LOCUS       XM_047424197            2218 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens maternal embryonic leucine zipper kinase
            (MELK), transcript variant X35, mRNA.
ACCESSION   XM_047424197
VERSION     XM_047424197.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000009.12) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2218
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
     gene            1..2218
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /note="maternal embryonic leucine zipper kinase; Derived
                     by automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 19 ESTs, 790 long SRA reads, 1 Protein, and 93%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 7 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:9833"
                     /db_xref="HGNC:HGNC:16870"
                     /db_xref="MIM:607025"
     CDS             245..1873
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /codon_start=1
                     /product="maternal embryonic leucine zipper kinase isoform
                     X14"
                     /protein_id="XP_047280153.1"
                     /db_xref="GeneID:9833"
                     /db_xref="HGNC:HGNC:16870"
                     /db_xref="MIM:607025"
                     /translation="MMNFSNIMNYMKLLGQSDLPRIKTEIEALKNLRHQHICQLYHVL
                     ETANKIFMVLEENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELIQG
                     KSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLL
                     QQMLQVDPKKRISMKNLLNHPWIMQDYNYPVEWQSKNPWQYDHLTATYLLLLAKKARG
                     KPVRLRLSSFSCGQASATPFTDIKSNNWSLEDVTASDKNYVAGLIDYDWCEDDLSTGA
                     ATPRTSQFTKYWTESNGVESKSLTPALCRTPANKLKNKENVYTPKSAVKNEEYFMFPE
                     PKTPVNKNQHKREILTTPNRYTTPSKARNQCLKETPIKIPVNSTGTDKLMTGVISPER
                     RCRSVELDLNQAHMEETPKRKGAKVFGSLERGLDKVITVLTRSKRKGSARDGPRRLKL
                     HYNVTTTRLVNPDQLLNEIMSILPKKHVDFVQKGYTLKCQTQSDFGKVTMQFELEVCQ
                     LQKPDVVGIRRQRLKGDAWVYKRLVEDILSSCKV"
ORIGIN      
        1 acaacccggc gatcgaaaag attcttagga acgccgtacc agccgcgtct ctcaggacag
       61 caggcccctg tccttctgtc gggcgccgct cagccgtgcc ctccgcccct cagaatctcg
      121 ctccgttgcc caggctggag tgcagtggcg tgatctcggc tcactgcaac ctctgcctcc
      181 tgcctcagcc tcccaagttc tttttctaat tccaaataaa cttgcaagag gactatgaaa
      241 gattatgatg aacttctcaa atattatgaa ttacatgaaa ctattgggac agagtgattt
      301 gccccggatc aaaacggaga ttgaggcctt gaagaacctg agacatcagc atatatgtca
      361 actctaccat gtgctagaga cagccaacaa aatattcatg gttcttgagg aaaatttgct
      421 gtttgatgaa tatcataaat taaagctgat tgactttggt ctctgtgcaa aacccaaggg
      481 taacaaggat taccatctac agacatgctg tgggagtctg gcttatgcag cacctgagtt
      541 aatacaaggc aaatcatatc ttggatcaga ggcagatgtt tggagcatgg gcatactgtt
      601 atatgttctt atgtgtggat ttctaccatt tgatgatgat aatgtaatgg ctttatacaa
      661 gaagattatg agaggaaaat atgatgttcc caagtggctc tctcccagta gcattctgct
      721 tcttcaacaa atgctgcagg tggacccaaa gaaacggatt tctatgaaaa atctattgaa
      781 ccatccctgg atcatgcaag attacaacta tcctgttgag tggcaaagca agaatccttg
      841 gcagtatgat cacctcacgg ctacctatct tctgcttcta gccaagaagg ctcggggaaa
      901 accagttcgt ttaaggcttt cttctttctc ctgtggacaa gccagtgcta ccccattcac
      961 agacatcaag tcaaataatt ggagtctgga agatgtgacc gcaagtgata aaaattatgt
     1021 ggcgggatta atagactatg attggtgtga agatgattta tcaacaggtg ctgctactcc
     1081 ccgaacatca cagtttacca agtactggac agaatcaaat ggggtggaat ctaaatcatt
     1141 aactccagcc ttatgcagaa cacctgcaaa taaattaaag aacaaagaaa atgtatatac
     1201 tcctaagtct gctgtaaaga atgaagagta ctttatgttt cctgagccaa agactccagt
     1261 taataagaac cagcataaga gagaaatact cactacgcca aatcgttaca ctacaccctc
     1321 aaaagctaga aaccagtgcc tgaaagaaac tccaattaaa ataccagtaa attcaacagg
     1381 aacagacaag ttaatgacag gtgtcattag ccctgagagg cggtgccgct cagtggaatt
     1441 ggatctcaac caagcacata tggaggagac tccaaaaaga aagggagcca aagtgtttgg
     1501 gagccttgaa agggggttgg ataaggttat cactgtgctc accaggagca aaaggaaggg
     1561 ttctgccaga gacgggccca gaagactaaa gcttcactat aacgtgacta caactagatt
     1621 agtgaatcca gatcaactgt tgaatgaaat aatgtctatt cttccaaaga agcatgttga
     1681 ctttgtacaa aagggttata cactgaagtg tcaaacacag tcagattttg ggaaagtgac
     1741 aatgcaattt gaattagaag tgtgccagct tcaaaaaccc gatgtggtgg gtatcaggag
     1801 gcagcggctt aagggcgatg cctgggttta caaaagatta gtggaagaca tcctatctag
     1861 ctgcaaggta taattgatgg attcttccat cctgccggat gagtgtgggt gtgatacagc
     1921 ctacataaag actgttatga tcgctttgat tttaaagttc attggaacta ccaacttgtt
     1981 tctaaagagc tatcttaaga ccaatatctc tttgttttta aacaaaagat attattttgt
     2041 gtatgaatct aaatcaagcc catctgtcat tatgttactg tcttttttaa tcatgtggtt
     2101 ttgtatatta ataattgttg actttcttag attcacttcc atatgtgaat gtaagctctt
     2161 aactatgtct ctttgtaatg tgtaatttct ttctgaaata aaaccatttg tgaatata
//
