LOCUS       NM_015935               3368 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens methyltransferase 13, eEF1A N-terminus and K55
            (METTL13), transcript variant 1, mRNA.
ACCESSION   NM_015935
VERSION     NM_015935.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3368)
  AUTHORS   Boulter,M. and Biggar,K.K.
  TITLE     Biological Relevance of Dual Lysine and N-Terminal
            Methyltransferase METTL13
  JOURNAL   Biomolecules 14 (9), 1112 (2024)
   PUBMED   39334878
  REMARK    GeneRIF: Biological Relevance of Dual Lysine and N-Terminal
            Methyltransferase METTL13.
            Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3368)
  AUTHORS   Ni,H., Liang,C., Zhou,Z., Jiang,B., Li,Y., Shang,H. and Yu,X.
  TITLE     METTL13 promotes nasopharyngeal carcinoma progression through
            regulating the ZEB1/TPT1 axis
  JOURNAL   J Gene Med 25 (5), e3476 (2023)
   PUBMED   36735630
  REMARK    GeneRIF: METTL13 promotes nasopharyngeal carcinoma progression
            through regulating the ZEB1/TPT1 axis.
REFERENCE   3  (bases 1 to 3368)
  AUTHORS   Liu,Z., Sun,T., Piao,C., Zhang,Z. and Kong,C.
  TITLE     METTL13 inhibits progression of clear cell renal cell carcinoma
            with repression on PI3K/AKT/mTOR/HIF-1alpha pathway and c-Myc
            expression
  JOURNAL   J Transl Med 19 (1), 209 (2021)
   PUBMED   33985542
  REMARK    GeneRIF: METTL13 inhibits progression of clear cell renal cell
            carcinoma with repression on PI3K/AKT/mTOR/HIF-1alpha pathway and
            c-Myc expression.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3368)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 3368)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 3368)
  AUTHORS   Yu,H., Tardivo,L., Tam,S., Weiner,E., Gebreab,F., Fan,C.,
            Svrzikapa,N., Hirozane-Kishikawa,T., Rietman,E., Yang,X.,
            Sahalie,J., Salehi-Ashtiani,K., Hao,T., Cusick,M.E., Hill,D.E.,
            Roth,F.P., Braun,P. and Vidal,M.
  TITLE     Next-generation sequencing to generate interactome datasets
  JOURNAL   Nat Methods 8 (6), 478-480 (2011)
   PUBMED   21516116
REFERENCE   7  (bases 1 to 3368)
  AUTHORS   Takahashi,A., Tokita,H., Takahashi,K., Takeoka,T., Murayama,K.,
            Tomotsune,D., Ohira,M., Iwamatsu,A., Ohara,K., Yazaki,K., Koda,T.,
            Nakagawara,A. and Tani,K.
  TITLE     A novel potent tumour promoter aberrantly overexpressed in most
            human cancers
  JOURNAL   Sci Rep 1, 15 (2011)
   PUBMED   22355534
  REMARK    Erratum:[Sci Rep. 2013;3:49]
REFERENCE   8  (bases 1 to 3368)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   9  (bases 1 to 3368)
  AUTHORS   Wilcox,E., Riazuddin,S. and Riazuddin,S.
  TITLE     Some deafness-causing mutations can be silenced with the
            appropriate gene partner
  JOURNAL   ScientificWorldJournal 1, 202-203 (2001)
   PUBMED   12805671
  REMARK    GeneRIF: The DFNM1 gene modified the phenotype of a inherited
            deafness family possibly by silencing the DFNB26 mutated gene.
            Review article
            Publication Status: Online-Only
REFERENCE   10 (bases 1 to 3368)
  AUTHORS   Riazuddin,S., Castelein,C.M., Ahmed,Z.M., Lalwani,A.K.,
            Mastroianni,M.A., Naz,S., Smith,T.N., Liburd,N.A., Friedman,T.B.,
            Griffith,A.J., Riazuddin,S. and Wilcox,E.R.
  TITLE     Dominant modifier DFNM1 suppresses recessive deafness DFNB26
  JOURNAL   Nat Genet 26 (4), 431-434 (2000)
   PUBMED   11101839
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BI091265.1, AF132936.1, AB020666.2, AL049669.1 and BX094025.1.
            
            On Nov 23, 2018 this sequence version replaced NM_015935.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.186366.1,
                                           SRR1660805.174699.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361735.4/ ENSP00000354920.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                BI091265.1         156-191
            37-1243             AF132936.1         1-1207
            1244-2610           AB020666.2         1038-2404
            2611-3366           AL049669.1         2107-2862
            3367-3368           BX094025.1         727-728
FEATURES             Location/Qualifiers
     source          1..3368
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q24.3"
     gene            1..3368
                     /gene="METTL13"
                     /gene_synonym="5630401D24Rik; CGI-01; DFNB26; DFNB26M;
                     DFNM1; EEF1AKNMT; feat; KIAA0859"
                     /note="methyltransferase 13, eEF1A N-terminus and K55"
                     /db_xref="GeneID:51603"
                     /db_xref="HGNC:HGNC:24248"
                     /db_xref="MIM:617987"
     exon            1..461
                     /gene="METTL13"
                     /gene_synonym="5630401D24Rik; CGI-01; DFNB26; DFNB26M;
                     DFNM1; EEF1AKNMT; feat; KIAA0859"
                     /inference="alignment:Splign:2.1.0"
     CDS             309..2408
                     /gene="METTL13"
                     /gene_synonym="5630401D24Rik; CGI-01; DFNB26; DFNB26M;
                     DFNM1; EEF1AKNMT; feat; KIAA0859"
                     /note="isoform 1 is encoded by transcript variant 1;
                     methyltransferase-like protein 13; antiapoptotic protein
                     FEAT; methyltransferase like 13; eEF1A-KNMT; deafness
                     (recessive, non-syndromic) modifier 1; deafness (autosomal
                     recessive, nonsyndromic) modifier 1; deafness (recessive,
                     nonsyndromic) modifier 1; faint expression in normal
                     tissues, aberrant overexpression in tumors; eEF1A lysine
                     and N-terminal methyltransferase; methyltransferase 13,
                     eEF1A lysine and N-terminal methyltransferase"
                     /codon_start=1
                     /product="eEF1A lysine and N-terminal methyltransferase
                     isoform 1"
                     /protein_id="NP_057019.3"
                     /db_xref="CCDS:CCDS1299.1"
                     /db_xref="GeneID:51603"
                     /db_xref="HGNC:HGNC:24248"
                     /db_xref="MIM:617987"
                     /translation="MNLLPKSSREFGSVDYWEKFFQQRGKKAFEWYGTYLELCGVLHK
                     YIKPREKVLVIGCGNSELSEQLYDVGYRDIVNIDISEVVIKQMKECNATRRPQMSFLK
                     MDMTQMEFPDASFQVVLDKGTLDAVLTDEEEKTLQQVDRMLAEVGRVLQVGGRYLCIS
                     LAQAHILKKAVGHFSREGWMVRVHQVANSQDQVLEAEPQFSLPVFAFIMTKFRPVPGS
                     ALQIFELCAQEQRKPVRLESAERLAEAVQERQQYAWLCSQLRRKARLGSVSLDLCDGD
                     TGEPRYTLHVVDSPTVKPSRDNHFAIFIIPQGRETEWLFGMDEGRKQLAASAGFRRLI
                     TVALHRGQQYESMDHIQAELSARVMELAPAGMPTQQQVPFLSVGGDIGVRTVQHQDCS
                     PLSGDYVIEDVQGDDKRYFRRLIFLSNRNVVQSEARLLKDVSHKAQKKRKKDRKKQRP
                     ADAEDLPAAPGQSIDKSYLCCEHHKAMIAGLALLRNPELLLEIPLALLVVGLGGGSLP
                     LFVHDHFPKSCIDAVEIDPSMLEVATQWFGFSQSDRMKVHIADGLDYIASLAGGGEAR
                     PCYDVIMFDVDSKDPTLGMSCPPPAFVEQSFLQKVKSILTPEGVFILNLVCRDLGLKD
                     SVLAGLKAVFPLLYVRRIEGEVNEILFCQLHPEQKLATPELLETAQALERTLRKPGRG
                     WDDTYVLSDMLKTVKIV"
     exon            462..1221
                     /gene="METTL13"
                     /gene_synonym="5630401D24Rik; CGI-01; DFNB26; DFNB26M;
                     DFNM1; EEF1AKNMT; feat; KIAA0859"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1421
                     /gene="METTL13"
                     /gene_synonym="5630401D24Rik; CGI-01; DFNB26; DFNB26M;
                     DFNM1; EEF1AKNMT; feat; KIAA0859"
                     /inference="alignment:Splign:2.1.0"
     exon            1422..1617
                     /gene="METTL13"
                     /gene_synonym="5630401D24Rik; CGI-01; DFNB26; DFNB26M;
                     DFNM1; EEF1AKNMT; feat; KIAA0859"
                     /inference="alignment:Splign:2.1.0"
     exon            1618..1782
                     /gene="METTL13"
                     /gene_synonym="5630401D24Rik; CGI-01; DFNB26; DFNB26M;
                     DFNM1; EEF1AKNMT; feat; KIAA0859"
                     /inference="alignment:Splign:2.1.0"
     exon            1783..2001
                     /gene="METTL13"
                     /gene_synonym="5630401D24Rik; CGI-01; DFNB26; DFNB26M;
                     DFNM1; EEF1AKNMT; feat; KIAA0859"
                     /inference="alignment:Splign:2.1.0"
     exon            2002..2133
                     /gene="METTL13"
                     /gene_synonym="5630401D24Rik; CGI-01; DFNB26; DFNB26M;
                     DFNM1; EEF1AKNMT; feat; KIAA0859"
                     /inference="alignment:Splign:2.1.0"
     exon            2134..3368
                     /gene="METTL13"
                     /gene_synonym="5630401D24Rik; CGI-01; DFNB26; DFNB26M;
                     DFNM1; EEF1AKNMT; feat; KIAA0859"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2576..2581
                     /regulatory_class="polyA_signal_sequence"
                     /gene="METTL13"
                     /gene_synonym="5630401D24Rik; CGI-01; DFNB26; DFNB26M;
                     DFNM1; EEF1AKNMT; feat; KIAA0859"
                     /note="hexamer: AATAAA"
     polyA_site      2611
                     /gene="METTL13"
                     /gene_synonym="5630401D24Rik; CGI-01; DFNB26; DFNB26M;
                     DFNM1; EEF1AKNMT; feat; KIAA0859"
                     /note="major polyA site"
     regulatory      3348..3353
                     /regulatory_class="polyA_signal_sequence"
                     /gene="METTL13"
                     /gene_synonym="5630401D24Rik; CGI-01; DFNB26; DFNB26M;
                     DFNM1; EEF1AKNMT; feat; KIAA0859"
                     /note="hexamer: ATTAAA"
     polyA_site      3368
                     /gene="METTL13"
                     /gene_synonym="5630401D24Rik; CGI-01; DFNB26; DFNB26M;
                     DFNM1; EEF1AKNMT; feat; KIAA0859"
                     /note="major polyA site"
ORIGIN      
        1 acccggatat ggttatgggc tcggaaatct agttcgggaa aagtgtgagg ggctcttcac
       61 gtggggaagg aacagcaggc gcggaggagg gggcaagcgt gtgtgagatt cagtggtcca
      121 tgcgtgcgtt tgtcgtgtaa gggtcattcc tggggtttgg agtgggggaa caaatcaatg
      181 tggctgtttt tccgtggaaa gaattcccac tgcagtgtcc cggagcctgc gtgtggtggg
      241 caagctcctc aaatggtatc tcacagggaa taggggagtc ttgaaaacgc agcttcggca
      301 gtaggaacat gaacctctta cctaaaagtt ccagggagtt tggctccgtt gactattggg
      361 agaagttctt ccagcagcga ggaaagaaag ctttcgagtg gtatggaacc tacctggaac
      421 tgtgcggggt gctacataaa tatatcaagc ccagggaaaa ggtgctggtg attgggtgtg
      481 gcaactcaga actgagtgag caactgtatg atgtgggcta tcgggatata gtgaacatcg
      541 acatcagtga ggttgtcatc aagcaaatga aggaatgtaa tgccacccga cggccccaga
      601 tgagcttctt gaagatggac atgacgcaga tggagtttcc tgatgcctcg ttccaggtgg
      661 tgttggacaa gggcaccctg gatgctgtcc tgacagatga ggaagagaag accttacaac
      721 aggtggacag gatgctggct gaggttggcc gtgtcctgca ggtgggcggt cgctatctct
      781 gcatctccct ggctcaggct cacatcctga agaaagcagt gggccacttc tcccgggagg
      841 ggtggatggt gagggtgcac caagtggcca acagccagga ccaggtgttg gaagcagagc
      901 ctcagttctc cttgcctgtc tttgccttca tcatgaccaa gttcaggcca gtccctggct
      961 ctgcccttca gatctttgag ctgtgtgctc aggagcagcg caagcctgtg cggctggaga
     1021 gtgccgagcg gctggccgag gcggtgcagg agcgacagca gtatgcctgg ctgtgcagcc
     1081 agctgcgccg caaggccagg ctggggagtg tgtctctgga cttgtgcgat ggggacacgg
     1141 gggagccacg ctacaccctc cacgtggtgg acagccccac tgtgaaacca tcgcgggaca
     1201 atcattttgc gattttcatc atccctcagg gccgggagac cgagtggctc tttggcatgg
     1261 atgagggccg gaaacagctg gcggccagtg ctggcttcag gaggttgatt acagtggccc
     1321 ttcaccgagg tcagcagtat gaaagcatgg accacatcca agctgagctg tcggctagag
     1381 tcatggagct ggccccagct gggatgccca cccagcagca ggtccccttt ctgtctgtgg
     1441 gtggggacat tggggtccgg accgttcagc accaagactg cagccccttg agcggtgact
     1501 atgtcattga ggatgtgcaa ggggatgaca agcgatactt ccgtcgactg atcttcctca
     1561 gcaacaggaa tgtggtgcag tccgaagcca ggttgctgaa ggatgtgtct cacaaagccc
     1621 agaagaagcg gaaaaaggac aggaagaagc agcggcctgc tgatgcggag gacctccctg
     1681 cagccccggg gcagtccatt gataagagtt acctgtgttg tgaacaccac aaagccatga
     1741 tcgctggcct tgccctgctg agaaacccag agctactcct agagatccca ctggcattgt
     1801 tggtggtagg cctgggcggg ggcagcctcc ccctctttgt ccacgatcat tttccaaagt
     1861 cctgcattga tgctgtggag atcgatccct ccatgttgga agtggccacc cagtggtttg
     1921 gcttctccca gagtgaccga atgaaggtcc acattgcaga tggcctggac tatatcgcca
     1981 gcttggcagg aggaggagaa gcacggcctt gctacgatgt cataatgttt gatgttgaca
     2041 gtaaggaccc aacactggga atgagttgtc cgcccccagc atttgtggag caatcttttc
     2101 tacagaaggt taaaagcatc ttgactcctg aaggtgtttt tattctcaac cttgtgtgcc
     2161 gagacttggg gctaaaagac tcagtgctgg ctgggctcaa ggcagtgttc cccctcctat
     2221 atgtccggcg aattgagggt gaagtgaatg agatcctgtt ctgtcagctg caccctgagc
     2281 aaaaacttgc cacaccagag ctcctagaaa cagcccaggc tttggagcgg accctgagga
     2341 agcctgggag gggttgggat gacacgtatg tcttgtcaga tatgctcaag acggtgaaaa
     2401 ttgtgtgact gcttaggcca agcagccctc ctgcctagac tgaccttgga ctcccagcct
     2461 gccagagaat gaagaaatac aacgcacagt acttttgaag cttcgtattt ttcttggttt
     2521 cacactcagc tacatgtgac ctccagcttg gtgaggttgc ctgaagatta gggaaaataa
     2581 aaatgtcctt cccatcttgt cctcttcagt accacttggg ttggtttgtc tttgcttcct
     2641 acaccacgtc cttgagtgga gttccctgct gaagccccta gcacacactg catgccttaa
     2701 caagtgtgtg caagcccctc agaactcaag acatccaaat tttattgcgt ctctacttat
     2761 actggtttgc ttttgattta ttcctctatt agttctatag gagtgatctc aagtgagata
     2821 gcagagcaag atgccaaaag accataaata gagtaaggtt tctatagatg tgagacagat
     2881 ttgagagagc atttactctg tctccctgtg gatgaaactg ctgctgaaat ggttccaatt
     2941 tttaggaatc tgcttaccca cttcattatt tgacagcttt ccttggtgac ccaaaccttg
     3001 tagcctaagc catttgtctt tttctcagtg gagggagtgt atggacctgg ccccatggct
     3061 ttgcatgtta gagacctggc agactaaagt ctctagtgtt tgtttgctca catttgctga
     3121 gtgacagcta tgtgccagac tgcataaagg gtggtggcag aagtgaaaat gtttaagaat
     3181 gaccaaaaac attagtaatg aaagttaatg tgttccaggc attcttctaa gtggtttaca
     3241 tgcactgtct catttaatct gagataaagg atacttaagc ccaaactata tctaaaccca
     3301 aatctcactt ggctggaaac atcaatctta accatttatt cagaaccatt aaaccaatga
     3361 ttccaaga
//
