LOCUS       NM_004527               2674 bp    mRNA    linear   PRI 23-MAR-2024
DEFINITION  Homo sapiens mesenchyme homeobox 1 (MEOX1), transcript variant 1,
            mRNA.
ACCESSION   NM_004527
VERSION     NM_004527.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2674)
  AUTHORS   Li,J., Sun,Y., Zhi,X., Sun,Y., Abudousalamu,Z., Lin,Q., Li,B.,
            Yao,L. and Chen,M.
  TITLE     Unraveling the molecular mechanisms of lymph node metastasis in
            ovarian cancer: focus on MEOX1
  JOURNAL   J Ovarian Res 17 (1), 61 (2024)
   PUBMED   38486335
  REMARK    GeneRIF: Unraveling the molecular mechanisms of lymph node
            metastasis in ovarian cancer: focus on MEOX1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2674)
  AUTHORS   Bassler,K., Schmidleithner,L., Shakiba,M.H., Elmzzahi,T., Kohne,M.,
            Floess,S., Scholz,R., Ohkura,N., Sadlon,T., Klee,K., Neubauer,A.,
            Sakaguchi,S., Barry,S.C., Huehn,J., Bonaguro,L., Ulas,T. and
            Beyer,M.
  TITLE     Identification of the novel FOXP3-dependent Treg cell transcription
            factor MEOX1 by high-dimensional analysis of human CD4+ T cells
  JOURNAL   Front Immunol 14, 1107397 (2023)
   PUBMED   37559728
  REMARK    GeneRIF: Identification of the novel FOXP3-dependent Treg cell
            transcription factor MEOX1 by high-dimensional analysis of human
            CD4[+] T cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2674)
  AUTHORS   Xiao,X., Rui,B., Rui,H., Ju,M. and Hongtao,L.
  TITLE     MEOX1 suppresses the progression of lung cancer cells by inhibiting
            the cell-cycle checkpoint gene CCNB1
  JOURNAL   Environ Toxicol 37 (3), 504-513 (2022)
   PUBMED   34837450
  REMARK    GeneRIF: MEOX1 suppresses the progression of lung cancer cells by
            inhibiting the cell-cycle checkpoint gene CCNB1.
REFERENCE   4  (bases 1 to 2674)
  AUTHORS   Yatagai,Y., Oshima,H., Sakamoto,T., Shigemasa,R., Kitazawa,H.,
            Hyodo,K., Masuko,H., Iijima,H., Naito,T., Saito,T., Hirota,T.,
            Tamari,M. and Hizawa,N.
  TITLE     Expression quantitative trait loci for ETV4 and MEOX1 are
            associated with adult asthma in Japanese populations
  JOURNAL   Sci Rep 11 (1), 18791 (2021)
   PUBMED   34552174
  REMARK    GeneRIF: Expression quantitative trait loci for ETV4 and MEOX1 are
            associated with adult asthma in Japanese populations.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2674)
  AUTHORS   Danoy,M., Jellali,R., Tauran,Y., Bruce,J., Leduc,M., Gilard,F.,
            Gakiere,B., Scheidecker,B., Kido,T., Miyajima,A., Soncin,F.,
            Sakai,Y. and Leclerc,E.
  TITLE     Characterization of the proteome and metabolome of human liver
            sinusoidal endothelial-like cells derived from induced pluripotent
            stem cells
  JOURNAL   Differentiation 120, 28-35 (2021)
   PUBMED   34229994
  REMARK    GeneRIF: Characterization of the proteome and metabolome of human
            liver sinusoidal endothelial-like cells derived from induced
            pluripotent stem cells.
REFERENCE   6  (bases 1 to 2674)
  AUTHORS   Petropoulos,H., Gianakopoulos,P.J., Ridgeway,A.G. and Skerjanc,I.S.
  TITLE     Disruption of Meox or Gli activity ablates skeletal myogenesis in
            P19 cells
  JOURNAL   J Biol Chem 279 (23), 23874-23881 (2004)
   PUBMED   15039437
REFERENCE   7  (bases 1 to 2674)
  AUTHORS   Stamataki,D., Kastrinaki,M., Mankoo,B.S., Pachnis,V. and
            Karagogeos,D.
  TITLE     Homeodomain proteins Mox1 and Mox2 associate with Pax1 and Pax3
            transcription factors
  JOURNAL   FEBS Lett 499 (3), 274-278 (2001)
   PUBMED   11423130
REFERENCE   8  (bases 1 to 2674)
  AUTHORS   Stelnicki,E.J., Komuves,L.G., Holmes,D., Clavin,W., Harrison,M.R.,
            Adzick,N.S. and Largman,C.
  TITLE     The human homeobox genes MSX-1, MSX-2, and MOX-1 are differentially
            expressed in the dermis and epidermis in fetal and adult skin
  JOURNAL   Differentiation 62 (1), 33-41 (1997)
   PUBMED   9373945
REFERENCE   9  (bases 1 to 2674)
  AUTHORS   Jones,K.A., Black,D.M., Brown,M.A., Griffiths,B.L., Nicolai,H.M.,
            Chambers,J.A., Bonjardim,M., Xu,C.F., Boyd,M., McFarlane,R. et al.
  TITLE     The detailed characterisation of a 400 kb cosmid walk in the BRCA1
            region: identification and localisation of 10 genes including a
            dual-specificity phosphatase
  JOURNAL   Hum Mol Genet 3 (11), 1927-1934 (1994)
   PUBMED   7874108
REFERENCE   10 (bases 1 to 2674)
  AUTHORS   Futreal,P.A., Cochran,C., Rosenthal,J., Miki,Y., Swenson,J.,
            Hobbs,M., Bennett,L.M., Haugen-Strano,A., Marks,J., Barrett,J.C. et
            al.
  TITLE     Isolation of a diverged homeobox gene, MOX1, from the BRCA1 region
            on 17q21 by solution hybrid capture
  JOURNAL   Hum Mol Genet 3 (8), 1359-1364 (1994)
   PUBMED   7987315
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC004149.1, U10492.1,
            BG677020.1 and BQ028272.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_004527.3.
            
            Summary: This gene encodes a member of a subfamily of
            non-clustered, diverged, antennapedia-like homeobox-containing
            genes. The encoded protein may play a role in the molecular
            signaling network regulating somite development. Alternatively
            spliced transcript variants encoding different isoforms have been
            described. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant represents the longest transcript
            and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK291139.1, U10492.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2155751, SAMEA2467150
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000318579.9/ ENSP00000321684.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-359               AC004149.1         51293-51651         c
            360-1809            U10492.1           1-1450
            1810-2289           BG677020.1         262-741
            2290-2674           BQ028272.1         16-400              c
FEATURES             Location/Qualifiers
     source          1..2674
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.31"
     gene            1..2674
                     /gene="MEOX1"
                     /gene_synonym="KFS2; MOX1"
                     /note="mesenchyme homeobox 1"
                     /db_xref="GeneID:4222"
                     /db_xref="HGNC:HGNC:7013"
                     /db_xref="MIM:600147"
     exon            1..857
                     /gene="MEOX1"
                     /gene_synonym="KFS2; MOX1"
                     /inference="alignment:Splign:2.1.0"
     CDS             389..1153
                     /gene="MEOX1"
                     /gene_synonym="KFS2; MOX1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     homeobox protein MOX-1"
                     /codon_start=1
                     /product="homeobox protein MOX-1 isoform 1"
                     /protein_id="NP_004518.1"
                     /db_xref="CCDS:CCDS11466.1"
                     /db_xref="GeneID:4222"
                     /db_xref="HGNC:HGNC:7013"
                     /db_xref="MIM:600147"
                     /translation="MDPAASSCMRSLQPPAPVWGCLRNPHSEGNGASGLPHYPPTPFS
                     FHQKPDFLATATAAYPDFSASCLAATPHSLPQEEHIFTEQHPAFPQSPNWHFPVSDAR
                     RRPNSGPAGGSKEMGTSSLGLVDTTGGPGDDYGVLGSTANETEKKSSRRRKESSDNQE
                     NRGKPEGSSKARKERTAFTKEQLRELEAEFAHHNYLTRLRRYEIAVNLDLSERQVKVW
                     FQNRRMKWKRVKGGQPISPNGQDPEDGDSTASPSSE"
     exon            858..1030
                     /gene="MEOX1"
                     /gene_synonym="KFS2; MOX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..2674
                     /gene="MEOX1"
                     /gene_synonym="KFS2; MOX1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2653..2658
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MEOX1"
                     /gene_synonym="KFS2; MOX1"
                     /note="hexamer: AATAAA"
     polyA_site      2674
                     /gene="MEOX1"
                     /gene_synonym="KFS2; MOX1"
                     /note="major polyA site"
ORIGIN      
        1 agccctctgc aggcatttgc tctgggctcc aggacgaact cctcgtcagc tggtgcgtct
       61 gggttgggac agtgaaaatg tttagtgtca ttggcgacaa atacacatac aggggatccc
      121 agtaggtagg ctggtgcatt ggaggggcag gagcaagccc gacataggtg tgtgcacaca
      181 cataggagta gctggccaca tgtgtgtgta ctttaaggag agactttagt tttgggtttt
      241 tttttttttt tggttcctgg ggtaaatttt ctgttgaaca tttttccctc ctatttagtt
      301 ttttttcttt tgcattttta aaaatttgaa cataaaaagt ataaagaatc aaatctttga
      361 aaggaccgag gcgtgcagcg gacagcagat ggatcccgcg gccagcagct gcatgaggag
      421 cctccagccc ccagcccctg tctggggctg ccttcgaaac ccccactcgg aaggcaatgg
      481 ggcctcaggg ctaccccact acccgcccac cccgttctcc ttccaccaga aaccagactt
      541 cctggcgaca gcgacggcag cgtaccctga cttctcagcc tcctgcctgg cagccacccc
      601 acacagcctg ccccaggagg agcacatctt cactgagcag caccccgctt tcccacagtc
      661 ccccaactgg cacttccctg tctcagacgc ccggcgcagg cccaactcag gcccggcagg
      721 gggttccaag gaaatgggga ccagcagcct gggcctggtg gacaccacag gaggcccagg
      781 cgatgactac ggggtgcttg ggagcactgc caatgagaca gagaagaaat catccaggcg
      841 gagaaaggag agttcagaca accaggagaa cagagggaag ccggagggca gcagcaaagc
      901 ccgcaaggag aggacggcct tcaccaagga gcagctgcga gagctggagg cagagtttgc
      961 ccatcataac tacctgactc ggctccgcag atatgagatt gcggtaaacc tggacctctc
     1021 tgagcgccag gtcaaagtgt ggttccagaa ccgaaggatg aagtggaagc gtgtgaaggg
     1081 aggtcagccc atctccccca atgggcagga ccctgaggat ggggactcca cagcctctcc
     1141 aagttcagag tgagattctg catggaggaa aaatgactaa ggactgagcc ccctacccaa
     1201 ctacccccac cccaatccca ccttcaccct cttccttccc cagccagggc agcctctcca
     1261 catctttccc tgactcttgg atatgaaact gcccagcatt cctgggagtc ttaggatttt
     1321 ctaggaagtt ctgtccagcc tcttagcagc ctcttcccta gggcctttgc tcccacactc
     1381 tcatggaatc agacagagat cctaccgggc cggatgaatc tggaaacagc ttcagagata
     1441 ctgcttctca gcgtctcttg gctgccaccc atgcctcctc ctaccgctgt tctcctaggt
     1501 cagccaggcc tcctcctggt ctggacacca cctggcctgg tgggagagga gctttggaac
     1561 cagctggcga ctcggaaagt aaatgcttca aaaggaagga aatgacagag acacacgccc
     1621 ttgcccacct tcctctgtag gctgcacatc tgaggctttg gggcccctta gttgtcccga
     1681 aaccccaaga aaaatcagaa tgaggagagt caaggacagc aactcagctg ctgcaagcca
     1741 gaaacacatc cctgtctcca aatttgttgg ctaagtggag acacttctga gaactgacta
     1801 gagaagacag aaaaatagcc cgatgtaggt ttcggtgtcc ccatataggc ccgtccacac
     1861 aggcttgact gggtggacaa gaatgaaccc atgacagcac ctgctgcttc aaaatcaaaa
     1921 tcaatttagg gatacagcag gggctgttgg gctgtgctcc agagaaaagg agcagctact
     1981 ccttttaaat ccacgatttc tggattgaaa acctgtccag atgctgagtt gttgggctga
     2041 acaactagga gctgaaaaca acgtagaggc tggaaagtgt cccctgcatt ctggagggga
     2101 ggggagataa taaggagggc tgctgggtga gggcctggag atgtggaacc ctggagtgga
     2161 aggttctcca gtgacagtgt cctgtgactg caaaagggga caagaaaatc cctcttcctc
     2221 catgggatgg atttaagctc ttgctgtgtg ttctacaaat gctgttattg tgggaggaaa
     2281 tgctaggttt ttgtgtgtgg actgcccaga cctcagccag gtcttctgga gatgacattt
     2341 gaggactgat ggccaaagag catgggggac tgaagccctg gctgcctcag cgctctgtct
     2401 cccaacacca gctggtgttg cagagggagg tcaacgtgag tttggatctc ttgtacgcag
     2461 atgtaatcat tcacatgtaa aaataacccc acctccccac cccaaaaagg gcaagagctg
     2521 tggaaaatga ttgccaaatg agatggctgg ttagagcatg attttttcta aagcatactt
     2581 catatatttt cttaagatta catcaagcta attgtgcgag ctcaattcac tttgtaagaa
     2641 aactctcgga gaaataaaat caataaaaag caaa
//
