LOCUS       NM_005924               2371 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens mesenchyme homeobox 2 (MEOX2), mRNA.
ACCESSION   NM_005924
VERSION     NM_005924.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2371)
  AUTHORS   Schonrock,A., Heinzelmann,E., Steffl,B., Demirdizen,E.,
            Narayanan,A., Krunic,D., Bahr,M., Park,J.W., Schmidt,C.,
            Ozduman,K., Pamir,M.N., Wick,W., Bestvater,F., Weichenhan,D.,
            Plass,C., Taranda,J., Mall,M. and Turcan,S.
  TITLE     MEOX2 homeobox gene promotes growth of malignant gliomas
  JOURNAL   Neuro Oncol 24 (11), 1911-1924 (2022)
   PUBMED   35468210
  REMARK    GeneRIF: MEOX2 homeobox gene promotes growth of malignant gliomas.
REFERENCE   2  (bases 1 to 2371)
  AUTHORS   Wang,H., Tang,Y., Wang,M., Zhao,J., Ding,C., Yang,X., Han,P. and
            Liu,P.
  TITLE     Low expression of MEOX2 is associated with poor survival in
            patients with breast cancer
  JOURNAL   Biomark Med 16 (16), 1161-1170 (2022)
   PUBMED   36625258
  REMARK    GeneRIF: Low expression of MEOX2 is associated with poor survival
            in patients with breast cancer.
REFERENCE   3  (bases 1 to 2371)
  AUTHORS   Wang,J., Chen,Y., Wang,Q., Xu,H., Wu,C., Jiang,Q., Wu,G., Zhou,H.,
            Xiao,Z., Chen,Y., Zhang,T. and Lan,Q.
  TITLE     MEOX2-mediated regulation of Cathepsin S promotes cell
            proliferation and motility in glioma
  JOURNAL   Cell Death Dis 13 (4), 360 (2022)
   PUBMED   35436995
  REMARK    GeneRIF: MEOX2-mediated regulation of Cathepsin S promotes cell
            proliferation and motility in glioma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2371)
  AUTHORS   Cai,Y., Liu,Y., Sun,Y. and Ren,Y.
  TITLE     Mesenchyme homeobox 2 has a cancer-inhibiting function in breast
            carcinoma via affection of the PI3K/AKT/mTOR and ERK1/2 pathways
  JOURNAL   Biochem Biophys Res Commun 593, 20-27 (2022)
   PUBMED   35051778
  REMARK    GeneRIF: Mesenchyme homeobox 2 has a cancer-inhibiting function in
            breast carcinoma via affection of the PI3K/AKT/mTOR and ERK1/2
            pathways.
REFERENCE   5  (bases 1 to 2371)
  AUTHORS   Yu,R., Zhang,J., Zhuo,Y., Hong,X., Ye,J., Tang,S. and Zhang,Y.
  TITLE     Identification of Diagnostic Signatures and Immune Cell
            Infiltration Characteristics in Rheumatoid Arthritis by Integrating
            Bioinformatic Analysis and Machine-Learning Strategies
  JOURNAL   Front Immunol 12, 724934 (2021)
   PUBMED   34691030
  REMARK    GeneRIF: Identification of Diagnostic Signatures and Immune Cell
            Infiltration Characteristics in Rheumatoid Arthritis by Integrating
            Bioinformatic Analysis and Machine-Learning Strategies.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2371)
  AUTHORS   Quinn,L.M., Latham,S.E. and Kalionis,B.
  TITLE     The homeobox genes MSX2 and MOX2 are candidates for regulating
            epithelial-mesenchymal cell interactions in the human placenta
  JOURNAL   Placenta 21 Suppl A, S50-S54 (2000)
   PUBMED   10831122
REFERENCE   7  (bases 1 to 2371)
  AUTHORS   Quinn,L.M., Johnson,B.V., Nicholl,J., Sutherland,G.R. and
            Kalionis,B.
  TITLE     Isolation and identification of homeobox genes from the human
            placenta including a novel member of the Distal-less family, DLX4
  JOURNAL   Gene 187 (1), 55-61 (1997)
   PUBMED   9073066
REFERENCE   8  (bases 1 to 2371)
  AUTHORS   Grigoriou,M., Kastrinaki,M.C., Modi,W.S., Theodorakis,K.,
            Mankoo,B., Pachnis,V. and Karagogeos,D.
  TITLE     Isolation of the human MOX2 homeobox gene and localization to
            chromosome 7p22.1-p21.3
  JOURNAL   Genomics 26 (3), 550-555 (1995)
   PUBMED   7607679
REFERENCE   9  (bases 1 to 2371)
  AUTHORS   LePage,D.F., Altomare,D.A., Testa,J.R. and Walsh,K.
  TITLE     Molecular cloning and localization of the human GAX gene to 7p21
  JOURNAL   Genomics 24 (3), 535-540 (1994)
   PUBMED   7713505
REFERENCE   10 (bases 1 to 2371)
  AUTHORS   Reardon,W., McManus,S.P., Summers,D. and Winter,R.M.
  TITLE     Cytogenetic evidence that the Saethre-Chotzen gene maps to 7p21.2
  JOURNAL   Am J Med Genet 47 (5), 633-636 (1993)
   PUBMED   8266988
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA586635.1, BC017021.1 and
            BQ025060.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_005924.4.
            
            Summary: This gene encodes a member of a subfamily of
            non-clustered, diverged, antennapedia-like homeobox-containing
            genes. The encoded protein may play a role in the regulation of
            vertebrate limb myogenesis. Mutations in the related mouse protein
            may be associated with craniofacial and/or skeletal abnormalities,
            in addition to neurovascular dysfunction observed in Alzheimer's
            disease. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC017021.1, X82629.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2162568, SAMEA2467143
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262041.6/ ENSP00000262041.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-512               DA586635.1         1-512
            513-2049            BC017021.1         410-1946
            2050-2371           BQ025060.1         13-334              c
FEATURES             Location/Qualifiers
     source          1..2371
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p21.2"
     gene            1..2371
                     /gene="MEOX2"
                     /gene_synonym="GAX; MOX2"
                     /note="mesenchyme homeobox 2"
                     /db_xref="GeneID:4223"
                     /db_xref="HGNC:HGNC:7014"
                     /db_xref="MIM:600535"
     exon            1..798
                     /gene="MEOX2"
                     /gene_synonym="GAX; MOX2"
                     /inference="alignment:Splign:2.1.0"
     CDS             282..1196
                     /gene="MEOX2"
                     /gene_synonym="GAX; MOX2"
                     /note="growth arrest-specific homeobox"
                     /codon_start=1
                     /product="homeobox protein MOX-2"
                     /protein_id="NP_005915.2"
                     /db_xref="CCDS:CCDS34605.1"
                     /db_xref="GeneID:4223"
                     /db_xref="HGNC:HGNC:7014"
                     /db_xref="MIM:600535"
                     /translation="MEHPLFGCLRSPHATAQGLHPFSQSSLALHGRSDHMSYPELSTS
                     SSSCIIAGYPNEEGMFASQHHRGHHHHHHHHHHHHHQQQQHQALQTNWHLPQMSSPPS
                     AARHSLCLQPDSGGPPELGSSPPVLCSNSSSLGSSTPTGAACAPGDYGRQALSPAEAE
                     KRSGGKRKSDSSDSQEGNYKSEVNSKPRKERTAFTKEQIRELEAEFAHHNYLTRLRRY
                     EIAVNLDLTERQVKVWFQNRRMKWKRVKGGQQGAAAREKELVNVKKGTLLPSELSGIG
                     AATLQQTGDSIANEDSHDSDHSSEHAHL"
     exon            799..971
                     /gene="MEOX2"
                     /gene_synonym="GAX; MOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            972..2371
                     /gene="MEOX2"
                     /gene_synonym="GAX; MOX2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2349..2354
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MEOX2"
                     /gene_synonym="GAX; MOX2"
                     /note="hexamer: AATAAA"
     polyA_site      2371
                     /gene="MEOX2"
                     /gene_synonym="GAX; MOX2"
                     /note="major polyA site"
ORIGIN      
        1 gaaagcagtt ctctgggacc accttctttt ggcttcaacc tctcccactc ttgacatctg
       61 agtagctcag ggaagctctt ccaggtccga ctgttcatat gtaaaggaga ctggccgctg
      121 gggctcagga ccgggattat ccgagctctg cagaagtgca ccgctattgc tttgggaggt
      181 taaaaaaaaa atcacacggt ttccagtgaa aaagtgacag agggtggtgg cctttggaac
      241 cgccgtgaag tcttctgcct ggaacccgaa acttgcatgc tatggaacac ccgctctttg
      301 gctgcctgcg cagccctcac gccacggcgc aaggcttgca cccgttctcc caatcctctc
      361 tcgccctcca tggaagatct gaccatatgt cttaccccga gctctctact tcttcctcat
      421 cttgcataat cgcgggatac cccaacgaag agggcatgtt tgccagccag catcacaggg
      481 ggcaccacca ccaccaccac caccaccacc atcaccacca tcagcagcag cagcaccagg
      541 ctctgcaaac caactggcac ctcccgcaga tgtcttcccc accgagtgcg gctcggcaca
      601 gcctctgcct ccagcccgac tctggagggc ccccagagtt ggggagcagc ccgcccgtcc
      661 tgtgctccaa ctcttccagc ttgggctcca gcaccccgac tggggccgcg tgcgcgccgg
      721 gggactacgg ccgccaggca ctgtcacctg cggaggcgga gaagcgaagc ggcggcaaga
      781 ggaaaagcga cagctcagac tcccaggaag gaaattacaa gtcagaagtc aacagcaaac
      841 ccaggaaaga aaggacagca tttaccaaag agcaaatcag agaacttgaa gcagaatttg
      901 cccatcataa ttatctcacc agactgaggc gatacgagat agcagtgaat ctggatctca
      961 ctgaaagaca ggtgaaagtc tggttccaaa acaggcggat gaagtggaag agggtaaagg
     1021 gtggacagca aggagctgcg gctcgggaaa aggaactggt gaatgtgaaa aagggaacac
     1081 ttctcccatc agagctgtcg ggaattggtg cagccaccct ccagcaaaca ggggactcta
     1141 tagcaaatga agacagtcac gacagtgacc acagctcaga gcatgcgcac ttatgatata
     1201 aacagaggac cagctccatt ctcaggaaag aaatgttgtg atggcaagcc ttacccaaat
     1261 atcgtttaca cagagagatg actatggcag tgatgtttaa tattattaaa tccaggcatt
     1321 tcgaatctgt ttttcatgat ttatagaggg tttacacaaa gtgccactta ttaaagagct
     1381 tccacagtga agatggagaa ggtgaacttg ctttgaatat tccagatgtg tttggtcgtg
     1441 cgtatggcag tgagcaggta tgtgtttgct tttgcttgca ctgaaaatta aattgctatc
     1501 aagagcaaac tatgaacggt tttttattca agatgtctcc agagtgaaga tgccgaggat
     1561 gaacttgcat tgaacattcc agatgtgtga gatcatgtgt attacagtgg gcaggtattt
     1621 gcttttgctt gcactgaaaa ttaaattgct atcaagaata aaccatgaaa cattttatcc
     1681 tgaacagcca cagtgcctga attcactcaa gtggataaaa agtgtatttt aactctgtat
     1741 atattaccct taagtcattt tcctgtcttc actaatttag caatgcattc atattagctg
     1801 atgaaaatag gcactcacaa tgacaaccag agccagtttc ttgtcttttt tatacatttt
     1861 gtcatcccag agacaatcag tatgtgctta cctgtgttca agtagagaaa aatacagtag
     1921 agtctgatag gacatattct tgtaccacag acaaaacaaa tcttatgttg catttactat
     1981 caactgctgc taatacgtta ttataaaact tacctagctc ctgaattctt cctatcttat
     2041 agcttaaaac aattaggatc ataggcaaat cagttacctt gcagaaagag ctttgtatga
     2101 cagacattgt cttattttat ttctgtaaaa tattagctgt atgaatatga tttaattaac
     2161 aagaaaacat ttcttcctga ttgacaacag tgttagacaa ggtgcaaagc gaaactggtt
     2221 gctcaagttg atagaaaaca aaattctgaa tatcttcaaa ttaaattcgg taaaaacaca
     2281 ttattttttc atatgtgatg tattcatgca gaacaactat ctttgtattt tgtttttaaa
     2341 atgtgtttaa taaatgatcc tttgtaaata a
//
