LOCUS       NM_024109               4974 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens methyltransferase 22, Kin17 lysine (METTL22),
            transcript variant 1, mRNA.
ACCESSION   NM_024109
VERSION     NM_024109.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4974)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 4974)
  AUTHORS   Cloutier,P., Lavallee-Adam,M., Faubert,D., Blanchette,M. and
            Coulombe,B.
  TITLE     Methylation of the DNA/RNA-binding protein Kin17 by METTL22 affects
            its association with chromatin
  JOURNAL   J Proteomics 100, 115-124 (2014)
   PUBMED   24140279
REFERENCE   3  (bases 1 to 4974)
  AUTHORS   Cloutier,P., Lavallee-Adam,M., Faubert,D., Blanchette,M. and
            Coulombe,B.
  TITLE     A newly uncovered group of distantly related lysine
            methyltransferases preferentially interact with molecular
            chaperones to regulate their activity
  JOURNAL   PLoS Genet 9 (1), e1003210 (2013)
   PUBMED   23349634
  REMARK    GeneRIF: METTL22 trimethylates Lys-135 in Kin17
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC138420.2 and AC007224.5.
            
            On Jun 2, 2019 this sequence version replaced NM_024109.3.
            
            Summary: This gene encodes a member of the non-histone lysine
            methyltransferases. It interacts with its substrate, Kin17, which
            is involved in DNA repair and replication and mRNA processing.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Jan 2016].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the supported protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.197711.1,
                                           SRR7410570.572388.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000381920.8/ ENSP00000371345.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-78                AC138420.2         7933-8010           c
            79-381              AC138420.2         3910-4212           c
            382-762             AC138420.2         598-978             c
            763-803             AC007224.5         38282-38322
            804-948             AC007224.5         38411-38555
            949-1020            AC007224.5         42334-42405
            1021-1074           AC007224.5         44374-44427
            1075-1155           AC007224.5         45370-45450
            1156-1258           AC007224.5         45706-45808
            1259-1427           AC007224.5         47800-47968
            1428-4974           AC007224.5         49351-52897
FEATURES             Location/Qualifiers
     source          1..4974
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.2"
     gene            1..4974
                     /gene="METTL22"
                     /gene_synonym="C16orf68"
                     /note="methyltransferase 22, Kin17 lysine"
                     /db_xref="GeneID:79091"
                     /db_xref="HGNC:HGNC:28368"
                     /db_xref="MIM:615261"
     exon            1..78
                     /gene="METTL22"
                     /gene_synonym="C16orf68"
                     /inference="alignment:Splign:2.1.0"
     exon            79..381
                     /gene="METTL22"
                     /gene_synonym="C16orf68"
                     /inference="alignment:Splign:2.1.0"
     CDS             249..1463
                     /gene="METTL22"
                     /gene_synonym="C16orf68"
                     /note="LP8272; methyltransferase like 22"
                     /codon_start=1
                     /product="methyltransferase-like protein 22"
                     /protein_id="NP_077014.4"
                     /db_xref="CCDS:CCDS10533.2"
                     /db_xref="GeneID:79091"
                     /db_xref="HGNC:HGNC:28368"
                     /db_xref="MIM:615261"
                     /translation="MVQLAPAAAMDEVTFRSDTVLSDVHLYTPNHRHLMVRLNSVGQP
                     VFLSQFKLLWSQDSWTDSGAKGGSHRDVHTKEPPSAETGSTGSPPGSGHGNEGFSLQA
                     GTDTTGQEVAEAQLDEDGDLDVVRRPRAASDSNPAGPLRDKVHPMILAQEEDDVLGEE
                     AQGSPHDIIRIEHTMATPLEDVGKQVWRGALLLADYILFRQDLFRGCTALELGAGTGL
                     ASIIAATMARTVYCTDVGADLLSMCQRNIALNSHLAATGGGIVRVKELDWLKDDLCTD
                     PKVPFSWSQEEISDLYDHTTILFAAEVFYDDDLTDAVFKTLSRLAHRLKNACTAILSV
                     EKRLNFTLRHLDVTCEAYDHFRSCLHALEQLADGKLRFVVEPVEASFPQLLVYERLQQ
                     LELWKIIAEPVT"
     exon            382..762
                     /gene="METTL22"
                     /gene_synonym="C16orf68"
                     /inference="alignment:Splign:2.1.0"
     exon            763..803
                     /gene="METTL22"
                     /gene_synonym="C16orf68"
                     /inference="alignment:Splign:2.1.0"
     exon            804..948
                     /gene="METTL22"
                     /gene_synonym="C16orf68"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1020
                     /gene="METTL22"
                     /gene_synonym="C16orf68"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1074
                     /gene="METTL22"
                     /gene_synonym="C16orf68"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1155
                     /gene="METTL22"
                     /gene_synonym="C16orf68"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1258
                     /gene="METTL22"
                     /gene_synonym="C16orf68"
                     /inference="alignment:Splign:2.1.0"
     exon            1259..1427
                     /gene="METTL22"
                     /gene_synonym="C16orf68"
                     /inference="alignment:Splign:2.1.0"
     exon            1428..4974
                     /gene="METTL22"
                     /gene_synonym="C16orf68"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1516..1521
                     /regulatory_class="polyA_signal_sequence"
                     /gene="METTL22"
                     /gene_synonym="C16orf68"
                     /note="hexamer: AGTAAA"
     polyA_site      1538
                     /gene="METTL22"
                     /gene_synonym="C16orf68"
                     /note="major polyA site"
     regulatory      2052..2057
                     /regulatory_class="polyA_signal_sequence"
                     /gene="METTL22"
                     /gene_synonym="C16orf68"
                     /note="hexamer: AATAAA"
     polyA_site      2092
                     /gene="METTL22"
                     /gene_synonym="C16orf68"
     regulatory      3120..3125
                     /regulatory_class="polyA_signal_sequence"
                     /gene="METTL22"
                     /gene_synonym="C16orf68"
                     /note="hexamer: TATAAA"
     polyA_site      3143
                     /gene="METTL22"
                     /gene_synonym="C16orf68"
     regulatory      3477..3482
                     /regulatory_class="polyA_signal_sequence"
                     /gene="METTL22"
                     /gene_synonym="C16orf68"
                     /note="hexamer: ATTAAA"
     polyA_site      3496
                     /gene="METTL22"
                     /gene_synonym="C16orf68"
ORIGIN      
        1 agaccgcctg ttatggcggc cgcctaagtc ccacagagac gggagtcggg tgggatccca
       61 ggctgggccc cgcggcggct ggattctctt ccctggccaa gtctctgaga tcttctccca
      121 gggcgatgca aagctactcg ctaccagctt ggacctgtct gcagtatctc ctctgggacc
      181 tgccatgctg aggacccatt ctcacctctg agggactcct gtcctaggac taaggtggag
      241 cctgggccat ggtacagctg gctcctgcgg cagccatgga cgaggtcacc tttaggagcg
      301 acactgtgct gtcagatgtc cacctctata ccccgaacca tagacatctc atggtacggc
      361 tgaacagcgt ggggcagcca gttttcctgt cccaattcaa gcttctatgg agccaagact
      421 cttggacaga ttcaggagcc aagggtggca gtcacagaga tgttcacaca aaggagcctc
      481 cttctgctga gacaggcagc acagggtccc ctccaggaag tggccatggt aatgagggtt
      541 tctccctcca ggccgggact gacaccactg gccaggaagt ggctgaagct cagctggatg
      601 aggatgggga tttggacgtg gtgagaagac cacgagccgc ctctgattcc aacccagcag
      661 ggcctctgag agacaaggta catcccatga ttctagcaca ggaagaagac gacgtcctgg
      721 gagaggaagc acaaggcagc ccgcacgata tcatcagaat agagcacacc atggccacgc
      781 ccctggagga tgttggcaag caggtgtggc ggggcgccct gctcctggca gactacatcc
      841 tgttccgaca ggacctcttc cgaggatgta cagcgctgga gctcggggcc ggcacggggc
      901 tcgctagcat catcgcagcc accatggcac ggaccgttta ttgtacagat gtcggtgcag
      961 atctcttgtc catgtgccag cgaaacattg ccctcaacag ccacctggct gccactggag
     1021 gtggtatagt tagggtcaaa gaactggact ggctgaagga cgacctctgc acagatccca
     1081 aggtcccctt cagttggtca caagaggaaa tttctgactt gtacgatcac accaccatcc
     1141 tgtttgcagc cgaagtgttt tacgacgacg acttgactga tgctgtgttt aaaacgctct
     1201 cccgactcgc ccacagattg aaaaatgcct gcacagccat actgtcggtg gagaagaggc
     1261 tcaacttcac attgagacac ttggacgtca catgtgaagc ctacgatcac ttccgctcct
     1321 gcctgcacgc gctggagcag ctcgcagatg gcaagctgcg cttcgtggtg gagcccgtgg
     1381 aggcctcctt cccacagctc ctggtttacg agcgcctcca gcaactggag ctctggaaga
     1441 tcatcgcaga accagtaaca tgacccatcg cctccacaag gcgcggcgtc tcgactgttc
     1501 ttagagtgta tttctagtaa aatcagaagc tcaccaaagc aacatgcttg agattttgtc
     1561 attttaaaaa tatggttaca cgtaccttag atgacccaag atggttttct ggggtctgtc
     1621 cctgcctccc agttgtagcc agagaaggtt gttgctgtgg gctggaggtc actttagttg
     1681 cctgtttctc atggttgtga tgtgtgctcc agggtcaagc cgagccacgt tccttctcag
     1741 ctcagttcca cccacgtcag tcatttcagc tgtgtgcttt acttgcggtt gcggccctgg
     1801 ctgtgaggtg gattcttgta ctgccctctg tcagctgttt acagatgggt tgactaccac
     1861 tgccagtatt gccatcatat tgccgctcgg cacaaaagcc tcatttcctc ccagggttgg
     1921 gtatgctcca ccccatcact ctggtgaggg ccccatgaga aggaagaggc aggagctggc
     1981 gccaggaatg gactggcatt ggcctttgta tttaatttta actctttatc acccaaatca
     2041 ggtacgtttg gaataaacct aagagccact ctttggggtc atgtgcagct gaccagggtt
     2101 tgtgcagtga tcttcctcag aggtgttccc ttccgcctgg actcattttc cctccgcccc
     2161 ttggtctctc tgtcttatca cgtgtgtaca tgtctgtctg tctggttttt tatcttctcc
     2221 atctgtgcct ctctcctccc atctccaccc cttcctgtca tcctctatgt cccactgtct
     2281 ctctccttct ctccagtttt ggtcccatct tcctgctacc cttggccctc cctgcagccc
     2341 ctttcccctg ccttgctgct gccgcacact ttgcaccagg gcctttcatg gcccctttcc
     2401 gcctcccttg cagctcaggt ttcctggctt ctccatgcac tgtccctgcc cacactcgct
     2461 tctccccaag ctcccaggtt ccatccctag gcccatcata cccctggcat tggctaatcc
     2521 ctcatgccag gggccaggca cttgcaagtc taacttcatc ttcccaacaa atttaggagg
     2581 tccgcagcct tgtgataccc acattacagc ggagaagact gaggtccaaa aaggaaaaag
     2641 tctccatgag gtcagggacc ttgtttgtct taaatatcac tacatccctg ctgtatggtc
     2701 tggcaaacag tagatgctca acacatattg ttgaatgaat tgctaatgta agttactaat
     2761 taggtcatta tttcctattt gtgagtgatt ttgcctccag gaacatttgg cagtgcctgg
     2821 agacattttc ggtggtcaca agtaggggag acgggtgcca ccagtatcca gtgggtgagg
     2881 ccagagatgc tgctgaacgt tctataatgc ggtaatcacg gagcatcccc cacaacacaa
     2941 aatgatccag cccaaaatgt gagtagcgcc gaggcggaga aatcctgact tggaagaaga
     3001 aagccaagta ctttagagaa gaaaaacggt ctcagctgaa cctgtagtga gagcatgcag
     3061 gagagtgacc tcaccctgcc cctctgggag caagaagaaa acctatgcat gtacgttatt
     3121 ataaatcttc aaagaaccta aaaggcagaa gtgatcccta ttttgcacat gagaaatcca
     3181 aaattcagag aggttcagca acttgcccaa catcacacag caaccaaggg cagagtcagg
     3241 tttagagccc atgtccaccc atgtccatct gactcctgag cctgtgcttt tcccacattc
     3301 ccgctggagc agcagcagca tctgtggcat cacgtggatg ctggttagaa atgcaacatc
     3361 aggctgagca tgttggctca ctcctgcaat cccgatactt tgggaggcca aggcaggagg
     3421 atcaattaag gccaggagtt caaccagcct ggacaacaaa gcaagacccc atctctatta
     3481 aaaattaaac agccaattag tctggcatgg tggtttgcgc ctgcagtccc agctacttgg
     3541 gaggccgagg caggagaatc gcttgaacct gggaggcgaa ggttgcagtg agccaagatc
     3601 gcaacactgc cctccagcct gggcaacaga gccagacatc tcaaaaatta aaaagccagg
     3661 cgaggtgccg ggcatggtgg ctcatgcctg tcatcccagc actttgggag gccgaggcgg
     3721 gtggatcacc caaagtcagg agttcaagac cagcctggcc aacatggtga aaccctgcct
     3781 ctactaaaaa tacaaaatta gccgggtgtg gtggctcatg cctgtaatcc cagctacttg
     3841 ggaggctgag gcaggagaat cacttgaacc caggaggcag aggttgcagt gagccaagac
     3901 catgccattg cactctagcc tgggcaacaa gagcaaaact ccatctcaaa aaaaaaaaaa
     3961 agccaggcgt agtggctaac gcctgtagtc ccaactactc agaaggcaag gtgagaggat
     4021 tgcttgagcc taagaatttg aggctgcagt gagccatgac tgcaccattg cactctggcc
     4081 tgggcaacag agagagatcc tgtctccaaa aaagaagaaa agtatcaagc ctcagctcag
     4141 gacgtgattc cgaatctgca tctcaacgag accctgggtg atttgtgtgc acagtagttt
     4201 gagaagctct ggggcctacc acatagccct caacctattg ctgttttcta aaattcctac
     4261 acaaactccg ttcctgacag acttgccata atggagcagc attgcagatc actacaggga
     4321 atattaataa tgagtcttca aatcagaacc ccactagaca gagccaacaa ctggcagtac
     4381 gtcagcacta atggtgacaa tttcctagca ctcctgggta caagtccata aatgtaattg
     4441 gcaccaagca atagagttgt cacagctttc acctgccgca ttagggcaaa ctgcttttat
     4501 gtctaaacca ctgggcctga aagcttcctc taagtagagc ctggaattaa tcttgatcca
     4561 ctgtaattca aagtatcgtc agattttcat ttcccagagt gggagcgcgc ccccattgcc
     4621 atgttttatg gccttgtttg agcctctaca agtgcttgtt tggcagcgat attcagaatc
     4681 accaaaccat ggggatgttc tgctaggtaa ttagcccagg ccagtggact caattttttt
     4741 ataacatttt cagaaaaata tgtgacccaa ggaggggact tggctgttca gctgcagcct
     4801 gcatgggaaa gaactgttaa aaccaacaaa gccaggcaca gtggctcaca cctgtaattc
     4861 cagcattttg ggaggccgag gtgggtggat cacctaaggt caggagttcg agaccagcct
     4921 ggccaacatg gtgaaacccc gtctctacta aaaatacaaa aaaaaaaaaa aaaa
//
