LOCUS       NM_005371               1378 bp    mRNA    linear   PRI 17-SEP-2024
DEFINITION  Homo sapiens methyltransferase 1, tRNA methylguanosine (METTL1),
            transcript variant 1, mRNA.
ACCESSION   NM_005371
VERSION     NM_005371.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1378)
  AUTHORS   Yu,S., Sun,Z., Ju,T., Liu,Y., Mei,Z., Wang,C., Qu,Z., Li,N., Wu,F.,
            Liu,K., Lu,M., Huang,M., Pang,X., Jia,Y., Li,Y., Zhang,Y., Dou,S.,
            Jiang,J., Dong,X., Huang,C., Li,W., Zhang,Y., Yuan,Y., Yang,B. and
            Du,W.
  TITLE     The m7G Methyltransferase Mettl1 Drives Cardiac Hypertrophy by
            Regulating SRSF9-Mediated Splicing of NFATc4
  JOURNAL   Adv Sci (Weinh) 11 (29), e2308769 (2024)
   PUBMED   38810124
  REMARK    GeneRIF: The m7G Methyltransferase Mettl1 Drives Cardiac
            Hypertrophy by Regulating SRSF9-Mediated Splicing of NFATc4.
REFERENCE   2  (bases 1 to 1378)
  AUTHORS   Peng,W., Fu,J., Zhou,L. and Duan,H.
  TITLE     METTL1/FOXM1 promotes lung adenocarcinoma progression and gefitinib
            resistance by inhibiting PTPN13 expression
  JOURNAL   Cancer Med 13 (13), e7420 (2024)
   PUBMED   38967523
  REMARK    GeneRIF: METTL1/FOXM1 promotes lung adenocarcinoma progression and
            gefitinib resistance by inhibiting PTPN13 expression.
REFERENCE   3  (bases 1 to 1378)
  AUTHORS   Dong,R., Wang,C., Tang,B., Cheng,Y., Peng,X., Yang,X., Ni,B. and
            Li,J.
  TITLE     WDR4 promotes HCC pathogenesis through N7-methylguanosine by
            regulating and interacting with METTL1
  JOURNAL   Cell Signal 118, 111145 (2024)
   PUBMED   38493882
  REMARK    GeneRIF: WDR4 promotes HCC pathogenesis through
            N[7]-methylguanosine by regulating and interacting with METTL1.
REFERENCE   4  (bases 1 to 1378)
  AUTHORS   Du,D., Zhou,M., Ju,C., Yin,J., Wang,C., Xu,X., Yang,Y., Li,Y.,
            Cui,L., Wang,Z., Lei,Y., Li,H., He,F. and He,J.
  TITLE     METTL1-mediated tRNA m7G methylation and translational dysfunction
            restricts breast cancer tumorigenesis by fueling cell cycle
            blockade
  JOURNAL   J Exp Clin Cancer Res 43 (1), 154 (2024)
   PUBMED   38822363
  REMARK    GeneRIF: METTL1-mediated tRNA m[7]G methylation and translational
            dysfunction restricts breast cancer tumorigenesis by fueling cell
            cycle blockade.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1378)
  AUTHORS   Wang,Y., Xiong,G., Cai,W. and Tao,Q.
  TITLE     METTL1 facilitates ameloblastoma invasive growth via MAPK signaling
            pathway
  JOURNAL   Gene 905, 148234 (2024)
   PUBMED   38309318
  REMARK    GeneRIF: METTL1 facilitates ameloblastoma invasive growth via MAPK
            signaling pathway.
REFERENCE   6  (bases 1 to 1378)
  CONSRTM   Australia and New Zealand Multiple Sclerosis Genetics Consortium
            (ANZgene)
  TITLE     Genome-wide association study identifies new multiple sclerosis
            susceptibility loci on chromosomes 12 and 20
  JOURNAL   Nat Genet 41 (7), 824-828 (2009)
   PUBMED   19525955
REFERENCE   7  (bases 1 to 1378)
  AUTHORS   Cartlidge,R.A., Knebel,A., Peggie,M., Alexandrov,A., Phizicky,E.M.
            and Cohen,P.
  TITLE     The tRNA methylase METTL1 is phosphorylated and inactivated by PKB
            and RSK in vitro and in cells
  JOURNAL   EMBO J 24 (9), 1696-1705 (2005)
   PUBMED   15861136
REFERENCE   8  (bases 1 to 1378)
  AUTHORS   Alexandrov,A., Martzen,M.R. and Phizicky,E.M.
  TITLE     Two proteins that form a complex are required for 7-methylguanosine
            modification of yeast tRNA
  JOURNAL   RNA 8 (10), 1253-1266 (2002)
   PUBMED   12403464
REFERENCE   9  (bases 1 to 1378)
  AUTHORS   Bahr,A., Hankeln,T., Fiedler,T., Hegemann,J. and Schmidt,E.R.
  TITLE     Molecular analysis of METTL1, a novel human methyltransferase-like
            gene with a high degree of phylogenetic conservation
  JOURNAL   Genomics 57 (3), 424-428 (1999)
   PUBMED   10329009
REFERENCE   10 (bases 1 to 1378)
  AUTHORS   Adams,M.D., Kerlavage,A.R., Fleischmann,R.D., Fuldner,R.A.,
            Bult,C.J., Lee,N.H., Kirkness,E.F., Weinstock,K.G., Gocayne,J.D.,
            White,O. et al.
  TITLE     Initial assessment of human gene diversity and expression patterns
            based upon 83 million nucleotides of cDNA sequence
  JOURNAL   Nature 377 (6547 Suppl), 3-174 (1995)
   PUBMED   7566098
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from Y18643.1, AI168455.1 and
            AC025165.27.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_005371.5.
            
            Summary: This gene is similar in sequence to the S. cerevisiae
            YDL201w gene. The gene product contains a conserved
            S-adenosylmethionine-binding motif and is inactivated by
            phosphorylation. Alternative splice variants encoding different
            protein isoforms have been described for this gene. A pseudogene
            has been identified on chromosome X. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (1) is the longer transcript and
            it encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC000550.1, SRR5189667.128460.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000324871.12/ ENSP00000314441.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1266              Y18643.1           27-1292
            1267-1281           AI168455.1         5-19                c
            1282-1378           AC025165.27        162390-162486       c
FEATURES             Location/Qualifiers
     source          1..1378
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q14.1"
     gene            1..1378
                     /gene="METTL1"
                     /gene_synonym="C12orf1; TRM8; TRMT8; YDL201w"
                     /note="methyltransferase 1, tRNA methylguanosine"
                     /db_xref="GeneID:4234"
                     /db_xref="HGNC:HGNC:7030"
                     /db_xref="MIM:604466"
     exon            1..132
                     /gene="METTL1"
                     /gene_synonym="C12orf1; TRM8; TRMT8; YDL201w"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..853
                     /gene="METTL1"
                     /gene_synonym="C12orf1; TRM8; TRMT8; YDL201w"
                     /EC_number="2.1.1.33"
                     /note="isoform a is encoded by transcript variant 1;
                     D1075-like gene product; tRNA
                     (guanine-N(7)-)-methyltransferase; methyltransferase like
                     1; tRNA(m7G46)-methyltransferase; methyltransferase-like
                     protein 1; tRNA (guanine(46)-N(7))-methyltransferase; mRNA
                     (guanine-N(7)-)-methyltransferase; miRNA
                     (guanine-N(7)-)-methyltransferase"
                     /codon_start=1
                     /product="tRNA (guanine-N(7)-)-methyltransferase isoform
                     a"
                     /protein_id="NP_005362.3"
                     /db_xref="CCDS:CCDS8955.3"
                     /db_xref="GeneID:4234"
                     /db_xref="HGNC:HGNC:7030"
                     /db_xref="MIM:604466"
                     /translation="MAAETRNVAGAEAPPPQKRYYRQRAHSNPMADHTLRYPVKPEEM
                     DWSELYPEFFAPLTQNQSHDDPKDKKEKRAQAQVEFADIGCGYGGLLVELSPLFPDTL
                     ILGLEIRVKVSDYVQDRIRALRAAPAGGFQNIACLRSNAMKHLPNFFYKGQLTKMFFL
                     FPDPHFKRTKHKWRIISPTLLAEYAYVLRVGGLVYTITDVLELHDWMCTHFEEHPLFE
                     RVPLEDLSEDPVVGHLGTSTEEGKKVLRNGGKNFPAIFRRIQDPVLQAVTSQTSLPGH
                     "
     exon            133..296
                     /gene="METTL1"
                     /gene_synonym="C12orf1; TRM8; TRMT8; YDL201w"
                     /inference="alignment:Splign:2.1.0"
     exon            297..481
                     /gene="METTL1"
                     /gene_synonym="C12orf1; TRM8; TRMT8; YDL201w"
                     /inference="alignment:Splign:2.1.0"
     exon            482..595
                     /gene="METTL1"
                     /gene_synonym="C12orf1; TRM8; TRMT8; YDL201w"
                     /inference="alignment:Splign:2.1.0"
     exon            596..697
                     /gene="METTL1"
                     /gene_synonym="C12orf1; TRM8; TRMT8; YDL201w"
                     /inference="alignment:Splign:2.1.0"
     exon            698..1378
                     /gene="METTL1"
                     /gene_synonym="C12orf1; TRM8; TRMT8; YDL201w"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1213
                     /gene="METTL1"
                     /gene_synonym="C12orf1; TRM8; TRMT8; YDL201w"
                     /note="major polyA site"
     polyA_site      1267
                     /gene="METTL1"
                     /gene_synonym="C12orf1; TRM8; TRMT8; YDL201w"
     polyA_site      1293
                     /gene="METTL1"
                     /gene_synonym="C12orf1; TRM8; TRMT8; YDL201w"
     polyA_site      1378
                     /gene="METTL1"
                     /gene_synonym="C12orf1; TRM8; TRMT8; YDL201w"
ORIGIN      
        1 agagaaaccc cggactggga tcatggcagc cgagactcgg aacgtggccg gagcagaggc
       61 cccaccgccc cagaagcgct actaccggca acgtgctcac tccaacccca tggcggacca
      121 cacgctgcgc taccctgtga agccagagga gatggactgg tctgagctat acccagagtt
      181 cttcgctcca ctcactcaaa atcagagcca cgatgaccca aaggataaga aagaaaagag
      241 agctcaggcc caagtggagt ttgcagacat aggctgtggc tatggtggcc tgttagtgga
      301 actgtcaccg ctgttcccag acacacttat tctgggtctg gagatccggg tgaaggtctc
      361 agactatgta caagaccgga ttcgggccct acgcgcagct cctgcaggtg gcttccagaa
      421 catcgcctgt ctccgtagca atgccatgaa gcaccttcct aacttcttct acaagggcca
      481 gctgacaaag atgttcttcc tcttccccga cccacatttc aagcggacaa agcacaagtg
      541 gcgaatcatc agtcccaccc tgctagcaga atatgcctac gtgctaagag ttggggggct
      601 ggtgtatacc ataaccgatg tgctggagct acacgactgg atgtgcactc atttcgaaga
      661 gcacccactg tttgagcgtg tgcctctgga ggacctgagt gaagaccccg ttgtgggaca
      721 tctaggcacc tcaactgagg aggggaagaa agttctacgt aatggaggga agaatttccc
      781 agccatcttc cgaagaatac aagatcccgt cctccaggca gtgacctccc aaaccagcct
      841 gcctggtcac tgactgctta ctctacctta gctggacctc gtctcccagg gattagagaa
      901 aagagcagga gtcctgggtc ttcccagttg agactgctgg agctgagaca cagtactctc
      961 ttaaagaagg tggggagctg cccagggcag aacccactgg tgttcatgac tacccctggc
     1021 tcctctcacc ttgtccctcc actgccaaca gaaaacaaag cagctgactg agatggtcaa
     1081 aggactttgg accatagggg atctttggaa ggctgtgggg tcttgctctt ccttagcact
     1141 cctttctcct tgtgagatct ctcctcagct ggaatgagga atgtagtcca tctaaactgc
     1201 ttgctaggct caattaccac ttctgtttgc tttgtggatc ctgggataac atgtatatgt
     1261 gtacacatgc ctattctgcc atttctcagg aaagggtgga gtatgtatca tatgccttct
     1321 accatcctcc tgtcctctcc ctgcgtaaga cttgacctgg ggaatctgtg ttccctaa
//
