LOCUS       NM_020961               6642 bp    mRNA    linear   PRI 08-DEC-2024
DEFINITION  Homo sapiens methyltransferase 14, N6-adenosine-methyltransferase
            non-catalytic subunit (METTL14), mRNA.
ACCESSION   NM_020961
VERSION     NM_020961.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6642)
  AUTHORS   Zhang,M., Xie,Z., Tan,Y., Wu,Y., Wang,M., Zhang,P., Yuan,Y. and
            Li,J.
  TITLE     METTL14-mediated N6-methyladenosine modification of TCP1 mRNA
            promotes acute myeloid leukemia progression
  JOURNAL   Cell Signal 122, 111304 (2024)
   PUBMED   39033992
  REMARK    GeneRIF: METTL14-mediated N6-methyladenosine modification of TCP1
            mRNA promotes acute myeloid leukemia progression.
REFERENCE   2  (bases 1 to 6642)
  AUTHORS   Chen,J.H., Li,J.J., Yuan,Y., Tian,Q., Feng,D.D., Zhuang,L.L.,
            Cao,Q., Zhou,G.P. and Jin,R.
  TITLE     ETS1 and RBPJ transcriptionally regulate METTL14 to suppress
            TGF-beta1-induced epithelial-mesenchymal transition in human
            bronchial epithelial cells
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (7), 167349 (2024)
   PUBMED   39002703
  REMARK    GeneRIF: ETS1 and RBPJ transcriptionally regulate METTL14 to
            suppress TGF-beta1-induced epithelial-mesenchymal transition in
            human bronchial epithelial cells.
REFERENCE   3  (bases 1 to 6642)
  AUTHORS   Zhang,Z., Mao,H., Li,F., Wang,D. and Liu,Y.
  TITLE     METTL14-mediated lncRNA-FAS-AS1 promotes osteoarthritis progression
            by up-regulating ADAM8
  JOURNAL   Int J Rheum Dis 27 (9), e15323 (2024)
   PUBMED   39221886
  REMARK    GeneRIF: METTL14-mediated lncRNA-FAS-AS1 promotes osteoarthritis
            progression by up-regulating ADAM8.
REFERENCE   4  (bases 1 to 6642)
  AUTHORS   Gu,X., Song,Y., Liu,X., Cheng,Z., Min,J. and Zhang,Y.
  TITLE     METTL14-Mediated m6A Modification of TUG1 Represses Ferroptosis in
            Alzheimer's Disease via Inhibiting GDF15 Ubiquitination
  JOURNAL   Front Biosci (Landmark Ed) 29 (8), 298 (2024)
   PUBMED   39206905
  REMARK    GeneRIF: METTL14-Mediated m6A Modification of TUG1 Represses
            Ferroptosis in Alzheimer's Disease via Inhibiting GDF15
            Ubiquitination.
REFERENCE   5  (bases 1 to 6642)
  AUTHORS   Hu,C., Song,S., Zhao,S., Xue,Z. and Zhu,X.
  TITLE     METTL14 contributes to the progression of nasopharyngeal carcinoma
            through regulating the stability of AOC1 mRNA
  JOURNAL   Hereditas 161 (1), 20 (2024)
   PUBMED   38956710
  REMARK    GeneRIF: METTL14 contributes to the progression of nasopharyngeal
            carcinoma through regulating the stability of AOC1 mRNA.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6642)
  AUTHORS   Bystrom,S., Ayoglu,B., Haggmark,A., Mitsios,N., Hong,M.G.,
            Drobin,K., Forsstrom,B., Fredolini,C., Khademi,M., Amor,S.,
            Uhlen,M., Olsson,T., Mulder,J., Nilsson,P. and Schwenk,J.M.
  TITLE     Affinity proteomic profiling of plasma, cerebrospinal fluid, and
            brain tissue within multiple sclerosis
  JOURNAL   J Proteome Res 13 (11), 4607-4619 (2014)
   PUBMED   25231264
REFERENCE   7  (bases 1 to 6642)
  AUTHORS   Schwartz,S., Mumbach,M.R., Jovanovic,M., Wang,T., Maciag,K.,
            Bushkin,G.G., Mertins,P., Ter-Ovanesyan,D., Habib,N.,
            Cacchiarelli,D., Sanjana,N.E., Freinkman,E., Pacold,M.E.,
            Satija,R., Mikkelsen,T.S., Hacohen,N., Zhang,F., Carr,S.A.,
            Lander,E.S. and Regev,A.
  TITLE     Perturbation of m6A writers reveals two distinct classes of mRNA
            methylation at internal and 5' sites
  JOURNAL   Cell Rep 8 (1), 284-296 (2014)
   PUBMED   24981863
REFERENCE   8  (bases 1 to 6642)
  AUTHORS   Wang,Y., Li,Y., Toth,J.I., Petroski,M.D., Zhang,Z. and Zhao,J.C.
  TITLE     N6-methyladenosine modification destabilizes developmental
            regulators in embryonic stem cells
  JOURNAL   Nat Cell Biol 16 (2), 191-198 (2014)
   PUBMED   24394384
REFERENCE   9  (bases 1 to 6642)
  AUTHORS   Liu,J., Yue,Y., Han,D., Wang,X., Fu,Y., Zhang,L., Jia,G., Yu,M.,
            Lu,Z., Deng,X., Dai,Q., Chen,W. and He,C.
  TITLE     A METTL3-METTL14 complex mediates mammalian nuclear RNA
            N6-adenosine methylation
  JOURNAL   Nat Chem Biol 10 (2), 93-95 (2014)
   PUBMED   24316715
  REMARK    GeneRIF: methyltransferase-like protein 14 in a complex with METTL3
            mediates nuclear RNA methylation
REFERENCE   10 (bases 1 to 6642)
  AUTHORS   Kalsi,G., Kuo,P.H., Aliev,F., Alexander,J., McMichael,O.,
            Patterson,D.G., Walsh,D., Zhao,Z., Schuckit,M., Nurnberger,J. Jr.,
            Edenberg,H., Kramer,J., Hesselbrock,V., Tischfield,J.A.,
            Vladimirov,V., Prescott,C.A., Dick,D.M., Kendler,K.S. and
            Riley,B.P.
  TITLE     A systematic gene-based screen of chr4q22-q32 identifies
            association of a novel susceptibility gene, DKK2, with the
            quantitative trait of alcohol dependence symptom counts
  JOURNAL   Hum Mol Genet 19 (12), 2497-2506 (2010)
   PUBMED   20332099
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Erratum:[Hum Mol Genet. 2010 Oct 15;19(20):4121. Hesselbrock,
            Victor [added]; Tischfield, Jay A [added]]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BG773151.1, AB046847.1, AC110079.3 and AW206149.1.
            
            On Nov 23, 2018 this sequence version replaced NM_020961.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.236387.1,
                                           SRR1803614.73332.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000388822.10/ ENSP00000373474.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                BG773151.1         28-50
            24-2048             AB046847.1         1-2025
            2049-2049           AC110079.3         128028-128028
            2050-2132           AB046847.1         2027-2109
            2133-3150           AC110079.3         128112-129129
            3151-3482           AW206149.1         17-348              c
            3483-6642           AC110079.3         129462-132621
FEATURES             Location/Qualifiers
     source          1..6642
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q26"
     gene            1..6642
                     /gene="METTL14"
                     /gene_synonym="hMETTL14"
                     /note="methyltransferase 14,
                     N6-adenosine-methyltransferase non-catalytic subunit"
                     /db_xref="GeneID:57721"
                     /db_xref="HGNC:HGNC:29330"
                     /db_xref="MIM:616504"
     exon            1..209
                     /gene="METTL14"
                     /gene_synonym="hMETTL14"
                     /inference="alignment:Splign:2.1.0"
     CDS             144..1514
                     /gene="METTL14"
                     /gene_synonym="hMETTL14"
                     /EC_number="2.1.1.62"
                     /note="methyltransferase-like protein 14;
                     N6-adenosine-methyltransferase subunit METTL14;
                     N6-adenosine-methyltransferase non-catalytic subunit;
                     methyltransferase like 14; methyltransferase 14,
                     N6-adenosine-methyltransferase subunit"
                     /codon_start=1
                     /product="N(6)-adenosine-methyltransferase non-catalytic
                     subunit METTL14"
                     /protein_id="NP_066012.1"
                     /db_xref="CCDS:CCDS34053.1"
                     /db_xref="GeneID:57721"
                     /db_xref="HGNC:HGNC:29330"
                     /db_xref="MIM:616504"
                     /translation="MDSRLQEIRERQKLRRQLLAQQLGAESADSIGAVLNSKDEQREI
                     AETRETCRASYDTSAPNAKRKYLDEGETDEDKMEEYKDELEMQQDEENLPYEEEIYKD
                     SSTFLKGTQSLNPHNDYCQHFVDTGHRPQNFIRDVGLADRFEEYPKLRELIRLKDELI
                     AKSNTPPMYLQADIEAFDIRELTPKFDVILLEPPLEEYYRETGITANEKCWTWDDIMK
                     LEIDEIAAPRSFIFLWCGSGEGLDLGRVCLRKWGYRRCEDICWIKTNKNNPGKTKTLD
                     PKAVFQRTKEHCLMGIKGTVKRSTDGDFIHANVDIDLIITEEPEIGNIEKPVEIFHII
                     EHFCLGRRRLHLFGRDSTIRPGWLTVGPTLTNSNYNAETYASYFSAPNSYLTGCTEEI
                     ERLRPKSPPPKSKSDRGGGAPRGGGRGGTSAGRGRERNRSNFRGERGGFRGGRGGAHR
                     GGFPPR"
     exon            210..298
                     /gene="METTL14"
                     /gene_synonym="hMETTL14"
                     /inference="alignment:Splign:2.1.0"
     exon            299..386
                     /gene="METTL14"
                     /gene_synonym="hMETTL14"
                     /inference="alignment:Splign:2.1.0"
     exon            387..467
                     /gene="METTL14"
                     /gene_synonym="hMETTL14"
                     /inference="alignment:Splign:2.1.0"
     exon            468..555
                     /gene="METTL14"
                     /gene_synonym="hMETTL14"
                     /inference="alignment:Splign:2.1.0"
     exon            556..646
                     /gene="METTL14"
                     /gene_synonym="hMETTL14"
                     /inference="alignment:Splign:2.1.0"
     exon            647..788
                     /gene="METTL14"
                     /gene_synonym="hMETTL14"
                     /inference="alignment:Splign:2.1.0"
     exon            789..881
                     /gene="METTL14"
                     /gene_synonym="hMETTL14"
                     /inference="alignment:Splign:2.1.0"
     exon            882..998
                     /gene="METTL14"
                     /gene_synonym="hMETTL14"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1209
                     /gene="METTL14"
                     /gene_synonym="hMETTL14"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..6642
                     /gene="METTL14"
                     /gene_synonym="hMETTL14"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2587..2592
                     /regulatory_class="polyA_signal_sequence"
                     /gene="METTL14"
                     /gene_synonym="hMETTL14"
                     /note="hexamer: ATTATA"
     polyA_site      2612
                     /gene="METTL14"
                     /gene_synonym="hMETTL14"
                     /note="major polyA site"
     regulatory      2640..2645
                     /regulatory_class="polyA_signal_sequence"
                     /gene="METTL14"
                     /gene_synonym="hMETTL14"
                     /note="hexamer: AATGAA"
     polyA_site      2660
                     /gene="METTL14"
                     /gene_synonym="hMETTL14"
                     /note="major polyA site"
     regulatory      6621..6626
                     /regulatory_class="polyA_signal_sequence"
                     /gene="METTL14"
                     /gene_synonym="hMETTL14"
                     /note="hexamer: AATAAA"
     polyA_site      6642
                     /gene="METTL14"
                     /gene_synonym="hMETTL14"
ORIGIN      
        1 aagtctctac tgaggaaagc tatgaggata ctctgttcgt aagctcccgg tgaattttgt
       61 tccacagact cggaagaaag gttggataag agttcactgg agattgacaa gtactcggga
      121 tagtgaaaag ccggagttgg aacatggata gccgcttgca ggagatccgg gagcggcaga
      181 agttacggcg acagctcctc gcgcagcagt tgggagctga aagtgccgac agcattggtg
      241 ccgtgttaaa tagcaaagat gagcagagag aaattgctga aacaagagaa acttgcaggg
      301 cttcctatga tacctctgct ccaaatgcaa aacgtaagta tctggatgaa ggagagacag
      361 atgaagacaa aatggaagaa tataaggatg aactagaaat gcaacaggat gaagaaaatt
      421 tgccatatga agaagagatt tacaaagatt ctagtacttt tcttaaggga acacagagct
      481 taaatcccca taatgattac tgccaacatt ttgtagacac tggacataga cctcagaatt
      541 tcatcaggga tgtaggttta gctgacagat ttgaagaata tcctaaactg agggagctca
      601 tcaggctaaa ggatgagtta atagctaaat ctaacactcc tcccatgtac ttacaagccg
      661 atatagaagc ctttgacatc agagaactaa cacccaaatt tgatgtgatt cttctggaac
      721 cccctttaga agaatattac agagaaactg gcatcactgc taatgaaaaa tgctggactt
      781 gggatgatat tatgaagtta gaaattgatg agattgcagc acctcgatca tttatttttc
      841 tctggtgtgg ttctggggag gggttggacc ttggaagagt gtgtttacga aaatggggtt
      901 acagaagatg tgaagatatt tgttggatta aaaccaataa aaacaatcct gggaagacta
      961 agactttaga tccaaaggct gtctttcaga gaacaaagga acactgcctc atggggatca
     1021 aaggaactgt gaagcgtagc acagacgggg acttcattca tgctaatgtt gacattgact
     1081 taattatcac agaagaacct gaaattggca atatagaaaa acctgtagaa atttttcata
     1141 taattgagca tttttgtctt ggtagaagac gccttcatct atttggaaga gatagtacaa
     1201 ttcgaccagg ctggctcaca gttggaccaa cgcttacaaa tagcaactac aatgcagaaa
     1261 catatgcatc ctatttcagt gctcctaatt cctacttgac tggttgtaca gaagaaattg
     1321 agagacttcg accaaaatcg cctcctccca aatctaaatc tgaccgagga ggtggagctc
     1381 ccagaggtgg aggaagaggt ggaacttctg ctggccgtgg acgagaaaga aatagatcta
     1441 acttccgagg agaaagaggt ggctttagag ggggccgtgg aggagcacac agaggtggct
     1501 ttccacctcg ataattgttg aagacattga acctattcat cctcctctaa ccttctttat
     1561 tgtaattaaa tttcaagtgg gagacttaac tttagaactc acttccagct tgcactttgc
     1621 tttaatttct ctgagctgca agaatgtctt agcgagcctt gcttgcagtt gtcacacaca
     1681 ctgtctggtt tttttcagga taaatgaatg attctgcctt ttgttatgtg cgtgaacaga
     1741 atggaacaac tcaagtagct tcatcttcag agactgaatt tattctgata gacttcagct
     1801 aattacaaag gattttgcta atttttggga ataaataatg gaaaaagatc cagtctgtgg
     1861 tatcatgcta gtgctgacag ggccttgata gaatagagtt ggaaaagatg gtaagctttt
     1921 gtcagggttt taacattttc ttgatgaaac aataaaaaga ggtaagcttt tttcttcttt
     1981 ttttttaagt tttaaataaa ctcagatata atttgaatac tgaagaaatt aagagacttt
     2041 gaacaaaaac tcttcccaaa tctaaatttg ataggggagg tggagattcc aggggtgggt
     2101 gaaagaagag atagaactta gcaggcagac ttaaaaaaaa aaaaaaagtt tatcatcata
     2161 atctcaattt tgtggctatg actcctaatc acgcttccta agaagcaaag gaggacaaat
     2221 attcatgtgc tagatagcac tgtggtgtgg acttgaactt ggattgacct taaattttat
     2281 attcctcaaa taaaagagag gcagcgacaa gatacctcat tatcagatgc ttggtttata
     2341 cattttggga ctaaaatact tggtgatgaa atgacataca cctttaaact tgttatggag
     2401 atagtttaat gtaaaaccaa ctacggaaaa ccctcaactt aaggatacag cttggaaatt
     2461 ggaactgcaa ttgcctttta ttaaaaccat atggtgtgat gtttgttttt aaaattatat
     2521 aagactttat gctgtcactt ctcttgctgt actgtaattc atgttttaaa tgaatttgat
     2581 aatgaaatta tactattatc attcttgatg aatacttttc ttatttttat gatttttcta
     2641 atgaaacttt aaacttttga gatttgagag tctgttttct ataagtagaa ttactgttgt
     2701 tacaaaatga aaaaggactg acctaaaatc agtctcttct tttggtctgt gatggatttt
     2761 aatggccgtt ctgtgctcat atatacctaa gatgagatta tattacatcc accaaagact
     2821 cagtttgaag ataaggaatg agtgatagaa gaaataaggc tgagatcctt aaaagcctaa
     2881 ttaatttaac tcgcttaacc cattagtact atctagtaca agaccccttt ttttttgctg
     2941 aaattatggt atattttcaa cttcactaat tacaaattat ctagatttag aactctatat
     3001 gtcagcattg acctgggaat gaagtcagga tagagaaatt ccacttgcct gtgatgggtc
     3061 cttagaagta tcagctaagg agtgaccctg tcctatacac agggctctct attacgttcc
     3121 ataccctggg cctacccaag gtgacattcc tgctgtttac atggcatagg cacctgtgag
     3181 atcagtgtca caatttcatc ttagaaagag gtaggtatgg ctgctttgtc ggttgaaagt
     3241 taaggggagc catgatctac catatttagg aaaaagttat ttaaaaaaga gcagatggtg
     3301 gaaaaagaat gtaagaccca gaatttatcc ctttgacaat gaatctggcc tttttaatag
     3361 caggatggaa ttgattcact agtttttgct aactttcact ttcagtaaag gttgaggtgt
     3421 tgtttttgca atgactgtgt attcattgag gaaaggtttc caatgaaatt tcattactct
     3481 gacctcttct aatttttggt cttctttata tttacatgtc ttacattcca caaaattatt
     3541 tagaaatgct gggcatggtg gctcatgcct gtaatcccag cactttgtga ggccgatgtg
     3601 ggtggatcac ttgaggtcag gagtttgaga ccagcctgac caatatggag aaatcccatc
     3661 tctactaaaa atacaaaatt agctgggcgt ggtggcatgt gcacgcctgt aatccccgct
     3721 actcgggagg ctgtggcagg agaattgcct gaacccagga ggcggaggtt gcagtgagcc
     3781 gagattgtgc cactgcactc cagcctgggc gacagagtga gactctgtct caaaaaaaaa
     3841 aaaaaaaatt gtatagaaat aaatttttag ttgctttatg cactaattcc ttactgggga
     3901 tagaagctaa ttattgtgaa ataacctagt ttagaagtta gaagatcagc atgtctgagt
     3961 ttttacagaa ttataattca tggtattcca aaccaactgt tgttatttat ttccagtgag
     4021 aaccattttc ccactgacct tcctcctttc agaggatggg gattaggagg cccaaagtac
     4081 tgattgagta ggaatacttt tttactcttc ttcactgtgg agaaagaaga gggcaggtag
     4141 ttgatgatgt caggagaaca gattttatgg tgtggaatac catacctaaa cacaaatgaa
     4201 tcagattaga ccacagaatt gtgatgatgg cagtcagaat gtaatacggt catcatgaaa
     4261 cagcacagtg tgagaggtca aggtgtcaac ctgggaagtg agaatcaagc aggagtgtgg
     4321 catggcaacc aactcacaga tccagagttg agagggatca ctactgcagc agttctgctc
     4381 tgttactctg gtaagtagta gagccacttt atgagccctt atttcctatc tcccttattc
     4441 tgaggccagg tcagtgatat gctatagttt catttaagtt aatggagtat aaagatggga
     4501 tacttgggag ctatattgtg catcagggtg tcacagctgc tactaggagt tactcctttt
     4561 catgtctttt aaaatacttt ctacccatct taattgctaa attatctttc agttagttac
     4621 agcgcttaat ttaaaacctg tactgttttc atcctgaatt tagaacataa gatttagcct
     4681 ttgaagtata gtttcagact ttactaattt gtttaatata atccttatta acatgacaaa
     4741 atgaaagccc tgttgggact tagtctaaac agtagtcttt gatctgaaag tgtctcatat
     4801 tttgtgatct attagaaaca taaacctttg cttatgcaga aggtctttct tagaacaatc
     4861 ctgtaatctt agggttcatg tgtgactagc attatcctct ctttgatgtt gggtaataga
     4921 ggctgaactt ttcttgtgta tatatagtta gttttgaggc cataaatcta ggacttctca
     4981 aaagattaga acatttatcc agtaaactga ctccattgaa gacttcattt ctggaaatac
     5041 cacattgctt ctgctctcaa taactctatc atttactcgt ataaatattg ctagctgtaa
     5101 tgcacagaga aaaactacct cattcaatct agataattgg gacatccttt tccagtaaac
     5161 cctttttcca ctactggata aaatattaaa atgatcagtt tgagtgtatg ttagagttca
     5221 tgtttctgta actaaaggtg ctaataaact gaaatcagat aaggtaggtt tttccaaaaa
     5281 tacttctaaa taattgacaa cctagaagtc aacaatgtaa aatgcatatg ggactctata
     5341 ttaatagaga agcaggccaa gaacttttta atgggataat tgtcttcttt aggcacattg
     5401 tttgcatatt aacgacatgg aaatattttc actcatttac tttcatccat ctatctgtgc
     5461 tttttctcac tttgatgagt tctctcaact cctttctaag aaaagcagag cagagcagca
     5521 tagagtgcgt tagtaaatgg ccactgactc ttggtctcag gccatagcaa ctatagagag
     5581 aagagtgggg ctggagacct cataccctgg gtaaagtgga catcacttgt cagctccagc
     5641 taattgtcac cacagagaga agagggtaag tctgagatgt tcatgtgcat ttccctacat
     5701 tttagaggtt gacaaaatag tttgtgactt ttgcttacat ttgcattcat agaactaaaa
     5761 aaaatttaac ttggctaaca aaataccaca tgcatatttt cttttttatt tttatttttt
     5821 gagacagagt ctctgttacc caggctgggg ggcagtgata agatcttggc tcactgcaac
     5881 ctccgcctcc agggttgaag cgattcttct gcctcagcct cctgagtagc tggaattaca
     5941 ggtgcccacc accacaccca gctaatttta gtattcttag tagagacagg atttcaccat
     6001 gttggccagg ctggtctcaa actcccgacc tcaactgatc cacccaccct ggcctcccaa
     6061 agtgtcagga ttacaggcgt gagcctctgc aactggccaa catgcatatt taaattatgc
     6121 atgcattgta gctgtatact gtgtgaccac atttacttaa aaaagaggaa aaaaggttac
     6181 ttgcttgaga caggaaacta tcacctttga aagcatatta agtagttggc ttactttgga
     6241 acacacagta gactgaaaat gtgaactaat actttaaaat tgccgtataa tgatgtcatt
     6301 gcaagccatt catctatcca atgggggaaa atgtggaggt ctaggcttgt gttgtcacaa
     6361 aatacacctt ttagataatc cttacctgta cagattttta taactgttgt tatcataaga
     6421 gaatggctac atcattatcc tgccttttct gggtgtttat tttgttgttt ttgaaagtgg
     6481 acaaaacctc aaagcacaat tttgttctga tatatccagt ttagtagttt atgctggtta
     6541 aatgatcaaa gtaattgctt aaatgtcttg tggaattagc tgtcacttta tagtttatgt
     6601 attgtggtgg gtaccttaat aataaaaaga tttttaatgt aa
//
