LOCUS       NM_001301059            2021 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens Meis homeobox 3 (MEIS3), transcript variant 3, mRNA.
ACCESSION   NM_001301059 XM_005259086
VERSION     NM_001301059.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2021)
  AUTHORS   Cai,P., Xie,Y., Dong,M. and Zhu,Q.
  TITLE     Inhibition of MEIS3 Generates Cetuximab Resistance through c-Met
            and Akt
  JOURNAL   Biomed Res Int 2020, 2046248 (2020)
   PUBMED   33376716
  REMARK    GeneRIF: Inhibition of MEIS3 Generates Cetuximab Resistance through
            c-Met and Akt.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2021)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2021)
  AUTHORS   Yin,Y., Morgunova,E., Jolma,A., Kaasinen,E., Sahu,B.,
            Khund-Sayeed,S., Das,P.K., Kivioja,T., Dave,K., Zhong,F.,
            Nitta,K.R., Taipale,M., Popov,A., Ginno,P.A., Domcke,S., Yan,J.,
            Schubeler,D., Vinson,C. and Taipale,J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
REFERENCE   4  (bases 1 to 2021)
  AUTHORS   Toyotome,T., Takahashi,H. and Kamei,K.
  TITLE     MEIS3 is repressed in A549 lung epithelial cells by deoxynivalenol
            and the repression contributes to the deleterious effect
  JOURNAL   J Toxicol Sci 41 (1), 25-31 (2016)
   PUBMED   26763390
REFERENCE   5  (bases 1 to 2021)
  AUTHORS   Uribe,R.A. and Bronner,M.E.
  TITLE     Meis3 is required for neural crest invasion of the gut during
            zebrafish enteric nervous system development
  JOURNAL   Mol Biol Cell 26 (21), 3728-3740 (2015)
   PUBMED   26354419
  REMARK    GeneRIF: Findings support a model in which Meis3 is required for
            neural crest proliferation, migration into, and colonization of the
            gut such that its loss leads to severe defects in enteric nervous
            system development.
REFERENCE   6  (bases 1 to 2021)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   7  (bases 1 to 2021)
  AUTHORS   Shim,S., Kim,Y., Shin,J., Kim,J. and Park,S.
  TITLE     Regulation of EphA8 gene expression by TALE homeobox transcription
            factors during development of the mesencephalon
  JOURNAL   Mol Cell Biol 27 (5), 1614-1630 (2007)
   PUBMED   17178831
REFERENCE   8  (bases 1 to 2021)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   9  (bases 1 to 2021)
  AUTHORS   Steelman,S., Moskow,J.J., Muzynski,K., North,C., Druck,T.,
            Montgomery,J.C., Huebner,K., Daar,I.O. and Buchberg,A.M.
  TITLE     Identification of a conserved family of Meis1-related homeobox
            genes
  JOURNAL   Genome Res 7 (2), 142-156 (1997)
   PUBMED   9049632
REFERENCE   10 (bases 1 to 2021)
  AUTHORS   Nakamura,T., Jenkins,N.A. and Copeland,N.G.
  TITLE     Identification of a new family of Pbx-related homeobox genes
  JOURNAL   Oncogene 13 (10), 2235-2242 (1996)
   PUBMED   8950991
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CF993984.1, AL537583.3,
            BM783223.1, BI522513.1 and BC045741.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_001301059.1.
            
            Summary: This gene encodes a homeobox protein and probable
            transcriptional regulator. The orthologous protein in mouse
            controls expression of 3-phosphoinositide dependent protein kinase
            1, which promotes survival of pancreatic beta-cells. [provided by
            RefSeq, Sep 2016].
            
            Transcript Variant: This variant (3) uses an alternate in-frame
            splice site in the 3' coding region, compared to variant 1. It
            encodes isoform 3, which lacks an internal segment and is shorter,
            compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA2162568
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000558555.6/ ENSP00000454073.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-268               CF993984.1         28-295
            269-1098            AL537583.3         11-840
            1099-1287           BM783223.1         476-664
            1288-1964           BI522513.1         82-758
            1965-2021           BC045741.1         1056-1112
FEATURES             Location/Qualifiers
     source          1..2021
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.32"
     gene            1..2021
                     /gene="MEIS3"
                     /gene_synonym="MRG2"
                     /note="Meis homeobox 3"
                     /db_xref="GeneID:56917"
                     /db_xref="HGNC:HGNC:29537"
                     /db_xref="MIM:619443"
     exon            1..458
                     /gene="MEIS3"
                     /gene_synonym="MRG2"
                     /inference="alignment:Splign:2.1.0"
     CDS             447..1574
                     /gene="MEIS3"
                     /gene_synonym="MRG2"
                     /note="isoform 3 is encoded by transcript variant 3;
                     homeobox protein Meis3; meis1-related protein 2; Meis1,
                     myeloid ecotropic viral integration site 1 homolog 3"
                     /codon_start=1
                     /product="homeobox protein Meis3 isoform 3"
                     /protein_id="NP_001287988.1"
                     /db_xref="CCDS:CCDS74406.1"
                     /db_xref="GeneID:56917"
                     /db_xref="HGNC:HGNC:29537"
                     /db_xref="MIM:619443"
                     /translation="MARRYDELPHYPGIVDGPAALASFPETVPAVPGPYGPHRPPQPL
                     PPGLDSDGLKREKDEIYGHPLFPLLALVFEKCELATCSPRDGAGAGLGTPPGGDVCSS
                     DSFNEDIAAFAKQVRSERPLFSSNPELDNLMIQAIQVLRFHLLELEKVHDLCDNFCHR
                     YITCLKGKMPIDLVIEDRDGGCREDFEDYPASCPSLPDQNNMWIRDHEDSGSVHLGTP
                     GPSSGGLASQSGDNSSDQGDGLDTSVASPSSGGEDEDLDQERRRNKKRGIFPKVATNI
                     MRAWLFQHLSHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRTGQG
                     AAFSPEGQPIGGYTETQPHVAVRPPGSVGMSLNLEGEWHYL"
     exon            459..631
                     /gene="MEIS3"
                     /gene_synonym="MRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            632..791
                     /gene="MEIS3"
                     /gene_synonym="MRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            792..842
                     /gene="MEIS3"
                     /gene_synonym="MRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            843..893
                     /gene="MEIS3"
                     /gene_synonym="MRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            894..1043
                     /gene="MEIS3"
                     /gene_synonym="MRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1155
                     /gene="MEIS3"
                     /gene_synonym="MRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1304
                     /gene="MEIS3"
                     /gene_synonym="MRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1381
                     /gene="MEIS3"
                     /gene_synonym="MRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1382..1440
                     /gene="MEIS3"
                     /gene_synonym="MRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1441..1524
                     /gene="MEIS3"
                     /gene_synonym="MRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1525..1591
                     /gene="MEIS3"
                     /gene_synonym="MRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1592..2021
                     /gene="MEIS3"
                     /gene_synonym="MRG2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2000..2005
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MEIS3"
                     /gene_synonym="MRG2"
                     /note="hexamer: GATAAA"
     polyA_site      2021
                     /gene="MEIS3"
                     /gene_synonym="MRG2"
                     /note="major polyA site"
ORIGIN      
        1 gagagaccgg gaacggggag cgcggctgcc agcacccctg agccgccgcc ggaccctccg
       61 tcgccccggg ccgccccccg ccccctgcgg tccccggtgt gtccgtctcg ggacggttcg
      121 attccctcca gagccgggga agggacgggg ggggcccaga ggagggggcc tcgggcgccc
      181 cgcctgcgcc tgctgccccc gccccggcgg cgatgcgctc ctggccgtga cccccgctgg
      241 gggcgggggc cggggtccat gcgcggagtc cccacccggc ccggcgcctg ccgctgacgg
      301 cggcgggggt gggggggcgc gcgcctggcc tcctgcccac cccctggcgt caacaccgcg
      361 ggccgtcagg ggctgcggcc ccgggctgcg ccctcccccg cggccaggct ctggagggac
      421 ccaggagctg ccgccggcct cagcccatgg cccggaggta tgatgagctg ccgcactacc
      481 caggcatcgt ggatggcccc gcagccctgg ctagcttccc agagacagtg cccgcagtac
      541 cagggcccta tggcccgcac cggcctcccc agcccctgcc cccaggcttg gacagcgacg
      601 gcctgaagag ggagaaggat gagatctatg gacacccgct cttccccctc ttggccctgg
      661 tctttgagaa atgtgaactg gctacatgct ctccccgtga cggggccgga gctgggctgg
      721 ggacaccccc tggaggtgac gtctgctcct ctgattcctt caacgaggac atcgctgcct
      781 ttgccaagca ggttcgctct gagaggcccc tcttctcctc caacccagaa ctggacaatc
      841 tgatgatcca ggccatccag gtgctgcggt tccacctgct ggagctggag aaggtccacg
      901 acctgtgcga caacttctgt caccgctaca tcacctgcct caagggaaag atgcccatcg
      961 acctggtcat cgaggatcgg gacggcggct gcagggagga cttcgaggac tacccagcct
     1021 cctgccccag cctcccagac cagaataata tgtggattcg agaccatgag gatagtgggt
     1081 ctgtacattt ggggacccca ggtccatcca gtgggggcct ggcctcccag agtggggaca
     1141 actccagtga ccaaggagac gggctggaca ccagcgtggc ctctcccagt tctggtggag
     1201 aagatgagga cttggaccag gagcgacggc gaaacaagaa gagggggatc ttccccaagg
     1261 tggccaccaa catcatgcga gcctggttgt tccagcacct ctcgcacccg tacccctcgg
     1321 aggagcagaa gaaacagctg gcgcaggaca cggggctcac catcctgcaa gtcaacaact
     1381 ggttcattaa cgcccggaga cgcatcgtgc aacctatgat cgatcaatcc aaccgcacag
     1441 ggcagggtgc agccttcagc ccagagggcc agcccatcgg gggctatacc gagacgcagc
     1501 cacacgtggc cgtccggcct ccgggatcag tggggatgag tttgaacttg gaaggagaat
     1561 ggcattatct atagaggctg atgcaggaga gacccagcct ccggctgtga cccccagcct
     1621 cacacctgcc tctggttccc gcctggtcct ccagcttcag gaccccacct ccaaaggccc
     1681 ctctgctcaa tgcctacctc cctagggccc tgctgggaca tgggggcctg agtgcccatc
     1741 caagggctct caaggacacc ggcaaggcct ccaggccctg agccccactt ctgccttcac
     1801 ctctgcctgg gacccgagct gggctcctgg gccttggtcc ccagaagatg gcggctaggg
     1861 cctcgccgcc aggacagaga agggacgggg tggctgggca gtcagggaag gagggtcgcc
     1921 cggatccgac attttggaga gattccttca ctctcctgtc ccccctacct cccttctcta
     1981 atttcttctt ttttttaatg ataaagtctt aaaaacacgg a
//
