LOCUS       NM_001123364            3184 bp    mRNA    linear   PRI 06-NOV-2022
DEFINITION  Homo sapiens methyltransferase like 24 (METTL24), transcript
            variant 1, mRNA.
ACCESSION   NM_001123364 XM_001722591
VERSION     NM_001123364.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3184)
  AUTHORS   Jiang Z, Zhang W, Zeng Z, Tang D, Li C, Cai W, Chen Y, Li Y, Jin Q,
            Zhang X, Yin L, Liu X, Xu Y and Dai Y.
  TITLE     A comprehensive investigation discovered the novel
            methyltransferase METTL24 as one presumably prognostic gene for
            kidney renal clear cell carcinoma potentially modulating tumor
            immune microenvironment
  JOURNAL   Front Immunol 13, 926461 (2022)
   PUBMED   36311770
  REMARK    GeneRIF: A comprehensive investigation discovered the novel
            methyltransferase METTL24 as one presumably prognostic gene for
            kidney renal clear cell carcinoma potentially modulating tumor
            immune microenvironment.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3184)
  AUTHORS   Lund RJ, Osmala M, Malonzo M, Lukkarinen M, Leino A, Salmi J,
            Vuorikoski S, Turunen R, Vuorinen T, Akdis C, Lahdesmaki H,
            Lahesmaa R and Jartti T.
  TITLE     Atopic asthma after rhinovirus-induced wheezing is associated with
            DNA methylation change in the SMAD3 gene promoter
  JOURNAL   Allergy 73 (8), 1735-1740 (2018)
   PUBMED   29729188
  REMARK    GeneRIF: The strongest DNA methylation changes in atopic asthma
            were detected in the promoter region of SMAD3 gene at chr 15q22.33
            and introns of DDO/METTL24 genes at 6q21.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL050350.14 and AL445068.6.
            
            On Sep 25, 2020 this sequence version replaced NM_001123364.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.239548.1,
                                           SRR1803612.149005.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1966682,
                                           SAMEA1968189 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000338882.5/ ENSP00000344071.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-395               AL050350.14        84264-84658
            396-494             AL050350.14        119741-119839
            495-634             AL050350.14        127132-127271
            635-863             AL445068.6         61354-61582         c
            864-3184            AL445068.6         6372-8692           c
FEATURES             Location/Qualifiers
     source          1..3184
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q21"
     gene            1..3184
                     /gene="METTL24"
                     /gene_synonym="C6orf186"
                     /note="methyltransferase like 24"
                     /db_xref="GeneID:728464"
                     /db_xref="HGNC:HGNC:21566"
     exon            1..395
                     /gene="METTL24"
                     /gene_synonym="C6orf186"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..1178
                     /gene="METTL24"
                     /gene_synonym="C6orf186"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; UPF0624 protein C6orf186; probable
                     methyltransferase-like protein 24"
                     /codon_start=1
                     /product="probable methyltransferase-like protein 24
                     isoform 1 precursor"
                     /protein_id="NP_001116836.1"
                     /db_xref="CCDS:CCDS43489.1"
                     /db_xref="GeneID:728464"
                     /db_xref="HGNC:HGNC:21566"
                     /translation="MARERPPGRGCGVLRRCLLGAVLLFGLRLCAELRRAGPGSPTRS
                     APPGPAWRPPGPHLPPAPGQPRGASRRQVTYVRSGRRAPPGGGGSGTPEPGCCAPRGR
                     PRRKGPRWHIDLQPWAGSAQSLDEEAWRFLRYISTTQIACNHMNTDSLATDSSPTHKP
                     WSVCLDDRFNLAHQIRNKQCRLYSLGLGSDDTHFEVSMANNGCEVHRFDPSVKSAHIL
                     ESQHLWYHRLSIDWRDPHPAVAAQKPHSNTRKLGSILNEFGHHKIDVLKADLESAEWK
                     VLENLILEDVLEQIGQLIFEIHLHWPGFEVSGSDSSVVRFWYSLLKELEQKDFRLFHS
                     YKDLSKPQLFLKKDIFNASSCYTLSWVNTRWK"
     exon            396..494
                     /gene="METTL24"
                     /gene_synonym="C6orf186"
                     /inference="alignment:Splign:2.1.0"
     exon            495..634
                     /gene="METTL24"
                     /gene_synonym="C6orf186"
                     /inference="alignment:Splign:2.1.0"
     exon            635..863
                     /gene="METTL24"
                     /gene_synonym="C6orf186"
                     /inference="alignment:Splign:2.1.0"
     exon            864..3184
                     /gene="METTL24"
                     /gene_synonym="C6orf186"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3165..3170
                     /regulatory_class="polyA_signal_sequence"
                     /gene="METTL24"
                     /gene_synonym="C6orf186"
                     /note="hexamer: AATAAA"
     polyA_site      3184
                     /gene="METTL24"
                     /gene_synonym="C6orf186"
                     /note="major polyA site"
ORIGIN      
        1 agttggccgc tccggcctgt ggggctacat ccctgctgcc ggccaggcgc ggcccgcggg
       61 accccgagtg tagcgccatg gcccgggaga ggccgcccgg gaggggctgc ggcgtcctgc
      121 gccggtgtct actcggggct gtgctgttgt tcggcctgcg gctctgcgca gagctgcggc
      181 gcgccgggcc cgggtccccc acccgcagcg ccccgccggg cccggcctgg cggccacctg
      241 ggccgcacct gccgcccgcg ccgggccagc cgcgcggcgc cagcaggagg caggtgacct
      301 acgtgcgcag cggtcgccgg gcgccgccgg ggggcggcgg gagcgggacg ccggagcctg
      361 gctgctgtgc cccgcgcggg cgcccccgcc ggaagggtcc ccggtggcat atagatctcc
      421 agccttgggc aggctctgct cagtccctgg atgaagaagc ctggaggttc ctgagatata
      481 tcagcaccac ccagattgca tgcaatcaca tgaatacaga cagcctggct actgactcta
      541 gtcctacaca caagccctgg tcagtgtgtc ttgacgacag gttcaattta gctcatcaaa
      601 tccgcaacaa gcagtgccgc ctctactcct tagggctagg aagtgatgat acccattttg
      661 aggttagcat ggccaacaac ggatgtgaag tgcatcgttt tgatcctagt gtcaagtcag
      721 ctcacattct ggagagtcag cacctttggt atcaccgctt gtccattgac tggcgggatc
      781 cccatccagc tgttgctgcc caaaaaccac atagcaacac cagaaaactg ggaagcattt
      841 tgaatgaatt tggacatcac aagattgacg ttctcaaggc agatctggaa agtgcagaat
      901 ggaaagtttt ggaaaatctt attctggaag atgttcttga gcagattgga cagctcatct
      961 ttgagatcca tctccactgg cctgggtttg aggtcagtgg cagtgacagc agcgttgtgc
     1021 ggttctggta cagccttctc aaagagttag aacaaaagga tttcaggctt tttcacagtt
     1081 acaaagactt atctaaacct cagctattct tgaagaaaga cattttcaat gcaagtagct
     1141 gttatactct gagttgggtg aatacaagat ggaaatagga tgcaggatgt catcaagagc
     1201 acaagaaaat atttgcagaa tgcagcatgt ccataattct aatcatgagt ttactcatcc
     1261 agtctcctgc tagcctgtgc cctgcttgag gcagggagtg tgttattgcg ggcatgcagc
     1321 ctagtgcttg gcatgtgatg gggcacagtc aatacttgtt aaagggataa acacagtcac
     1381 ccctatttgc ccagactctt ccttcacctt aacttggaag attatcccca gctcatcaca
     1441 gttttcccta aaattctcta tgtatctata atctatgaat tcaccaacat tgaaatgaaa
     1501 ttatataaat ttcctatttt tactaggttg gtgagatttt taagttcttc ccctactgtt
     1561 taaaataggg ttttaaattt gaatttgacc ctcctttttc aaggtttttc ttatttacct
     1621 tgttaatgat attctttaca accttgtaga tttcagtcat tccttctcag cctttgctga
     1681 ggccatgctg tggctttcta agcagcaata cttctgattt ctgggaactc ggatgcacca
     1741 aattctgtca ctgagttaaa gagactagac tatcaagagc ttcaacacga aggtgtaagt
     1801 tccagttcga gaccaagtct gaaggtcttg acctcaccaa gacccatgtc ccagcttgaa
     1861 gacagccaga cagagaatta attcttcctt actgccttag gttctattca ggccttcaac
     1921 tggttgaatg aggtccactt acactgaggt gaagaatctg atttatttag tctactgatt
     1981 taaatattaa tttcatctgg aaatatcctt acagatacac ctagaataat gtttaactaa
     2041 agatctggac accctttagt ccagttaagt tgacacataa aattaaccat tgtaggtagg
     2101 taggtagata aatagataga tgatagatag atagatagat agatagatag ataagataga
     2161 ttttcctact ggcatgtttc accattttct tgactcacat attctggttt ccatctggct
     2221 ccttcggtct gtgctctcct cactgaagta aggcctttaa tgattacttc attataagtc
     2281 catgagtaat atggtttggc tacgtcccca accaaatctc atcttgaatt gtagttccca
     2341 taatccccac gtgttgtggg agggacctgg tgagaggtaa ttgaatcatg gggttggttt
     2401 cctccatgct attctcatga tactgagtaa gttctcatga gatctgatgg ttttataaga
     2461 ggtgtccccc ttcacttggc tctcattttt ctccttcctg ctgccatatg aagaaggatg
     2521 tgtttgcttc cccttccacc acgactgtaa gtttcctgag gcctcgccag ccatgctaaa
     2581 ctgtgagtca attaaatctc tttcctctat aaattactca gtctcaggta tatcttcata
     2641 gcagtgtgag aatggactaa tactttgggt attacacttt ttagatttta cgtatttgaa
     2701 aaagcacttg ctttttatac ctgaataaag tttatttgtt cacagaaaaa aaaaagagct
     2761 tcaactcaag atgcttttta tactcagcct taattcccct tcacttccta ttaaactaag
     2821 cacagagcag aatctgggta tctttgctgt tgcctcttct gccttcaaac atgatttacc
     2881 acccacagac ttgcctatgc tgtcaaatct tttttaaaaa aatacattat ctctaataat
     2941 gttaagtgca tttttcttta ctcccagttg gcatcactta catgattgtg gcctgaagac
     3001 catcgtctca ctttcgtagg atagttagac agtttttcaa tagcaccgat cctttctaca
     3061 ttaaaagtta agtggaaagt ttaggttctc agcggttcaa atgctctctc tcattactat
     3121 ttacaggatt aaacacgtgc ataattttct aaaattctat ttcaaataaa tagcataaaa
     3181 acca
//
