LOCUS       NM_001010977            1625 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens methyltransferase 21C, AARS1 lysine (METTL21C), mRNA.
ACCESSION   NM_001010977 XM_116936
VERSION     NM_001010977.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1625)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1625)
  AUTHORS   Zoabi,M., Zhang,L., Li,T.M., Elias,J.E., Carlson,S.M. and Gozani,O.
  TITLE     Methyltransferase-like 21C (METTL21C) methylates alanine tRNA
            synthetase at Lys-943 in muscle tissue
  JOURNAL   J Biol Chem 295 (33), 11822-11832 (2020)
   PUBMED   32611769
REFERENCE   3  (bases 1 to 1625)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1625)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1625)
  AUTHORS   Zhao,F., Gao,L.H., Li,S.S., Wei,Z.Y., Fu,W.Z., He,J.W., Liu,Y.J.,
            Hu,Y.Q., Dong,J. and Zhang,Z.L.
  TITLE     Association between SNPs and haplotypes in the METTL21C gene and
            peak bone mineral density and body composition in Chinese male
            nuclear families
  JOURNAL   J Bone Miner Metab 35 (4), 437-447 (2017)
   PUBMED   27628047
  REMARK    GeneRIF: the polymorphisms and haplotypes of METTL21C contribute to
            the peak bone mineral density and total fat mass in Chinese males.
REFERENCE   6  (bases 1 to 1625)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   7  (bases 1 to 1625)
  AUTHORS   Cloutier,P., Lavallee-Adam,M., Faubert,D., Blanchette,M. and
            Coulombe,B.
  TITLE     A newly uncovered group of distantly related lysine
            methyltransferases preferentially interact with molecular
            chaperones to regulate their activity
  JOURNAL   PLoS Genet 9 (1), e1003210 (2013)
   PUBMED   23349634
REFERENCE   8  (bases 1 to 1625)
  AUTHORS   Kernstock,S., Davydova,E., Jakobsson,M., Moen,A., Pettersen,S.,
            Maelandsmo,G.M., Egge-Jacobsen,W. and Falnes,P.O.
  TITLE     Lysine methylation of VCP by a member of a novel human protein
            methyltransferase family
  JOURNAL   Nat Commun 3, 1038 (2012)
   PUBMED   22948820
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL158063.12.
            
            On Jul 31, 2020 this sequence version replaced NM_001010977.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC132748.1, AL576607.3 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2153307 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000267273.7/ ENSP00000267273.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-676               AL158063.12        137469-138144       c
            677-828             AL158063.12        133913-134064       c
            829-946             AL158063.12        130040-130157       c
            947-1625            AL158063.12        128847-129525       c
FEATURES             Location/Qualifiers
     source          1..1625
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q33.1"
     gene            1..1625
                     /gene="METTL21C"
                     /gene_synonym="C13orf39"
                     /note="methyltransferase 21C, AARS1 lysine"
                     /db_xref="GeneID:196541"
                     /db_xref="HGNC:HGNC:33717"
                     /db_xref="MIM:615259"
     exon            1..676
                     /gene="METTL21C"
                     /gene_synonym="C13orf39"
                     /inference="alignment:Splign:2.1.0"
     CDS             547..1341
                     /gene="METTL21C"
                     /gene_synonym="C13orf39"
                     /note="methyltransferase-like protein 21C;
                     methyltransferase like 21C"
                     /codon_start=1
                     /product="protein-lysine methyltransferase METTL21C"
                     /protein_id="NP_001010977.1"
                     /db_xref="CCDS:CCDS32003.1"
                     /db_xref="GeneID:196541"
                     /db_xref="HGNC:HGNC:33717"
                     /db_xref="MIM:615259"
                     /translation="MDVCLSSAQQPGRRGEGLSSPGGWLEAEKKGAPQKDSTGGVLEE
                     SNKIEPSLHSLQKFVPTDYASYTQEHYRFAGKEIVIQESIESYGAVVWPGAMALCQYL
                     EEHAEELNFQDAKILEIGAGPGLVSIVASILGAQVTATDLPDVLGNLQYNLLKNTLQC
                     TAHLPEVKELVWGEDLDKNFPKSAFYYDYVLASDVVYHHYFLDKLLTTMVYLSQPGTV
                     LLWANKFRFSTDYEFLDKFKQVFDTTLLAEYPESSVKLFKGILKWD"
     exon            677..828
                     /gene="METTL21C"
                     /gene_synonym="C13orf39"
                     /inference="alignment:Splign:2.1.0"
     exon            829..946
                     /gene="METTL21C"
                     /gene_synonym="C13orf39"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1625
                     /gene="METTL21C"
                     /gene_synonym="C13orf39"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1601..1606
                     /regulatory_class="polyA_signal_sequence"
                     /gene="METTL21C"
                     /gene_synonym="C13orf39"
                     /note="hexamer: AATAAA"
     polyA_site      1625
                     /gene="METTL21C"
                     /gene_synonym="C13orf39"
                     /note="major polyA site"
ORIGIN      
        1 aacgtttcga accacatcgc agcaactgga tgccacaggg gcagcctctg ttctgttcca
       61 gtgatattcc tgaaactttt gaagggaatt ccattgaatg ttgctaggac tgtgcgtgtg
      121 tgtgtgtgtg tgtgtgtgtg tgtgagagag agagagagag agagagagag aaagagagag
      181 aattctagca aagtaatgtg tctatgagga ctggtagata atgctaccct aaataacttg
      241 ggcttccact ggctggattt tgttcatcaa atgctaatcc tttcaggtgt agacctatat
      301 aaaacactgg ggattaaaga gtgcacagaa gcctcacatc tcttctgctg cataaggtaa
      361 agatacgtgt aacaattcaa aattattttg ggcatactaa caaggagtca tttccaattc
      421 tgtattaatt acgaacatgc gatgtagatc atagatgtgc tgaactagta acagtcagtc
      481 agtagattat agtcgttctt ttgtagattg cttttcaatg cacagctgtc tttgggacag
      541 ccggctatgg acgtgtgtct gagctccgcg cagcagcctg ggcgccgggg ggaaggactc
      601 agctccccgg gtggctggtt agaggctgag aagaaggggg ctccgcagaa agacagcacc
      661 gggggagtcc tagaagaatc caacaagata gaaccatctc ttcatagcct ccagaaattt
      721 gttcctacag attacgccag ctacactcag gagcattatc ggtttgcagg aaaggagatt
      781 gtcatccagg aatccataga gagttacgga gcggtggtgt ggccaggggc tatggctttg
      841 tgtcaatact tggaggaaca tgccgaggaa ttgaatttcc aagatgcaaa aatacttgaa
      901 attggtgccg gaccaggcct tgtttccatt gtggccagta ttttaggagc tcaagtcaca
      961 gcaacagatt tgcctgatgt cctgggaaac cttcaataca atcttttaaa aaacacacta
     1021 caatgtacag cacatctgcc tgaagtgaaa gaactggtat ggggggaaga cctggacaaa
     1081 aactttccca agtcagcttt ttactatgat tacgtcctag cctcagatgt ggtctaccat
     1141 cactacttcc tggacaagct gctcaccacc atggtgtacc tttcccagcc agggacggtg
     1201 ctgctttggg caaacaaatt caggttcagc accgactatg aatttttaga taaattcaag
     1261 caagtttttg acacaacact gttggctgaa tatccagagt catcagtcaa actttttaag
     1321 gggatactaa aatgggacta aatccaacaa aatgcctttc acaacgttac tgtgtctttt
     1381 gagcaatgtg ttagaaattg ctttggtaat agacttcttt cacaggattg agaaggtagt
     1441 gcatagaaac aacttgtata cttggaacaa atgtaacaat actgcagaaa ctttctaatt
     1501 tctaagataa tttaagatta tctggttaat ctaaatatct aaaaagaaca acataaaaac
     1561 atgaaagtag ctttgttggt tccaacgaag ttacatgttt aataaatctt acatggataa
     1621 agtaa
//
