LOCUS       NM_006343               3826 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens MER proto-oncogene, tyrosine kinase (MERTK), mRNA.
ACCESSION   NM_006343
VERSION     NM_006343.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3826)
  AUTHORS   Chen,F., Li,Y., Zhao,L., Lin,C., Zhou,Y., Ye,W., Wan,W., Zou,H. and
            Xue,Y.
  TITLE     Anti-inflammatory effects of MerTK by inducing M2 macrophage
            polarization via PI3K/Akt/GSK-3beta pathway in gout
  JOURNAL   Int Immunopharmacol 142 (Pt A), 112942 (2024)
   PUBMED   39217874
  REMARK    GeneRIF: Anti-inflammatory effects of MerTK by inducing M2
            macrophage polarization via PI3K/Akt/GSK-3beta pathway in gout.
REFERENCE   2  (bases 1 to 3826)
  AUTHORS   Iida,M., Crossman,B.E., Kostecki,K.L., Glitchev,C.E., Kranjac,C.A.,
            Crow,M.T., Adams,J.M., Liu,P., Ong,I., Yang,D.T., Kang,I.,
            Salgia,R. and Wheeler,D.L.
  TITLE     MerTK Drives Proliferation and Metastatic Potential in
            Triple-Negative Breast Cancer
  JOURNAL   Int J Mol Sci 25 (10), 5109 (2024)
   PUBMED   38791148
  REMARK    GeneRIF: MerTK Drives Proliferation and Metastatic Potential in
            Triple-Negative Breast Cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3826)
  AUTHORS   Lahey,K.C., Varsanyi,C., Wang,Z., Aquib,A., Gadiyar,V.,
            Rodrigues,A.A., Pulica,R., Desind,S., Davra,V., Calianese,D.C.,
            Liu,D., Cho,J.H., Kotenko,S.V., De Lorenzo,M.S. and Birge,R.B.
  TITLE     Regulation of Mertk Surface Expression via ADAM17 and
            gamma-Secretase Proteolytic Processing
  JOURNAL   Int J Mol Sci 25 (8), 4404 (2024)
   PUBMED   38673989
  REMARK    GeneRIF: Regulation of Mertk Surface Expression via ADAM17 and
            gamma-Secretase Proteolytic Processing.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3826)
  AUTHORS   Purnama,C.A., Meiliana,A., Barliana,M.I., Lestari,K. and Wijaya,A.
  TITLE     The Important Role of Phosphatidylserine, ADAM17, TNF-Alpha, and
            Soluble MER on Efferocytosis Activity in Central Obesity
  JOURNAL   J Obes 2024, 1424404 (2024)
   PUBMED   38550672
  REMARK    GeneRIF: The Important Role of Phosphatidylserine, ADAM17,
            TNF-Alpha, and Soluble MER on Efferocytosis Activity in Central
            Obesity.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3826)
  AUTHORS   Nerviani,A., Boutet,M.A., Ghirardi,G.M., Goldmann,K., Sciacca,E.,
            Rivellese,F., Pontarini,E., Prediletto,E., Abatecola,F.,
            Caliste,M., Pagani,S., Mauro,D., Bellan,M., Cubuk,C., Lau,R.,
            Church,S.E., Hudson,B.M., Humby,F., Bombardieri,M., Lewis,M.J. and
            Pitzalis,C.
  TITLE     Axl and MerTK regulate synovial inflammation and are modulated by
            IL-6 inhibition in rheumatoid arthritis
  JOURNAL   Nat Commun 15 (1), 2398 (2024)
   PUBMED   38493215
  REMARK    GeneRIF: Axl and MerTK regulate synovial inflammation and are
            modulated by IL-6 inhibition in rheumatoid arthritis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3826)
  AUTHORS   Ling,L., Templeton,D. and Kung,H.J.
  TITLE     Identification of the major autophosphorylation sites of Nyk/Mer,
            an NCAM-related receptor tyrosine kinase
  JOURNAL   J Biol Chem 271 (31), 18355-18362 (1996)
   PUBMED   8702477
REFERENCE   7  (bases 1 to 3826)
  AUTHORS   Mark,M.R., Chen,J., Hammonds,R.G., Sadick,M. and Godowsk,P.J.
  TITLE     Characterization of Gas6, a member of the superfamily of G
            domain-containing proteins, as a ligand for Rse and Axl
  JOURNAL   J Biol Chem 271 (16), 9785-9789 (1996)
   PUBMED   8621659
REFERENCE   8  (bases 1 to 3826)
  AUTHORS   Graham,D.K., Dawson,T.L., Mullaney,D.L., Snodgrass,H.R. and
            Earp,H.S.
  TITLE     Cloning and mRNA expression analysis of a novel human
            protooncogene, c-mer
  JOURNAL   Cell Growth Differ 5 (6), 647-657 (1994)
   PUBMED   8086340
  REMARK    Erratum:[Cell Growth Differ 1994 Sep;5(9):1022]
REFERENCE   9  (bases 1 to 3826)
  AUTHORS   Iwase,T., Tanaka,M., Suzuki,M., Naito,Y., Sugimura,H. and Kino,I.
  TITLE     Identification of protein-tyrosine kinase genes preferentially
            expressed in embryo stomach and gastric cancer
  JOURNAL   Biochem Biophys Res Commun 194 (2), 698-705 (1993)
   PUBMED   7688222
REFERENCE   10 (bases 1 to 3826)
  AUTHORS   Fahim,A.T., Daiger,S.P. and Weleber,R.G.
  TITLE     Nonsyndromic Retinitis Pigmentosa Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301590
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC104651.2, BX474860.1,
            U08023.1, CN371299.1, AL705756.1, CA454601.1, CN371300.1,
            AC093675.4, BM719997.1 and AW627665.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_006343.2.
            
            Summary: This gene is a member of the MER/AXL/TYRO3 receptor kinase
            family and encodes a transmembrane protein with two fibronectin
            type-III domains, two Ig-like C2-type (immunoglobulin-like)
            domains, and one tyrosine kinase domain. Mutations in this gene
            have been associated with disruption of the retinal pigment
            epithelium (RPE) phagocytosis pathway and onset of autosomal
            recessive retinitis pigmentosa (RP). [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.32704.1,
                                           SRR1660805.254570.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000295408.9/ ENSP00000295408.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 AC104651.2         16201-16207
            8-41                BX474860.1         2-35
            42-481              U08023.1           50-489
            482-557             CN371299.1         110-185
            558-867             U08023.1           566-875
            868-869             CN371299.1         496-497
            870-948             U08023.1           878-956
            949-950             CN371299.1         577-578
            951-1110            U08023.1           959-1118
            1111-1112           AL705756.1         564-565
            1113-1256           U08023.1           1121-1264
            1257-1258           CA454601.1         640-641
            1259-2011           U08023.1           1267-2019
            2012-2013           CN371300.1         271-272
            2014-2508           U08023.1           2022-2516
            2509-2510           AC093675.4         34928-34929
            2511-2790           U08023.1           2519-2798
            2791-2792           BM719997.1         304-305
            2793-3270           U08023.1           2801-3278
            3271-3633           AW627665.1         7-369               c
            3634-3826           AC093675.4         42009-42201
FEATURES             Location/Qualifiers
     source          1..3826
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q13"
     gene            1..3826
                     /gene="MERTK"
                     /gene_synonym="c-Eyk; c-mer; MER; RP38; Tyro12"
                     /note="MER proto-oncogene, tyrosine kinase"
                     /db_xref="GeneID:10461"
                     /db_xref="HGNC:HGNC:7027"
                     /db_xref="MIM:604705"
     exon            1..190
                     /gene="MERTK"
                     /gene_synonym="c-Eyk; c-mer; MER; RP38; Tyro12"
                     /inference="alignment:Splign:2.1.0"
     CDS             130..3129
                     /gene="MERTK"
                     /gene_synonym="c-Eyk; c-mer; MER; RP38; Tyro12"
                     /EC_number="2.7.10.1"
                     /note="STK kinase; tyrosine-protein kinase Mer; c-mer
                     proto-oncogene tyrosine kinase; MER receptor tyrosine
                     kinase; proto-oncogene c-Mer; receptor tyrosine kinase
                     MerTK"
                     /codon_start=1
                     /product="tyrosine-protein kinase Mer precursor"
                     /protein_id="NP_006334.2"
                     /db_xref="CCDS:CCDS2094.1"
                     /db_xref="GeneID:10461"
                     /db_xref="HGNC:HGNC:7027"
                     /db_xref="MIM:604705"
                     /translation="MGPAPLPLLLGLFLPALWRRAITEAREEAKPYPLFPGPFPGSLQ
                     TDHTPLLSLPHASGYQPALMFSPTQPGRPHTGNVAIPQVTSVESKPLPPLAFKHTVGH
                     IILSEHKGVKFNCSISVPNIYQDTTISWWKDGKELLGAHHAITQFYPDDEVTAIIASF
                     SITSVQRSDNGSYICKMKINNEEIVSDPIYIEVQGLPHFTKQPESMNVTRNTAFNLTC
                     QAVGPPEPVNIFWVQNSSRVNEQPEKSPSVLTVPGLTEMAVFSCEAHNDKGLTVSKGV
                     QINIKAIPSPPTEVSIRNSTAHSILISWVPGFDGYSPFRNCSIQVKEADPLSNGSVMI
                     FNTSALPHLYQIKQLQALANYSIGVSCMNEIGWSAVSPWILASTTEGAPSVAPLNVTV
                     FLNESSDNVDIRWMKPPTKQQDGELVGYRISHVWQSAGISKELLEEVGQNGSRARISV
                     QVHNATCTVRIAAVTRGGVGPFSDPVKIFIPAHGWVDYAPSSTPAPGNADPVLIIFGC
                     FCGFILIGLILYISLAIRKRVQETKFGNAFTEEDSELVVNYIAKKSFCRRAIELTLHS
                     LGVSEELQNKLEDVVIDRNLLILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLD
                     NSSQREIEEFLSEAACMKDFSHPNVIRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTY
                     LLYSRLETGPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVA
                     DFGLSKKIYSGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGM
                     TPYPGVQNHEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEK
                     LLESLPDVRNQADVIYVNTQLLESSEGLAQGSTLAPLDLNIDPDSIIASCTPRAAISV
                     VTAEVHDSKPHEGRYILNGGSEEWEDLTSAPSAAVTAEKNSVLPGERLVRNGVSWSHS
                     SMLPLGSSLPDELLFADDSSEGSEVLM"
     exon            191..611
                     /gene="MERTK"
                     /gene_synonym="c-Eyk; c-mer; MER; RP38; Tyro12"
                     /inference="alignment:Splign:2.1.0"
     exon            612..712
                     /gene="MERTK"
                     /gene_synonym="c-Eyk; c-mer; MER; RP38; Tyro12"
                     /inference="alignment:Splign:2.1.0"
     exon            713..886
                     /gene="MERTK"
                     /gene_synonym="c-Eyk; c-mer; MER; RP38; Tyro12"
                     /inference="alignment:Splign:2.1.0"
     exon            887..973
                     /gene="MERTK"
                     /gene_synonym="c-Eyk; c-mer; MER; RP38; Tyro12"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1089
                     /gene="MERTK"
                     /gene_synonym="c-Eyk; c-mer; MER; RP38; Tyro12"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1273
                     /gene="MERTK"
                     /gene_synonym="c-Eyk; c-mer; MER; RP38; Tyro12"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..1425
                     /gene="MERTK"
                     /gene_synonym="c-Eyk; c-mer; MER; RP38; Tyro12"
                     /inference="alignment:Splign:2.1.0"
     exon            1426..1579
                     /gene="MERTK"
                     /gene_synonym="c-Eyk; c-mer; MER; RP38; Tyro12"
                     /inference="alignment:Splign:2.1.0"
     exon            1580..1733
                     /gene="MERTK"
                     /gene_synonym="c-Eyk; c-mer; MER; RP38; Tyro12"
                     /inference="alignment:Splign:2.1.0"
     exon            1734..1819
                     /gene="MERTK"
                     /gene_synonym="c-Eyk; c-mer; MER; RP38; Tyro12"
                     /inference="alignment:Splign:2.1.0"
     exon            1820..1915
                     /gene="MERTK"
                     /gene_synonym="c-Eyk; c-mer; MER; RP38; Tyro12"
                     /inference="alignment:Splign:2.1.0"
     exon            1916..1996
                     /gene="MERTK"
                     /gene_synonym="c-Eyk; c-mer; MER; RP38; Tyro12"
                     /inference="alignment:Splign:2.1.0"
     exon            1997..2089
                     /gene="MERTK"
                     /gene_synonym="c-Eyk; c-mer; MER; RP38; Tyro12"
                     /inference="alignment:Splign:2.1.0"
     exon            2090..2208
                     /gene="MERTK"
                     /gene_synonym="c-Eyk; c-mer; MER; RP38; Tyro12"
                     /inference="alignment:Splign:2.1.0"
     exon            2209..2318
                     /gene="MERTK"
                     /gene_synonym="c-Eyk; c-mer; MER; RP38; Tyro12"
                     /inference="alignment:Splign:2.1.0"
     exon            2319..2478
                     /gene="MERTK"
                     /gene_synonym="c-Eyk; c-mer; MER; RP38; Tyro12"
                     /inference="alignment:Splign:2.1.0"
     exon            2479..2615
                     /gene="MERTK"
                     /gene_synonym="c-Eyk; c-mer; MER; RP38; Tyro12"
                     /inference="alignment:Splign:2.1.0"
     exon            2616..3826
                     /gene="MERTK"
                     /gene_synonym="c-Eyk; c-mer; MER; RP38; Tyro12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3613..3618
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MERTK"
                     /gene_synonym="c-Eyk; c-mer; MER; RP38; Tyro12"
                     /note="hexamer: AATAAA"
     polyA_site      3632
                     /gene="MERTK"
                     /gene_synonym="c-Eyk; c-mer; MER; RP38; Tyro12"
                     /note="major polyA site"
     regulatory      3800..3805
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MERTK"
                     /gene_synonym="c-Eyk; c-mer; MER; RP38; Tyro12"
                     /note="hexamer: AATAAA"
     polyA_site      3826
                     /gene="MERTK"
                     /gene_synonym="c-Eyk; c-mer; MER; RP38; Tyro12"
ORIGIN      
        1 actcggcact cactgcccgg gccgcccgga cagggagctt cgctggcgcg cttggccggc
       61 gacaggacag gttcgggacg tccatctgtc catccgtccg gagagaaatt acagatccgc
      121 agccccggga tggggccggc cccgctgccg ctgctgctgg gcctcttcct ccccgcgctc
      181 tggcgtagag ctatcactga ggcaagggaa gaagccaagc cttacccgct attcccggga
      241 ccttttccag ggagcctgca aactgaccac acaccgctgt tatcccttcc tcacgccagt
      301 gggtaccagc ctgccttgat gttttcacca acccagcctg gaagaccaca tacaggaaac
      361 gtagccattc cccaggtgac ctctgtcgaa tcaaagcccc taccgcctct tgccttcaaa
      421 cacacagttg gacacataat actttctgaa cataaaggtg tcaaatttaa ttgctcaatc
      481 agtgtaccta atatatacca ggacaccaca atttcttggt ggaaagatgg gaaggaattg
      541 cttggggcac atcatgcaat tacacagttt tatccagatg atgaagttac agcaataatc
      601 gcttccttca gcataaccag tgtgcagcgt tcagacaatg ggtcgtatat ctgtaagatg
      661 aaaataaaca atgaagagat cgtgtctgat cccatctaca tcgaagtaca aggacttcct
      721 cactttacta agcagcctga gagcatgaat gtcaccagaa acacagcctt caacctcacc
      781 tgtcaggctg tgggcccgcc tgagcccgtc aacattttct gggttcaaaa cagtagccgt
      841 gttaacgaac agcctgaaaa atccccctcc gtgctaactg ttccaggcct gacggagatg
      901 gcggtcttca gttgtgaggc ccacaatgac aaagggctga ccgtgtccaa gggagtgcag
      961 atcaacatca aagcaattcc ctccccacca actgaagtca gcatccgtaa cagcactgca
     1021 cacagcattc tgatctcctg ggttcctggt tttgatggat actccccgtt caggaattgc
     1081 agcattcagg tcaaggaagc tgatccgctg agtaatggct cagtcatgat ttttaacacc
     1141 tctgccttac cacatctgta ccaaatcaag cagctgcaag ccctggctaa ttacagcatt
     1201 ggtgtttcct gcatgaatga aataggctgg tctgcagtga gcccttggat tctagccagc
     1261 acgactgaag gagccccatc agtagcacct ttaaatgtca ctgtgtttct gaatgaatct
     1321 agtgataatg tggacatcag atggatgaag cctccgacta agcagcagga tggagaactg
     1381 gtgggctacc ggatatccca cgtgtggcag agtgcaggga tttccaaaga gctcttggag
     1441 gaagttggcc agaatggcag ccgagctcgg atctctgttc aagtccacaa tgctacgtgc
     1501 acagtgagga ttgcagccgt caccagaggg ggagttgggc ccttcagtga tccagtgaaa
     1561 atatttatcc ctgcacacgg ttgggtagat tatgccccct cttcaactcc ggcgcctggc
     1621 aacgcagatc ctgtgctcat catctttggc tgcttttgtg gatttatttt gattgggttg
     1681 attttataca tctccttggc catcagaaaa agagtccagg agacaaagtt tgggaatgca
     1741 ttcacagagg aggattctga attagtggtg aattatatag caaagaaatc cttctgtcgg
     1801 cgagccattg aacttacctt acatagcttg ggagtcagtg aggaactaca aaataaacta
     1861 gaagatgttg tgattgacag gaatcttcta attcttggaa aaattctggg tgaaggagag
     1921 tttgggtctg taatggaagg aaatcttaag caggaagatg ggacctctct gaaagtggca
     1981 gtgaagacca tgaagttgga caactcttca cagcgggaga tcgaggagtt tctcagtgag
     2041 gcagcgtgca tgaaagactt cagccaccca aatgtcattc gacttctagg tgtgtgtata
     2101 gaaatgagct ctcaaggcat cccaaagccc atggtaattt tacccttcat gaaatacggg
     2161 gacctgcata cttacttact ttattcccga ttggagacag gaccaaagca tattcctctg
     2221 cagacactat tgaagttcat ggtggatatt gccctgggaa tggagtatct gagcaacagg
     2281 aattttcttc atcgagattt agctgctcga aactgcatgt tgcgagatga catgactgtc
     2341 tgtgttgcgg acttcggcct ctctaagaag atttacagtg gcgattatta ccgccaaggc
     2401 cgcattgcta agatgcctgt taaatggatc gccatagaaa gtcttgcaga ccgagtctac
     2461 acaagtaaaa gtgatgtgtg ggcatttggc gtgaccatgt gggaaatagc tacgcgggga
     2521 atgactccct atcctggggt ccagaaccat gagatgtatg actatcttct ccatggccac
     2581 aggttgaagc agcccgaaga ctgcctggat gaactgtatg aaataatgta ctcttgctgg
     2641 agaaccgatc ccttagaccg ccccaccttt tcagtattga ggctgcagct agaaaaactc
     2701 ttagaaagtt tgcctgacgt tcggaaccaa gcagacgtta tttacgtcaa tacacagttg
     2761 ctggagagct ctgagggcct ggcccagggc tccacccttg ctccactgga cttgaacatc
     2821 gaccctgact ctataattgc ctcctgcact ccccgcgctg ccatcagtgt ggtcacagca
     2881 gaagttcatg acagcaaacc tcatgaagga cggtacatcc tgaatggggg cagtgaggaa
     2941 tgggaagatc tgacttctgc cccctctgct gcagtcacag ctgaaaagaa cagtgtttta
     3001 ccgggggaga gacttgttag gaatggggtc tcctggtccc attcgagcat gctgcccttg
     3061 ggaagctcat tgcccgatga acttttgttt gctgacgact cctcagaagg ctcagaagtc
     3121 ctgatgtgag gagaggtgcg gggagacatt ccaaaaatca agccaattct tctgctgtag
     3181 gagaatccaa ttgtacctga tgtttttggt atttgtcttc cttaccaagt gaactccatg
     3241 gccccaaagc accagatgaa tgttgttaag taagctgtca ttaaaaatac ataatatata
     3301 tttatttaaa gagaaaaaat atgtgtatat catggaaaaa gacaaggata ttttaataaa
     3361 acattactta tttcatttca cttatcttgc atatcttaaa attaagcttc agctgctcct
     3421 tgatattaac atttgtacag agttgaagtt gttttttcaa gttcttttct ttttcatgac
     3481 tattaaatgt aaaaatattt gtaaaatgaa atgccatatt tgacttggct tctggtcttg
     3541 atgtatttga taagaatgat tcattcaatg tttaaagttg tataactgat taattttctg
     3601 atatggcttc ctaataaaat atgaataagg aaggatatgt tgaacttact tgagacttga
     3661 aagacagtgg tcggcagcgg ccttgtggcc tttgcaaagg aattccctta atgcctggtc
     3721 cttggggcaa ttgctctgac cattcttggc attgctttat agagatatgg aaaaaccaca
     3781 ccagggtctg tagataagga ataaagaata ttgaaggatt gaaaaa
//
