LOCUS       NM_001407146            2768 bp    mRNA    linear   PRI 14-OCT-2024
DEFINITION  Homo sapiens menin 1 (MEN1), transcript variant 13, mRNA.
ACCESSION   NM_001407146
VERSION     NM_001407146.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2768)
  AUTHORS   Xu,J., Lou,X., Wang,F., Zhang,W., Xu,X., Ye,Z., Zhuo,Q., Wang,Y.,
            Jing,D., Fan,G., Chen,X., Zhang,Y., Zhou,C., Chen,J., Qin,Y., Yu,X.
            and Ji,S.
  TITLE     MEN1 Deficiency-Driven Activation of the beta-Catenin-MGMT Axis
            Promotes Pancreatic Neuroendocrine Tumor Growth and Confers
            Temozolomide Resistance
  JOURNAL   Adv Sci (Weinh) 11 (35), e2308417 (2024)
   PUBMED   39041891
  REMARK    GeneRIF: MEN1 Deficiency-Driven Activation of the beta-Catenin-MGMT
            Axis Promotes Pancreatic Neuroendocrine Tumor Growth and Confers
            Temozolomide Resistance.
REFERENCE   2  (bases 1 to 2768)
  AUTHORS   Liu,P., Shi,C., Qiu,L., Shang,D., Lu,Z., Tu,Z. and Liu,H.
  TITLE     Menin signaling and therapeutic targeting in breast cancer
  JOURNAL   Curr Probl Cancer 51, 101118 (2024)
   PUBMED   38968834
  REMARK    GeneRIF: Menin signaling and therapeutic targeting in breast
            cancer.
            Review article
REFERENCE   3  (bases 1 to 2768)
  AUTHORS   Fuentes,M.E., Lu,X., Flores,N.M., Hausmann,S. and Mazur,P.K.
  TITLE     Combined deletion of MEN1, ATRX and PTEN triggers development of
            high-grade pancreatic neuroendocrine tumors in mice
  JOURNAL   Sci Rep 14 (1), 8510 (2024)
   PUBMED   38609433
  REMARK    GeneRIF: Combined deletion of MEN1, ATRX and PTEN triggers
            development of high-grade pancreatic neuroendocrine tumors in mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2768)
  AUTHORS   Wolffhardt,T.M., Ketzer,F., Telese,S., Wirth,T. and Ushmorov,A.
  TITLE     Dependency of B-Cell Acute Lymphoblastic Leukemia and Multiple
            Myeloma Cell Lines on MEN1 Extends beyond MEN1-KMT2A Interaction
  JOURNAL   Int J Mol Sci 24 (22), 16472 (2023)
   PUBMED   38003662
  REMARK    GeneRIF: Dependency of B-Cell Acute Lymphoblastic Leukemia and
            Multiple Myeloma Cell Lines on MEN1 Extends beyond MEN1-KMT2A
            Interaction.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2768)
  AUTHORS   Kimura,N., Hirata,Y., Iwashiro,N., Kijima,H., Takayasu,S.,
            Yamagata,S., Sakihara,S., Uchino,S. and Ohara,M.
  TITLE     Multiple endocrine neoplasia type 1 with Zollinger-Ellison
            syndrome: clinicopathological analysis of a Japanese family with
            focus on menin immunohistochemistry
  JOURNAL   Front Endocrinol (Lausanne) 14, 1221514 (2023)
   PUBMED   37867522
  REMARK    GeneRIF: Multiple endocrine neoplasia type 1 with Zollinger-Ellison
            syndrome: clinicopathological analysis of a Japanese family with
            focus on menin immunohistochemistry.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2768)
  AUTHORS   Heppner,C., Kester,M.B., Agarwal,S.K., Debelenko,L.V.,
            Emmert-Buck,M.R., Guru,S.C., Manickam,P., Olufemi,S.E.,
            Skarulis,M.C., Doppman,J.L., Alexander,R.H., Kim,Y.S., Saggar,S.K.,
            Lubensky,I.A., Zhuang,Z., Liotta,L.A., Chandrasekharappa,S.C.,
            Collins,F.S., Spiegel,A.M., Burns,A.L. and Marx,S.J.
  TITLE     Somatic mutation of the MEN1 gene in parathyroid tumours
  JOURNAL   Nat Genet 16 (4), 375-378 (1997)
   PUBMED   9241276
REFERENCE   7  (bases 1 to 2768)
  AUTHORS   Agarwal,S.K., Kester,M.B., Debelenko,L.V., Heppner,C.,
            Emmert-Buck,M.R., Skarulis,M.C., Doppman,J.L., Kim,Y.S.,
            Lubensky,I.A., Zhuang,Z., Green,J.S., Guru,S.C., Manickam,P.,
            Olufemi,S.E., Liotta,L.A., Chandrasekharappa,S.C., Collins,F.S.,
            Spiegel,A.M., Burns,A.L. and Marx,S.J.
  TITLE     Germline mutations of the MEN1 gene in familial multiple endocrine
            neoplasia type 1 and related states
  JOURNAL   Hum Mol Genet 6 (7), 1169-1175 (1997)
   PUBMED   9215689
REFERENCE   8  (bases 1 to 2768)
  AUTHORS   Chandrasekharappa,S.C., Guru,S.C., Manickam,P., Olufemi,S.E.,
            Collins,F.S., Emmert-Buck,M.R., Debelenko,L.V., Zhuang,Z.,
            Lubensky,I.A., Liotta,L.A., Crabtree,J.S., Wang,Y., Roe,B.A.,
            Weisemann,J., Boguski,M.S., Agarwal,S.K., Kester,M.B., Kim,Y.S.,
            Heppner,C., Dong,Q., Spiegel,A.M., Burns,A.L. and Marx,S.J.
  TITLE     Positional cloning of the gene for multiple endocrine
            neoplasia-type 1
  JOURNAL   Science 276 (5311), 404-407 (1997)
   PUBMED   9103196
REFERENCE   9  (bases 1 to 2768)
  AUTHORS   Giusti,F., Marini,F. and Brandi,M.L.
  TITLE     Multiple Endocrine Neoplasia Type 1
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301710
REFERENCE   10 (bases 1 to 2768)
  AUTHORS   Bystrom,C., Larsson,C., Blomberg,C., Sandelin,K., Falkmer,U.,
            Skogseid,B., Oberg,K., Werner,S. and Nordenskjold,M.
  TITLE     Localization of the MEN1 gene to a small region within chromosome
            11q13 by deletion mapping in tumors
  JOURNAL   Proc Natl Acad Sci U S A 87 (5), 1968-1972 (1990)
   PUBMED   1968641
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP001462.3.
            
            Summary: This gene encodes menin, a tumor suppressor associated
            with a syndrome known as multiple endocrine neoplasia type 1. Menin
            is a scaffold protein that functions in histone modification and
            epigenetic gene regulation. It is thought to regulate several
            pathways and processes by altering chromatin structure through the
            modification of histones. [provided by RefSeq, May 2019].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038195.33556.1,
                                           SRR14038193.1057712.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-94                AP001462.3         94733-94826         c
            95-562              AP001462.3         93940-94407         c
            563-771             AP001462.3         92166-92374         c
            772-900             AP001462.3         91827-91955         c
            901-941             AP001462.3         91454-91494         c
            942-1029            AP001462.3         91286-91373         c
            1030-1166           AP001462.3         90507-90643         c
            1167-1302           AP001462.3         89910-90045         c
            1303-1467           AP001462.3         89309-89473         c
            1468-2768           AP001462.3         87791-89091         c
FEATURES             Location/Qualifiers
     source          1..2768
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.1"
     gene            1..2768
                     /gene="MEN1"
                     /gene_synonym="MEAI; SCG2"
                     /note="menin 1"
                     /db_xref="GeneID:4221"
                     /db_xref="HGNC:HGNC:7010"
                     /db_xref="MIM:613733"
     exon            1..94
                     /gene="MEN1"
                     /gene_synonym="MEAI; SCG2"
                     /inference="alignment:Splign:2.1.0"
     exon            95..562
                     /gene="MEN1"
                     /gene_synonym="MEAI; SCG2"
                     /inference="alignment:Splign:2.1.0"
     CDS             118..1950
                     /gene="MEN1"
                     /gene_synonym="MEAI; SCG2"
                     /note="isoform 2 is encoded by transcript variant 13"
                     /codon_start=1
                     /product="menin isoform 2"
                     /protein_id="NP_001394075.1"
                     /db_xref="GeneID:4221"
                     /db_xref="HGNC:HGNC:7010"
                     /db_xref="MIM:613733"
                     /translation="MGLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFV
                     EHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVD
                     LSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFA
                     VVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAER
                     SWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERY
                     PMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNV
                     REALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGE
                     QSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQ
                     VRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQ
                     GAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLV
                     ATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL"
     exon            563..771
                     /gene="MEN1"
                     /gene_synonym="MEAI; SCG2"
                     /inference="alignment:Splign:2.1.0"
     exon            772..900
                     /gene="MEN1"
                     /gene_synonym="MEAI; SCG2"
                     /inference="alignment:Splign:2.1.0"
     exon            901..941
                     /gene="MEN1"
                     /gene_synonym="MEAI; SCG2"
                     /inference="alignment:Splign:2.1.0"
     exon            942..1029
                     /gene="MEN1"
                     /gene_synonym="MEAI; SCG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1166
                     /gene="MEN1"
                     /gene_synonym="MEAI; SCG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1302
                     /gene="MEN1"
                     /gene_synonym="MEAI; SCG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1303..1467
                     /gene="MEN1"
                     /gene_synonym="MEAI; SCG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..2768
                     /gene="MEN1"
                     /gene_synonym="MEAI; SCG2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgcgccgcg gtgcctagtg tgggatgtaa gcgcggaggt gggcgagggg gaccgaggcc
       61 aggactctcc ttggggtttg ggggcttgac ctgggccgcc gcccaccgcc cgccgccatg
      121 gggctgaagg ccgcccagaa gacgctgttc ccgctgcgct ccatcgacga cgtggtgcgc
      181 ctgtttgctg ccgagctggg ccgagaggag ccggacctgg tgctcctttc cttggtgctg
      241 ggcttcgtgg agcattttct ggctgtcaac cgcgtcatcc ctaccaacgt tcccgagctc
      301 accttccagc ccagccccgc ccccgacccg cctggcggcc tcacctactt tcccgtggcc
      361 gacctgtcta tcatcgccgc cctctatgcc cgcttcaccg cccagatccg aggcgccgtc
      421 gacctgtccc tctatcctcg agaagggggt gtctccagcc gtgagctggt gaagaaggtc
      481 tccgatgtca tatggaacag cctcagccgc tcctacttca aggatcgggc ccacatccag
      541 tccctcttca gcttcatcac aggcaccaaa ttggacagct ccggtgtggc ctttgctgtg
      601 gttggggcct gccaggccct gggtctccgg gatgtccacc tcgccctgtc tgaggatcat
      661 gcctgggtag tgtttgggcc caatggggag cagacagctg aggtcacctg gcacggcaag
      721 ggcaacgagg accgcagggg ccagacagtc aatgccggtg tggctgagcg gagctggctg
      781 tacctgaaag gatcatacat gcgctgtgac cgcaagatgg aggtggcgtt catggtgtgt
      841 gccatcaacc cttccattga cctgcacacc gactcgctgg agcttctgca gctgcagcag
      901 aagctgctct ggctgctcta tgacctggga catctggaaa ggtaccccat ggccttaggg
      961 aacctggcag atctagagga gctggagccc acccctggcc ggccagaccc actcaccctc
     1021 taccacaagg gcattgcctc agccaagacc tactatcggg atgaacacat ctacccctac
     1081 atgtacctgg ctggctacca ctgtcgcaac cgcaatgtgc gggaagccct gcaggcctgg
     1141 gcggacacgg ccactgtcat ccaggactac aactactgcc gggaagacga ggagatctac
     1201 aaggagttct ttgaagtagc caatgatgtc atccccaacc tgctgaagga ggcagccagc
     1261 ttgctggagg cgggcgagga gcggccgggg gagcaaagcc agggcaccca gagccaaggt
     1321 tccgccctcc aggaccctga gtgcttcgcc cacctgctgc gattctacga cggcatctgc
     1381 aaatgggagg agggcagtcc cacgcctgtg ctgcatgtgg gctgggccac ctttcttgtg
     1441 cagtccctag gccgttttga gggacaggtg cggcagaagg tgcgcatagt gagccgagag
     1501 gccgaggcgg ccgaggccga ggagccgtgg ggcgaggaag cccgggaagg ccggcggcgg
     1561 ggcccacggc gggagtccaa gccagaggag cccccgccgc ccaagaagcc agcactggac
     1621 aagggcctgg gcaccggcca gggtgcagtg tcaggacccc cccggaagcc tcctgggact
     1681 gtcgctggca cagcccgagg ccctgaaggt ggcagcacgg ctcaggtgcc agcacccaca
     1741 gcatcaccac cgccggaggg tccagtgctc actttccaga gtgagaagat gaagggcatg
     1801 aaggagctgc tggtggccac caagatcaac tcgagcgcca tcaagctgca actcacggca
     1861 cagtcgcaag tgcagatgaa gaagcagaaa gtgtccaccc ctagtgacta cactctgtct
     1921 ttcctcaagc ggcagcgcaa aggcctctga actactgggg acttcggacc gcttgtgggg
     1981 acccaggctc cgcccttagt cccccaactc tgagcccatg ttctgccccc agcccaaagg
     2041 ggacaggcct cacctctacc caaaccctag gttcccggtc ccgagtacag tctgtatcaa
     2101 acccacgatt ttctccagct cagaacccag ggctctgccc cagtcgttag aatataggtc
     2161 tcttctccca gaatcccagc cggccaatgg aaacctcacg ctgggtccta attaccagtc
     2221 tttaaaggcc cagcccctag aaacccaagc tcctcctcgg aaccgctcac ctagagccag
     2281 accaacgtta ctcagggctc ctcccagctt gtaggagctg aggtttcacc cttaacccaa
     2341 ggagcacagg tcccacctcc agcccgggag cctaggacca ctcagcccct aggagtatat
     2401 ttccgcactt cagaattcca tatcttgcga atccaagctc cctgccccaa ataacttcag
     2461 tcctgctcca gaatttggaa atcctagttt cctctccttc gtatcccgag tctgggacac
     2521 aaaactccgc ccccagccta tgagcatcct gagccccgcc ctcttcctga cgaaactggc
     2581 cccggatcag agcaggacct cccttccgac cctctgggaa cctcccagag gtccagccca
     2641 tctcggagca tcccggagga aatctgcaga gggttaggag tgggtgacaa gagcctgatc
     2701 tcttcctgtt ttgtacatag atttattttt cagttccaag aaagatgaat acattttgtt
     2761 aaaaaaaa
//
