LOCUS       NM_033418               1462 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens methyltransferase 18, RPL3 N3(tau)-histidine
            (METTL18), transcript variant 1, mRNA.
ACCESSION   NM_033418
VERSION     NM_033418.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1462)
  AUTHORS   Matsuura-Suzuki,E., Shimazu,T., Takahashi,M., Kotoshiba,K.,
            Suzuki,T., Kashiwagi,K., Sohtome,Y., Akakabe,M., Sodeoka,M.,
            Dohmae,N., Ito,T., Shinkai,Y. and Iwasaki,S.
  TITLE     METTL18-mediated histidine methylation of RPL3 modulates
            translation elongation for proteostasis maintenance
  JOURNAL   Elife 11, e72780 (2022)
   PUBMED   35674491
  REMARK    GeneRIF: METTL18-mediated histidine methylation of RPL3 modulates
            translation elongation for proteostasis maintenance.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1462)
  AUTHORS   Malecki,J.M., Odonohue,M.F., Kim,Y., Jakobsson,M.E., Gessa,L.,
            Pinto,R., Wu,J., Davydova,E., Moen,A., Olsen,J.V., Thiede,B.,
            Gleizes,P.E., Leidel,S.A. and Falnes,P.O.
  TITLE     Human METTL18 is a histidine-specific methyltransferase that
            targets RPL3 and affects ribosome biogenesis and function
  JOURNAL   Nucleic Acids Res 49 (6), 3185-3203 (2021)
   PUBMED   33693809
  REMARK    GeneRIF: Human METTL18 is a histidine-specific methyltransferase
            that targets RPL3 and affects ribosome biogenesis and function.
REFERENCE   3  (bases 1 to 1462)
  AUTHORS   Cloutier,P., Lavallee-Adam,M., Faubert,D., Blanchette,M. and
            Coulombe,B.
  TITLE     A newly uncovered group of distantly related lysine
            methyltransferases preferentially interact with molecular
            chaperones to regulate their activity
  JOURNAL   PLoS Genet 9 (1), e1003210 (2013)
   PUBMED   23349634
REFERENCE   4  (bases 1 to 1462)
  AUTHORS   Webb,K.J., Zurita-Lopez,C.I., Al-Hadid,Q., Laganowsky,A.,
            Young,B.D., Lipson,R.S., Souda,P., Faull,K.F., Whitelegge,J.P. and
            Clarke,S.G.
  TITLE     A novel 3-methylhistidine modification of yeast ribosomal protein
            Rpl3 is dependent upon the YIL110W methyltransferase
  JOURNAL   J Biol Chem 285 (48), 37598-37606 (2010)
   PUBMED   20864530
REFERENCE   5  (bases 1 to 1462)
  AUTHORS   Ehret,G.B., O'Connor,A.A., Weder,A., Cooper,R.S. and Chakravarti,A.
  TITLE     Follow-up of a major linkage peak on chromosome 1 reveals
            suggestive QTLs associated with essential hypertension: GenNet
            study
  JOURNAL   Eur J Hum Genet 17 (12), 1650-1657 (2009)
   PUBMED   19536175
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 1462)
  AUTHORS   Cheung,C.L., Chan,B.Y., Chan,V., Ikegawa,S., Kou,I., Ngai,H.,
            Smith,D., Luk,K.D., Huang,Q.Y., Mori,S., Sham,P.C. and Kung,A.W.
  TITLE     Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible
            genetic association with bone mineral density variation
  JOURNAL   Hum Mol Genet 18 (4), 679-687 (2009)
   PUBMED   19064610
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY159746.1 and BC008679.1.
            
            On Nov 23, 2018 this sequence version replaced NM_033418.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. All three variants encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.705390.1,
                                           SRR5189658.94145.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000310392.5/ ENSP00000307975.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-434               HY159746.1         70-503
            435-1462            BC008679.1         399-1426
FEATURES             Location/Qualifiers
     source          1..1462
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q24.2"
     gene            1..1462
                     /gene="METTL18"
                     /gene_synonym="AsTP2; C1orf156; HPM1"
                     /note="methyltransferase 18, RPL3 N3(tau)-histidine"
                     /db_xref="GeneID:92342"
                     /db_xref="HGNC:HGNC:28793"
                     /db_xref="MIM:615255"
     exon            1..93
                     /gene="METTL18"
                     /gene_synonym="AsTP2; C1orf156; HPM1"
                     /inference="alignment:Splign:2.1.0"
     exon            94..1462
                     /gene="METTL18"
                     /gene_synonym="AsTP2; C1orf156; HPM1"
                     /inference="alignment:Splign:2.1.0"
     CDS             296..1414
                     /gene="METTL18"
                     /gene_synonym="AsTP2; C1orf156; HPM1"
                     /EC_number="2.1.1.85"
                     /note="arsenic-transactivated protein 2;
                     methyltransferase-like protein 18; methyltransferase like
                     18; methyltransferase 18, RPL3 N3-histidine"
                     /codon_start=1
                     /product="histidine protein methyltransferase 1 homolog"
                     /protein_id="NP_219486.1"
                     /db_xref="CCDS:CCDS1284.1"
                     /db_xref="GeneID:92342"
                     /db_xref="HGNC:HGNC:28793"
                     /db_xref="MIM:615255"
                     /translation="MTFQFNFTIEDHLENELTPIRDGALTLDSSKELSVSESQKGEER
                     DRKCSAEQFDLPQDHLWEHKSMENAAPSQDTDSPLSAASSSRNLEPHGKQPSLRAAKE
                     HAMPKDLKKMLENKVIETLPGFQHVKLSVVKTILLKENFPGENIVSKSFSSHSDLITG
                     VYEGGLKIWECTFDLLAYFTKAKVKFAGKKVLDLGCGSGLLGITAFKGGSKEIHFQDY
                     NSMVIDEVTLPNVVANSTLEDEENDVNEPDVKRCRKPKVTQLYKCRFFSGEWSEFCKL
                     VLSSEKLFVKYDLILTSETIYNPDYYSNLHQTFLRLLSKNGRVLLASKAHYFGVGGGV
                     HLFQKFVEERDVFKTRILKIIDEGLKRFIIEITFKFPG"
     regulatory      1442..1447
                     /regulatory_class="polyA_signal_sequence"
                     /gene="METTL18"
                     /gene_synonym="AsTP2; C1orf156; HPM1"
                     /note="hexamer: AATAAA"
     polyA_site      1462
                     /gene="METTL18"
                     /gene_synonym="AsTP2; C1orf156; HPM1"
                     /note="major polyA site"
ORIGIN      
        1 actggtgcgc gatttaggtc cggaggaggc gttgtgaggt gagctttttc agaagcgcga
       61 tcccaggaca cgtcgggaag caagcatccc cagagctgct tggaaagagg accaaagacg
      121 tctaaaaagt catttggaaa tatctctaaa tatttgttac catgtataag ctgctaaaga
      181 gaaattgggc ccaacaaaac taattgaata attgaggcag atttgtgtgt atcatcaaat
      241 tctatccaga agttgaagaa tctgaattta aagattgtgt gcatttaata agaggatgac
      301 ctttcagttt aatttcacta tagaagacca tctggaaaat gaattaacac ccattagaga
      361 tggagctttg accctggatt cctcaaaaga gctgtcagtc tcagaaagtc aaaaaggaga
      421 agagagggac agaaaatgtt ctgcagaaca atttgacttg cctcaggatc acttgtggga
      481 acataagtca atggaaaatg cagctccctc tcaagacaca gacagtccac tcagtgcagc
      541 cagcagttca aggaacttgg agccacatgg aaaacagccc tccttgagag ctgccaaaga
      601 gcatgctatg cctaaagatt taaagaagat gttagaaaat aaagtcatag aaacattacc
      661 aggtttccag catgttaagt tatcagtagt gaaaaccatc ttgttgaaag agaacttccc
      721 tggagaaaac atagtttcaa aaagcttttc ttctcactct gatctgatta caggtgttta
      781 tgagggaggc ttaaaaatct gggaatgtac ctttgacctc ctggcttatt tcacaaaggc
      841 caaagtgaaa tttgctggga aaaaagtctt ggatcttggt tgtggatcag gtttactagg
      901 tataactgca ttcaagggag ggtccaaaga aattcacttt caagattata acagtatggt
      961 gattgatgaa gtaaccttac ctaatgtagt agctaactcc actttggaag atgaagaaaa
     1021 tgatgtaaat gagccagatg tgaaaagatg caggaaacca aaagtaacac aactatataa
     1081 atgccgattt ttttctggtg agtggtctga gttttgtaag cttgtactaa gtagtgaaaa
     1141 actttttgta aaatatgatc tcattctcac ctcagaaacc atttacaacc cagattatta
     1201 tagtaatttg caccagactt tccttagact gttaagtaaa aatggacgtg tacttttggc
     1261 cagcaaagca cattattttg gtgtaggtgg aggtgttcat ctctttcaga agtttgtaga
     1321 agaaagagat gtttttaaga ccagaatact caaaataatt gatgaaggat tgaagaggtt
     1381 cataattgaa ataactttta agtttcctgg ttaattaaca ttcactgagt atccaaaatg
     1441 aaataaacag aaggaccaaa aa
//
