LOCUS       NM_015143               2686 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens methionyl aminopeptidase 1 (METAP1), mRNA.
ACCESSION   NM_015143
VERSION     NM_015143.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2686)
  AUTHORS   Caglayan,A.O., Aktar,F., Bilguvar,K., Baranoski,J.F., Akgumus,G.T.,
            Harmanci,A.S., Erson-Omay,E.Z., Yasuno,K., Caksen,H. and Gunel,M.
  TITLE     METAP1 mutation is a novel candidate for autosomal recessive
            intellectual disability
  JOURNAL   J Hum Genet 66 (2), 215-218 (2021)
   PUBMED   32764695
  REMARK    GeneRIF: METAP1 mutation is a novel candidate for autosomal
            recessive intellectual disability.
REFERENCE   2  (bases 1 to 2686)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2686)
  AUTHORS   Frottin,F., Bienvenut,W.V., Bignon,J., Jacquet,E., Vaca
            Jacome,A.S., Van Dorsselaer,A., Cianferani,S., Carapito,C.,
            Meinnel,T. and Giglione,C.
  TITLE     MetAP1 and MetAP2 drive cell selectivity for a potent anti-cancer
            agent in synergy, by controlling glutathione redox state
  JOURNAL   Oncotarget 7 (39), 63306-63323 (2016)
   PUBMED   27542228
  REMARK    GeneRIF: MetAP1 and MetAP2 have roles in driving cell selectivity
            for a potent anti-cancer agent in synergy, by controlling
            glutathione redox state
REFERENCE   4  (bases 1 to 2686)
  AUTHORS   Kishor,C., Arya,T., Reddi,R., Chen,X., Saddanapu,V., Marapaka,A.K.,
            Gumpena,R., Ma,D., Liu,J.O. and Addlagatta,A.
  TITLE     Identification, biochemical and structural evaluation of
            species-specific inhibitors against type I methionine
            aminopeptidases
  JOURNAL   J Med Chem 56 (13), 5295-5305 (2013)
   PUBMED   23767698
  REMARK    GeneRIF: Data indicate that pyridinylpyrimidine-based molecules
            displayed species specificity behavior against methionine
            aminopeptidases (MetAPs).
REFERENCE   5  (bases 1 to 2686)
  AUTHORS   Frobel,J., Cadeddu,R.P., Hartwig,S., Bruns,I., Wilk,C.M.,
            Kundgen,A., Fischer,J.C., Schroeder,T., Steidl,U.G., Germing,U.,
            Lehr,S., Haas,R. and Czibere,A.
  TITLE     Platelet proteome analysis reveals integrin-dependent aggregation
            defects in patients with myelodysplastic syndromes
  JOURNAL   Mol Cell Proteomics 12 (5), 1272-1280 (2013)
   PUBMED   23382103
REFERENCE   6  (bases 1 to 2686)
  AUTHORS   Addlagatta,A., Hu,X., Liu,J.O. and Matthews,B.W.
  TITLE     Structural basis for the functional differences between type I and
            type II human methionine aminopeptidases
  JOURNAL   Biochemistry 44 (45), 14741-14749 (2005)
   PUBMED   16274222
  REMARK    GeneRIF: A comparison of the structual differences between Type I
            and Type II methionine aminopeptidases.
REFERENCE   7  (bases 1 to 2686)
  AUTHORS   Andersen,J.S., Lam,Y.W., Leung,A.K., Ong,S.E., Lyon,C.E.,
            Lamond,A.I. and Mann,M.
  TITLE     Nucleolar proteome dynamics
  JOURNAL   Nature 433 (7021), 77-83 (2005)
   PUBMED   15635413
REFERENCE   8  (bases 1 to 2686)
  AUTHORS   Rush,J., Moritz,A., Lee,K.A., Guo,A., Goss,V.L., Spek,E.J.,
            Zhang,H., Zha,X.M., Polakiewicz,R.D. and Comb,M.J.
  TITLE     Immunoaffinity profiling of tyrosine phosphorylation in cancer
            cells
  JOURNAL   Nat Biotechnol 23 (1), 94-101 (2005)
   PUBMED   15592455
REFERENCE   9  (bases 1 to 2686)
  AUTHORS   Serero,A., Giglione,C., Sardini,A., Martinez-Sanz,J. and Meinnel,T.
  TITLE     An unusual peptide deformylase features in the human mitochondrial
            N-terminal methionine excision pathway
  JOURNAL   J Biol Chem 278 (52), 52953-52963 (2003)
   PUBMED   14532271
REFERENCE   10 (bases 1 to 2686)
  AUTHORS   Dummitt,B., Fei,Y. and Chang,Y.H.
  TITLE     Functional expression of human methionine aminopeptidase type 1 in
            Saccharomyces cerevisiae
  JOURNAL   Protein Pept Lett 9 (4), 295-303 (2002)
   PUBMED   12144506
  REMARK    GeneRIF: Data show that human methionine aminopeptidase 1 (MetAP1)
            fully rescued the slow growth phenotype associated with deletion of
            yeast MetAP1, suggesting that the yeast and human proteins may have
            similar roles in vivo.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA178462.1, D42084.1 and BC030054.1.
            
            On Nov 22, 2018 this sequence version replaced NM_015143.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.387744.1,
                                           SRR1660803.154438.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000296411.11/ ENSP00000296411.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 DA178462.1         102-109
            9-2679              D42084.1           1-2671
            2680-2686           BC030054.1         2322-2328
FEATURES             Location/Qualifiers
     source          1..2686
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q23"
     gene            1..2686
                     /gene="METAP1"
                     /gene_synonym="MAP1A; MetAP1A"
                     /note="methionyl aminopeptidase 1"
                     /db_xref="GeneID:23173"
                     /db_xref="HGNC:HGNC:15789"
                     /db_xref="MIM:610151"
     exon            1..147
                     /gene="METAP1"
                     /gene_synonym="MAP1A; MetAP1A"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..1194
                     /gene="METAP1"
                     /gene_synonym="MAP1A; MetAP1A"
                     /EC_number="3.4.11.18"
                     /note="MAP 1; metAP 1; peptidase M 1"
                     /codon_start=1
                     /product="methionine aminopeptidase 1"
                     /protein_id="NP_055958.2"
                     /db_xref="CCDS:CCDS47110.1"
                     /db_xref="GeneID:23173"
                     /db_xref="HGNC:HGNC:15789"
                     /db_xref="MIM:610151"
                     /translation="MAAVETRVCETDGCSSEAKLQCPTCIKLGIQGSYFCSQECFKGS
                     WATHKLLHKKAKDEKAKREVSSWTVEGDINTDPWAGYRYTGKLRPHYPLMPTRPVPSY
                     IQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPG
                     VTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVN
                     VDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNII
                     QKHAQANGFSVVRSYCGHGIHKLFHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGG
                     WQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMSQF"
     exon            148..199
                     /gene="METAP1"
                     /gene_synonym="MAP1A; MetAP1A"
                     /inference="alignment:Splign:2.1.0"
     exon            200..312
                     /gene="METAP1"
                     /gene_synonym="MAP1A; MetAP1A"
                     /inference="alignment:Splign:2.1.0"
     exon            313..373
                     /gene="METAP1"
                     /gene_synonym="MAP1A; MetAP1A"
                     /inference="alignment:Splign:2.1.0"
     exon            374..465
                     /gene="METAP1"
                     /gene_synonym="MAP1A; MetAP1A"
                     /inference="alignment:Splign:2.1.0"
     exon            466..549
                     /gene="METAP1"
                     /gene_synonym="MAP1A; MetAP1A"
                     /inference="alignment:Splign:2.1.0"
     exon            550..688
                     /gene="METAP1"
                     /gene_synonym="MAP1A; MetAP1A"
                     /inference="alignment:Splign:2.1.0"
     exon            689..820
                     /gene="METAP1"
                     /gene_synonym="MAP1A; MetAP1A"
                     /inference="alignment:Splign:2.1.0"
     exon            821..964
                     /gene="METAP1"
                     /gene_synonym="MAP1A; MetAP1A"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1030
                     /gene="METAP1"
                     /gene_synonym="MAP1A; MetAP1A"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..2686
                     /gene="METAP1"
                     /gene_synonym="MAP1A; MetAP1A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2661..2666
                     /regulatory_class="polyA_signal_sequence"
                     /gene="METAP1"
                     /gene_synonym="MAP1A; MetAP1A"
                     /note="hexamer: ATTAAA"
     polyA_site      2686
                     /gene="METAP1"
                     /gene_synonym="MAP1A; MetAP1A"
                     /note="major polyA site"
ORIGIN      
        1 ctcggtgagg cgctcttcca gcgggcaggc agcatggcgg ccgtggagac gcgggtgtgc
       61 gagacagacg gctgcagcag tgaggccaag ctccagtgtc ccacttgcat caagctgggc
      121 atccagggct cgtacttctg ctcgcaggaa tgttttaaag gaagttgggc tactcacaag
      181 ttactacata agaaagcaaa agatgaaaag gcgaagcgag aagtgtcttc ctggactgtg
      241 gaaggtgata ttaatactga cccatgggca ggttatcgat atactggtaa actcagacca
      301 cattatccac tgatgccaac aaggccagtg ccaagttata ttcaaagacc agattatgct
      361 gatcatccct taggaatgtc tgaatctgaa caggctctta aaggtacttc tcagattaaa
      421 ttactctcat ctgaagatat agaagggatg cgacttgtat gtaggcttgc tagagaagtt
      481 ttggatgttg ctgccggcat gattaaacca ggtgtaacta ctgaagaaat agatcacgct
      541 gtacacttag catgtattgc aagaaattgc tacccttctc ccctgaatta ttataatttc
      601 ccaaagtctt gttgtacctc agtgaatgaa gtcatttgcc atggaatacc agacagaagg
      661 cccttacaag aaggtgacat tgttaatgtg gatatcactc tttatcgcaa tggttatcat
      721 ggggacctga atgagacatt ttttgttgga gaagtggatg atggagcacg gaaacttgtt
      781 cagaccacat atgagtgcct gatgcaagcc attgatgcag tgaagcctgg tgttcggtac
      841 agagaattgg gaaacattat ccagaagcat gcccaagcaa atgggttttc agttgttcga
      901 agctattgtg ggcatggaat ccacaagctt tttcatacag ctcccaatgt accccactat
      961 gctaaaaata aagcagttgg agtgatgaag tcgggccatg tatttacaat tgagccaatg
     1021 atttgtgaag gcggatggca ggatgaaacc tggccagatg gttggactgc ggtgacaaga
     1081 gacggaaagc ggtctgctca gtttgagcac accctcctgg tcacagacac tggctgtgaa
     1141 atcctaaccc ggcgacttga cagtgcacgg cctcacttca tgtctcaatt ttaatttctc
     1201 ccaagatggc acatctcagt accttcttac tgtgctatgc attttattga gagtacagaa
     1261 aggaagagga accttttttt aatcacttgt tttgttttga ctatagataa gaaaggacta
     1321 cagcatttga tgtgtgtcct caagaacttg tcttgggtct gaaaaagctg agaagaataa
     1381 aggaaacatt gctcaactct tcagccccct ccccctgcac acctgttttc tcatttgccc
     1441 tttgagcact tttacttaaa cttgcttgta gttgctttta tcactgccgc aaaacagcca
     1501 tcaagagcca tctgctttcc aggtgaacat tggaaatgag aatctttgaa acttagcaat
     1561 atgtgttgca ccagattttt taaattatat atatggaaat atatatgtat acattttaag
     1621 ttctgtatac ataattacca aacactatgt gacctggagt ttgtgttgtt tctgctctga
     1681 caggtttata tgttcttaca aatggatcca tagtttgcag tgatttaatt cctggttggg
     1741 atttggcctc ccctctcccc catgctaatt atttaccctt gtaattgtgc atagggaagc
     1801 actcacccaa tgagactttc tccaatgtgg actctgtgtg tcagtgaatg aatgtagtaa
     1861 aattcacttt ggaaggttat caggctttta aaaatctagt ttatggcaaa aatagccatt
     1921 ttccaagtgg tggctgactg ttgcagggaa tgagaatttc ataatacact gctatttcag
     1981 acctctgttt ggtcagaaat ggaaaagaaa aagccccctt tcttcccttt tctgttttac
     2041 ttcaagggca taccttggag gtgctcagag aagcgtgaag tttgcactat ggtggaggat
     2101 ggggaaagag ttctaaagtg tctccagctg tgaacccagg aggtcaagtg ggctattaaa
     2161 atctaacgtt gagtaaatgt gatagtgatg agaaaggaat tttgtgtact gtaaccttgc
     2221 agtagagatg cagctgtcct tcgtgtgtgg aaacacacct ctcctttaca tagttgggaa
     2281 cctcattaga aatgacctca gctgccccat atctacgttc ctttcagcag ttgtccaagt
     2341 aggagtgtat ccagtgaaga catatcaaat cacaaagtca ttgtcattag agtgtacttg
     2401 attactgggc atccttgtaa tataatttca taccactgac acattatact tgtaagagaa
     2461 catctttccc agagtgcctc agaccttatt gctttaaaat ataataatgt tttcattact
     2521 tttattattt gaatgattta gtaaagttga ctgaatctgg tatagacttt gggagtatgt
     2581 gtgtgaagtt tttatcaaac tgtaatattt gtgaatggaa tgccttgcaa tatgaatgtt
     2641 aatataatgt gtaaagggag attaaaaagt ttgaatgatt atccta
//
