LOCUS       NM_005929               3964 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens melanotransferrin (MELTF), transcript variant 1, mRNA.
ACCESSION   NM_005929
VERSION     NM_005929.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3964)
  AUTHORS   Shein,M., Hitzenberger,M., Cheng,T.C., Rout,S.R., Leitl,K.D.,
            Sato,Y., Zacharias,M., Sakata,E. and Schutz,A.K.
  TITLE     Characterizing ATP processing by the AAA+ protein p97 at the atomic
            level
  JOURNAL   Nat Chem 16 (3), 363-372 (2024)
   PUBMED   38326645
  REMARK    GeneRIF: Characterizing ATP processing by the AAA+ protein p97 at
            the atomic level.
REFERENCE   2  (bases 1 to 3964)
  AUTHORS   Zhang,L. and Shi,L.
  TITLE     The E2F1/MELTF axis fosters the progression of lung adenocarcinoma
            by regulating the Notch signaling pathway
  JOURNAL   Mutat Res 827, 111837 (2023)
   PUBMED   37820570
  REMARK    GeneRIF: The E2F1/MELTF axis fosters the progression of lung
            adenocarcinoma by regulating the Notch signaling pathway.
REFERENCE   3  (bases 1 to 3964)
  AUTHORS   Mao,Y., Wang,M., Xiong,Y., Wen,X., Zhang,M., Ma,L. and Zhang,Y.
  TITLE     MELTF Might Regulate Ferroptosis, Pyroptosis, and Autophagy in
            Platelet-Rich Plasma-Mediated Endometrial Epithelium Regeneration
  JOURNAL   Reprod Sci 30 (5), 1506-1520 (2023)
   PUBMED   36303086
  REMARK    GeneRIF: MELTF Might Regulate Ferroptosis, Pyroptosis, and
            Autophagy in Platelet-Rich Plasma-Mediated Endometrial Epithelium
            Regeneration.
REFERENCE   4  (bases 1 to 3964)
  AUTHORS   Lim,S.H., Snider,J., Birimberg-Schwartz,L., Ip,W., Serralha,J.C.,
            Botelho,H.M., Lopes-Pacheco,M., Pinto,M.C., Moutaoufik,M.T.,
            Zilocchi,M., Laselva,O., Esmaeili,M., Kotlyar,M., Lyakisheva,A.,
            Tang,P., Lopez Vazquez,L., Akula,I., Aboualizadeh,F., Wong,V.,
            Grozavu,I., Opacak-Bernardi,T., Yao,Z., Mendoza,M., Babu,M.,
            Jurisica,I., Gonska,T., Bear,C.E., Amaral,M.D. and Stagljar,I.
  TITLE     CFTR interactome mapping using the mammalian membrane two-hybrid
            high-throughput screening system
  JOURNAL   Mol Syst Biol 18 (2), e10629 (2022)
   PUBMED   35156780
REFERENCE   5  (bases 1 to 3964)
  AUTHORS   Valsecchi,V., Laudati,G., Cuomo,O., Sirabella,R., Del Prete,A.,
            Annunziato,L. and Pignataro,G.
  TITLE     The hypoxia sensitive metal transcription factor MTF-1 activates
            NCX1 brain promoter and participates in remote postconditioning
            neuroprotection in stroke
  JOURNAL   Cell Death Dis 12 (5), 423 (2021)
   PUBMED   33931586
  REMARK    GeneRIF: The hypoxia sensitive metal transcription factor MTF-1
            activates NCX1 brain promoter and participates in remote
            postconditioning neuroprotection in stroke.
            Erratum:[Cell Death Dis. 2023 Jul 31;14(7):484. doi:
            10.1038/s41419-023-05942-6.. PMID: 37524689]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3964)
  AUTHORS   Garratt,R.C. and Jhoti,H.
  TITLE     A molecular model for the tumour-associated antigen, p97, suggests
            a Zn-binding function
  JOURNAL   FEBS Lett 305 (1), 55-61 (1992)
   PUBMED   1633859
REFERENCE   7  (bases 1 to 3964)
  AUTHORS   Baker,E.N., Baker,H.M., Smith,C.A., Stebbins,M.R., Kahn,M.,
            Hellstrom,K.E. and Hellstrom,I.
  TITLE     Human melanotransferrin (p97) has only one functional iron-binding
            site
  JOURNAL   FEBS Lett 298 (2-3), 215-218 (1992)
   PUBMED   1544447
REFERENCE   8  (bases 1 to 3964)
  AUTHORS   Sciot,R., de Vos,R., van Eyken,P., van der Steen,K., Moerman,P. and
            Desmet,V.J.
  TITLE     In situ localization of melanotransferrin (melanoma-associated
            antigen P97) in human liver. A light- and electronmicroscopic
            immunohistochemical study
  JOURNAL   Liver 9 (2), 110-119 (1989)
   PUBMED   2540389
REFERENCE   9  (bases 1 to 3964)
  AUTHORS   Furukawa,K.S., Furukawa,K., Real,F.X., Old,L.J. and Lloyd,K.O.
  TITLE     A unique antigenic epitope of human melanoma is carried on the
            common melanoma glycoprotein gp95/p97
  JOURNAL   J Exp Med 169 (2), 585-590 (1989)
   PUBMED   2463331
REFERENCE   10 (bases 1 to 3964)
  AUTHORS   Rose,T.M., Plowman,G.D., Teplow,D.B., Dreyer,W.J., Hellstrom,K.E.
            and Brown,J.P.
  TITLE     Primary structure of the human melanoma-associated antigen p97
            (melanotransferrin) deduced from the mRNA sequence
  JOURNAL   Proc Natl Acad Sci U S A 83 (5), 1261-1265 (1986)
   PUBMED   2419904
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC068302.18, AA442552.1,
            AH002920.2 and BQ447289.1.
            
            On Nov 22, 2018 this sequence version replaced NM_005929.5.
            
            Summary: The protein encoded by this gene is a cell-surface
            glycoprotein found on melanoma cells. The protein shares sequence
            similarity and iron-binding properties with members of the
            transferrin superfamily. The importance of the iron binding
            function has not yet been identified. This gene resides in the same
            region of chromosome 3 as members of the transferrin superfamily.
            Alternative splicing results in two transcript variants. [provided
            by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1), as compared to variant 2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9304712.153639.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000296350.10/ ENSP00000296350.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AC068302.18        41225-41225         c
            2-62                AA442552.1         1-61
            63-171              AH002920.2         8-116
            172-172             AC068302.18        39311-39311         c
            173-1284            AH002920.2         118-1229
            1285-1285           AC068302.18        26836-26836         c
            1286-1374           AH002920.2         1231-1319
            1375-1432           AC068302.18        22119-22176         c
            1433-2388           AH002920.2         1378-2333
            2389-3815           AC068302.18        13297-14723         c
            3816-3964           BQ447289.1         14-162              c
FEATURES             Location/Qualifiers
     source          1..3964
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q29"
     gene            1..3964
                     /gene="MELTF"
                     /gene_synonym="CD228; MAP97; MFI2; MTf; MTF1"
                     /note="melanotransferrin"
                     /db_xref="GeneID:4241"
                     /db_xref="HGNC:HGNC:7037"
                     /db_xref="MIM:155750"
     exon            1..164
                     /gene="MELTF"
                     /gene_synonym="CD228; MAP97; MFI2; MTf; MTF1"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..2332
                     /gene="MELTF"
                     /gene_synonym="CD228; MAP97; MFI2; MTf; MTF1"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1; membrane-bound transferrin-like protein;
                     antigen p97 (melanoma associated) identified by monoclonal
                     antibodies 133.2 and 96.5"
                     /codon_start=1
                     /product="melanotransferrin isoform 1 preproprotein"
                     /protein_id="NP_005920.2"
                     /db_xref="CCDS:CCDS3325.1"
                     /db_xref="GeneID:4241"
                     /db_xref="HGNC:HGNC:7037"
                     /db_xref="MIM:155750"
                     /translation="MRGPSGALWLLLALRTVLGGMEVRWCATSDPEQHKCGNMSEAFR
                     EAGIQPSLLCVRGTSADHCVQLIAAQEADAITLDGGAIYEAGKEHGLKPVVGEVYDQE
                     VGTSYYAVAVVRRSSHVTIDTLKGVKSCHTGINRTVGWNVPVGYLVESGRLSVMGCDV
                     LKAVSDYFGGSCVPGAGETSYSESLCRLCRGDSSGEGVCDKSPLERYYDYSGAFRCLA
                     EGAGDVAFVKHSTVLENTDGKTLPSWGQALLSQDFELLCRDGSRADVTEWRQCHLARV
                     PAHAVVVRADTDGGLIFRLLNEGQRLFSHEGSSFQMFSSEAYGQKDLLFKDSTSELVP
                     IATQTYEAWLGHEYLHAMKGLLCDPNRLPPYLRWCVLSTPEIQKCGDMAVAFRRQRLK
                     PEIQCVSAKSPQHCMERIQAEQVDAVTLSGEDIYTAGKTYGLVPAAGEHYAPEDSSNS
                     YYVVAVVRRDSSHAFTLDELRGKRSCHAGFGSPAGWDVPVGALIQRGFIRPKDCDVLT
                     AVSEFFNASCVPVNNPKNYPSSLCALCVGDEQGRNKCVGNSQERYYGYRGAFRCLVEN
                     AGDVAFVRHTTVFDNTNGHNSEPWAAELRSEDYELLCPNGARAEVSQFAACNLAQIPP
                     HAVMVRPDTNIFTVYGLLDKAQDLFGDDHNKNGFKMFDSSNYHGQDLLFKDATVRAVP
                     VGEKTTYRGWLGLDYVAALEGMSSQQCSGAAAPAPGAPLLPLLLPALAARLLPPAL"
     exon            165..319
                     /gene="MELTF"
                     /gene_synonym="CD228; MAP97; MFI2; MTf; MTF1"
                     /inference="alignment:Splign:2.1.0"
     exon            320..419
                     /gene="MELTF"
                     /gene_synonym="CD228; MAP97; MFI2; MTf; MTF1"
                     /inference="alignment:Splign:2.1.0"
     exon            420..602
                     /gene="MELTF"
                     /gene_synonym="CD228; MAP97; MFI2; MTf; MTF1"
                     /inference="alignment:Splign:2.1.0"
     exon            603..759
                     /gene="MELTF"
                     /gene_synonym="CD228; MAP97; MFI2; MTf; MTF1"
                     /inference="alignment:Splign:2.1.0"
     exon            760..827
                     /gene="MELTF"
                     /gene_synonym="CD228; MAP97; MFI2; MTf; MTF1"
                     /inference="alignment:Splign:2.1.0"
     exon            828..1015
                     /gene="MELTF"
                     /gene_synonym="CD228; MAP97; MFI2; MTf; MTF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1196
                     /gene="MELTF"
                     /gene_synonym="CD228; MAP97; MFI2; MTf; MTF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1348
                     /gene="MELTF"
                     /gene_synonym="CD228; MAP97; MFI2; MTf; MTF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1445
                     /gene="MELTF"
                     /gene_synonym="CD228; MAP97; MFI2; MTf; MTF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1446..1640
                     /gene="MELTF"
                     /gene_synonym="CD228; MAP97; MFI2; MTf; MTF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1641..1797
                     /gene="MELTF"
                     /gene_synonym="CD228; MAP97; MFI2; MTf; MTF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1798..1865
                     /gene="MELTF"
                     /gene_synonym="CD228; MAP97; MFI2; MTf; MTF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1866..2053
                     /gene="MELTF"
                     /gene_synonym="CD228; MAP97; MFI2; MTf; MTF1"
                     /inference="alignment:Splign:2.1.0"
     exon            2054..2252
                     /gene="MELTF"
                     /gene_synonym="CD228; MAP97; MFI2; MTf; MTF1"
                     /inference="alignment:Splign:2.1.0"
     exon            2253..3964
                     /gene="MELTF"
                     /gene_synonym="CD228; MAP97; MFI2; MTf; MTF1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3925..3930
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MELTF"
                     /gene_synonym="CD228; MAP97; MFI2; MTf; MTF1"
                     /note="hexamer: AACAAG"
     polyA_site      3964
                     /gene="MELTF"
                     /gene_synonym="CD228; MAP97; MFI2; MTf; MTF1"
                     /note="major polyA site"
ORIGIN      
        1 gcacttaagg agctcgggcc agcgcgaggg ggagcaggga ggaagcccgg ctgctgcgga
       61 cctcctcgga cccggaccca gccccagccc ggccccagcc agccccgacg gcgccatgcg
      121 gggtccgagc ggggctctgt ggctgctcct ggctctgcgc accgtgctcg gtggcatgga
      181 ggtgcggtgg tgcgccacct cggacccaga gcagcacaag tgcggcaaca tgagcgaggc
      241 cttccgggaa gcgggcatcc agccctccct cctctgcgtc cggggcacct ccgccgacca
      301 ctgcgtccag ctcatcgcgg cccaggaggc tgacgccatc actctggatg gaggagccat
      361 ctatgaggcg ggaaaggagc acggcctgaa gccggtggtg ggcgaagtgt acgatcaaga
      421 ggtcggtacc tcctattacg ccgtggctgt ggtcaggagg agctcccatg tgaccattga
      481 caccctgaaa ggcgtgaagt cctgccacac gggcatcaat cgcacagtgg gctggaacgt
      541 gcccgtgggc tacctggtgg agagcggccg cctctcggtg atgggctgcg atgtactcaa
      601 agctgtcagc gactattttg ggggcagctg cgtcccgggg gcaggagaga ccagttactc
      661 tgagtccctc tgtcgcctct gcaggggtga cagctctggg gaaggggtgt gtgacaagag
      721 ccccctggag agatactacg actacagcgg ggccttccgg tgcctggcgg aaggggcagg
      781 ggacgtggct tttgtgaagc acagcacggt actggagaac acggatggga agacgcttcc
      841 ctcctggggc caggccctgc tgtcacagga cttcgagctg ctgtgccggg atggtagccg
      901 ggccgatgtc accgagtgga ggcagtgcca tctggcccgg gtgcctgctc acgccgtggt
      961 ggtccgggcc gacacagatg ggggcctcat cttccggctg ctcaacgaag gccagcgtct
     1021 gttcagccac gagggcagca gcttccagat gttcagctct gaggcctatg gccagaagga
     1081 tctactcttc aaagactcta cctcggagct tgtgcccatc gccacacaga cctatgaggc
     1141 gtggctgggc catgagtacc tgcacgccat gaagggtctg ctctgtgacc ccaaccggct
     1201 gcccccctac ctgcgctggt gtgtgctctc cactcccgag atccagaagt gtggagacat
     1261 ggccgtggcc ttccgccggc agcggctcaa gccagagatc cagtgcgtgt cagccaagtc
     1321 cccccaacac tgcatggagc ggatccaggc tgagcaggtc gacgctgtga ccctgagtgg
     1381 cgaggacatt tacacggcgg ggaagacgta cggcctggtt cccgcagccg gggagcacta
     1441 tgccccggaa gacagcagca actcgtacta cgtggtggcc gtggtgagac gggacagctc
     1501 ccacgccttc accttggatg agcttcgggg caagcgctcc tgccacgccg gtttcggcag
     1561 ccctgcaggc tgggatgtcc ccgtgggtgc ccttattcag agaggcttca tccggcccaa
     1621 ggactgtgac gtcctcacag cagtgagcga gttcttcaat gccagctgcg tgcccgtgaa
     1681 caaccccaag aactacccct cctcgctgtg tgcactgtgc gtgggggacg agcagggccg
     1741 caacaagtgt gtgggcaaca gccaggagcg gtattacggc taccgcggcg ccttcaggtg
     1801 cctggtggag aatgcgggtg acgttgcctt cgtcaggcac acaaccgtct ttgacaacac
     1861 aaacggccac aattccgagc cctgggctgc tgagctcagg tcagaggact atgaactgct
     1921 gtgccccaac ggggcccgag ccgaggtgtc ccagtttgca gcctgcaacc tggcacagat
     1981 accaccccac gccgtgatgg tccggcccga caccaacatc ttcaccgtgt atggactgct
     2041 ggacaaggcc caggacctgt ttggagacga ccacaataag aacgggttca aaatgttcga
     2101 ctcctccaac tatcatggcc aagacctgct tttcaaggat gccaccgtcc gggcggtgcc
     2161 tgtcggagag aaaaccacct accgcggctg gctggggctg gactacgtgg cggcgctgga
     2221 agggatgtcg tctcagcagt gctcgggcgc agcggccccg gcgcccgggg cgcccctgct
     2281 cccgctgctg ctgcccgccc tcgccgcccg cctgctcccg cccgccctct gagcccggcc
     2341 gccccgcccc agagctccga tgcccgcccg gggagtttcc gcggcggctt cgcgctggaa
     2401 tccagaagga agctcgcgaa ggccgggccc ggcgtgggcg ggagcaggcg cctccccggg
     2461 agccccgccg cccacgggcg ccacctggcg ctgctacctg aggcgccgcc cccgggcccg
     2521 cgcggccctt cccgccaacc gccgcctccc gccacctgga gccgcgcggg ccgcgccgga
     2581 ggaggccggt tgcccaggaa accgctgagt ccgggcttcc cgccgcccgc cccgcggtgt
     2641 cgcccgaggg gcccgcccgc ctcctccccg cagccccgcg cccccgtccg cgaggccccc
     2701 tggggacgcg gtggccgccg aggcgcctac acccgcaggc cgcggccagg ccgtcccagg
     2761 aggccccggc gccaacggga cccggcgcgt gggacagcgg cctctgctgg cggcggcggg
     2821 agggaggccg gaccggggcg acggggagaa gccttcgccc gcgggaccgt gtccggggtg
     2881 ggggctccag ttcctccgac cgcccgtgcg ctgggaggga ggccgagccc ggggaacgcc
     2941 gcgtgccctg cctcgtcccc cactgtggcc gcgccagctc catcccgggc cagccgcgtc
     3001 cacgggcccc ctcccgagtc tcctcaggct ctcgcctccc ctacccccgt gggatgccca
     3061 ccgcccgcac ccacgcccga gcctggcggc agcagccgcc ccccgcctga agggagccgg
     3121 aggtgaccca ggccgcgggc tcccgaggcc cctgaagggc tgcgcgtggg gacccgccat
     3181 gcttctgggt tccgaacggg ggtgagctcc gtctcctcac ccggccccgc acccgctggg
     3241 cctggggacc cctcactccc cgtgcccgcc cctccgcgag gcagcagaaa gcgcccggcc
     3301 ggggcctctc tctactccat cttgccacag ttgtctgaga agccagaaaa agtttccaga
     3361 actggcagcc cttaaaaaaa atgaagagga agagaagaaa tgggagcagg cagccctcgt
     3421 cagcagaccg ggagccgcgt gggcgcggag ccatttgcat tccggtctgc gggggctcgg
     3481 ggatgctggt gacaggcccg gttcccggtg gctcgccccc acctgcgggc gtcgggaagg
     3541 atcccttcca tctctcagcc gcagaggagg ccctggcagc gccccggctg tagccatgca
     3601 accccgagga gtcccgggca ccttcacccc accgggaggg gccacaagga cctgggcctc
     3661 ggccaccaag ctttgtcccc tctcgctgtg gggggctagt gattctcctc cgacctgacg
     3721 attgcttggt tttttcaaaa gggagttttg tgcggtgaga agtgtgtttc tgtgtggcta
     3781 actctgggct agcgtgccgt ggccattgaa ggtgtggcct gcgtgggtgc agtgtaagtg
     3841 acgctggatt gtcaggtggc agcaggggac ccctgctgtg tcagtgctaa tgaaacatgt
     3901 tggttggttt ctaaaataaa gccaaacaag ccagcacatg cagaggcttg gaccctgata
     3961 gaaa
//
