LOCUS       NM_024086               5740 bp    mRNA    linear   PRI 08-DEC-2024
DEFINITION  Homo sapiens methyltransferase 16, RNA N6-adenosine (METTL16),
            mRNA.
ACCESSION   NM_024086
VERSION     NM_024086.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5740)
  AUTHORS   Wang,J., Xiu,M., Wang,J., Gao,Y. and Li,Y.
  TITLE     METTL16-SENP3-LTF axis confers ferroptosis resistance and
            facilitates tumorigenesis in hepatocellular carcinoma
  JOURNAL   J Hematol Oncol 17 (1), 78 (2024)
   PUBMED   39218945
  REMARK    GeneRIF: METTL16-SENP3-LTF axis confers ferroptosis resistance and
            facilitates tumorigenesis in hepatocellular carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5740)
  AUTHORS   Wu,J., Ouyang,P., Huang,R., Cui,Y., Yang,Z., Xu,W., Ma,R.,
            Xiang,G., Zeng,W., Wu,W. and Li,J.
  TITLE     METTL16 Promotes Stability of SYNPO2L mRNA and leading to Cancer
            Cell Lung Metastasis by Secretion of COL10A1 and attract the
            Cancer-Associated Fibroblasts
  JOURNAL   Int J Biol Sci 20 (11), 4128-4145 (2024)
   PUBMED   39247832
  REMARK    GeneRIF: METTL16 Promotes Stability of SYNPO2L mRNA and leading to
            Cancer Cell Lung Metastasis by Secretion of COL10A1 and attract the
            Cancer-Associated Fibroblasts.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5740)
  AUTHORS   Han,Y., Sun,K., Yu,S., Qin,Y., Zhang,Z., Luo,J., Hu,H., Dai,L.,
            Cui,M., Jiang,C., Liu,F., Huang,Y., Gao,P., Chen,X., Xin,T.,
            Ren,X., Wu,X., Song,J., Wang,Q., Tang,Z., Chen,J., Zhang,H.,
            Zhang,X., Liu,M. and Luo,D.
  TITLE     A Mettl16/m6A/mybl2b/Igf2bp1 axis ensures cell cycle progression of
            embryonic hematopoietic stem and progenitor cells
  JOURNAL   EMBO J 43 (10), 1990-2014 (2024)
   PUBMED   38605226
  REMARK    GeneRIF: A Mettl16/m[6]A/mybl2b/Igf2bp1 axis ensures cell cycle
            progression of embryonic hematopoietic stem and progenitor cells.
REFERENCE   4  (bases 1 to 5740)
  AUTHORS   Li,Q., Wang,Y., Meng,X., Wang,W., Duan,F., Chen,S., Zhang,Y.,
            Sheng,Z., Gao,Y. and Zhou,L.
  TITLE     METTL16 inhibits papillary thyroid cancer tumorigenicity through
            m6A/YTHDC2/SCD1-regulated lipid metabolism
  JOURNAL   Cell Mol Life Sci 81 (1), 81 (2024)
   PUBMED   38334797
  REMARK    GeneRIF: METTL16 inhibits papillary thyroid cancer tumorigenicity
            through m[6]A/YTHDC2/SCD1-regulated lipid metabolism.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5740)
  AUTHORS   Yu,H., Zhuang,J., Zhou,Z., Song,Q., Lv,J., Yang,X., Yang,H. and
            Lu,Q.
  TITLE     METTL16 suppressed the proliferation and cisplatin-chemoresistance
            of bladder cancer by degrading PMEPA1 mRNA in a m6A manner through
            autophagy pathway
  JOURNAL   Int J Biol Sci 20 (4), 1471-1491 (2024)
   PUBMED   38385084
  REMARK    GeneRIF: METTL16 suppressed the proliferation and
            cisplatin-chemoresistance of bladder cancer by degrading PMEPA1
            mRNA in a m6A manner through autophagy pathway.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5740)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   7  (bases 1 to 5740)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   8  (bases 1 to 5740)
  AUTHORS   Docherty,S.J., Kovas,Y., Petrill,S.A. and Plomin,R.
  TITLE     Generalist genes analysis of DNA markers associated with
            mathematical ability and disability reveals shared influence across
            ages and abilities
  JOURNAL   BMC Genet 11, 61 (2010)
   PUBMED   20602751
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 5740)
  AUTHORS   Sergiev,P.V., Serebryakova,M.V., Bogdanov,A.A. and Dontsova,O.A.
  TITLE     The ybiN gene of Escherichia coli encodes adenine-N6
            methyltransferase specific for modification of A1618 of 23 S
            ribosomal RNA, a methylated residue located close to the ribosomal
            exit tunnel
  JOURNAL   J Mol Biol 375 (1), 291-300 (2008)
   PUBMED   18021804
REFERENCE   10 (bases 1 to 5740)
  AUTHORS   Sudo,K., Chinen,K. and Nakamura,Y.
  TITLE     2058 expressed sequence tags (ESTs) from a human fetal lung cDNA
            library
  JOURNAL   Genomics 24 (2), 276-279 (1994)
   PUBMED   7698749
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB227557.1, BC050603.1 and AC006435.7.
            
            On Nov 22, 2018 this sequence version replaced NM_024086.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.110068.1,
                                           SRR1803613.48805.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000263092.11/ ENSP00000263092.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                DB227557.1         19-60
            43-1565             BC050603.1         1-1523
            1566-5740           AC006435.7         89169-93343         c
FEATURES             Location/Qualifiers
     source          1..5740
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.3"
     gene            1..5740
                     /gene="METTL16"
                     /gene_synonym="METT10D"
                     /note="methyltransferase 16, RNA N6-adenosine"
                     /db_xref="GeneID:79066"
                     /db_xref="HGNC:HGNC:28484"
     exon            1..130
                     /gene="METTL16"
                     /gene_synonym="METT10D"
                     /inference="alignment:Splign:2.1.0"
     CDS             131..1819
                     /gene="METTL16"
                     /gene_synonym="METT10D"
                     /EC_number="2.1.1.346"
                     /EC_number="2.1.1.348"
                     /note="methyltransferase 10 domain containing;
                     methyltransferase 16, N6-methyladenosine; putative
                     methyltransferase METT10D; methyltransferase-like protein
                     16; methyltransferase 10 domain-containing protein;
                     N6-adenosine-methyltransferase METTL16; U6 small nuclear
                     RNA (adenine-(43)-N(6))-methyltransferase; U6 snRNA
                     methyltransferase; RNA N6-adenosine-methyltransferase
                     METTL16; methyltransferase like 16; N6-methyladenosine
                     methyltransferase"
                     /codon_start=1
                     /product="RNA N(6)-adenosine-methyltransferase METTL16"
                     /protein_id="NP_076991.3"
                     /db_xref="CCDS:CCDS42232.1"
                     /db_xref="GeneID:79066"
                     /db_xref="HGNC:HGNC:28484"
                     /translation="MALSKSMHARNRYKDKPPDFAYLASKYPDFKQHVQINLNGRVSL
                     NFKDPEAVRALTCTLLREDFGLSIDIPLERLIPTVPLRLNYIHWVEDLIGHQDSDKST
                     LRRGIDIGTGASCIYPLLGATLNGWYFLATEVDDMCFNYAKKNVEQNNLSDLIKVVKV
                     PQKTLLMDALKEESEIIYDFCMCNPPFFANQLEAKGVNSRNPRRPPPSSVNTGGITEI
                     MAEGGELEFVKRIIHDSLQLKKRLRWYSCMLGKKCSLAPLKEELRIQGVPKVTYTEFC
                     QGRTMRWALAWSFYDDVTVPSPPSKRRKLEKPRKPITFVVLASVMKELSLKASPLRSE
                     TAEGIVVVTTWIEKILTDLKVQHKRVPCGKEEVSLFLTAIENSWIHLRRKKRERVRQL
                     REVPRAPEDVIQALEEKKPTPKESGNSQELARGPQERTPCGPALREGEAAAVEGPCPS
                     QESLSQEENPEPTEDERSEEKGGVEVLESCQGSSNGAQDQEASEQFGSPVAERGKRLP
                     GVAGQYLFKCLINVKKEVDDALVEMHWVEGQNRDLMNQLCTYIRNQIFRLVAVN"
     exon            131..258
                     /gene="METTL16"
                     /gene_synonym="METT10D"
                     /inference="alignment:Splign:2.1.0"
     exon            259..458
                     /gene="METTL16"
                     /gene_synonym="METT10D"
                     /inference="alignment:Splign:2.1.0"
     exon            459..599
                     /gene="METTL16"
                     /gene_synonym="METT10D"
                     /inference="alignment:Splign:2.1.0"
     exon            600..715
                     /gene="METTL16"
                     /gene_synonym="METT10D"
                     /inference="alignment:Splign:2.1.0"
     exon            716..858
                     /gene="METTL16"
                     /gene_synonym="METT10D"
                     /inference="alignment:Splign:2.1.0"
     exon            859..928
                     /gene="METTL16"
                     /gene_synonym="METT10D"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1018
                     /gene="METTL16"
                     /gene_synonym="METT10D"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1192
                     /gene="METTL16"
                     /gene_synonym="METT10D"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..5740
                     /gene="METTL16"
                     /gene_synonym="METT10D"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5717..5722
                     /regulatory_class="polyA_signal_sequence"
                     /gene="METTL16"
                     /gene_synonym="METT10D"
                     /note="hexamer: AATAAA"
     polyA_site      5740
                     /gene="METTL16"
                     /gene_synonym="METT10D"
                     /note="major polyA site"
ORIGIN      
        1 acaagatggc ggcgcgctgg gagcgtatca tctgcgtttc taggagcttc gctatgcggc
       61 tgctttaaga ttctagggtt gtacaggccc acgccagaca cgacgtctgg caggaacctc
      121 ggcctcagag atggctctga gtaaatcaat gcatgcaaga aatagataca aggacaaacc
      181 tcctgacttt gcatatctgg catccaaata tccagatttt aagcagcatg ttcagataaa
      241 tctgaatgga agagtgagcc ttaattttaa agaccccgaa gcagtcagag ctctgacgtg
      301 tactctccta agggaagatt ttggactttc tattgatatt ccattggaga gactaattcc
      361 cacagttccc ttgagactca actatattca ctgggtagaa gatctgatcg gtcaccagga
      421 ttctgacaaa agtactctcc gaagaggaat tgacataggc acgggggcat cttgcatcta
      481 ccccttactt ggagcaacct tgaatggctg gtatttcctc gcaacagaag tggatgatat
      541 gtgtttcaac tatgcaaaga aaaatgtgga acagaataac ttatctgatc tcataaaagt
      601 ggtgaaagtg ccacagaaga cactcctgat ggatgctctt aaagaagaat ctgagataat
      661 ctatgacttt tgcatgtgca accctccctt ttttgccaat caattggaag ccaagggagt
      721 aaactcacga aatcctcgaa gacctccgcc tagttctgtt aatacaggag gcatcacaga
      781 gatcatggca gaaggaggtg aattagagtt tgttaaaagg atcatccatg acagtctaca
      841 acttaaaaaa agattaagat ggtatagctg catgctggga aagaaatgca gcctggcgcc
      901 tctgaaggag gagcttcgca tacaaggggt tcccaaagta acgtacactg aattctgtca
      961 aggtcggaca atgagatggg ccttagcttg gagtttttat gatgatgtca cagtaccatc
     1021 accaccaagt aagcgaagaa aattagagaa accgagaaaa cccataacat tcgtggtgct
     1081 ggcgtccgtg atgaaggaat tatccctcaa agcatcacct ctgcgctcgg agacggcgga
     1141 aggcatagtc gttgtcacga catggattga aaaaattctc actgatttga aggtccagca
     1201 taaacgagtt ccctgtggaa aagaggaagt cagccttttc ctaacggcca tagaaaactc
     1261 ctggattcat ttaaggagaa agaaaagaga gcgtgtgaga cagctgagag aagttccccg
     1321 agctcctgag gacgtcattc aggccttgga agagaaaaag cccaccccca aagagtctgg
     1381 caatagccaa gaactggcca ggggccccca ggagaggacc ccctgtgggc ctgctctgcg
     1441 ggaaggcgag gctgccgctg tggagggccc gtgcccgagc caggagtccc tgtcccagga
     1501 ggaaaacccg gaacccacgg aggatgaaag gagtgaggaa aagggagggg tggaggtttt
     1561 ggaaagttgt caaggctcta gcaacggagc ccaggaccaa gaggcttctg agcagttcgg
     1621 cagcccagtg gctgaaaggg ggaaacgtct cccaggagtg gccggacagt acctgtttaa
     1681 gtgtttgata aacgttaaga aggaggtgga cgatgcctta gtggagatgc actgggttga
     1741 gggccagaac agggatctga tgaaccagct ttgcacctac atacgtaacc aaattttcag
     1801 gcttgttgca gttaactaga aacctcctgc acagttggaa acgtgttgat agtaacttgc
     1861 tttggagtgg cctgtggggt ggcaagagga atcctaccag cggcccatta gtagcacgat
     1921 gtggaattat cttcgaaaac aaaaacctat gaatctgtcc cccacctccc cccgcctcct
     1981 tcccgctttt tgagttacag ggagtcgtag tgtggtcatt tacaaggagg aattgtggtc
     2041 atcagtaaca acagaaagcc ctcagtaaac tcccgaggga ttgcaagctg gctcaagctg
     2101 gcccctcagc tctggactgc ctctgcaagg tcagaagggt tgtttgtgga gtctgggctg
     2161 ggcagcactg cctagaatat catgctgtct ctgtcaccca agggtgtttc ttgaggaggg
     2221 gtggctctct ctgcctccag ctggaggccc tggtaccctg ttctaggtca ctcttcaaga
     2281 tggggcctac cttgcatcaa tcccacaaag ggagctgtat ggtgggtggt ggggaatctg
     2341 ggagagaaac cttagtaatg ctgggaagga gcagcagagt ctggggacca cccggtaaat
     2401 ggcacattcc tgacacctgg ctgttttgat gttgcttatt tcagaagcag aattaggtaa
     2461 gcaaaactcc ccggtgtgac tgaggcacac agaaggcacc cataccccca cctccagcct
     2521 gttgacagta ccattttgta gcagttttac tactgtgtga tttttgtttg gacatctgaa
     2581 gtagagcttg ttttgttttt aaataagaat attcacaaat taaaaaccag cggtcctatt
     2641 tgaatcctgg ggttagctga gtgagcggct gatgatagaa atgagaaata gaacaaaata
     2701 gtatgtgccg taggtagctt aagaaagtct cagatatttt gttgctgatc aaatactgtt
     2761 tttttgtggc ttcacttgta atcccccctg tacttaccta ctcacattgg agagttctga
     2821 ggccggagta actgtgtcct tgaaacacgt ttctaattgg aatgccaggg ttcagtagcc
     2881 gtccccccgg aaaggggtga ccttttgctg tgcttgatgt tgcatcagca gcctagggtt
     2941 ctgtttagac taaaatcttg gccagagctc cttgccatct gctaagaaga ctggggctga
     3001 gtagttaagc cagccttctg agaggtggct gttggtcagg acgggaagct ggtgaccttg
     3061 gcatgtcttg gcagcagcta gatcaggccc tcggcagaga cacaggaagc ggaactgctg
     3121 tgccttaact tggctgtgga gctggagctg gagaaggcag catactgacc agtggctttt
     3181 tgattgattg tttgttatga ggtggagttt tactcttgtt gtctaggctg gagtgccgtg
     3241 gtgcgatctt agctcactgc aacccccgcc tcccgggttc aagcgattct cctgcctcag
     3301 cctcccaagt agctgggatt acaggcacgc gccaccacgc ctggctaatt ttgtgttttt
     3361 ggtagagatg ggatttcacc atgttggcca ggctaatctc gaactcatga tctcgggtga
     3421 tccgcccacc ttggcctccc aaagtgctgg gattacagcc gtgagccact actcccagcc
     3481 tctgaccagt gttcttaacc tggtccgtgg acctccagag agtccatgta cctcctagag
     3541 ttacttctaa aagctctgtg agcatgtgtg tgtgtgtgtg tgtgtgtgtg tatttttttt
     3601 cctggagaga gggttcccag aaccctcaga cacagacaaa ggggtcaata acccactaag
     3661 gattaagaat cattattcta gtccaagcat tcatgtgtca ggctgcaaaa aacaataccc
     3721 agggtcacac agagccaaga ctcaattcag gaccgtggat tcccctggtc tagaaatttt
     3781 ctgctgtgcc agcccacacc accccactgt ccttacctcg agtgaatatt acatttgagt
     3841 catttgctgg gcccaaacct agtttccttg gtataatttt aggataattg tttaagtggc
     3901 aactattcat tcagtaagta gtaagtactt attgtttgct tgtttcatta tgaaagagtg
     3961 gcacatgctc attaaagatt tggaaaaatg aaagtcaaaa caacaaaatc accccgagtc
     4021 ccaaccttct gtaacataac cactcttggc attggcgtgt tcctttctag tctctctgta
     4081 gacggggtgt gtgagtgtgt gggtttaact ttggttgtcc tcatgctgcg tattcagttt
     4141 tgtattctgg tcctttgttc atttaacatc ttacaagtat ttgtccatgt tgtaacagta
     4201 gtgtattagc ttacactcct tgcctgttca aaatgtcttt caggcacagc actggccttt
     4261 aagcctgtgt cgtagggatt tccagagaat gctctgtgta ttgaagcaca gaaggtgttt
     4321 ctgtgtctca gtgtgtttct gtccctaggt ttaaggcttc atgtcatgga ggagatttta
     4381 tagatgtcaa gctaatgacc ttagagtttt aaaaaatccg tgaccgtggc caggcgcagt
     4441 ggctcacgcc tgtaatccca gcactgtgag gctgagatgg gcgcatcgca tgaggtcggg
     4501 agtttgagac cagcctggcc aacatggcga aaccccgtct ctactcaaaa tacaaaaatt
     4561 agccgggcat gatagcacgt gcctgtaatc ccagctactc gggaggctga ggcaggagac
     4621 tcgcttgaac ctgggaggtg gaggttgcag tgagccgaga atgccactgc actacagcct
     4681 gggcgacaaa gtgggactgt ctcaaaaaaa aaaaaaaaaa aaaaaaaaaa ggaacccatg
     4741 agcaggccag ctttcagtct ggagccgagt gccttctgtg catttggatg tttccatttc
     4801 cttccctgag aagattttct taggctacct agtgagagaa cattgaaaat atttttaaag
     4861 gacatctaag cattgttttg gtcatgcata tgctttataa ttgtgtgttg tttcatagca
     4921 tatacctctg gtacaggtgg gcaagttttt ctttgaagaa atgggttatt gactcatatg
     4981 tcataacctt gagtgttact ctcccggtgt ccagaggtca cattcatgtt gcggggttgg
     5041 tatgaaatta aatcttggtg atgtgaccct acattctctt ctggtcccta gaatcggctt
     5101 ctggtctcct gataactgaa gtggagacag aagttgagcc tgttgcccag gcaaactaaa
     5161 gctgcttttg ttcttcggaa tctgctttgc ctccgtcagc ctgcttcctt ccccacacat
     5221 gctggccgca ctgtccccac tccagacctc tgctgtgtgt cctgggcagg gccgcgtttt
     5281 ggcagtaccc tttcaactca tcctaagctt cgtgtagatt actttagtat atatttttta
     5341 taaaacataa agcctttcct ctcgatggaa atcaaagctt accatgtgag cactcgaact
     5401 tctaagttgt gacaggaata acaaaactgc aaggagtgga aaagatggaa aagcctgtgg
     5461 gaaatccgag gccttttgaa agaagggagc tgatgacttc acgaccagct cctggagccc
     5521 ctcctttctg ctgaagccgc ggcatttccc tccgtggcca cacgagggca cccttggccc
     5581 ttttatcaaa gcgccttcac ttccccgtgg gaatggagac aagtctgtcc acggtgtttt
     5641 cttgaaatac ccagttgcta cccagatttg tatttttatg taaacaaata cattttcaca
     5701 gaaataaaat ttgaaaaata aaagtagaaa gagaaaaaaa
//
