LOCUS       NM_018670               1094 bp    mRNA    linear   PRI 08-APR-2024
DEFINITION  Homo sapiens mesoderm posterior bHLH transcription factor 1
            (MESP1), mRNA.
ACCESSION   NM_018670
VERSION     NM_018670.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1094)
  AUTHORS   Ji,S., Xu,M., Cai,C. and He,X.
  TITLE     MESP1-knockdown inhibits the proliferation and epithelial
            mesenchymal transition of hepatocellular carcinoma and enhances the
            tumor-suppressive effect of 5-fluorouracil
  JOURNAL   Biochem Biophys Res Commun 670, 1-11 (2023)
   PUBMED   37271034
  REMARK    GeneRIF: MESP1-knockdown inhibits the proliferation and epithelial
            mesenchymal transition of hepatocellular carcinoma and enhances the
            tumor-suppressive effect of 5-fluorouracil.
REFERENCE   2  (bases 1 to 1094)
  AUTHORS   Liang,Q., Wang,S., Zhou,X., Li,Y., Xing,S., Sha,Y., Yang,F.,
            Huang,W., Liu,N., Li,Z., Chen,Y., Xu,Y., Zhu,P., Lan,F. and Sun,N.
  TITLE     Essential role of MESP1-RING1A complex in cardiac differentiation
  JOURNAL   Dev Cell 57 (22), 2533-2549 (2022)
   PUBMED   36413948
  REMARK    GeneRIF: Essential role of MESP1-RING1A complex in cardiac
            differentiation.
REFERENCE   3  (bases 1 to 1094)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 1094)
  AUTHORS   Tandon,N., Goller,K., Wang,F., Soibam,B., Gagea,M., Jain,A.K.,
            Schwartz,R.J. and Liu,Y.
  TITLE     Aberrant expression of embryonic mesendoderm factor MESP1 promotes
            tumorigenesis
  JOURNAL   EBioMedicine 50, 55-66 (2019)
   PUBMED   31761621
  REMARK    GeneRIF: we demonstrate that upregulation of MESP1, a key
            tumor-promoting alteration, functions to create tumor dependency on
            an inbuilt lineage-survival process. MESP1, being the nodal point
            of this survival process, sustains the tumor dependency by
            transcriptionally activating key genes involved in tumor cell
            initiation, proliferation and progression including EMT
REFERENCE   5  (bases 1 to 1094)
  AUTHORS   Eskildsen,T.V., Ayoubi,S., Thomassen,M., Burton,M., Mandegar,M.A.,
            Conklin,B.R., Jensen,C.H., Andersen,D.C. and Sheikh,S.P.
  TITLE     MESP1 knock-down in human iPSC attenuates early vascular progenitor
            cell differentiation after completed primitive streak specification
  JOURNAL   Dev Biol 445 (1), 1-7 (2019)
   PUBMED   30389344
  REMARK    GeneRIF: Study demonstrates that while leaving primitive streak
            markers unaffected, MESP1 expression is required for timely
            vascular progenitor specification. Thus, MESP1 expression is
            essential for the molecular features of early CM, EC and VSMC
            lineage specification.
REFERENCE   6  (bases 1 to 1094)
  AUTHORS   Islas,J.F., Liu,Y., Weng,K.C., Robertson,M.J., Zhang,S.,
            Prejusa,A., Harger,J., Tikhomirova,D., Chopra,M., Iyer,D.,
            Mercola,M., Oshima,R.G., Willerson,J.T., Potaman,V.N. and
            Schwartz,R.J.
  TITLE     Transcription factors ETS2 and MESP1 transdifferentiate human
            dermal fibroblasts into cardiac progenitors
  JOURNAL   Proc Natl Acad Sci U S A 109 (32), 13016-13021 (2012)
   PUBMED   22826236
  REMARK    GeneRIF: Transcription factors ETS2 and MESP1 transdifferentiate
            human dermal fibroblasts into cardiac progenitors.
REFERENCE   7  (bases 1 to 1094)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   8  (bases 1 to 1094)
  AUTHORS   David,R., Brenner,C., Stieber,J., Schwarz,F., Brunner,S.,
            Vollmer,M., Mentele,E., Muller-Hocker,J., Kitajima,S., Lickert,H.,
            Rupp,R. and Franz,W.M.
  TITLE     MesP1 drives vertebrate cardiovascular differentiation through
            Dkk-1-mediated blockade of Wnt-signalling
  JOURNAL   Nat Cell Biol 10 (3), 338-345 (2008)
   PUBMED   18297060
  REMARK    GeneRIF: MesP1 drives vertebrate cardiovascular differentiation
            through Dkk-1-mediated blockade of Wnt-signalling
REFERENCE   9  (bases 1 to 1094)
  AUTHORS   Haraguchi,S., Kitajima,S., Takagi,A., Takeda,H., Inoue,T. and
            Saga,Y.
  TITLE     Transcriptional regulation of Mesp1 and Mesp2 genes: differential
            usage of enhancers during development
  JOURNAL   Mech Dev 108 (1-2), 59-69 (2001)
   PUBMED   11578861
REFERENCE   10 (bases 1 to 1094)
  AUTHORS   Saga,Y., Hata,N., Kobayashi,S., Magnuson,T., Seldin,M.F. and
            Taketo,M.M.
  TITLE     MesP1: a novel basic helix-loop-helix protein expressed in the
            nascent mesodermal cells during mouse gastrulation
  JOURNAL   Development 122 (9), 2769-2778 (1996)
   PUBMED   8787751
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC079075.6.
            
            On Apr 29, 2021 this sequence version replaced NM_018670.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC006219.1, AL357534.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2161674 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000300057.5/ ENSP00000300057.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-741               AC079075.6         48977-49717
            742-1094            AC079075.6         49999-50351
FEATURES             Location/Qualifiers
     source          1..1094
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q26.1"
     gene            1..1094
                     /gene="MESP1"
                     /gene_synonym="bHLHc5"
                     /note="mesoderm posterior bHLH transcription factor 1"
                     /db_xref="GeneID:55897"
                     /db_xref="HGNC:HGNC:29658"
                     /db_xref="MIM:608689"
     exon            1..741
                     /gene="MESP1"
                     /gene_synonym="bHLHc5"
                     /inference="alignment:Splign:2.1.0"
     CDS             19..825
                     /gene="MESP1"
                     /gene_synonym="bHLHc5"
                     /note="class C basic helix-loop-helix protein 5; mesoderm
                     posterior 1 homolog; mesoderm posterior basic
                     helix-loop-helix transcription factor 1"
                     /codon_start=1
                     /product="mesoderm posterior protein 1"
                     /protein_id="NP_061140.1"
                     /db_xref="CCDS:CCDS10355.1"
                     /db_xref="GeneID:55897"
                     /db_xref="HGNC:HGNC:29658"
                     /db_xref="MIM:608689"
                     /translation="MAQPLCPPLSESWMLSAAWGPTRRPPPSDKDCGRSLVSSPDSWG
                     STPADSPVASPARPGTLRDPRAPSVGRRGARSSRLGSGQRQSASEREKLRMRTLARAL
                     HELRRFLPPSVAPAGQSLTKIETLRLAIRYIGHLSAVLGLSEESLQRRCRQRGDAGSP
                     RGCPLCPDDCPAQMQTRTQAEGQGQGRGLGLVSAVRAGASWGSPPACPGARAAPEPRD
                     PPALFAEAACPEGQAMEPSPPSPLLPGDVLALLETWMPLSPLEWLPEEPK"
     exon            742..1094
                     /gene="MESP1"
                     /gene_synonym="bHLHc5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1075..1080
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MESP1"
                     /gene_synonym="bHLHc5"
                     /note="hexamer: AATAAA"
     polyA_site      1094
                     /gene="MESP1"
                     /gene_synonym="bHLHc5"
                     /note="major polyA site"
ORIGIN      
        1 agacgcgccg ccgctgccat ggcccagccc ctgtgcccgc cgctctccga gtcctggatg
       61 ctctctgcgg cctggggccc aactcggcgg ccgccgccct ccgacaagga ctgcggccgc
      121 tccctcgtct cgtccccaga ctcatggggc agcaccccag ccgacagccc cgtggcgagc
      181 cccgcgcggc caggcaccct ccgggacccc cgcgccccct ccgtaggtag gcgcggcgcg
      241 cgcagcagcc gcctgggcag cgggcagagg cagagcgcca gtgagcggga gaaactgcgc
      301 atgcgcacgc tggcccgcgc cctgcacgag ctgcgccgct ttctaccgcc gtccgtggcg
      361 cccgcgggcc agagcctgac caagatcgag acgctgcgcc tggctatccg ctatatcggc
      421 cacctgtcgg ccgtgctagg cctcagcgag gagagtctcc agcgccggtg ccggcagcgc
      481 ggtgacgcgg ggtcccctcg gggctgcccg ctgtgccccg acgactgccc cgcgcagatg
      541 cagacacgga cgcaggctga ggggcagggg caggggcgcg ggctgggcct ggtatccgcc
      601 gtccgcgccg gggcgtcctg gggatccccg cctgcctgcc ccggagcccg agctgcaccc
      661 gagccgcgcg acccgcctgc gctgttcgcc gaggcggcgt gccctgaagg gcaggcgatg
      721 gagccaagcc caccgtcccc gctccttccg ggcgacgtgc tggctctgtt ggagacctgg
      781 atgcccctct cgcctctgga gtggctgcct gaggagccca agtgacaagg gacaactgac
      841 gccgtctctg tgagcaccga ggctttttgg cctcagcacc ttcgaagtgg ttccttggca
      901 gactgccttt cctggaagag ggcacgggcg atcccgacgg gggcattcct gcgggtgaga
      961 gccgtcccca ccgcggcggc ccttctcagc ccctccctcc atggagggac ccatagggct
     1021 agacactttg aggcaagcag gaggctctgc ctaatgtgaa tttatttatt tgtgaataaa
     1081 ctgtactggt gtca
//
