LOCUS       NM_001004431            1690 bp    mRNA    linear   PRI 06-AUG-2024
DEFINITION  Homo sapiens meteorin like, glial cell differentiation regulator
            (METRNL), transcript variant 1, mRNA.
ACCESSION   NM_001004431 XM_209073
VERSION     NM_001004431.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1690)
  AUTHORS   Freedman,P., Schock,B. and O'Reilly,S.
  TITLE     The Novel Cytokine Interleukin-41/Meteorin-like Is Reduced in
            Diffuse Systemic Sclerosis
  JOURNAL   Cells 13 (14), 1205 (2024)
   PUBMED   39056787
  REMARK    GeneRIF: The Novel Cytokine Interleukin-41/Meteorin-like Is Reduced
            in Diffuse Systemic Sclerosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1690)
  AUTHORS   Inan Yuksel,E., Cicek,D., Demir,B., Kocaman,N., Calik,I. and
            Kuloglu,T.
  TITLE     Role of asprosin and meteorin-like peptide in progression of
            actinic keratosis to squamous cell carcinoma
  JOURNAL   Biotech Histochem 99 (2), 61-68 (2024)
   PUBMED   38192243
  REMARK    GeneRIF: Role of asprosin and meteorin-like peptide in progression
            of actinic keratosis to squamous cell carcinoma.
REFERENCE   3  (bases 1 to 1690)
  AUTHORS   Liu,J., Diao,L., Xia,W., Zeng,X., Li,W., Zou,J., Liu,T., Pang,X.
            and Wang,Y.
  TITLE     Meteorin-like protein elevation post-exercise improved vascular
            inflammation among coronary artery disease patients by
            downregulating NLRP3 inflammasome activity
  JOURNAL   Aging (Albany NY) 15 (24), 14720-14732 (2023)
   PUBMED   38054817
  REMARK    GeneRIF: Meteorin-like protein elevation post-exercise improved
            vascular inflammation among coronary artery disease patients by
            downregulating NLRP3 inflammasome activity.
REFERENCE   4  (bases 1 to 1690)
  AUTHORS   Altintas,N., Fazlioglu,N., Guzel,S., Yilmaz,A. and Aydin,C.
  TITLE     Is meteorin-like (Metrnl) a novel biomarker to distinguish patients
            with obstructive sleep apnea (OSA) and patients with OSA at
            vascular risk
  JOURNAL   Sleep Breath 27 (5), 1865-1874 (2023)
   PUBMED   36877355
  REMARK    GeneRIF: Is meteorin-like (Metrnl) a novel biomarker to distinguish
            patients with obstructive sleep apnea (OSA) and patients with OSA
            at vascular risk.
REFERENCE   5  (bases 1 to 1690)
  AUTHORS   Yavuz,A., Aydin,M.A., Ugur,K., Aydin,S., Senol,A., Baykus,Y.,
            Deniz,R., Sahin,I., Yalcin,M.H., Gencer,B.T., Deniz,Y.K.,
            Ustebay,S., Karagoz,Z.K., Emre,E. and Aydin,S.
  TITLE     Betatrophin, elabela, asprosin, glucagon and subfatin peptides in
            breast tissue, blood and milk in gestational diabetes
  JOURNAL   Biotech Histochem 98 (4), 243-254 (2023)
   PUBMED   36825397
  REMARK    GeneRIF: Betatrophin, elabela, asprosin, glucagon and subfatin
            peptides in breast tissue, blood and milk in gestational diabetes.
REFERENCE   6  (bases 1 to 1690)
  AUTHORS   Dadmanesh,M., Aghajani,H., Fadaei,R. and Ghorban,K.
  TITLE     Lower serum levels of Meteorin-like/Subfatin in patients with
            coronary artery disease and type 2 diabetes mellitus are negatively
            associated with insulin resistance and inflammatory cytokines
  JOURNAL   PLoS One 13 (9), e0204180 (2018)
   PUBMED   30212581
  REMARK    GeneRIF: Lower serum levels of Metrnl in patients with coronary
            artery disease and type 2 diabetes mellitus are negatively
            associated with insulin resistance and inflammatory cytokines.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1690)
  AUTHORS   Loffler,D., Landgraf,K., Rockstroh,D., Schwartze,J.T.,
            Dunzendorfer,H., Kiess,W. and Korner,A.
  TITLE     METRNL decreases during adipogenesis and inhibits adipocyte
            differentiation leading to adipocyte hypertrophy in humans
  JOURNAL   Int J Obes (Lond) 41 (1), 112-119 (2017)
   PUBMED   27748745
  REMARK    GeneRIF: downregulation of METRNL during adipogenesis and
            functional induction of increased proliferation in stromal vascular
            fraction cells with concomitant inhibition of adipocyte
            differentiation may result in hypertrophic AT accumulation
REFERENCE   8  (bases 1 to 1690)
  AUTHORS   Gong,W., Liu,Y., Wu,Z., Wang,S., Qiu,G. and Lin,S.
  TITLE     Meteorin-Like Shows Unique Expression Pattern in Bone and Its
            Overexpression Inhibits Osteoblast Differentiation
  JOURNAL   PLoS One 11 (10), e0164446 (2016)
   PUBMED   27716826
  REMARK    GeneRIF: Overexpression of METRNL inhibited mineralized nodule
            formation.
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 1690)
  AUTHORS   Li,Z.Y., Song,J., Zheng,S.L., Fan,M.B., Guan,Y.F., Qu,Y., Xu,J.,
            Wang,P. and Miao,C.Y.
  TITLE     Adipocyte Metrnl Antagonizes Insulin Resistance Through PPARgamma
            Signaling
  JOURNAL   Diabetes 64 (12), 4011-4022 (2015)
   PUBMED   26307585
  REMARK    GeneRIF: Data suggest that there is no correlation between serum
            Metrnl levels and BMI (body mass index) in humans.
REFERENCE   10 (bases 1 to 1690)
  AUTHORS   Li,Z.Y., Zheng,S.L., Wang,P., Xu,T.Y., Guan,Y.F., Zhang,Y.J. and
            Miao,C.Y.
  TITLE     Subfatin is a novel adipokine and unlike Meteorin in adipose and
            brain expression
  JOURNAL   CNS Neurosci Ther 20 (4), 344-354 (2014)
   PUBMED   24393292
  REMARK    GeneRIF: Results show that Subfatin is a novel adipokine regulated
            by adipogenesis and obesity, with tissue distribution different
            from its homologue Meteorin
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC130371.4, BC082252.1, DR760693.1 and CF264755.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001004431.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.261913.1, BC082252.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000320095.12/ ENSP00000315731.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-82                AC130371.4         23888-23969         c
            83-602              BC082252.1         1-520
            603-1071            DR760693.1         241-709
            1072-1415           BC082252.1         990-1333
            1416-1690           CF264755.1         26-300              c
FEATURES             Location/Qualifiers
     source          1..1690
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.3"
     gene            1..1690
                     /gene="METRNL"
                     /note="meteorin like, glial cell differentiation
                     regulator"
                     /db_xref="GeneID:284207"
                     /db_xref="HGNC:HGNC:27584"
                     /db_xref="MIM:616241"
     exon            1..377
                     /gene="METRNL"
                     /inference="alignment:Splign:2.1.0"
     CDS             208..1143
                     /gene="METRNL"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; meteorin-like protein; subfatin; meteorin,
                     glial cell differentiation regulator-like; cometin"
                     /codon_start=1
                     /product="meteorin-like protein isoform 1 precursor"
                     /protein_id="NP_001004431.1"
                     /db_xref="CCDS:CCDS32779.1"
                     /db_xref="GeneID:284207"
                     /db_xref="HGNC:HGNC:27584"
                     /db_xref="MIM:616241"
                     /translation="MRGAARAAWGRAGQPWPRPPAPGPPPPPLPLLLLLLAGLLGGAG
                     AQYSSDRCSWKGSGLTHEAHRKEVEQVYLRCAAGAVEWMYPTGALIVNLRPNTFSPAR
                     HLTVCIRSFTDSSGANIYLEKTGELRLLVPDGDGRPGRVQCFGLEQGGLFVEATPQQD
                     IGRRTTGFQYELVRRHRASDLHELSAPCRPCSDTEVLLAVCTSDFAVRGSIQQVTHEP
                     ERQDSAIHLRVSRLYRQKSRVFEPVPEGDGHWQGRVRTLLECGVRPGHGDFLFTGHMH
                     FGEARLGCAPRFKDFQRMYRDAQERGLNPCEVGTD"
     exon            378..763
                     /gene="METRNL"
                     /inference="alignment:Splign:2.1.0"
     exon            764..823
                     /gene="METRNL"
                     /inference="alignment:Splign:2.1.0"
     exon            824..1690
                     /gene="METRNL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1393..1398
                     /regulatory_class="polyA_signal_sequence"
                     /gene="METRNL"
                     /note="hexamer: AAGAAA"
     polyA_site      1415
                     /gene="METRNL"
     regulatory      1669..1674
                     /regulatory_class="polyA_signal_sequence"
                     /gene="METRNL"
                     /note="hexamer: AATAAA"
     polyA_site      1690
                     /gene="METRNL"
                     /note="major polyA site"
ORIGIN      
        1 agaggctcgg cggcggcggc gggcgcggag ctctgcgcgc ggctccagcg ggccgggatg
       61 ggcgggcggc cgcgcggagg acgcgggggg cgcgcgacgt gaccacccgg actcgaagcc
      121 cgccccgccc ccgcccggct cgccggctcc ggggtctgct ccgggggtcg cggacgcggg
      181 gccgggcggc ggagccggcg ccagagcatg cggggcgcgg cgcgggcggc ctgggggcgc
      241 gcggggcagc cgtggccgcg accccccgcc ccgggcccgc ccccgccgcc gctcccgctg
      301 ctgctcctgc tcctggccgg gctgctgggc ggcgcgggcg cgcagtactc cagcgaccgg
      361 tgcagctgga aggggagcgg gctgacgcac gaggcacaca ggaaggaggt ggagcaggtg
      421 tatctgcgct gtgcggcggg tgccgtggag tggatgtacc caacaggtgc tctcatcgtt
      481 aacctgcggc ccaacacctt ctcgcctgcc cggcacctga ccgtgtgcat caggtccttc
      541 acggactcct cgggggccaa tatttatttg gaaaaaactg gagaactgag actgctggta
      601 ccagacgggg acggcaggcc cggccgggtg cagtgttttg gcctggagca gggcggcctg
      661 ttcgtggagg ccacgccgca gcaggatatc ggccggagga ccacaggctt ccagtacgag
      721 ctggttagga ggcacagggc gtcggacctg cacgagctgt ctgcgccgtg ccgtccctgc
      781 agtgacaccg aggtgctcct agccgtctgc accagcgact tcgccgttcg aggctccatc
      841 cagcaagtta cccacgagcc tgagcggcag gactcagcca tccacctgcg cgtgagcaga
      901 ctctatcggc agaaaagcag ggtcttcgag ccggtgcccg agggtgacgg ccactggcag
      961 gggcgcgtca ggacgctgct ggagtgtggc gtgcggccgg ggcatggcga cttcctcttc
     1021 actggccaca tgcacttcgg ggaggcgcgg ctcggctgtg ccccacgctt caaggacttc
     1081 cagaggatgt acagggatgc ccaggagagg gggctgaacc cttgtgaggt tggcacggac
     1141 tgactccgtg ggccgctgcc cttcctctcc tgatgagtca caggctgcgg tgggcgctgc
     1201 ggtcctggtg gggccgtgcg gtgagggccg cgcgctggga gccgcatgcc ctgggcccag
     1261 gcctgaccct ggtaccgaag ctgtggacgt tctcgccaca ctcaacccca tgagcttcca
     1321 gccaaggatg ccctggccga ttggaaatgc tgtaaaatgc aaactaagtt attatatttt
     1381 tttttggtaa aaaagaaatg tccataggaa acaaattccc gtgtcttaaa acgccttggt
     1441 gtgccgtctg atactgttct ctaaagacgt taggagtcac ggcatctggc ctgcggttgg
     1501 gtgaagcact ggccgttggg cacagtggat gtgtgaaaag gtgccattca gagttgttat
     1561 tctcatgacg gaagttttgg agccaaataa tacgtttttt attttcattt tatttttaaa
     1621 ggatgagctt tggtcctttt caggccgccg gttgtttccg ttcccgagaa taaagacgag
     1681 gatccgacca
//
