carcinoma
  JOURNAL   Clin Transl Med 12 (11), e1107 (2022)
   PUBMED   36354136
REFERENCE   2  (residues 1 to 472)
  AUTHORS   van den Homberg,D.A.L., van der Kwast,R.V.C.T., Quax,P.H.A. and
            Nossent,A.Y.
  TITLE     N-6-Methyladenosine in Vasoactive microRNAs during Hypoxia; A Novel
            Role for METTL4
  JOURNAL   Int J Mol Sci 23 (3), 1057 (2022)
   PUBMED   35162982
  REMARK    GeneRIF: N-6-Methyladenosine in Vasoactive microRNAs during
            Hypoxia; A Novel Role for METTL4.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 472)
  AUTHORS   Goh,Y.T., Koh,C.W.Q., Sim,D.Y., Roca,X. and Goh,W.S.S.
  TITLE     METTL4 catalyzes m6Am methylation in U2 snRNA to regulate pre-mRNA
            splicing
  JOURNAL   Nucleic Acids Res 48 (16), 9250-9261 (2020)
   PUBMED   32813009
  REMARK    GeneRIF: METTL4 catalyzes m6Am methylation in U2 snRNA to regulate
            pre-mRNA splicing.
            GeneRIF: METTL4 methylates U2 snRNA Am at position 30 to generate
            m6Am in vivo. 'HMAGKD', where H = A/C/U, M = A/C, K = G/U, D =
            A/G/U, and A is the methylation site, is METTL4's in vivo preferred
            target motif.
REFERENCE   4  (residues 1 to 472)
  AUTHORS   Chen,H., Gu,L., Orellana,E.A., Wang,Y., Guo,J., Liu,Q., Wang,L.,
            Shen,Z., Wu,H., Gregory,R.I., Xing,Y. and Shi,Y.
  TITLE     METTL4 is an snRNA m6Am methyltransferase that regulates RNA
            splicing
  JOURNAL   Cell Res 30 (6), 544-547 (2020)
   PUBMED   31913360
  REMARK    GeneRIF: METTL4 is an snRNA m(6)Am methyltransferase that regulates
            RNA splicing.
REFERENCE   5  (residues 1 to 472)
  AUTHORS   Hao,Z., Wu,T., Cui,X., Zhu,P., Tan,C., Dou,X., Hsu,K.W., Lin,Y.T.,
            Peng,P.H., Zhang,L.S., Gao,Y., Hu,L., Sun,H.L., Zhu,A., Liu,J.,
            Wu,K.J. and He,C.
  TITLE     N6-Deoxyadenosine Methylation in Mammalian Mitochondrial DNA
  JOURNAL   Mol Cell 78 (3), 382-395 (2020)
   PUBMED   32183942
  REMARK    GeneRIF: N(6)-Deoxyadenosine Methylation in Mammalian Mitochondrial
            DNA.
REFERENCE   6  (residues 1 to 472)
  AUTHORS   Kweon,S.M., Chen,Y., Moon,E., Kvederaviciute,K., Klimasauskas,S.
            and Feldman,D.E.
  TITLE     An Adversarial DNA N6-Methyladenine-Sensor Network Preserves
            Polycomb Silencing
  JOURNAL   Mol Cell 74 (6), 1138-1147 (2019)
   PUBMED   30982744
REFERENCE   7  (residues 1 to 472)
  AUTHORS   Wang,P., Doxtader,K.A. and Nam,Y.
  TITLE     Structural Basis for Cooperative Function of Mettl3 and Mettl14
            Methyltransferases
  JOURNAL   Mol Cell 63 (2), 306-317 (2016)
   PUBMED   27373337
  REMARK    GeneRIF: For the methylation of adenosine in RNA, Mettl3 is the
            catalytically active subunit, while Mettl14 plays a structural role
            critical for substrate recognition.
REFERENCE   8  (residues 1 to 472)
  AUTHORS   Cai,D.C., Fonteijn,H., Guadalupe,T., Zwiers,M., Wittfeld,K.,
            Teumer,A., Hoogman,M., Arias-Vasquez,A., Yang,Y., Buitelaar,J.,
            Fernandez,G., Brunner,H.G., van Bokhoven,H., Franke,B.,
            Hegenscheid,K., Homuth,G., Fisher,S.E., Grabe,H.J., Francks,C. and
            Hagoort,P.
  TITLE     A genome-wide search for quantitative trait loci affecting the
            cortical surface area and thickness of Heschl's gyrus
  JOURNAL   Genes Brain Behav 13 (7), 675-685 (2014)
   PUBMED   25130324
REFERENCE   9  (residues 1 to 472)
  AUTHORS   Kobayashi,D., Nishizawa,D., Takasaki,Y., Kasai,S., Kakizawa,T.,
            Ikeda,K. and Fukuda,K.
  TITLE     Genome-wide association study of sensory disturbances in the
            inferior alveolar nerve after bilateral sagittal split ramus
            osteotomy
  JOURNAL   Mol Pain 9, 34 (2013)
   PUBMED   23834954
  REMARK    GeneRIF: associations revealed between genetic polymorphisms
            located in the flanking region of the ARID1B genes and hypoesthesia
            Publication Status: Online-Only
REFERENCE   10 (residues 1 to 472)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP005136.2, HY026088.1, BC111020.1 and BU741018.1.
            
            On Apr 13, 2007 this sequence version replaced NP_073751.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.135717.1,
                                           SRR1803612.133169.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000574538.2/ ENSP00000458290.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18p11.32"
     Protein         1..472
                     /product="N(6)-adenine-specific methyltransferase METTL4
                     isoform 1"
                     /EC_number="2.1.1.72"
                     /note="methyltransferase-like protein 4; snRNA
                     (2'-O-methyladenosine-N(6)-)-methyltransferase METTL4;
                     N(6)-adenine-specific methyltransferase METTL4;
                     N(6)-adenine-specific DNA methyltransferase METTL4;
                     methyltransferase like 4"
                     /calculated_mol_wt=53910
     Region          281..455
                     /region_name="MT-A70"
                     /note="cl01947"
                     /db_xref="CDD:470404"
     CDS             1..472
                     /gene="METTL4"
                     /gene_synonym="HsT661"
                     /coded_by="NM_022840.5:796..2214"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS11826.1"
                     /db_xref="GeneID:64863"
                     /db_xref="HGNC:HGNC:24726"
                     /db_xref="MIM:619626"
ORIGIN      
        1 msvvhqlsag wlldhlsfin kinyqlhqhh epccrkkeft tsvhfeslqm dsvsssgvca
       61 afiasdsstk penddggnye mftrkfvfrp elfdvtkpyi tpavhkecqq snekedlmng
      121 vkkeisisii gkkrkrcvvf nqgeldamey htkirelild gslqliqegl ksgflyplfe
      181 kqdkgskpit lpldacslse lcemakhlps lnemehqtlq lveedtsvte qdlflrvven
      241 nssftkvitl mgqkyllppk ssfllsdisc mqpllnyrkt fdvividppw qnksvkrsnr
      301 ysylsplqiq qipipklaap ncllvtwvtn rqkhlrfike elypswsvev vaewhwvkit
      361 nsgefvfpld sphkkpyegl ilgrvqekta lplrnadvnv lpipdhkliv svpctlhshk
      421 pplaevlkdy ikpdgeylel farnlqpgwt swgnevlkfq hvdyfiaves gs
//
