LOCUS       NM_015997               2271 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens methyltransferase like 25B (METTL25B), transcript
            variant 1, mRNA.
ACCESSION   NM_015997
VERSION     NM_015997.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2271)
  AUTHORS   Willer,C.J., Schmidt,E.M., Sengupta,S., Peloso,G.M., Gustafsson,S.,
            Kanoni,S., Ganna,A., Chen,J., Buchkovich,M.L., Mora,S.,
            Beckmann,J.S., Bragg-Gresham,J.L., Chang,H.Y., Demirkan,A., Den
            Hertog,H.M., Do,R., Donnelly,L.A., Ehret,G.B., Esko,T.,
            Feitosa,M.F., Ferreira,T., Fischer,K., Fontanillas,P., Fraser,R.M.,
            Freitag,D.F., Gurdasani,D., Heikkila,K., Hypponen,E., Isaacs,A.,
            Jackson,A.U., Johansson,A., Johnson,T., Kaakinen,M., Kettunen,J.,
            Kleber,M.E., Li,X., Luan,J., Lyytikainen,L.P., Magnusson,P.K.E.,
            Mangino,M., Mihailov,E., Montasser,M.E., Muller-Nurasyid,M.,
            Nolte,I.M., O'Connell,J.R., Palmer,C.D., Perola,M., Petersen,A.K.,
            Sanna,S., Saxena,R., Service,S.K., Shah,S., Shungin,D., Sidore,C.,
            Song,C., Strawbridge,R.J., Surakka,I., Tanaka,T., Teslovich,T.M.,
            Thorleifsson,G., Van den Herik,E.G., Voight,B.F., Volcik,K.A.,
            Waite,L.L., Wong,A., Wu,Y., Zhang,W., Absher,D., Asiki,G.,
            Barroso,I., Been,L.F., Bolton,J.L., Bonnycastle,L.L., Brambilla,P.,
            Burnett,M.S., Cesana,G., Dimitriou,M., Doney,A.S.F., Doring,A.,
            Elliott,P., Epstein,S.E., Ingi Eyjolfsson,G., Gigante,B.,
            Goodarzi,M.O., Grallert,H., Gravito,M.L., Groves,C.J., Hallmans,G.,
            Hartikainen,A.L., Hayward,C., Hernandez,D., Hicks,A.A., Holm,H.,
            Hung,Y.J., Illig,T., Jones,M.R., Kaleebu,P., Kastelein,J.J.P.,
            Khaw,K.T., Kim,E., Klopp,N., Komulainen,P., Kumari,M.,
            Langenberg,C., Lehtimaki,T., Lin,S.Y., Lindstrom,J., Loos,R.J.F.,
            Mach,F., McArdle,W.L., Meisinger,C., Mitchell,B.D., Muller,G.,
            Nagaraja,R., Narisu,N., Nieminen,T.V.M., Nsubuga,R.N., Olafsson,I.,
            Ong,K.K., Palotie,A., Papamarkou,T., Pomilla,C., Pouta,A.,
            Rader,D.J., Reilly,M.P., Ridker,P.M., Rivadeneira,F., Rudan,I.,
            Ruokonen,A., Samani,N., Scharnagl,H., Seeley,J., Silander,K.,
            Stancakova,A., Stirrups,K., Swift,A.J., Tiret,L.,
            Uitterlinden,A.G., van Pelt,L.J., Vedantam,S., Wainwright,N.,
            Wijmenga,C., Wild,S.H., Willemsen,G., Wilsgaard,T., Wilson,J.F.,
            Young,E.H., Zhao,J.H., Adair,L.S., Arveiler,D., Assimes,T.L.,
            Bandinelli,S., Bennett,F., Bochud,M., Boehm,B.O., Boomsma,D.I.,
            Borecki,I.B., Bornstein,S.R., Bovet,P., Burnier,M., Campbell,H.,
            Chakravarti,A., Chambers,J.C., Chen,Y.I., Collins,F.S.,
            Cooper,R.S., Danesh,J., Dedoussis,G., de Faire,U., Feranil,A.B.,
            Ferrieres,J., Ferrucci,L., Freimer,N.B., Gieger,C., Groop,L.C.,
            Gudnason,V., Gyllensten,U., Hamsten,A., Harris,T.B., Hingorani,A.,
            Hirschhorn,J.N., Hofman,A., Hovingh,G.K., Hsiung,C.A.,
            Humphries,S.E., Hunt,S.C., Hveem,K., Iribarren,C., Jarvelin,M.R.,
            Jula,A., Kahonen,M., Kaprio,J., Kesaniemi,A., Kivimaki,M.,
            Kooner,J.S., Koudstaal,P.J., Krauss,R.M., Kuh,D., Kuusisto,J.,
            Kyvik,K.O., Laakso,M., Lakka,T.A., Lind,L., Lindgren,C.M.,
            Martin,N.G., Marz,W., McCarthy,M.I., McKenzie,C.A., Meneton,P.,
            Metspalu,A., Moilanen,L., Morris,A.D., Munroe,P.B., Njolstad,I.,
            Pedersen,N.L., Power,C., Pramstaller,P.P., Price,J.F., Psaty,B.M.,
            Quertermous,T., Rauramaa,R., Saleheen,D., Salomaa,V.,
            Sanghera,D.K., Saramies,J., Schwarz,P.E.H., Sheu,W.H.,
            Shuldiner,A.R., Siegbahn,A., Spector,T.D., Stefansson,K.,
            Strachan,D.P., Tayo,B.O., Tremoli,E., Tuomilehto,J., Uusitupa,M.,
            van Duijn,C.M., Vollenweider,P., Wallentin,L., Wareham,N.J.,
            Whitfield,J.B., Wolffenbuttel,B.H.R., Ordovas,J.M., Boerwinkle,E.,
            Palmer,C.N.A., Thorsteinsdottir,U., Chasman,D.I., Rotter,J.I.,
            Franks,P.W., Ripatti,S., Cupples,L.A., Sandhu,M.S., Rich,S.S.,
            Boehnke,M., Deloukas,P., Kathiresan,S., Mohlke,K.L., Ingelsson,E.
            and Abecasis,G.R.
  CONSRTM   Global Lipids Genetics Consortium
  TITLE     Discovery and refinement of loci associated with lipid levels
  JOURNAL   Nat Genet 45 (11), 1274-1283 (2013)
   PUBMED   24097068
REFERENCE   2  (bases 1 to 2271)
  AUTHORS   Chapuis,J., Hot,D., Hansmannel,F., Kerdraon,O., Ferreira,S.,
            Hubans,C., Maurage,C.A., Huot,L., Bensemain,F., Laumet,G.,
            Ayral,A.M., Fievet,N., Hauw,J.J., DeKosky,S.T., Lemoine,Y.,
            Iwatsubo,T., Wavrant-Devrieze,F., Dartigues,J.F., Tzourio,C.,
            Buee,L., Pasquier,F., Berr,C., Mann,D., Lendon,C., Alperovitch,A.,
            Kamboh,M.I., Amouyel,P. and Lambert,J.C.
  TITLE     Transcriptomic and genetic studies identify IL-33 as a candidate
            gene for Alzheimer's disease
  JOURNAL   Mol Psychiatry 14 (11), 1004-1016 (2009)
   PUBMED   19204726
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   3  (bases 1 to 2271)
  AUTHORS   Peterson,R.J. and Marsh,C.L.
  TITLE     The relationship of alpha1-antitrypsin to inflammatory periodontal
            disease
  JOURNAL   J Periodontol 50 (1), 31-35 (1979)
   PUBMED   310876
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL590666.8 and BX094595.1.
            
            On Nov 22, 2018 this sequence version replaced NM_015997.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC011382.1, SRR1163655.398205.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368216.9/ ENSP00000357199.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-747               AL590666.8         77094-77840
            748-872             AL590666.8         80616-80740
            873-1065            AL590666.8         80906-81098
            1066-1128           AL590666.8         81610-81672
            1129-1272           AL590666.8         82002-82145
            1273-1757           AL590666.8         82634-83118
            1758-1942           AL590666.8         84350-84534
            1943-2240           AL590666.8         85257-85554
            2241-2271           BX094595.1         586-616
FEATURES             Location/Qualifiers
     source          1..2271
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q23.1"
     gene            1..2271
                     /gene="METTL25B"
                     /gene_synonym="C1orf66; CGI-41; RRNAD1"
                     /note="methyltransferase like 25B"
                     /db_xref="GeneID:51093"
                     /db_xref="HGNC:HGNC:24273"
     exon            1..747
                     /gene="METTL25B"
                     /gene_synonym="C1orf66; CGI-41; RRNAD1"
                     /inference="alignment:Splign:2.1.0"
     CDS             637..2064
                     /gene="METTL25B"
                     /gene_synonym="C1orf66; CGI-41; RRNAD1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein RRNAD1; ribosomal RNA adenine dimethylase
                     domain-containing protein 1; ribosomal RNA adenine
                     dimethylase domain containing 1; methyltransferase-like
                     protein 25B"
                     /codon_start=1
                     /product="methyltransferase-like protein 25B isoform 1"
                     /protein_id="NP_057081.3"
                     /db_xref="CCDS:CCDS1154.1"
                     /db_xref="GeneID:51093"
                     /db_xref="HGNC:HGNC:24273"
                     /translation="MPGISARGLSHEGRKQLAVNLTRVLALYRSILDAYIIEFFTDNL
                     WDTLPCSWQEALDGLKPPQLATMLLGMPGEGEVVRYRSVWPLTLLALKSTACALAFTR
                     MPGFQTPSEFLENPSQSSRLTAPFRKHVRPKKQHEIRRLGELVKKLSDFTGCTQVVDV
                     GSGQGHLSRFMALGLGLMVKSIEGDQRLVERAQRLDQELLQALEKEEKRNPQVVQTSP
                     RHSPHHVVRWVDPTALCEELLLPLENPCQGRARLLLTGLHACGDLSVALLRHFSCCPE
                     VVALASVGCCYMKLSDPGGYPLSQWVAGLPGYELPYRLREGACHALEEYAERLQKAGP
                     GLRTHCYRAALETVIRRARPELRRPGVQGIPRVHELKIEEYVQRGLQRVGLDPQLPLN
                     LAALQAHVAQENRVVAFFSLALLLAPLVETLILLDRLLYLQEQGFHAELLPIFSPELS
                     PRNLVLVATKMPLGQALSVLETEDS"
     exon            748..872
                     /gene="METTL25B"
                     /gene_synonym="C1orf66; CGI-41; RRNAD1"
                     /inference="alignment:Splign:2.1.0"
     exon            873..1065
                     /gene="METTL25B"
                     /gene_synonym="C1orf66; CGI-41; RRNAD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1128
                     /gene="METTL25B"
                     /gene_synonym="C1orf66; CGI-41; RRNAD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1272
                     /gene="METTL25B"
                     /gene_synonym="C1orf66; CGI-41; RRNAD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..1757
                     /gene="METTL25B"
                     /gene_synonym="C1orf66; CGI-41; RRNAD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1758..1942
                     /gene="METTL25B"
                     /gene_synonym="C1orf66; CGI-41; RRNAD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1943..2271
                     /gene="METTL25B"
                     /gene_synonym="C1orf66; CGI-41; RRNAD1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2242..2247
                     /regulatory_class="polyA_signal_sequence"
                     /gene="METTL25B"
                     /gene_synonym="C1orf66; CGI-41; RRNAD1"
                     /note="hexamer: ATTAAA"
     polyA_site      2271
                     /gene="METTL25B"
                     /gene_synonym="C1orf66; CGI-41; RRNAD1"
                     /note="major polyA site"
ORIGIN      
        1 ggtgcgcgcc gacgaagccc gggaaggcag gcgcgcgggt tagaacgcgc cagaggtcgg
       61 cgcgcgcaca cccgcaccgc cccgacccca ggtagtgagg ccagtgattc cgagtgtgtg
      121 aggagcggca gtggcggcgg aggagggggc ggcgtgggtg ggggcggggg cgggatgcgc
      181 tccccggccc ctctagcccc gtggtggtac aacgcgaagg tgtgggaagg ccgcgataaa
      241 ccggaactgc agcccgccgg acacctccgg cttcacttcc gtaagaggag aggagtgtac
      301 ggcaaggggc gggaactgga acttggcccg cctcgttgtg agctgagctc agcggcacgc
      361 ttttgtggcg tcactgcact gttaccccgc cctacgtgtc tctgacgctg acaccttctc
      421 actgtgaaac gtcgcgacct gtgacgtctg gggggcgcct caaatcttcc actccagcat
      481 cggatcccgg aaaggcagcg tcggagactg gacccaaaac tcttcctgtt ctgcctgcag
      541 agttgagccc cgtccgggtc ctggacccgc gtagtactga ccctggatcc ctgttcactg
      601 cgttctcgct ccccgcgctc cctgctggac cccgggatgc cgggcatctc cgcccgaggc
      661 ctctctcatg aggggaggaa gcagctagct gttaacctca cccgtgtcct ggcactctac
      721 cgttccatct tggatgccta catcatcgaa tttttcacag acaacctatg ggacacactc
      781 ccttgctcat ggcaggaagc attggatgga ctgaaaccac cacagctggc cacaatgctg
      841 ctggggatgc ctggggaagg ggaggtcgtc aggtacaggt cagtgtggcc actcaccctg
      901 ctggccctga agtccacggc gtgtgccctg gcctttaccc ggatgcctgg ctttcagacc
      961 ccctcagaat tcctggagaa ccccagccag agctcccgac taacagctcc attccggaaa
     1021 catgtcaggc ccaagaagca gcatgagatc cggaggctgg gagagttggt gaagaagctg
     1081 agtgatttca caggctgcac ccaggttgta gacgtgggct caggccaggg ccatctctcc
     1141 cgcttcatgg ctcttggcct ggggttgatg gtgaagagca tcgaagggga tcagagactg
     1201 gtggagagag cccagcgcct ggaccaggag cttctgcagg ctctggagaa agaggagaag
     1261 aggaacccgc aggtggtcca aaccagccct cgtcactccc cacaccacgt ggttaggtgg
     1321 gtagacccca cagccctgtg tgaggagctt ctgcttccac tggagaaccc gtgtcagggc
     1381 agggcccgct tgctgctcac aggcctccac gcctgtgggg atctgagtgt tgccttgctg
     1441 agacacttct cctgctgtcc tgaggtggtg gccctggcct cagtgggctg ctgctacatg
     1501 aagctgagtg accctggcgg ctacccactg agtcagtggg tggctgggct gcctggctat
     1561 gaactgccct accggcttcg ggagggggcc tgccatgccc tggaggaata tgctgagcgg
     1621 ctacagaaag ctggccctgg ccttcgaact cactgctacc gtgcagcact ggagacagtc
     1681 atccgacggg cccggcccga gctccgtcgg ccaggcgtgc agggtatccc cagggtccac
     1741 gagctcaaga ttgaagaata tgtgcagcgg gggctacagc gagtggggct agatccccag
     1801 ctgccactga atctggctgc ccttcaggcc cacgtggccc aggagaaccg tgtggtggcc
     1861 ttcttcagcc tggctctact gcttgcccca ctggtggaga cgcttattct actggaccgg
     1921 ctgctgtacc ttcaggaaca gggtttccat gctgagctcc tgcccatctt cagtcctgaa
     1981 ctctctccca gaaacctggt tctggtggcc accaagatgc ccctgggtca ggctctttct
     2041 gttctggaga ctgaagacag ctgatgcagc ctgaggaaac atctcagacc ccatcatctg
     2101 aaagtgccca gagagcacag tggcagagta catctcatcc agagaaacag catcctgcat
     2161 cctccagagt cctggttcct tcagtttcat cccctttctc tccttccatg gattatgtaa
     2221 tacattgtaa agttttaatt aattaaaaat tggatatctg tttccttccc a
//
