LOCUS       NM_024042               3322 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens meteorin, glial cell differentiation regulator
            (METRN), mRNA.
ACCESSION   NM_024042 XM_003119646 XR_111624
VERSION     NM_024042.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3322)
  AUTHORS   Wang,X., Cao,Q., Shi,Y., Wu,X., Mi,Y., Liu,K., Kan,Q., Fan,R.,
            Liu,Z. and Zhang,M.
  TITLE     Identification of low-dose radiation-induced exosomal circ-METRN
            and miR-4709-3p/GRB14/PDGFRalpha pathway as a key regulatory
            mechanism in Glioblastoma progression and radioresistance:
            Functional validation and clinical theranostic significance
  JOURNAL   Int J Biol Sci 17 (4), 1061-1078 (2021)
   PUBMED   33867829
  REMARK    GeneRIF: Identification of low-dose radiation-induced exosomal
            circ-METRN and miR-4709-3p/GRB14/PDGFRalpha pathway as a key
            regulatory mechanism in Glioblastoma progression and
            radioresistance: Functional validation and clinical theranostic
            significance.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3322)
  AUTHORS   Xu,X., Zhang,C., Xia,Y. and Yu,J.
  TITLE     Over expression of METRN predicts poor clinical prognosis in
            colorectal cancer
  JOURNAL   Mol Genet Genomic Med 8 (3), e1102 (2020)
   PUBMED   31859449
  REMARK    GeneRIF: Over expression of METRN predicts poor clinical prognosis
            in colorectal cancer.
REFERENCE   3  (bases 1 to 3322)
  AUTHORS   Garces,M.F., Sanchez,E., Cardona,L.F., Simanca,E.L., Gonzalez,I.,
            Leal,L.G., Mora,J.A., Bedoya,A., Alzate,J.P., Sanchez,A.Y.,
            Eslava-Schmalbach,J.H., Franco-Vega,R., Parra,M.O.,
            Ruiz-Parra,A.I., Dieguez,C., Nogueiras,R. and Caminos,J.E.
  TITLE     Maternal Serum Meteorin Levels and the Risk of Preeclampsia
  JOURNAL   PLoS One 10 (6), e0131013 (2015)
   PUBMED   26121675
  REMARK    GeneRIF: The joint measurements of circulating METRN levels in the
            first trimester and systolic blood pressure and weight in the
            second trimester significantly increase the probabilities of
            predicting preeclampsia.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3322)
  AUTHORS   Martin,J., Han,C., Gordon,L.A., Terry,A., Prabhakar,S., She,X.,
            Xie,G., Hellsten,U., Chan,Y.M., Altherr,M., Couronne,O., Aerts,A.,
            Bajorek,E., Black,S., Blumer,H., Branscomb,E., Brown,N.C.,
            Bruno,W.J., Buckingham,J.M., Callen,D.F., Campbell,C.S.,
            Campbell,M.L., Campbell,E.W., Caoile,C., Challacombe,J.F.,
            Chasteen,L.A., Chertkov,O., Chi,H.C., Christensen,M., Clark,L.M.,
            Cohn,J.D., Denys,M., Detter,J.C., Dickson,M.,
            Dimitrijevic-Bussod,M., Escobar,J., Fawcett,J.J., Flowers,D.,
            Fotopulos,D., Glavina,T., Gomez,M., Gonzales,E., Goodstein,D.,
            Goodwin,L.A., Grady,D.L., Grigoriev,I., Groza,M., Hammon,N.,
            Hawkins,T., Haydu,L., Hildebrand,C.E., Huang,W., Israni,S.,
            Jett,J., Jewett,P.B., Kadner,K., Kimball,H., Kobayashi,A.,
            Krawczyk,M.C., Leyba,T., Longmire,J.L., Lopez,F., Lou,Y., Lowry,S.,
            Ludeman,T., Manohar,C.F., Mark,G.A., McMurray,K.L., Meincke,L.J.,
            Morgan,J., Moyzis,R.K., Mundt,M.O., Munk,A.C., Nandkeshwar,R.D.,
            Pitluck,S., Pollard,M., Predki,P., Parson-Quintana,B., Ramirez,L.,
            Rash,S., Retterer,J., Ricke,D.O., Robinson,D.L., Rodriguez,A.,
            Salamov,A., Saunders,E.H., Scott,D., Shough,T., Stallings,R.L.,
            Stalvey,M., Sutherland,R.D., Tapia,R., Tesmer,J.G., Thayer,N.,
            Thompson,L.S., Tice,H., Torney,D.C., Tran-Gyamfi,M., Tsai,M.,
            Ulanovsky,L.E., Ustaszewska,A., Vo,N., White,P.S., Williams,A.L.,
            Wills,P.L., Wu,J.R., Wu,K., Yang,J., Dejong,P., Bruce,D.,
            Doggett,N.A., Deaven,L., Schmutz,J., Grimwood,J., Richardson,P.,
            Rokhsar,D.S., Eichler,E.E., Gilna,P., Lucas,S.M., Myers,R.M.,
            Rubin,E.M. and Pennacchio,L.A.
  TITLE     The sequence and analysis of duplication-rich human chromosome 16
  JOURNAL   Nature 432 (7020), 988-994 (2004)
   PUBMED   15616553
REFERENCE   5  (bases 1 to 3322)
  AUTHORS   Nishino,J., Yamashita,K., Hashiguchi,H., Fujii,H., Shimazaki,T. and
            Hamada,H.
  TITLE     Meteorin: a secreted protein that regulates glial cell
            differentiation and promotes axonal extension
  JOURNAL   EMBO J 23 (9), 1998-2008 (2004)
   PUBMED   15085178
  REMARK    GeneRIF: Meteorin plays important roles in both glial cell
            differentiation and axonal network formation during neurogenesis.
REFERENCE   6  (bases 1 to 3322)
  AUTHORS   Daniels,R.J., Peden,J.F., Lloyd,C., Horsley,S.W., Clark,K.,
            Tufarelli,C., Kearney,L., Buckle,V.J., Doggett,N.A., Flint,J. and
            Higgs,D.R.
  TITLE     Sequence, structure and pathology of the fully annotated terminal 2
            Mb of the short arm of human chromosome 16
  JOURNAL   Hum Mol Genet 10 (4), 339-352 (2001)
   PUBMED   11157797
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            Z97653.14, BC000662.2, AL360260.1 and Z98258.1.
            
            On Nov 22, 2018 this sequence version replaced NM_024042.3.
            
            Summary: Meteorin regulates glial cell differentiation and promotes
            the formation of axonal networks during neurogenesis (Nishino et
            al., 2004 [PubMed 15085178]).[supplied by OMIM, Mar 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.584659.1,
                                           ERR279862.5956.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000568223.7/ ENSP00000455068.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                Z97653.14          21726-21780
            56-1147             BC000662.2         1-1092
            1148-1926           Z97653.14          24089-24867
            1927-3188           AL360260.1         1-1262
            3189-3189           Z98258.1           1188-1188
            3190-3322           AL360260.1         1264-1396
FEATURES             Location/Qualifiers
     source          1..3322
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..3322
                     /gene="METRN"
                     /gene_synonym="C16orf23; c380A1.2"
                     /note="meteorin, glial cell differentiation regulator"
                     /db_xref="GeneID:79006"
                     /db_xref="HGNC:HGNC:14151"
                     /db_xref="MIM:610998"
     exon            1..276
                     /gene="METRN"
                     /gene_synonym="C16orf23; c380A1.2"
                     /inference="alignment:Splign:2.1.0"
     CDS             173..1054
                     /gene="METRN"
                     /gene_synonym="C16orf23; c380A1.2"
                     /codon_start=1
                     /product="meteorin precursor"
                     /protein_id="NP_076947.1"
                     /db_xref="CCDS:CCDS10422.1"
                     /db_xref="GeneID:79006"
                     /db_xref="HGNC:HGNC:14151"
                     /db_xref="MIM:610998"
                     /translation="MGFPAAALLCALCCGLLAPAARAGYSEERCSWRGSGLTQEPGSV
                     GQLALACAEGAVEWLYPAGALRLTLGGPDPRARPGIACLRPVRPFAGAQVFAERAGGA
                     LELLLAEGPGPAGGRCVRWGPRERRALFLQATPHQDISRRVAAFRFELREDGRPELPP
                     QAHGLGVDGACRPCSDAELLLAACTSDFVIHGIIHGVTHDVELQESVITVVAARVLRQ
                     TPPLFQAGRSGDQGLTSIRTPLRCGVHPGPGTFLFMGWSRFGEARLGCAPRFQEFRRA
                     YEAARAAHLHPCEVALH"
     exon            277..677
                     /gene="METRN"
                     /gene_synonym="C16orf23; c380A1.2"
                     /inference="alignment:Splign:2.1.0"
     exon            678..737
                     /gene="METRN"
                     /gene_synonym="C16orf23; c380A1.2"
                     /inference="alignment:Splign:2.1.0"
     exon            738..3322
                     /gene="METRN"
                     /gene_synonym="C16orf23; c380A1.2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1126..1131
                     /regulatory_class="polyA_signal_sequence"
                     /gene="METRN"
                     /gene_synonym="C16orf23; c380A1.2"
                     /note="hexamer: AATAAG"
     polyA_site      1147
                     /gene="METRN"
                     /gene_synonym="C16orf23; c380A1.2"
                     /note="major polyA site"
     regulatory      3298..3303
                     /regulatory_class="polyA_signal_sequence"
                     /gene="METRN"
                     /gene_synonym="C16orf23; c380A1.2"
                     /note="hexamer: AATAAA"
     polyA_site      3322
                     /gene="METRN"
                     /gene_synonym="C16orf23; c380A1.2"
ORIGIN      
        1 aaggcggccc cggcgctggg gctgcgcggc aggcggagcg gccgcgggct tgggggcttc
       61 gccggggccg ggcggccggc gcccccggct gctcccgccg ccgcccggac ccgcgccccg
      121 ccggggcagc ggtggtgaga gccccgactc cccggacgcc gcccgccgtg ccatggggtt
      181 cccggccgcg gcgctgctct gcgcgctgtg ctgcggcctc ctggccccgg ctgcccgcgc
      241 cggctactcc gaggagcgct gcagctggag gggcagcggc ctcacccagg agcccggcag
      301 cgtggggcag ctggccctgg cctgtgcgga gggcgcggtt gagtggctgt acccggctgg
      361 ggcgctgcgc ctgaccctgg gcggccccga tcccagagcg cggcccggca tcgcctgtct
      421 gcggccggtg cggcccttcg cgggcgccca ggtcttcgcg gagcgcgcag ggggcgccct
      481 ggagctgctg ctggccgagg gcccgggccc ggcagggggc cgctgcgtgc gctggggtcc
      541 ccgcgagcgc cgggccctct tcctgcaggc cacgccgcac caggacatca gccgccgcgt
      601 ggccgccttc cgctttgagc tgcgcgagga cgggcgcccc gagctgcccc cgcaggccca
      661 cggtctcggc gtagacggtg cctgcaggcc ctgcagcgac gctgagctgc tcctggccgc
      721 atgcaccagc gacttcgtaa ttcacgggat catccatggg gtcacccatg acgtggagct
      781 gcaggagtct gtcatcactg tggtggccgc ccgtgtcctc cgccagacac cgccgctgtt
      841 ccaggcgggg cgatccgggg accaggggct gacctccatt cgtaccccac tgcgctgtgg
      901 cgtccacccg ggcccaggca ccttcctctt catgggctgg agccgctttg gggaggcccg
      961 gctgggctgt gccccacgat tccaggagtt ccgccgtgcc tacgaggctg cccgtgctgc
     1021 ccacctccac ccctgcgagg tggcgctgca ctgaggggct gggtgctggg gaggggctgg
     1081 taggagggag ggtgggccca ctgctttgga ggtgatggga ctatcaataa gaactctgtt
     1141 cacgcaagct gctgtggacc tggtctcctg tgtccagccc agccttgggc ctgcctcgca
     1201 gctgtgagga tggctccaat tcctgcctcc tggcgggaga ctgaggctca ggggaatggt
     1261 atcttgttca agaccatttg gcaactgaga gggagagcag atgtcaggag gagctacacc
     1321 cacattccgg ggaggggccg ctgctgggtg gggggcacgt ggggacctgc actcatgcaa
     1381 gcttctgctc tgctgcaccc accagccccg tccttgcccg cacccttgcc tgcttccctg
     1441 gctggctccc acttgcctcc cgtgccaggt gcttctgggg ctcagcagga gaggaaaggg
     1501 gcagaggggc atagggtccc tcgggtacgg tgggggcagg cgggcgcaca gcgctccggc
     1561 tctgagccag gcctgtgagg gaaggggctg caggctggca gggtgccgac ttcccccatg
     1621 gctgctgtga gcccgcagag tcatccttgg ccccgtcccg cccttgggga agaatgggcc
     1681 cctctgtcct caggcccctt cgacgtgctg agcatccaga cgtggcgagg agcccgaagg
     1741 gtgtggggtc ccctctgcag ggtcctgctt gttgcctgtt tccggcgggc ggggtgcaca
     1801 atggggtctc taaggaccgt ttcccgccac tggccccatt gtcactgtct ccgccttcct
     1861 cctcggcctt tcagccgcat aaagggccag tgaggtttgg gacagccaca gcccaaggct
     1921 ccgaggctaa aagcccctgg gtgggggtgt tccaggacac ctggccctgt gtgagctgcc
     1981 tcctctcacc ccaacccctc ggatcctggg aaagagacag ccatggctca agggccaggg
     2041 acccctgggc tgagccccag aaatggcttt ccattctcgc ctgggccggg gtgggggtgg
     2101 aggccagagg ccctgcccag gcagatgaag cccccagctt tcaaggggga aactgaggct
     2161 gtgtgaggga cacagctgtg cagggcccac aaacacggtc ctttctctag gttagcggat
     2221 gcagatgcct gatgagtgcc atgccctctg tggacacctg gggagggggg tcacctccag
     2281 cgccgccctg ggacttccac tgcacgtgca agagacttac cctttcacac agatcacctg
     2341 cctgccgcag ggctgatgag gatgggtgag gagcgcagcc actgggtgtc atgcactgtg
     2401 ggggttctcc caccttctgc ccctcctcag gttccttgct gcttctctcc tctcccaact
     2461 gtggcacgct gagggctcag gcacaggacc gctcctctgg ggcagcctcc aataaccctt
     2521 ggacaacctc cactttttca tcttcagccc tgaccactcc ctggggccca tagccttaca
     2581 tccatctgcc cccagcccaa acacttctgc aaacactaga aaaggaggta gcccgtgtgc
     2641 cctcctgcac cgcctcctcc actcctgtct tggagaggct ttcccgtggg ccgagcaacc
     2701 cccttacctt tggcacttgc cctgattctc tggccagctt cctacaacct ctccttttca
     2761 gccacaccca agtccacctg ttcacaaaca ccctgggctg ggccctggcc gaaccctggc
     2821 ttctacctac ctgtctcagg aagtgcctga gccttgcacc tacagaccct cccagagaaa
     2881 gccctggctt tgcaaccagc tgtcttctca tgagacacag ggccacagga gcaccacggt
     2941 gcccaaatgg gtcttggagc attagaccag gggcttcatg cctgccctgg ggacaggtgg
     3001 ccaaagtggc atgggagata gggagacagt gtgggtgagc aggtgggcag gagctacagg
     3061 agcctggggc ctgtggatca cagacaccgc caggcaagtg ccagttcaca caggtacagg
     3121 tggctgcaga gtgcccaaag gccaagcagc agagtgcctg gtgtggacgg gagaggagtg
     3181 gggaggttgg gcgcagtggc tcacgcctgt aatcccaaca ctttgggagg cccaggcaag
     3241 cagatcatga ggtcaggaga tggagaccat cctggccaac atggtgaaac cgtctctaat
     3301 aaaacacaaa aaattagcca ga
//
