LOCUS       NM_019606               2822 bp    mRNA    linear   PRI 19-AUG-2024
DEFINITION  Homo sapiens methylphosphate capping enzyme (MEPCE), transcript
            variant 1, mRNA.
ACCESSION   NM_019606
VERSION     NM_019606.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2822)
  AUTHORS   Kao,T.L., Huang,Y.C., Chen,Y.H., Baumann,P. and Tseng,C.K.
  TITLE     LARP3, LARP7, and MePCE are involved in the early stage of human
            telomerase RNA biogenesis
  JOURNAL   Nat Commun 15 (1), 5955 (2024)
   PUBMED   39009594
  REMARK    GeneRIF: LARP3, LARP7, and MePCE are involved in the early stage of
            human telomerase RNA biogenesis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2822)
  AUTHORS   Patel,P.S., Algouneh,A., Krishnan,R., Reynolds,J.J., Nixon,K.C.J.,
            Hao,J., Lee,J., Feng,Y., Fozil,C., Stanic,M., Yerlici,T., Su,P.,
            Soares,F., Liedtke,E., Prive,G., Baider,G.D., Pujana,M.A.,
            Mekhail,K., He,H.H., Hakem,A., Stewart,G.S. and Hakem,R.
  TITLE     Excessive transcription-replication conflicts are a vulnerability
            of BRCA1-mutant cancers
  JOURNAL   Nucleic Acids Res 51 (9), 4341-4362 (2023)
   PUBMED   36928661
  REMARK    GeneRIF: Excessive transcription-replication conflicts are a
            vulnerability of BRCA1-mutant cancers.
REFERENCE   3  (bases 1 to 2822)
  AUTHORS   Zhang,B., Liu,Z., Liu,J., Cao,K., Shan,W., Wen,Q. and Wang,R.
  TITLE     Long non-coding RNA ST8SIA6-AS1 promotes the migration and invasion
            of hypoxia-treated hepatocellular carcinoma cells through the
            miR-338/MEPCE axis
  JOURNAL   Oncol Rep 45 (1), 73-82 (2021)
   PUBMED   33416148
  REMARK    GeneRIF: Long noncoding RNA ST8SIA6AS1 promotes the migration and
            invasion of hypoxiatreated hepatocellular carcinoma cells through
            the miR338/MEPCE axis.
REFERENCE   4  (bases 1 to 2822)
  AUTHORS   Furlan,A., Gonzalez-Pisfil,M., Leray,A., Champelovier,D., Henry,M.,
            Le Nezet,C., Bensaude,O., Lefranc,M., Wohland,T., Vandenbunder,B.,
            Bidaux,G. and Heliot,L.
  TITLE     HEXIM1 Diffusion in the Nucleus Is Regulated by Its Interactions
            with Both 7SK and P-TEFb
  JOURNAL   Biophys J 117 (9), 1615-1625 (2019)
   PUBMED   31590891
  REMARK    GeneRIF: HEXIM1 Diffusion in the Nucleus Is Regulated by Its
            Interactions with Both 7SK and P-TEFb.
REFERENCE   5  (bases 1 to 2822)
  AUTHORS   Bugai,A., Quaresma,A.J.C., Friedel,C.C., Lenasi,T., Duster,R.,
            Sibley,C.R., Fujinaga,K., Kukanja,P., Hennig,T., Blasius,M.,
            Geyer,M., Ule,J., Dolken,L. and Barboric,M.
  TITLE     P-TEFb Activation by RBM7 Shapes a Pro-survival Transcriptional
            Response to Genotoxic Stress
  JOURNAL   Mol Cell 74 (2), 254-267 (2019)
   PUBMED   30824372
REFERENCE   6  (bases 1 to 2822)
  AUTHORS   Kaneko,S., Chu,C., Shatkin,A.J. and Manley,J.L.
  TITLE     Human capping enzyme promotes formation of transcriptional R loops
            in vitro
  JOURNAL   Proc Natl Acad Sci U S A 104 (45), 17620-17625 (2007)
   PUBMED   17978174
  REMARK    GeneRIF: Capping enzyme can play a direct role in transcription by
            modulating displacement of nascent RNA during transcription.
REFERENCE   7  (bases 1 to 2822)
  AUTHORS   Jeronimo,C., Forget,D., Bouchard,A., Li,Q., Chua,G., Poitras,C.,
            Therien,C., Bergeron,D., Bourassa,S., Greenblatt,J., Chabot,B.,
            Poirier,G.G., Hughes,T.R., Blanchette,M., Price,D.H. and
            Coulombe,B.
  TITLE     Systematic analysis of the protein interaction network for the
            human transcription machinery reveals the identity of the 7SK
            capping enzyme
  JOURNAL   Mol Cell 27 (2), 262-274 (2007)
   PUBMED   17643375
REFERENCE   8  (bases 1 to 2822)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   9  (bases 1 to 2822)
  AUTHORS   Rogers,S.A., Bowen,D.J., Ling,M., Thomson,P., Wang,Z. and Lim,S.H.
  TITLE     Identification and characterization of a novel gene encoding a
            SEREX antigen in chronic myeloid leukaemia
  JOURNAL   Br J Haematol 119 (1), 112-114 (2002)
   PUBMED   12358911
REFERENCE   10 (bases 1 to 2822)
  AUTHORS   Wistow,G., Bernstein,S.L., Ray,S., Wyatt,M.K., Behal,A.,
            Touchman,J.W., Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of adult human iris for the NEIBank
            Project: steroid-response factors and similarities with retinal
            pigment epithelium
  JOURNAL   Mol Vis 8, 185-195 (2002)
   PUBMED   12107412
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC016396.1 and BC018935.2.
            
            On Nov 23, 2018 this sequence version replaced NM_019606.5.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (A).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC016396.1, SRR3476690.457117.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000310512.4/ ENSP00000308546.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-75                BC016396.1         201-275
            76-2822             BC018935.2         1-2747
FEATURES             Location/Qualifiers
     source          1..2822
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.1"
     gene            1..2822
                     /gene="MEPCE"
                     /gene_synonym="BCDIN3"
                     /note="methylphosphate capping enzyme"
                     /db_xref="GeneID:56257"
                     /db_xref="HGNC:HGNC:20247"
                     /db_xref="MIM:611478"
     exon            1..1859
                     /gene="MEPCE"
                     /gene_synonym="BCDIN3"
                     /inference="alignment:Splign:2.1.0"
     CDS             189..2258
                     /gene="MEPCE"
                     /gene_synonym="BCDIN3"
                     /note="isoform A is encoded by transcript variant 1; 7SK
                     snRNA methylphosphate capping enzyme; bin3 homolog;
                     bicoid-interacting protein 3 homolog; bin3,
                     bicoid-interacting 3, homolog"
                     /codon_start=1
                     /product="7SK snRNA methylphosphate capping enzyme isoform
                     A"
                     /protein_id="NP_062552.2"
                     /db_xref="CCDS:CCDS5693.1"
                     /db_xref="GeneID:56257"
                     /db_xref="HGNC:HGNC:20247"
                     /db_xref="MIM:611478"
                     /translation="MIEMAAEKEPFLVPAPPPPLKDESGGGGGPTVPPHQEAASGELR
                     GGTERGPGRCAPSAGSPAAAVGRESPGAAATSSSGPQAQQHRGGGPQAQSHGEARLSD
                     PPGRAAPPDVGEERRGGGGTELGPPAPPRPRNGYQPHRPPGGGGGKRRNSCNVGGGGG
                     GFKHPAFKRRRRVNSDCDSVLPSNFLLGGNIFDPLNLNSLLDEEVSRTLNAETPKSSP
                     LPAKGRDPVEILIPKDITDPLSLNTCTDEGHVVLASPLKTGRKRHRHRGQHHQQQQAA
                     GGSESHPVPPTAPLTPLLHGEGASQQPRHRGQNRDAPQPYELNTAINCRDEVVSPLPS
                     ALQGPSGSLSAPPAASVISAPPSSSSRHRKRRRTSSKSEAGARGGGQGSKEKGRGSWG
                     GRHHHHHPLPAAGFKKQQRKFQYGNYCKYYGYRNPSCEDGRLRVLKPEWFRGRDVLDL
                     GCNVGHLTLSIACKWGPSRMVGLDIDSRLIHSARQNIRHYLSEELRLPPQTLEGDPGA
                     EGEEGTTTVRKRSCFPASLTASRGPIAAPQVPLDGADTSVFPNNVVFVTGNYVLDRDD
                     LVEAQTPEYDVVLCLSLTKWVHLNWGDEGLKRMFRRIYRHLRPGGILVLEPQPWSSYG
                     KRKTLTETIYKNYYRIQLKPEQFSSYLTSPDVGFSSYELVATPHNTSKGFQRPVYLFH
                     KARSPSH"
     exon            1860..2078
                     /gene="MEPCE"
                     /gene_synonym="BCDIN3"
                     /inference="alignment:Splign:2.1.0"
     exon            2079..2205
                     /gene="MEPCE"
                     /gene_synonym="BCDIN3"
                     /inference="alignment:Splign:2.1.0"
     exon            2206..2822
                     /gene="MEPCE"
                     /gene_synonym="BCDIN3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2791..2796
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MEPCE"
                     /gene_synonym="BCDIN3"
                     /note="hexamer: AATAAA"
     polyA_site      2822
                     /gene="MEPCE"
                     /gene_synonym="BCDIN3"
                     /note="major polyA site"
ORIGIN      
        1 ctcttgtttt ggtctcgcgg gctagtaggg cgcacttggc ggggaggcgc ttgggcgcga
       61 gactaggcgt gaagagcaga gctgcgcgcg cactcgggaa aggggggaag ggagcagggt
      121 ccaggcaggg ggggttaggc cccctgatcc ccctcgttac cccgactggc acggaataag
      181 gggaggaaat gatcgagatg gcggcggaga aggagccgtt tctggtgccg gccccgccgc
      241 cgccgctcaa agatgagtcg ggcggagggg gcggccccac ggtgccaccg caccaagagg
      301 ccgcctctgg ggagctccgc ggcgggacgg agcgtggtcc gggtcgttgc gcgccatctg
      361 cggggtcccc agccgctgcg gtcggtcggg aaagccccgg ggccgcggcc acctcctcca
      421 gtggtcccca ggcgcagcag caccgagggg gcggccccca ggcgcagtcg catggggagg
      481 cccgcctgtc ggatcccccg gggcgagccg ctcccccgga cgtgggggag gagcgccggg
      541 gagggggcgg gacagagctg ggtccccctg ctcctcctcg accccgcaat ggctatcagc
      601 cccaccggcc acctgggggg ggcgggggca agaggagaaa tagctgtaat gtagggggag
      661 gcgggggagg cttcaaacat ccggccttca agaggcgcag gcgggtgaat tcggactgtg
      721 actctgtgtt accctccaac ttcctcctgg ggggcaatat ctttgatccc ctgaacctga
      781 atagcctcct ggatgaggaa gtgagccgca ctctcaacgc ggagacccct aagtcatccc
      841 cccttccggc caaagggcga gatccggtgg agatcctcat ccccaaagat attactgacc
      901 cgctcagtct caatacttgc actgatgagg gccatgtagt tcttgcttcg ccactcaaga
      961 ctggtcggaa gcggcataga caccggggac agcaccacca gcagcagcag gcagccggag
     1021 ggagtgagag tcaccccgtg ccgcccacag cccctctcac ccccttactc cacggggagg
     1081 gcgcctcaca gcagccgcgg cacaggggcc agaaccggga tgccccccaa ccctatgaac
     1141 tcaacacagc catcaactgc agggatgaag tggtgtctcc ccttccatct gctctgcagg
     1201 gtccctcagg ctccctatca gcccctccag ctgcctcagt tatctctgca cccccatctt
     1261 cctcctcccg acatcgcaaa cgtcgcagga cttccagcaa gtcggaggca ggggctaggg
     1321 gtggaggcca gggttccaag gaaaagggcc gagggagttg gggaggccgc caccaccacc
     1381 accacccact gcctgcagca ggcttcaaaa agcaacagcg caagttccag tatgggaatt
     1441 attgcaaata ctatgggtac cgcaatcctt cctgtgagga tgggcgcctt cgggtgttga
     1501 agcctgagtg gtttcggggc cgggacgtcc tagatctggg ctgcaatgtg ggccatctga
     1561 ccctgagcat tgcctgcaag tggggcccgt cccgcatggt gggcctggat atcgattccc
     1621 ggctcatcca ttctgcccgc caaaacatcc gacactacct ttccgaggag ctgcgtctcc
     1681 caccccagac tttggaaggg gacccggggg cagagggtga ggaagggacc accaccgttc
     1741 gaaagaggag ctgcttccca gcctcgctga ctgccagccg gggtcccatc gctgcccccc
     1801 aagtgccctt ggatggagcg gacacatcag tcttccccaa caatgttgtc ttcgtcacgg
     1861 gtaattatgt gctggatcga gatgacctgg tggaggccca aacacctgag tatgatgtgg
     1921 tgctctgcct cagcctcacc aagtgggtgc atctgaactg gggagacgag ggcctgaagc
     1981 gcatgtttcg ccggatctac cggcacctac gccctggggg catcctggtc ctagagcccc
     2041 aaccctggtc gtcgtatggc aagagaaaga ctcttacaga aacgatctac aagaactact
     2101 accgaatcca attgaagcca gagcagttca gttcctacct gacatcccca gacgtgggct
     2161 tctccagcta tgagcttgtg gccacacccc acaacacctc taaaggcttc cagcgtcctg
     2221 tgtacctgtt ccacaaggcc cgatccccca gccactaagt ggccccctaa acagaaagtg
     2281 tgaagaggct gccctcgctg ctcataagga cctgggggaa gaggaaagtg tcccaaggtc
     2341 tttcctttct gactccaaaa atagtttcct ttcttggatc tgcaaagaaa gcttttcttc
     2401 cgtcgctgcc tcagcctcct ccctatgcct ctggcacctg cgcagcaagg ctggctgtgc
     2461 tggagtcacc atcatcttcc tctcccccag cctcccaggc tggatggcat ggactgtttg
     2521 ctgacctctg ttctcttagg gcatgggagg tgggaggata tcaaattctc tagccctttc
     2581 ctcctattct cccaaggaga gagattccca tttctcctcg gccattgtac ctagctcttg
     2641 tccctagctg catttcagtg gaccatggat agagggactg agggttagac ggggaagact
     2701 ggcagggagg cacgcaggta ctgtgaaaat ccttcccttt gccctccccc agtgggagag
     2761 ggggttgggt tttcaatgtg agaacagcac aataaacttg atgtctaggg cagtggcccc
     2821 ca
//
