LOCUS       NM_000245               6822 bp    mRNA    linear   PRI 07-MAR-2025
DEFINITION  Homo sapiens MET proto-oncogene, receptor tyrosine kinase (MET),
            transcript variant 2, mRNA.
ACCESSION   NM_000245
VERSION     NM_000245.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6822)
  AUTHORS   Li,Y., Arghittu,S.M., Dietz,M.S., Hella,G.J., Hasse,D.,
            Ferraris,D.M., Freund,P., Barth,H.D., Iamele,L., de Jonge,H.,
            Niemann,H.H., Covino,R. and Heilemann,M.
  TITLE     Single-molecule imaging and molecular dynamics simulations reveal
            early activation of the MET receptor in cells
  JOURNAL   Nat Commun 15 (1), 9486 (2024)
   PUBMED   39488533
  REMARK    GeneRIF: Single-molecule imaging and molecular dynamics simulations
            reveal early activation of the MET receptor in cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6822)
  AUTHORS   Reale,M.L., Passiglia,F., Cappuzzo,F., Minuti,G., Occhipinti,M.,
            Bulotta,A., Delmonte,A., Sini,C., Galetta,D., Roca,E.,
            Pelizzari,G., Cortinovis,D., Gariazzo,E., Pilotto,S., Citarella,F.,
            Bria,E., Muscolino,P., Pozzessere,D., Carta,A., Pignataro,D.,
            Calvetti,L., Leone,F., Banini,M., Di Micco,C., Baldini,E.,
            Favaretto,A., Malapelle,U., Novello,S., Pasello,G. and Tiseo,M.
  TITLE     MET exon 14 skipping mutations in non-small-cell lung cancer:
            real-world data from the Italian biomarker ATLAS database
  JOURNAL   ESMO Open 9 (9), 103680 (2024)
   PUBMED   39214048
  REMARK    GeneRIF: MET exon 14 skipping mutations in non-small-cell lung
            cancer: real-world data from the Italian biomarker ATLAS database.
REFERENCE   3  (bases 1 to 6822)
  AUTHORS   Boschert,V., Boenke,J., Bohm,A.K., Teusch,J., Steinacker,V.,
            Straub,A. and Hartmann,S.
  TITLE     Differential Immune Checkpoint Protein Expression in HNSCC: The
            Role of HGF/MET Signaling
  JOURNAL   Int J Mol Sci 25 (13), 7334 (2024)
   PUBMED   39000441
  REMARK    GeneRIF: Differential Immune Checkpoint Protein Expression in
            HNSCC: The Role of HGF/MET Signaling.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6822)
  AUTHORS   Barbosa-Matos,C., Borges-Pereira,C., Liborio-Ramos,S.,
            Fernandes,R., Oliveira,M., Mendes-Frias,A., Silvestre,R.,
            Osorio,N.S., Bastos,H.N., Santos,R.F., Guimaraes,S., Morais,A.,
            Mazzone,M., Carvalho,A., Cunha,C. and Costa,S.
  TITLE     Deregulated immune cell recruitment orchestrated by c-MET impairs
            pulmonary inflammation and fibrosis
  JOURNAL   Respir Res 25 (1), 257 (2024)
   PUBMED   38909206
  REMARK    GeneRIF: Deregulated immune cell recruitment orchestrated by c-MET
            impairs pulmonary inflammation and fibrosis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6822)
  AUTHORS   Atanelishvili,I., Shirai,Y., Akter,T., Buckner,T., Noguchi,A.,
            Silver,R.M. and Bogatkevich,G.S.
  TITLE     M10, a caspase cleavage product of the hepatocyte growth factor
            receptor, interacts with Smad2 and demonstrates antifibrotic
            properties in vitro and in vivo
  JOURNAL   Transl Res 170, 99-111 (2016)
   PUBMED   26772959
REFERENCE   6  (bases 1 to 6822)
  AUTHORS   Skead,G. and Govender,D.
  TITLE     Gene of the month: MET
  JOURNAL   J Clin Pathol 68 (6), 405-409 (2015)
   PUBMED   25987653
  REMARK    GeneRIF: we outline the key features of the MET gene, its protein
            product and the ligand HGF/SF, to provide an overview of this
            important signalling pathway and offer a summary of the relevant
            pathological and clinical directions of research.
            Review article
            Erratum:[J Clin Pathol. 2015 Jul;68(7):e2. doi:
            10.1136/jclinpath-2015-203050corr1. PMID: 26093021]
REFERENCE   7  (bases 1 to 6822)
  AUTHORS   Galland,F., Stefanova,M., Lafage,M. and Birnbaum,D.
  TITLE     Localization of the 5' end of the MCF2 oncogene to human chromosome
            15q15----q23
  JOURNAL   Cytogenet Cell Genet 60 (2), 114-116 (1992)
   PUBMED   1611909
REFERENCE   8  (bases 1 to 6822)
  AUTHORS   Ferracini,R., Longati,P., Naldini,L., Vigna,E. and Comoglio,P.M.
  TITLE     Identification of the major autophosphorylation site of the
            Met/hepatocyte growth factor receptor tyrosine kinase
  JOURNAL   J Biol Chem 266 (29), 19558-19564 (1991)
   PUBMED   1655790
REFERENCE   9  (bases 1 to 6822)
  AUTHORS   Naldini,L., Weidner,K.M., Vigna,E., Gaudino,G., Bardelli,A.,
            Ponzetto,C., Narsimhan,R.P., Hartmann,G., Zarnegar,R.,
            Michalopoulos,G.K. et al.
  TITLE     Scatter factor and hepatocyte growth factor are indistinguishable
            ligands for the MET receptor
  JOURNAL   EMBO J 10 (10), 2867-2878 (1991)
   PUBMED   1655405
REFERENCE   10 (bases 1 to 6822)
  AUTHORS   Naldini,L., Vigna,E., Narsimhan,R.P., Gaudino,G., Zarnegar,R.,
            Michalopoulos,G.K. and Comoglio,P.M.
  TITLE     Hepatocyte growth factor (HGF) stimulates the tyrosine kinase
            activity of the receptor encoded by the proto-oncogene c-MET
  JOURNAL   Oncogene 6 (4), 501-504 (1991)
   PUBMED   1827664
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC002080.1, DB223186.1,
            X54559.1, BX648782.1 and AA278232.1.
            
            On May 31, 2019 this sequence version replaced NM_000245.3.
            
            Summary: This gene encodes a member of the receptor tyrosine kinase
            family of proteins and the product of the proto-oncogene MET. The
            encoded preproprotein is proteolytically processed to generate
            alpha and beta subunits that are linked via disulfide bonds to form
            the mature receptor. Further processing of the beta subunit results
            in the formation of the M10 peptide, which has been shown to reduce
            lung fibrosis. Binding of its ligand, hepatocyte growth factor,
            induces dimerization and activation of the receptor, which plays a
            role in cellular survival, embryogenesis, and cellular migration
            and invasion. Mutations in this gene are associated with papillary
            renal cell carcinoma, hepatocellular carcinoma, and various head
            and neck cancers. Amplification and overexpression of this gene are
            also associated with multiple human cancers. [provided by RefSeq,
            May 2016].
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice junction at the end of an exon compared to variant 1. The
            resulting isoform (b) has the same N- and C-termini but is shorter
            compared to isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.55809.1,
                                           SRR1660803.200872.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000397752.8/ ENSP00000380860.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-194               AC002080.1         85467-85660
            195-209             DB223186.1         1-15
            210-4208            X54559.1           8-4006
            4209-5996           BX648782.1         1042-2829
            5997-6360           AA278232.1         70-433
            6361-6822           BX648782.1         3194-3655
FEATURES             Location/Qualifiers
     source          1..6822
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q31.2"
     gene            1..6822
                     /gene="MET"
                     /gene_synonym="AUTS9; c-Met; DA11; DFNB97; HGFR; RCCP2"
                     /note="MET proto-oncogene, receptor tyrosine kinase"
                     /db_xref="GeneID:4233"
                     /db_xref="HGNC:HGNC:7029"
                     /db_xref="MIM:164860"
     exon            1..382
                     /gene="MET"
                     /gene_synonym="AUTS9; c-Met; DA11; DFNB97; HGFR; RCCP2"
                     /inference="alignment:Splign:2.1.0"
     exon            383..1596
                     /gene="MET"
                     /gene_synonym="AUTS9; c-Met; DA11; DFNB97; HGFR; RCCP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             397..4569
                     /gene="MET"
                     /gene_synonym="AUTS9; c-Met; DA11; DFNB97; HGFR; RCCP2"
                     /EC_number="2.7.10.1"
                     /note="isoform b preproprotein is encoded by transcript
                     variant 2; HGF receptor; scatter factor receptor; SF
                     receptor; hepatocyte growth factor receptor; HGF/SF
                     receptor; proto-oncogene c-Met; tyrosine-protein kinase
                     Met"
                     /codon_start=1
                     /product="hepatocyte growth factor receptor isoform b
                     preproprotein"
                     /protein_id="NP_000236.2"
                     /db_xref="CCDS:CCDS43636.1"
                     /db_xref="GeneID:4233"
                     /db_xref="HGNC:HGNC:7029"
                     /db_xref="MIM:164860"
                     /translation="MKAPAVLAPGILVLLFTLVQRSNGECKEALAKSEMNVNMKYQLP
                     NFTAETPIQNVILHEHHIFLGATNYIYVLNEEDLQKVAEYKTGPVLEHPDCFPCQDCS
                     SKANLSGGVWKDNINMALVVDTYYDDQLISCGSVNRGTCQRHVFPHNHTADIQSEVHC
                     IFSPQIEEPSQCPDCVVSALGAKVLSSVKDRFINFFVGNTINSSYFPDHPLHSISVRR
                     LKETKDGFMFLTDQSYIDVLPEFRDSYPIKYVHAFESNNFIYFLTVQRETLDAQTFHT
                     RIIRFCSINSGLHSYMEMPLECILTEKRKKRSTKKEVFNILQAAYVSKPGAQLARQIG
                     ASLNDDILFGVFAQSKPDSAEPMDRSAMCAFPIKYVNDFFNKIVNKNNVRCLQHFYGP
                     NHEHCFNRTLLRNSSGCEARRDEYRTEFTTALQRVDLFMGQFSEVLLTSISTFIKGDL
                     TIANLGTSEGRFMQVVVSRSGPSTPHVNFLLDSHPVSPEVIVEHTLNQNGYTLVITGK
                     KITKIPLNGLGCRHFQSCSQCLSAPPFVQCGWCHDKCVRSEECLSGTWTQQICLPAIY
                     KVFPNSAPLEGGTRLTICGWDFGFRRNNKFDLKKTRVLLGNESCTLTLSESTMNTLKC
                     TVGPAMNKHFNMSIIISNGHGTTQYSTFSYVDPVITSISPKYGPMAGGTLLTLTGNYL
                     NSGNSRHISIGGKTCTLKSVSNSILECYTPAQTISTEFAVKLKIDLANRETSIFSYRE
                     DPIVYEIHPTKSFISGGSTITGVGKNLNSVSVPRMVINVHEAGRNFTVACQHRSNSEI
                     ICCTTPSLQQLNLQLPLKTKAFFMLDGILSKYFDLIYVHNPVFKPFEKPVMISMGNEN
                     VLEIKGNDIDPEAVKGEVLKVGNKSCENIHLHSEAVLCTVPNDLLKLNSELNIEWKQA
                     ISSTVLGKVIVQPDQNFTGLIAGVVSISTALLLLLGFFLWLKKRKQIKDLGSELVRYD
                     ARVHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEDQFPNSSQNGSCRQVQYPLTD
                     MSPILTSGDSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGH
                     FGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGIC
                     LRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRD
                     LAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTT
                     KSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCW
                     HPKAEMRPSFSELVSRISAIFSTFIGEHYVHVNATYVNVKCVAPYPSLLSSEDNADDE
                     VDTRPASFWETS"
     exon            1597..1788
                     /gene="MET"
                     /gene_synonym="AUTS9; c-Met; DA11; DFNB97; HGFR; RCCP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1789..1923
                     /gene="MET"
                     /gene_synonym="AUTS9; c-Met; DA11; DFNB97; HGFR; RCCP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1924..2097
                     /gene="MET"
                     /gene_synonym="AUTS9; c-Met; DA11; DFNB97; HGFR; RCCP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2098..2258
                     /gene="MET"
                     /gene_synonym="AUTS9; c-Met; DA11; DFNB97; HGFR; RCCP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2259..2361
                     /gene="MET"
                     /gene_synonym="AUTS9; c-Met; DA11; DFNB97; HGFR; RCCP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2362..2498
                     /gene="MET"
                     /gene_synonym="AUTS9; c-Met; DA11; DFNB97; HGFR; RCCP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2499..2660
                     /gene="MET"
                     /gene_synonym="AUTS9; c-Met; DA11; DFNB97; HGFR; RCCP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2661..2760
                     /gene="MET"
                     /gene_synonym="AUTS9; c-Met; DA11; DFNB97; HGFR; RCCP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2761..2979
                     /gene="MET"
                     /gene_synonym="AUTS9; c-Met; DA11; DFNB97; HGFR; RCCP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2980..3126
                     /gene="MET"
                     /gene_synonym="AUTS9; c-Met; DA11; DFNB97; HGFR; RCCP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3127..3283
                     /gene="MET"
                     /gene_synonym="AUTS9; c-Met; DA11; DFNB97; HGFR; RCCP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3284..3424
                     /gene="MET"
                     /gene_synonym="AUTS9; c-Met; DA11; DFNB97; HGFR; RCCP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3425..3655
                     /gene="MET"
                     /gene_synonym="AUTS9; c-Met; DA11; DFNB97; HGFR; RCCP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3656..3736
                     /gene="MET"
                     /gene_synonym="AUTS9; c-Met; DA11; DFNB97; HGFR; RCCP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3737..3918
                     /gene="MET"
                     /gene_synonym="AUTS9; c-Met; DA11; DFNB97; HGFR; RCCP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3919..4028
                     /gene="MET"
                     /gene_synonym="AUTS9; c-Met; DA11; DFNB97; HGFR; RCCP2"
                     /inference="alignment:Splign:2.1.0"
     exon            4029..4194
                     /gene="MET"
                     /gene_synonym="AUTS9; c-Met; DA11; DFNB97; HGFR; RCCP2"
                     /inference="alignment:Splign:2.1.0"
     exon            4195..4331
                     /gene="MET"
                     /gene_synonym="AUTS9; c-Met; DA11; DFNB97; HGFR; RCCP2"
                     /inference="alignment:Splign:2.1.0"
     exon            4332..6822
                     /gene="MET"
                     /gene_synonym="AUTS9; c-Met; DA11; DFNB97; HGFR; RCCP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6803..6808
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MET"
                     /gene_synonym="AUTS9; c-Met; DA11; DFNB97; HGFR; RCCP2"
                     /note="hexamer: ATTAAA"
     polyA_site      6822
                     /gene="MET"
                     /gene_synonym="AUTS9; c-Met; DA11; DFNB97; HGFR; RCCP2"
                     /note="major polyA site"
ORIGIN      
        1 agacacgtgc tggggcgggc aggcgagcgc ctcagtctgg tcgcctggcg gtgcctccgg
       61 ccccaacgcg cccgggccgc cgcgggccgc gcgcgccgat gcccggctga gtcactggca
      121 gggcagcgcg cgtgtgggaa ggggcggagg gagtgcggcc ggcgggcggg cggggcgctg
      181 ggctcagccc ggccgcaggt gacccggagg ccctcgccgc ccgcggcgcc ccgagcgctt
      241 tgtgagcaga tgcggagccg agtggagggc gcgagccaga tgcggggcga cagctgactt
      301 gctgagagga ggcggggagg cgcggagcgc gcgtgtggtc cttgcgccgc tgacttctcc
      361 actggttcct gggcaccgaa agataaacct ctcataatga aggcccccgc tgtgcttgca
      421 cctggcatcc tcgtgctcct gtttaccttg gtgcagagga gcaatgggga gtgtaaagag
      481 gcactagcaa agtccgagat gaatgtgaat atgaagtatc agcttcccaa cttcaccgcg
      541 gaaacaccca tccagaatgt cattctacat gagcatcaca ttttccttgg tgccactaac
      601 tacatttatg ttttaaatga ggaagacctt cagaaggttg ctgagtacaa gactgggcct
      661 gtgctggaac acccagattg tttcccatgt caggactgca gcagcaaagc caatttatca
      721 ggaggtgttt ggaaagataa catcaacatg gctctagttg tcgacaccta ctatgatgat
      781 caactcatta gctgtggcag cgtcaacaga gggacctgcc agcgacatgt ctttccccac
      841 aatcatactg ctgacataca gtcggaggtt cactgcatat tctccccaca gatagaagag
      901 cccagccagt gtcctgactg tgtggtgagc gccctgggag ccaaagtcct ttcatctgta
      961 aaggaccggt tcatcaactt ctttgtaggc aataccataa attcttctta tttcccagat
     1021 catccattgc attcgatatc agtgagaagg ctaaaggaaa cgaaagatgg ttttatgttt
     1081 ttgacggacc agtcctacat tgatgtttta cctgagttca gagattctta ccccattaag
     1141 tatgtccatg cctttgaaag caacaatttt atttacttct tgacggtcca aagggaaact
     1201 ctagatgctc agacttttca cacaagaata atcaggttct gttccataaa ctctggattg
     1261 cattcctaca tggaaatgcc tctggagtgt attctcacag aaaagagaaa aaagagatcc
     1321 acaaagaagg aagtgtttaa tatacttcag gctgcgtatg tcagcaagcc tggggcccag
     1381 cttgctagac aaataggagc cagcctgaat gatgacattc ttttcggggt gttcgcacaa
     1441 agcaagccag attctgccga accaatggat cgatctgcca tgtgtgcatt ccctatcaaa
     1501 tatgtcaacg acttcttcaa caagatcgtc aacaaaaaca atgtgagatg tctccagcat
     1561 ttttacggac ccaatcatga gcactgcttt aataggacac ttctgagaaa ttcatcaggc
     1621 tgtgaagcgc gccgtgatga atatcgaaca gagtttacca cagctttgca gcgcgttgac
     1681 ttattcatgg gtcaattcag cgaagtcctc ttaacatcta tatccacctt cattaaagga
     1741 gacctcacca tagctaatct tgggacatca gagggtcgct tcatgcaggt tgtggtttct
     1801 cgatcaggac catcaacccc tcatgtgaat tttctcctgg actcccatcc agtgtctcca
     1861 gaagtgattg tggagcatac attaaaccaa aatggctaca cactggttat cactgggaag
     1921 aagatcacga agatcccatt gaatggcttg ggctgcagac atttccagtc ctgcagtcaa
     1981 tgcctctctg ccccaccctt tgttcagtgt ggctggtgcc acgacaaatg tgtgcgatcg
     2041 gaggaatgcc tgagcgggac atggactcaa cagatctgtc tgcctgcaat ctacaaggtt
     2101 ttcccaaata gtgcacccct tgaaggaggg acaaggctga ccatatgtgg ctgggacttt
     2161 ggatttcgga ggaataataa atttgattta aagaaaacta gagttctcct tggaaatgag
     2221 agctgcacct tgactttaag tgagagcacg atgaatacat tgaaatgcac agttggtcct
     2281 gccatgaata agcatttcaa tatgtccata attatttcaa atggccacgg gacaacacaa
     2341 tacagtacat tctcctatgt ggatcctgta ataacaagta tttcgccgaa atacggtcct
     2401 atggctggtg gcactttact tactttaact ggaaattacc taaacagtgg gaattctaga
     2461 cacatttcaa ttggtggaaa aacatgtact ttaaaaagtg tgtcaaacag tattcttgaa
     2521 tgttataccc cagcccaaac catttcaact gagtttgctg ttaaattgaa aattgactta
     2581 gccaaccgag agacaagcat cttcagttac cgtgaagatc ccattgtcta tgaaattcat
     2641 ccaaccaaat cttttattag tggtgggagc acaataacag gtgttgggaa aaacctgaat
     2701 tcagttagtg tcccgagaat ggtcataaat gtgcatgaag caggaaggaa ctttacagtg
     2761 gcatgtcaac atcgctctaa ttcagagata atctgttgta ccactccttc cctgcaacag
     2821 ctgaatctgc aactccccct gaaaaccaaa gcctttttca tgttagatgg gatcctttcc
     2881 aaatactttg atctcattta tgtacataat cctgtgttta agccttttga aaagccagtg
     2941 atgatctcaa tgggcaatga aaatgtactg gaaattaagg gaaatgatat tgaccctgaa
     3001 gcagttaaag gtgaagtgtt aaaagttgga aataagagct gtgagaatat acacttacat
     3061 tctgaagccg ttttatgcac ggtccccaat gacctgctga aattgaacag cgagctaaat
     3121 atagagtgga agcaagcaat ttcttcaacc gtccttggaa aagtaatagt tcaaccagat
     3181 cagaatttca caggattgat tgctggtgtt gtctcaatat caacagcact gttattacta
     3241 cttgggtttt tcctgtggct gaaaaagaga aagcaaatta aagatctggg cagtgaatta
     3301 gttcgctacg atgcaagagt acacactcct catttggata ggcttgtaag tgcccgaagt
     3361 gtaagcccaa ctacagaaat ggtttcaaat gaatctgtag actaccgagc tacttttcca
     3421 gaagatcagt ttcctaattc atctcagaac ggttcatgcc gacaagtgca gtatcctctg
     3481 acagacatgt cccccatcct aactagtggg gactctgata tatccagtcc attactgcaa
     3541 aatactgtcc acattgacct cagtgctcta aatccagagc tggtccaggc agtgcagcat
     3601 gtagtgattg ggcccagtag cctgattgtg catttcaatg aagtcatagg aagagggcat
     3661 tttggttgtg tatatcatgg gactttgttg gacaatgatg gcaagaaaat tcactgtgct
     3721 gtgaaatcct tgaacagaat cactgacata ggagaagttt cccaatttct gaccgaggga
     3781 atcatcatga aagattttag tcatcccaat gtcctctcgc tcctgggaat ctgcctgcga
     3841 agtgaagggt ctccgctggt ggtcctacca tacatgaaac atggagatct tcgaaatttc
     3901 attcgaaatg agactcataa tccaactgta aaagatctta ttggctttgg tcttcaagta
     3961 gccaaaggca tgaaatatct tgcaagcaaa aagtttgtcc acagagactt ggctgcaaga
     4021 aactgtatgc tggatgaaaa attcacagtc aaggttgctg attttggtct tgccagagac
     4081 atgtatgata aagaatacta tagtgtacac aacaaaacag gtgcaaagct gccagtgaag
     4141 tggatggctt tggaaagtct gcaaactcaa aagtttacca ccaagtcaga tgtgtggtcc
     4201 tttggcgtgc tcctctggga gctgatgaca agaggagccc caccttatcc tgacgtaaac
     4261 acctttgata taactgttta cttgttgcaa gggagaagac tcctacaacc cgaatactgc
     4321 ccagacccct tatatgaagt aatgctaaaa tgctggcacc ctaaagccga aatgcgccca
     4381 tccttttctg aactggtgtc ccggatatca gcgatcttct ctactttcat tggggagcac
     4441 tatgtccatg tgaacgctac ttatgtgaac gtaaaatgtg tcgctccgta tccttctctg
     4501 ttgtcatcag aagataacgc tgatgatgag gtggacacac gaccagcctc cttctgggag
     4561 acatcatagt gctagtacta tgtcaaagca acagtccaca ctttgtccaa tggttttttc
     4621 actgcctgac ctttaaaagg ccatcgatat tctttgctct tgccaaaatt gcactattat
     4681 aggacttgta ttgttattta aattactgga ttctaaggaa tttcttatct gacagagcat
     4741 cagaaccaga ggcttggtcc cacaggccac ggaccaatgg cctgcagccg tgacaacact
     4801 cctgtcatat tggagtccaa aacttgaatt ctgggttgaa ttttttaaaa atcaggtacc
     4861 acttgatttc atatgggaaa ttgaagcagg aaatattgag ggcttcttga tcacagaaaa
     4921 ctcagaagag atagtaatgc tcaggacagg agcggcagcc ccagaacagg ccactcattt
     4981 agaattctag tgtttcaaaa cacttttgtg tgttgtatgg tcaataacat ttttcattac
     5041 tgatggtgtc attcacccat taggtaaaca ttccctttta aatgtttgtt tgttttttga
     5101 gacaggatct cactctgttg ccagggctgt agtgcagtgg tgtgatcata gctcactgca
     5161 acctccacct cccaggctca agcctcccga atagctggga ctacaggcgc acaccaccat
     5221 ccccggctaa tttttgtatt ttttgtagag acggggtttt gccatgttgc caaggctggt
     5281 ttcaaactcc tggactcaag aaatccaccc acctcagcct cccaaagtgc taggattaca
     5341 ggcatgagcc actgcgccca gcccttataa atttttgtat agacattcct ttggttggaa
     5401 gaatatttat aggcaataca gtcaaagttt caaaatagca tcacacaaaa catgtttata
     5461 aatgaacagg atgtaatgta catagatgac attaagaaaa tttgtatgaa ataatttagt
     5521 catcatgaaa tatttagttg tcatataaaa acccactgtt tgagaatgat gctactctga
     5581 tctaatgaat gtgaacatgt agatgttttg tgtgtatttt tttaaatgaa aactcaaaat
     5641 aagacaagta atttgttgat aaatattttt aaagataact cagcatgttt gtaaagcagg
     5701 atacatttta ctaaaaggtt cattggttcc aatcacagct cataggtaga gcaaagaaag
     5761 ggtggatgga ttgaaaagat tagcctctgt ctcggtggca ggttcccacc tcgcaagcaa
     5821 ttggaaacaa aacttttggg gagttttatt ttgcattagg gtgtgtttta tgttaagcaa
     5881 aacatacttt agaaacaaat gaaaaaggca attgaaaatc ccagctattt cacctagatg
     5941 gaatagccac cctgagcaga actttgtgat gcttcattct gtggaatttt gtgcttgcta
     6001 ctgtatagtg catgtggtgt aggttactct aactggtttt gtcgacgtaa acatttaaag
     6061 tgttatattt tttataaaaa tgtttatttt taatgatatg agaaaaattt tgttaggcca
     6121 caaaaacact gcactgtgaa cattttagaa aaggtatgtc agactgggat taatgacagc
     6181 atgattttca atgactgtaa attgcgataa ggaaatgtac tgattgccaa tacaccccac
     6241 cctcattaca tcatcaggac ttgaagccaa gggttaaccc agcaagctac aaagagggtg
     6301 tgtcacactg aaactcaata gttgagtttg gctgttgttg caggaaaatg attataacta
     6361 aaagctctct gatagtgcag agacttacca gaagacacaa ggaattgtac tgaagagcta
     6421 ttacaatcca aatattgccg tttcataaat gtaataagta atactaattc acagagtatt
     6481 gtaaatggtg gatgacaaaa gaaaatctgc tctgtggaaa gaaagaactg tctctaccag
     6541 ggtcaagagc atgaacgcat caatagaaag aactcgggga aacatcccat caacaggact
     6601 acacacttgt atatacattc ttgagaacac tgcaatgtga aaatcacgtt tgctatttat
     6661 aaacttgtcc ttagattaat gtgtctggac agattgtggg agtaagtgat tcttctaaga
     6721 attagatact tgtcactgcc tatacctgca gctgaactga atggtacttc gtatgttaat
     6781 agttgttctg ataaatcatg caattaaagt aaagtgatgc aa
//
