LOCUS       NM_170675               5486 bp    mRNA    linear   PRI 27-MAY-2024
DEFINITION  Homo sapiens Meis homeobox 2 (MEIS2), transcript variant c, mRNA.
ACCESSION   NM_170675
VERSION     NM_170675.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5486)
  AUTHORS   Xiao,Y., Liu,Y., Sun,Y., Huang,C. and Zhong,S.
  TITLE     MEIS2 suppresses breast cancer development by downregulating IL10
  JOURNAL   Cancer Rep (Hoboken) 7 (5), e2064 (2024)
   PUBMED   38711262
  REMARK    GeneRIF: MEIS2 suppresses breast cancer development by
            downregulating IL10.
REFERENCE   2  (bases 1 to 5486)
  AUTHORS   Li,D. and Hu,A.
  TITLE     LINC-PINT suppresses breast cancer cell proliferation and migration
            via MEIS2/PPP3CC/NF-kappaB pathway by sponging miR-576-5p
  JOURNAL   Am J Med Sci 367 (3), 201-211 (2024)
   PUBMED   37660994
  REMARK    GeneRIF: LINC-PINT suppresses breast cancer cell proliferation and
            migration via MEIS2/PPP3CC/NF-kappaB pathway by sponging
            miR-576-5p.
REFERENCE   3  (bases 1 to 5486)
  AUTHORS   Arunachalam,V., Lea,R., Hoy,W., Lee,S., Mott,S., Savige,J.,
            Mathews,J.D., McMorran,B.J. and Nagaraj,S.H.
  TITLE     Novel genetic markers for chronic kidney disease in a
            geographically isolated population of Indigenous Australians:
            Individual and multiple phenotype genome-wide association study
  JOURNAL   Genome Med 16 (1), 29 (2024)
   PUBMED   38347632
  REMARK    GeneRIF: Novel genetic markers for chronic kidney disease in a
            geographically isolated population of Indigenous Australians:
            Individual and multiple phenotype genome-wide association study.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5486)
  AUTHORS   Xu,H., Chen,S., Li,J., Weng,S., Ren,Y., Zhang,Y., Wang,L., Liu,L.,
            Guo,C., Xing,Z., Luo,P., Cheng,Q., Han,X. and Liu,Z.
  TITLE     Cellular Ligand-Receptor Perturbations Unravel MEIS2 as a Key
            Factor for the Aggressive Progression and Prognosis in Stage II/III
            Colorectal Cancer
  JOURNAL   J Proteome Res 23 (2), 760-774 (2024)
   PUBMED   38153233
  REMARK    GeneRIF: Cellular Ligand-Receptor Perturbations Unravel MEIS2 as a
            Key Factor for the Aggressive Progression and Prognosis in Stage
            II/III Colorectal Cancer.
REFERENCE   5  (bases 1 to 5486)
  AUTHORS   Dai,X., Chen,X., Chen,W., Ou,Y., Chen,Y., Wu,S., Zhou,Q., Yang,C.,
            Zhang,L. and Jiang,H.
  TITLE     CircDHRS3 inhibits prostate cancer cell proliferation and
            metastasis through the circDHRS3/miR-421/MEIS2 axis
  JOURNAL   Epigenetics 18 (1), 2178802 (2023)
   PUBMED   36840946
  REMARK    GeneRIF: CircDHRS3 inhibits prostate cancer cell proliferation and
            metastasis through the circDHRS3/miR-421/MEIS2 axis.
REFERENCE   6  (bases 1 to 5486)
  AUTHORS   Fujino,T., Yamazaki,Y., Largaespada,D.A., Jenkins,N.A.,
            Copeland,N.G., Hirokawa,K. and Nakamura,T.
  TITLE     Inhibition of myeloid differentiation by Hoxa9, Hoxb8, and Meis
            homeobox genes
  JOURNAL   Exp Hematol 29 (7), 856-863 (2001)
   PUBMED   11438208
REFERENCE   7  (bases 1 to 5486)
  AUTHORS   Liu,Y., MacDonald,R.J. and Swift,G.H.
  TITLE     DNA binding and transcriptional activation by a PDX1.PBX1b.MEIS2b
            trimer and cooperation with a pancreas-specific basic
            helix-loop-helix complex
  JOURNAL   J Biol Chem 276 (21), 17985-17993 (2001)
   PUBMED   11279116
REFERENCE   8  (bases 1 to 5486)
  AUTHORS   Yang,Y., Hwang,C.K., D'Souza,U.M., Lee,S.H., Junn,E. and
            Mouradian,M.M.
  TITLE     Three-amino acid extension loop homeodomain proteins Meis2 and TGIF
            differentially regulate transcription
  JOURNAL   J Biol Chem 275 (27), 20734-20741 (2000)
   PUBMED   10764806
REFERENCE   9  (bases 1 to 5486)
  AUTHORS   Smith,J.E., Afonja,O., Yee,H.T., Inghirami,G. and Takeshita,K.
  TITLE     Chromosomal mapping to 15q14 and expression analysis of the human
            MEIS2 homeobox gene
  JOURNAL   Mamm Genome 8 (12), 951-952 (1997)
   PUBMED   9383298
REFERENCE   10 (bases 1 to 5486)
  AUTHORS   Steelman,S., Moskow,J.J., Muzynski,K., North,C., Druck,T.,
            Montgomery,J.C., Huebner,K., Daar,I.O. and Buchberg,A.M.
  TITLE     Identification of a conserved family of Meis1-related homeobox
            genes
  JOURNAL   Genome Res 7 (2), 142-156 (1997)
   PUBMED   9049632
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC078909.7, AK056216.1,
            DA689122.1, AF179897.1, BC050431.1, BM679305.1 and AC018563.7.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_170675.4.
            
            Summary: This gene encodes a homeobox protein belonging to the TALE
            ('three amino acid loop extension') family of
            homeodomain-containing proteins. TALE homeobox proteins are highly
            conserved transcription regulators, and several members have been
            shown to be essential contributors to developmental programs.
            Multiple transcript variants encoding distinct isoforms have been
            described for this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (c) lacks the exon containing the
            stop codon compared to variant a, that causes a frameshift. The
            resulting isoform (c) contains a longer and distinct C-terminus
            compared to isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF179897.1, SRR1803616.227185.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000561208.6/ ENSP00000453793.1
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-409               AC078909.7         66902-67310
            410-744             AK056216.1         400-734
            745-828             DA689122.1         39-122
            829-3043            AF179897.1         1-2215
            3044-3616           BC050431.1         2361-2933
            3617-3669           BM679305.1         18-70               c
            3670-5486           AC018563.7         85998-87814         c
FEATURES             Location/Qualifiers
     source          1..5486
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q14"
     gene            1..5486
                     /gene="MEIS2"
                     /gene_synonym="CPCMR; HsT18361; MRG1"
                     /note="Meis homeobox 2"
                     /db_xref="GeneID:4212"
                     /db_xref="HGNC:HGNC:7001"
                     /db_xref="MIM:601740"
     exon            1..1095
                     /gene="MEIS2"
                     /gene_synonym="CPCMR; HsT18361; MRG1"
                     /inference="alignment:Splign:2.1.0"
     CDS             1084..2517
                     /gene="MEIS2"
                     /gene_synonym="CPCMR; HsT18361; MRG1"
                     /note="isoform c is encoded by transcript variant c; Meis
                     homolog 2; TALE homeobox protein Meis2; Meis1-related gene
                     1; meis1-related protein 1; Meis1, myeloid ecotropic viral
                     integration site 1 homolog 2"
                     /codon_start=1
                     /product="homeobox protein Meis2 isoform c"
                     /protein_id="NP_733775.1"
                     /db_xref="CCDS:CCDS10044.1"
                     /db_xref="GeneID:4212"
                     /db_xref="HGNC:HGNC:7001"
                     /db_xref="MIM:601740"
                     /translation="MAQRYDELPHYGGMDGVGVPASMYGDPHAPRPIPPVHHLNHGPP
                     LHATQHYGAHAPHPNVMPASMGSAVNDALKRDKDAIYGHPLFPLLALVFEKCELATCT
                     PREPGVAGGDVCSSDSFNEDIAVFAKQVRAEKPLFSSNPELDNLMIQAIQVLRFHLLE
                     LEKVHELCDNFCHRYISCLKGKMPIDLVIDERDGSSKSDHEELSGSSTNLADHNPSSW
                     RDHDDATSTHSAGTPGPSSGGHASQSGDNSSEQGDGLDNSVASPGTGDDDDPDKDKKR
                     QKKRGIFPKVATNIMRAWLFQHLTHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRI
                     VQPMIDQSNRAGFLLDPSVSQGAAYSPEGQPMGSFVLDGQQHMGIRPAGLQSMPGDYV
                     SQGGPMGMSMAQPSYTPPQMTPHPTQLRHGPPMHSYLPSHPHHPAMMMHGGPPTHPGM
                     TMSAQSPTMLNSVDPNVGGQVMDIHAQ"
     exon            1096..1328
                     /gene="MEIS2"
                     /gene_synonym="CPCMR; HsT18361; MRG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1329..1470
                     /gene="MEIS2"
                     /gene_synonym="CPCMR; HsT18361; MRG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1471..1521
                     /gene="MEIS2"
                     /gene_synonym="CPCMR; HsT18361; MRG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1522..1572
                     /gene="MEIS2"
                     /gene_synonym="CPCMR; HsT18361; MRG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1573..1722
                     /gene="MEIS2"
                     /gene_synonym="CPCMR; HsT18361; MRG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1723..1837
                     /gene="MEIS2"
                     /gene_synonym="CPCMR; HsT18361; MRG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1838..1983
                     /gene="MEIS2"
                     /gene_synonym="CPCMR; HsT18361; MRG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1984..2060
                     /gene="MEIS2"
                     /gene_synonym="CPCMR; HsT18361; MRG1"
                     /inference="alignment:Splign:2.1.0"
     exon            2061..2119
                     /gene="MEIS2"
                     /gene_synonym="CPCMR; HsT18361; MRG1"
                     /inference="alignment:Splign:2.1.0"
     exon            2120..2230
                     /gene="MEIS2"
                     /gene_synonym="CPCMR; HsT18361; MRG1"
                     /inference="alignment:Splign:2.1.0"
     exon            2231..5486
                     /gene="MEIS2"
                     /gene_synonym="CPCMR; HsT18361; MRG1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3640..3645
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MEIS2"
                     /gene_synonym="CPCMR; HsT18361; MRG1"
                     /note="hexamer: AATAAA"
     polyA_site      3659
                     /gene="MEIS2"
                     /gene_synonym="CPCMR; HsT18361; MRG1"
                     /note="major polyA site"
     regulatory      4451..4456
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MEIS2"
                     /gene_synonym="CPCMR; HsT18361; MRG1"
                     /note="hexamer: AATATA"
     polyA_site      4467
                     /gene="MEIS2"
                     /gene_synonym="CPCMR; HsT18361; MRG1"
     regulatory      5461..5466
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MEIS2"
                     /gene_synonym="CPCMR; HsT18361; MRG1"
                     /note="hexamer: AATAAA"
     polyA_site      5486
                     /gene="MEIS2"
                     /gene_synonym="CPCMR; HsT18361; MRG1"
ORIGIN      
        1 gcactcgttg catatcagag gctcggcgcg gcgcgctcct cctcgctccc gctccccact
       61 cccgggatgt gtctccgccg tacgacgggc tatggccacc acgacttccg ggttccgtca
      121 tttcgttctc ccgccgccga cccgcgccgc caaactgagg ctcttcaata agccaggcag
      181 cagccaacct gccaacacct actgacactc actcatctcc cagagagaga aagagagcga
      241 gagagagcga gcgcgagaga gcgagcgcga gtgagagcga gcgagcgagc gagaaagaga
      301 gagagggaga gacaaaatac ctaccaggaa agggggggag gaagtccaat ttttgcaaac
      361 tattcatttt tttttcttga tttttctcac tgctttcttt gaacaatact ttaaagagag
      421 aggatcgtat tatagatacc gcgggggcaa agctaaaaaa ggggggaggg gggaggaaaa
      481 aattcaagaa gcagaaaccc ctcgcggagt tttactggaa gaaaaaaacg ggtctgaaag
      541 attcctcctc ttcatcatca tcaaccatca ttcattcact accttgacat tccgggcttt
      601 gattgacagc tggagtggca aaaagccatg aaacacgaca gttcggttac atgtgggctg
      661 ctgacgggcc gctcgtaacc ttcagttcgg gggcttgaca atttttttct tctttttctt
      721 ctttttcttt tctttctttt tttttccaac tgaggggaag agaagagaaa gagggggaaa
      781 ggaggaccga agaggaggag gaggggaggg gggaggagga ggaggtggag gaggaggagg
      841 aagatcagga ggaggaggaa gaagaggaaa aaagagaaaa agaagaaata tcacagaaaa
      901 aaaaattctt cgttgtctag actgggcttt ttttcccccc taaaaaatag catattggag
      961 aattgggaga agtctctttg gtttggaaaa aaaaaaaagg aatcttcagc ctagatcact
     1021 ttcttatccg gactgggata ttaaatatac gacacatcca ggagtttatt ggagcgcaga
     1081 ctgatggcgc aaaggtacga tgagctgccc cattacggcg ggatggacgg agtaggggtt
     1141 cccgcttcca tgtacggaga ccctcacgcg ccgcggccga tccccccggt tcaccacctg
     1201 aaccacgggc cgccgctcca cgccacacag cactacggcg cgcacgcccc gcaccccaat
     1261 gtcatgccgg ccagtatggg atccgctgtc aacgacgcct tgaagcggga caaggacgcg
     1321 atctatgggc acccgttgtt tcctctgtta gctctggtct ttgagaagtg cgagctggcg
     1381 acctgcactc cccgggaacc tggagtggct ggcggagacg tctgctcctc cgactccttc
     1441 aacgaggaca tcgcggtctt cgccaagcag gttcgcgccg aaaagccact tttttcctca
     1501 aatccagagc tggacaattt gatgatacaa gcaatacaag tactaaggtt tcatcttttg
     1561 gagttagaaa aggtccacga actgtgcgat aacttctgcc accgatacat tagctgtttg
     1621 aaggggaaaa tgcccatcga cctcgtcatt gatgaaagag acggcagctc caagtcagat
     1681 catgaagaac tttcaggctc ctccacaaat ctcgctgacc ataacccttc ttcttggcga
     1741 gaccacgatg atgcaacctc aacccactca gcaggcaccc cagggccctc cagtgggggc
     1801 catgcttccc agagcggaga caacagcagt gagcaagggg atggtttaga caacagtgta
     1861 gcttcacctg gtacaggtga cgatgatgat ccggataagg acaaaaaacg ccagaagaaa
     1921 agaggcattt tccccaaagt agcaacaaat atcatgagag catggctctt ccagcatctc
     1981 acacatccgt acccttccga agagcagaag aaacagttag cgcaagacac aggacttaca
     2041 attctccaag taaacaactg gtttattaat gccagaagaa gaatagtaca gcccatgatt
     2101 gaccagtcaa atcgagcagg ttttcttctt gatccttcag tgagccaagg agcagcatat
     2161 agtccagagg gtcagcccat ggggagcttt gtgttggatg gtcagcaaca catggggatc
     2221 cggcctgcag gtttgcagag catgccaggg gactacgttt ctcagggtgg tcctatggga
     2281 atgagtatgg cacagccaag ttacactcct ccccagatga ccccacaccc tactcaatta
     2341 agacatggac ccccaatgca ttcatatttg ccaagccatc cccaccaccc agccatgatg
     2401 atgcacggag gaccccctac ccaccctgga atgactatgt cagcacagag ccccacaatg
     2461 ttaaattctg tagatcccaa tgttggcgga caggttatgg acattcatgc ccaatagtat
     2521 aagggaactc aagggaaaag gaaacacacg caaaaactat tttaagactt tctgaacttt
     2581 gaccagatgt tgacacttaa tatgaaattc cagacagctg tgattatttt ttacttttgt
     2641 catttttcat caagcaacag aggaccaatg caacaagaac acaaatgtga aatcatgggc
     2701 tgactgagac aattctgtcc atgtaaagat cctctggaaa aagactccga gagttataac
     2761 tactgtagta taaatatagg aactaagtta aacttgtaca tttctgttga tcacgccgtt
     2821 atgttgcctc aaatagtttt agaagagaaa aaaaaatata tccttgtttt ccacactatg
     2881 tgtgttgttc ccaaaagaat gactgttttg gttcatcagt gaattcacca tccaggagag
     2941 actgtggtat atattttaaa cctgttgggc caatgagaaa agaaccacac tggagatcat
     3001 gatgaacttt tggctgaacc tcatcactcg aactccagct tcaagaatgt gttttcatgc
     3061 ccggcctttg ttcctccata aatgtgtcct ttagtttcaa acagatcttt atagttcgtg
     3121 cttcataagc caattcttat tattattttt gggggactct tcttcaaaga gcttgccaat
     3181 gaagatttaa agacagagca ggagcttctt ccaggagttc tgagccttgg ttgtggacaa
     3241 aacaatctta agttgggcag ctttcctcaa cacaaaaaaa agttattaat ggtcattgaa
     3301 ccataactag gactttatca gaaactcaaa gcttggggga taaaaaggag caagagaata
     3361 ctgtaacaaa cttcgtacag agttcggtct attaattgtt tcatgttaga tattctatgt
     3421 gtttacctca attgaaaaaa aaaagaatgt ttttgctagt atcagatctg ctgtggaatt
     3481 ggtattgtat gtccatgaat tcttcttttc tcagcacgtg ttcctcacta gaagaaaatg
     3541 ctgttacctt taagctttgt caaatttaca ttaaaatact tgtatgagga ctgtgacgtt
     3601 atgttaaaaa aaaaaaggtg ttaagtcaca aaaagcggta ataaatattt catttttgat
     3661 tttttgttag gcttttgcgt ttttaatggt tttaggacaa gactgcacaa tgccaactct
     3721 atacagtgtt aaaagtaggt ttttcccccc agcagttgag tatattttaa actcatcaat
     3781 aatttttaag gtaatcatct atagcctttc aatgtctatt tgacctataa gttccaccag
     3841 cagaaaactt ctaaaggtac gaaactatgt gtacatgatg agccaggttg aaagatcccc
     3901 ttgaacatgc tcaacctcct ttttagatgc atgacgttaa aaaatatata ctttcagata
     3961 aagcttttca tgggcatcct ctgccagaat aaaggacttt tcagggttaa ttttacaaca
     4021 taagaaataa tgtctgtgct caaaggtaat ttatctgcct gtgtttttcc tctgcctgtc
     4081 ttactacaat attgttggat atgtaaatga aaatttacat atgggtgttc atagataagt
     4141 aaacaacttc tatggagttt gaaattctga ctttaaaaga ttacttaatc attaatattt
     4201 tataaattat attgtggtat atttttattt cagacacatc catgtgcagg gatgctagtg
     4261 tgatgatttg ataactaaac ttaaactttt ttctgaaaac aaaacaaaac aaaatggacg
     4321 gtataatgcc attttcaaaa ttttatgcaa cattcctgga aatctatacc attagcttat
     4381 tgatactgca caaacaatgt ctgctaaagt gtgcaaaaag ggtgaggcat gtcccctcaa
     4441 ttttcaaata aatatactat cctggaattt tttaactctt aaattttgaa tctttgttta
     4501 gaaagaataa tgtcatatac tttggctaga tatgtgatgt caaccggcta aggaaattat
     4561 tcatcatctc tgcaaactta aacttggaag aaatccatag ttattatttg gggctcttcc
     4621 atctttccat ttcagacagc atttatggag gttctatata aatgaacgag gaaatacact
     4681 tctattgttt tgtgttatat ttagtcaggt agaattttta caaatacatt tcagtttaag
     4741 tgttgtgttg ctgtttaaac atagaaataa tgcttctgac acaaactaac ttaatagaga
     4801 aattcagtgc cacttgggaa agagagatag cttccctctc atttttgcta ttctatttta
     4861 catgaagtct ttttgtaaat tttaaatatt tgcctatttt tactttaaat acttttatgt
     4921 aaactatgaa aattccccat tataaatcaa ctctcacatc aggtgggaaa aagaaccttt
     4981 ttttctttcc actcagtaaa ttctgaaggg tttccttggc aattggctcg tgtttaggat
     5041 gtgttttatg caattatcaa gttatctcat tgaagtttag agaccagagc tctcaactct
     5101 tggttttaat gaataaagtc atctcatgct tagtttattc gtcaaaccca cgtcctatca
     5161 tgttaacttt aaccttctta aatatttgga gatgaatgat aattgtaata tttgtttgca
     5221 ttaccttgct ctcccccacc cccaacccca tgataacaca gagaagtgat agatttgtcc
     5281 aatttttata atgctttttt tacaccaccc cggaaggcac ttgctcctat ctcgggttta
     5341 ctatttagtg taaagagttc cgatttgggt atatttaaga aagactcagc tgtcaaaagc
     5401 aaagaaactg ggaatggtgt tttgacaacc atatagtgtt aaaggaaata ctgtagtctg
     5461 aataaaattg cttatgttct ccaaaa
//
