LOCUS       NM_032230               2064 bp    mRNA    linear   PRI 21-NOV-2021
DEFINITION  Homo sapiens methyltransferase like 25 (METTL25), transcript
            variant 1, mRNA.
ACCESSION   NM_032230 XM_170697
VERSION     NM_032230.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC083811.22 and AC089998.17.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_032230.2.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC029120.1, SRR1803612.143396.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000248306.8/ ENSP00000248306.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-296               AC083811.22        108891-109186       c
            297-461             AC083811.22        80748-80912         c
            462-568             AC083811.22        77793-77899         c
            569-1168            AC083811.22        68321-68920         c
            1169-1316           AC083811.22        64585-64732         c
            1317-1411           AC083811.22        36728-36822         c
            1412-1441           AC083811.22        32991-33020         c
            1442-1515           AC083811.22        28924-28997         c
            1516-1609           AC083811.22        10895-10988         c
            1610-1684           AC089998.17        50352-50426         c
            1685-1756           AC089998.17        49718-49789         c
            1757-2064           AC089998.17        47831-48138         c
FEATURES             Location/Qualifiers
     source          1..2064
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q21.31"
     gene            1..2064
                     /gene="METTL25"
                     /gene_synonym="C12orf26"
                     /note="methyltransferase like 25"
                     /db_xref="GeneID:84190"
                     /db_xref="HGNC:HGNC:26228"
     exon            1..296
                     /gene="METTL25"
                     /gene_synonym="C12orf26"
                     /inference="alignment:Splign:2.1.0"
     CDS             38..1849
                     /gene="METTL25"
                     /gene_synonym="C12orf26"
                     /note="isoform 1 is encoded by transcript variant 1;
                     methyltransferase-like protein 25; probable
                     methyltransferase-like protein 25"
                     /codon_start=1
                     /product="probable methyltransferase-like protein 25
                     isoform 1"
                     /protein_id="NP_115606.2"
                     /db_xref="CCDS:CCDS9024.1"
                     /db_xref="GeneID:84190"
                     /db_xref="HGNC:HGNC:26228"
                     /translation="MAASCPLPVTPDLPTLRAKLQGLLQFLRDALSISNAHTVDFYTE
                     SVWEELVDLPPETVLAALRKSASETEALPSETRPLVEAEWEAGMTDFPKIFCETSQKL
                     VSVEAFALAAKYYSVQNLGICTPFEQLLVALRGNQNQRIGENQKAVEFMNMKKSHEVQ
                     AMSELISSIADYYGIKQVIDLGSGKGYLSSFLSLKYGLKVYGIDSSNTNTHGAEERNR
                     KLKKHWKLCHAQSRLDVNGLALKMAKERKVQNKVKNKADTEEVFNNSPTNQEKMPTSA
                     ILPDFSGSVISNIRNQMETLHSQPHQEENLCFENSFSLINLLPINAVEPTSSQQIPNR
                     ETSEANKERRKMTSKSSESNIYSPLTSFITADSELHDIIKDLEDCLMVGLHTCGDLAP
                     NTLRIFTSNSEIKGVCSVGCCYHLLSEEFENQHKERTQEKWGFPMCHYLKEERWCCGR
                     NARMSACLALERVAAGQGLPTESLFYRAVLQDIIKDCYGITKCDRHVGKIYSKCSSFL
                     DYVRRSLKKLGLDESKLPEKIIMNYYEKYKPRMNELEAFNMLKVVLAPCIETLILLDR
                     LCYLKEQEDIAWSALVKLFDPVKSPRCYAVIALKKQQ"
     exon            297..461
                     /gene="METTL25"
                     /gene_synonym="C12orf26"
                     /inference="alignment:Splign:2.1.0"
     exon            462..568
                     /gene="METTL25"
                     /gene_synonym="C12orf26"
                     /inference="alignment:Splign:2.1.0"
     exon            569..1168
                     /gene="METTL25"
                     /gene_synonym="C12orf26"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1316
                     /gene="METTL25"
                     /gene_synonym="C12orf26"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1411
                     /gene="METTL25"
                     /gene_synonym="C12orf26"
                     /inference="alignment:Splign:2.1.0"
     exon            1412..1441
                     /gene="METTL25"
                     /gene_synonym="C12orf26"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..1515
                     /gene="METTL25"
                     /gene_synonym="C12orf26"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..1609
                     /gene="METTL25"
                     /gene_synonym="C12orf26"
                     /inference="alignment:Splign:2.1.0"
     exon            1610..1684
                     /gene="METTL25"
                     /gene_synonym="C12orf26"
                     /inference="alignment:Splign:2.1.0"
     exon            1685..1756
                     /gene="METTL25"
                     /gene_synonym="C12orf26"
                     /inference="alignment:Splign:2.1.0"
     exon            1757..2064
                     /gene="METTL25"
                     /gene_synonym="C12orf26"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1970..1975
                     /regulatory_class="polyA_signal_sequence"
                     /gene="METTL25"
                     /gene_synonym="C12orf26"
                     /note="hexamer: AATAAA"
     regulatory      1975..1980
                     /regulatory_class="polyA_signal_sequence"
                     /gene="METTL25"
                     /gene_synonym="C12orf26"
                     /note="hexamer: AATAAT"
     polyA_site      1991
                     /gene="METTL25"
                     /gene_synonym="C12orf26"
                     /note="major polyA site"
     polyA_site      1994
                     /gene="METTL25"
                     /gene_synonym="C12orf26"
     regulatory      2032..2037
                     /regulatory_class="polyA_signal_sequence"
                     /gene="METTL25"
                     /gene_synonym="C12orf26"
                     /note="hexamer: AATAAA"
     polyA_site      2064
                     /gene="METTL25"
                     /gene_synonym="C12orf26"
ORIGIN      
        1 atgtttgcgc cacctacagc ctcggagggt gagcgtcatg gcggcttctt gccctctccc
       61 ggtgaccccg gacctgccca cgctgcgtgc caagttgcag ggactgctgc agttcctgag
      121 ggatgccctg tccatttcca atgcacatac cgtggatttc tacacagaat ccgtgtggga
      181 ggagctggtc gacttgccac cggagacagt gctggctgcg ctgaggaagt cagcgtcgga
      241 gacggaggcc ctgccctcag agacgcgccc cctagtggaa gcagagtggg aagcaggtat
      301 gactgatttt cccaaaatat tttgtgaaac ttctcagaag ttggtgagtg tggaagcctt
      361 tgctctggct gcgaaatact attctgtaca aaacttggga atatgtactc cttttgaaca
      421 gttgcttgta gcccttcgag gaaatcaaaa ccagagaatt ggtgaaaatc agaaggcagt
      481 tgagtttatg aatatgaaga aatctcatga agttcaggca atgtcagagc tgatcagcag
      541 tattgctgac tactatggaa taaagcaggt gattgacttg ggttccggta aaggctacct
      601 aagctctttt ttgtccttga agtatggctt aaaagtttat ggaattgatt cttcaaatac
      661 caatactcat ggagctgagg agagaaacag aaaattgaag aaacattgga aactctgtca
      721 tgctcagtca agattagatg tcaatggact agcattaaaa atggcaaaag aaaggaaagt
      781 gcaaaataaa gttaaaaata aagctgatac tgaggaagtg tttaacaaca gtcctacaaa
      841 tcaagaaaag atgcctacct cagctatttt gcctgatttt tctggctctg taatttctaa
      901 tatcagaaac caaatggaaa cccttcattc tcagccacat caagaagaaa atttgtgttt
      961 tgaaaattcc ttttctctta taaacctttt gcctattaat gctgtagagc ctacttcttc
     1021 acagcaaata cccaacagag aaacatctga agccaataaa gagagaagaa aaatgacatc
     1081 aaagtcaagt gaatcaaata tatattcacc tttaacctct tttatcactg ctgattcaga
     1141 actccatgac attattaaag atttggagga ttgtttgatg gtgggtctcc acacttgtgg
     1201 tgatctggct ccaaatactt tgcgaatatt tacctccaac tctgaaatca agggagtttg
     1261 cagtgtgggt tgttgctacc acctcttatc tgaagaattt gaaaaccagc ataaagaacg
     1321 tactcaggaa aagtggggat ttccaatgtg ccactattta aaggaagaga gatggtgctg
     1381 tggtcgtaat gccagaatgt cagcatgttt ggcattggag cgggttgcag ctggccaagg
     1441 gctgcctact gaatcactct tctatcgtgc tgttcttcag gatattatta aagattgtta
     1501 tggcatcacc aaatgtgatc ggcatgttgg taaaatttat tccaaatgtt cttcttttct
     1561 ggattatgtc agacggtctc taaagaagct tggattagat gagtccaagc tgccagaaaa
     1621 aattataatg aactactacg agaagtataa gcctcgaatg aatgagctgg aagcttttaa
     1681 tatgttgaaa gttgtactgg ctccctgtat agagactttg attcttctgg atcgactttg
     1741 ttacctgaaa gagcaggaag atattgcatg gtctgctctt gtgaagttgt ttgatcccgt
     1801 gaaatctccc agatgttatg ctgttattgc cctgaagaag cagcagtgat ttccattgaa
     1861 gcaaattatt agatgtattt ctctatgaga cctgttgctg agattgcttt tctaaacata
     1921 tatgtcctgt tatacaaaaa tttttaaatg actgttatgt attttaaata ataaaataat
     1981 ggctaacaac agaaggttat aatccatttt tccattgtca aagcatacat taataaaaga
     2041 agaacctgtc ataataatat aaaa
//
