LOCUS       NM_170674               5561 bp    mRNA    linear   PRI 27-MAY-2024
DEFINITION  Homo sapiens Meis homeobox 2 (MEIS2), transcript variant b, mRNA.
ACCESSION   NM_170674
VERSION     NM_170674.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5561)
  AUTHORS   Xiao,Y., Liu,Y., Sun,Y., Huang,C. and Zhong,S.
  TITLE     MEIS2 suppresses breast cancer development by downregulating IL10
  JOURNAL   Cancer Rep (Hoboken) 7 (5), e2064 (2024)
   PUBMED   38711262
  REMARK    GeneRIF: MEIS2 suppresses breast cancer development by
            downregulating IL10.
REFERENCE   2  (bases 1 to 5561)
  AUTHORS   Li,D. and Hu,A.
  TITLE     LINC-PINT suppresses breast cancer cell proliferation and migration
            via MEIS2/PPP3CC/NF-kappaB pathway by sponging miR-576-5p
  JOURNAL   Am J Med Sci 367 (3), 201-211 (2024)
   PUBMED   37660994
  REMARK    GeneRIF: LINC-PINT suppresses breast cancer cell proliferation and
            migration via MEIS2/PPP3CC/NF-kappaB pathway by sponging
            miR-576-5p.
REFERENCE   3  (bases 1 to 5561)
  AUTHORS   Arunachalam,V., Lea,R., Hoy,W., Lee,S., Mott,S., Savige,J.,
            Mathews,J.D., McMorran,B.J. and Nagaraj,S.H.
  TITLE     Novel genetic markers for chronic kidney disease in a
            geographically isolated population of Indigenous Australians:
            Individual and multiple phenotype genome-wide association study
  JOURNAL   Genome Med 16 (1), 29 (2024)
   PUBMED   38347632
  REMARK    GeneRIF: Novel genetic markers for chronic kidney disease in a
            geographically isolated population of Indigenous Australians:
            Individual and multiple phenotype genome-wide association study.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5561)
  AUTHORS   Xu,H., Chen,S., Li,J., Weng,S., Ren,Y., Zhang,Y., Wang,L., Liu,L.,
            Guo,C., Xing,Z., Luo,P., Cheng,Q., Han,X. and Liu,Z.
  TITLE     Cellular Ligand-Receptor Perturbations Unravel MEIS2 as a Key
            Factor for the Aggressive Progression and Prognosis in Stage II/III
            Colorectal Cancer
  JOURNAL   J Proteome Res 23 (2), 760-774 (2024)
   PUBMED   38153233
  REMARK    GeneRIF: Cellular Ligand-Receptor Perturbations Unravel MEIS2 as a
            Key Factor for the Aggressive Progression and Prognosis in Stage
            II/III Colorectal Cancer.
REFERENCE   5  (bases 1 to 5561)
  AUTHORS   Dai,X., Chen,X., Chen,W., Ou,Y., Chen,Y., Wu,S., Zhou,Q., Yang,C.,
            Zhang,L. and Jiang,H.
  TITLE     CircDHRS3 inhibits prostate cancer cell proliferation and
            metastasis through the circDHRS3/miR-421/MEIS2 axis
  JOURNAL   Epigenetics 18 (1), 2178802 (2023)
   PUBMED   36840946
  REMARK    GeneRIF: CircDHRS3 inhibits prostate cancer cell proliferation and
            metastasis through the circDHRS3/miR-421/MEIS2 axis.
REFERENCE   6  (bases 1 to 5561)
  AUTHORS   Fujino,T., Yamazaki,Y., Largaespada,D.A., Jenkins,N.A.,
            Copeland,N.G., Hirokawa,K. and Nakamura,T.
  TITLE     Inhibition of myeloid differentiation by Hoxa9, Hoxb8, and Meis
            homeobox genes
  JOURNAL   Exp Hematol 29 (7), 856-863 (2001)
   PUBMED   11438208
REFERENCE   7  (bases 1 to 5561)
  AUTHORS   Liu,Y., MacDonald,R.J. and Swift,G.H.
  TITLE     DNA binding and transcriptional activation by a PDX1.PBX1b.MEIS2b
            trimer and cooperation with a pancreas-specific basic
            helix-loop-helix complex
  JOURNAL   J Biol Chem 276 (21), 17985-17993 (2001)
   PUBMED   11279116
REFERENCE   8  (bases 1 to 5561)
  AUTHORS   Yang,Y., Hwang,C.K., D'Souza,U.M., Lee,S.H., Junn,E. and
            Mouradian,M.M.
  TITLE     Three-amino acid extension loop homeodomain proteins Meis2 and TGIF
            differentially regulate transcription
  JOURNAL   J Biol Chem 275 (27), 20734-20741 (2000)
   PUBMED   10764806
REFERENCE   9  (bases 1 to 5561)
  AUTHORS   Smith,J.E., Afonja,O., Yee,H.T., Inghirami,G. and Takeshita,K.
  TITLE     Chromosomal mapping to 15q14 and expression analysis of the human
            MEIS2 homeobox gene
  JOURNAL   Mamm Genome 8 (12), 951-952 (1997)
   PUBMED   9383298
REFERENCE   10 (bases 1 to 5561)
  AUTHORS   Steelman,S., Moskow,J.J., Muzynski,K., North,C., Druck,T.,
            Montgomery,J.C., Huebner,K., Daar,I.O. and Buchberg,A.M.
  TITLE     Identification of a conserved family of Meis1-related homeobox
            genes
  JOURNAL   Genome Res 7 (2), 142-156 (1997)
   PUBMED   9049632
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC078909.7, AK056216.1,
            DA689122.1, AF179896.1, BC050431.1, BM679305.1 and AC018563.7.
            
            On May 31, 2019 this sequence version replaced NM_170674.4.
            
            Summary: This gene encodes a homeobox protein belonging to the TALE
            ('three amino acid loop extension') family of
            homeodomain-containing proteins. TALE homeobox proteins are highly
            conserved transcription regulators, and several members have been
            shown to be essential contributors to developmental programs.
            Multiple transcript variants encoding distinct isoforms have been
            described for this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (b) uses an alternate in-frame
            splice junction at the 5' end of a coding exon compared to variant
            a. It encodes a shorter isoform (b) that is missing an internal
            segment compared to isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF179896.1, SRR1660809.178510.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-409               AC078909.7         66902-67310
            410-744             AK056216.1         400-734
            745-828             DA689122.1         39-122
            829-3118            AF179896.1         1-2290
            3119-3691           BC050431.1         2361-2933
            3692-3744           BM679305.1         18-70               c
            3745-5561           AC018563.7         85998-87814         c
FEATURES             Location/Qualifiers
     source          1..5561
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q14"
     gene            1..5561
                     /gene="MEIS2"
                     /gene_synonym="CPCMR; HsT18361; MRG1"
                     /note="Meis homeobox 2"
                     /db_xref="GeneID:4212"
                     /db_xref="HGNC:HGNC:7001"
                     /db_xref="MIM:601740"
     exon            1..1095
                     /gene="MEIS2"
                     /gene_synonym="CPCMR; HsT18361; MRG1"
                     /inference="alignment:Splign:2.1.0"
     CDS             1084..2268
                     /gene="MEIS2"
                     /gene_synonym="CPCMR; HsT18361; MRG1"
                     /note="isoform b is encoded by transcript variant b; Meis
                     homolog 2; TALE homeobox protein Meis2; Meis1-related gene
                     1; meis1-related protein 1; Meis1, myeloid ecotropic viral
                     integration site 1 homolog 2"
                     /codon_start=1
                     /product="homeobox protein Meis2 isoform b"
                     /protein_id="NP_733774.1"
                     /db_xref="CCDS:CCDS45218.1"
                     /db_xref="GeneID:4212"
                     /db_xref="HGNC:HGNC:7001"
                     /db_xref="MIM:601740"
                     /translation="MAQRYDELPHYGGMDGVGVPASMYGDPHAPRPIPPVHHLNHGPP
                     LHATQHYGAHAPHPNVMPASMGSAVNDALKRDKDAIYGHPLFPLLALVFEKCELATCT
                     PREPGVAGGDVCSSDSFNEDIAVFAKQVRAEKPLFSSNPELDNLMIQAIQVLRFHLLE
                     LEKVHELCDNFCHRYISCLKGKMPIDLVIDERDGSSKSDHEELSGSSTNLADHNPSSW
                     RDHDDATSTHSAGTPGPSSGGHASQSGDNSSEQGDGLDNSVASPGTGDDDDPDKDKKR
                     QKKRGIFPKVATNIMRAWLFQHLTHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRI
                     VQPMIDQSNRAVSQGAAYSPEGQPMGSFVLDGQQHMGIRPAGPMSGMGMNMGMDGQWH
                     YM"
     exon            1096..1328
                     /gene="MEIS2"
                     /gene_synonym="CPCMR; HsT18361; MRG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1329..1470
                     /gene="MEIS2"
                     /gene_synonym="CPCMR; HsT18361; MRG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1471..1521
                     /gene="MEIS2"
                     /gene_synonym="CPCMR; HsT18361; MRG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1522..1572
                     /gene="MEIS2"
                     /gene_synonym="CPCMR; HsT18361; MRG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1573..1722
                     /gene="MEIS2"
                     /gene_synonym="CPCMR; HsT18361; MRG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1723..1837
                     /gene="MEIS2"
                     /gene_synonym="CPCMR; HsT18361; MRG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1838..1983
                     /gene="MEIS2"
                     /gene_synonym="CPCMR; HsT18361; MRG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1984..2060
                     /gene="MEIS2"
                     /gene_synonym="CPCMR; HsT18361; MRG1"
                     /inference="alignment:Splign:2.1.0"
     exon            2061..2119
                     /gene="MEIS2"
                     /gene_synonym="CPCMR; HsT18361; MRG1"
                     /inference="alignment:Splign:2.1.0"
     exon            2120..2209
                     /gene="MEIS2"
                     /gene_synonym="CPCMR; HsT18361; MRG1"
                     /inference="alignment:Splign:2.1.0"
     exon            2210..2305
                     /gene="MEIS2"
                     /gene_synonym="CPCMR; HsT18361; MRG1"
                     /inference="alignment:Splign:2.1.0"
     exon            2306..5561
                     /gene="MEIS2"
                     /gene_synonym="CPCMR; HsT18361; MRG1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3715..3720
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MEIS2"
                     /gene_synonym="CPCMR; HsT18361; MRG1"
                     /note="hexamer: AATAAA"
     polyA_site      3734
                     /gene="MEIS2"
                     /gene_synonym="CPCMR; HsT18361; MRG1"
                     /note="major polyA site"
     regulatory      4526..4531
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MEIS2"
                     /gene_synonym="CPCMR; HsT18361; MRG1"
                     /note="hexamer: AATATA"
     polyA_site      4542
                     /gene="MEIS2"
                     /gene_synonym="CPCMR; HsT18361; MRG1"
     regulatory      5536..5541
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MEIS2"
                     /gene_synonym="CPCMR; HsT18361; MRG1"
                     /note="hexamer: AATAAA"
     polyA_site      5561
                     /gene="MEIS2"
                     /gene_synonym="CPCMR; HsT18361; MRG1"
ORIGIN      
        1 gcactcgttg catatcagag gctcggcgcg gcgcgctcct cctcgctccc gctccccact
       61 cccgggatgt gtctccgccg tacgacgggc tatggccacc acgacttccg ggttccgtca
      121 tttcgttctc ccgccgccga cccgcgccgc caaactgagg ctcttcaata agccaggcag
      181 cagccaacct gccaacacct actgacactc actcatctcc cagagagaga aagagagcga
      241 gagagagcga gcgcgagaga gcgagcgcga gtgagagcga gcgagcgagc gagaaagaga
      301 gagagggaga gacaaaatac ctaccaggaa agggggggag gaagtccaat ttttgcaaac
      361 tattcatttt tttttcttga tttttctcac tgctttcttt gaacaatact ttaaagagag
      421 aggatcgtat tatagatacc gcgggggcaa agctaaaaaa ggggggaggg gggaggaaaa
      481 aattcaagaa gcagaaaccc ctcgcggagt tttactggaa gaaaaaaacg ggtctgaaag
      541 attcctcctc ttcatcatca tcaaccatca ttcattcact accttgacat tccgggcttt
      601 gattgacagc tggagtggca aaaagccatg aaacacgaca gttcggttac atgtgggctg
      661 ctgacgggcc gctcgtaacc ttcagttcgg gggcttgaca atttttttct tctttttctt
      721 ctttttcttt tctttctttt tttttccaac tgaggggaag agaagagaaa gagggggaaa
      781 ggaggaccga agaggaggag gaggggaggg gggaggagga ggaggtggag gaggaggagg
      841 aagatcagga ggaggaggaa gaagaggaaa aaagagaaaa agaagaaata tcacagaaaa
      901 aaaaattctt cgttgtctag actgggcttt ttttcccccc taaaaaatag catattggag
      961 aattgggaga agtctctttg gtttggaaaa aaaaaaaagg aatcttcagc ctagatcact
     1021 ttcttatccg gactgggata ttaaatatac gacacatcca ggagtttatt ggagcgcaga
     1081 ctgatggcgc aaaggtacga tgagctgccc cattacggcg ggatggacgg agtaggggtt
     1141 cccgcttcca tgtacggaga ccctcacgcg ccgcggccga tccccccggt tcaccacctg
     1201 aaccacgggc cgccgctcca cgccacacag cactacggcg cgcacgcccc gcaccccaat
     1261 gtcatgccgg ccagtatggg atccgctgtc aacgacgcct tgaagcggga caaggacgcg
     1321 atctatgggc acccgttgtt tcctctgtta gctctggtct ttgagaagtg cgagctggcg
     1381 acctgcactc cccgggaacc tggagtggct ggcggagacg tctgctcctc cgactccttc
     1441 aacgaggaca tcgcggtctt cgccaagcag gttcgcgccg aaaagccact tttttcctca
     1501 aatccagagc tggacaattt gatgatacaa gcaatacaag tactaaggtt tcatcttttg
     1561 gagttagaaa aggtccacga actgtgcgat aacttctgcc accgatacat tagctgtttg
     1621 aaggggaaaa tgcccatcga cctcgtcatt gatgaaagag acggcagctc caagtcagat
     1681 catgaagaac tttcaggctc ctccacaaat ctcgctgacc ataacccttc ttcttggcga
     1741 gaccacgatg atgcaacctc aacccactca gcaggcaccc cagggccctc cagtgggggc
     1801 catgcttccc agagcggaga caacagcagt gagcaagggg atggtttaga caacagtgta
     1861 gcttcacctg gtacaggtga cgatgatgat ccggataagg acaaaaaacg ccagaagaaa
     1921 agaggcattt tccccaaagt agcaacaaat atcatgagag catggctctt ccagcatctc
     1981 acacatccgt acccttccga agagcagaag aaacagttag cgcaagacac aggacttaca
     2041 attctccaag taaacaactg gtttattaat gccagaagaa gaatagtaca gcccatgatt
     2101 gaccagtcaa atcgagcagt gagccaagga gcagcatata gtccagaggg tcagcccatg
     2161 gggagctttg tgttggatgg tcagcaacac atggggatcc ggcctgcagg acctatgagt
     2221 ggaatgggca tgaatatggg catggatggg caatggcact acatgtaacc ttcatcatgt
     2281 aaagcaatcg caaagcaagg gggaagtttg cagagcatgc caggggacta cgtttctcag
     2341 ggtggtccta tgggaatgag tatggcacag ccaagttaca ctcctcccca gatgacccca
     2401 caccctactc aattaagaca tggaccccca atgcattcat atttgccaag ccatccccac
     2461 cacccagcca tgatgatgca cggaggaccc cctacccacc ctggaatgac tatgtcagca
     2521 cagagcccca caatgttaaa ttctgtagat cccaatgttg gcggacaggt tatggacatt
     2581 catgcccaat agtataaggg aactcaaggg aaaaggaaac acacgcaaaa actattttaa
     2641 gactttctga actttgacca gatgttgaca cttaatatga aattccagac agctgtgatt
     2701 attttttact tttgtcattt ttcatcaagc aacagaggac caatgcaaca agaacacaaa
     2761 tgtgaaatca tgggctgact gagacaattc tgtccatgta aagatcctct ggaaaaagac
     2821 tccgagagtt ataactactg tagtataaat ataggaacta agttaaactt gtacatttct
     2881 gttgatcacg ccgttatgtt gcctcaaata gttttagaag agaaaaaaaa atatatcctt
     2941 gttttccaca ctatgtgtgt tgttcccaaa agaatgactg ttttggttca tcagtgaatt
     3001 caccatccag gagagactgt ggtatatatt ttaaacctgt tgggccaatg agaaaagaac
     3061 cacactggag atcatgatga acttttggct gaacctcatc actcgaactc cagcttcaag
     3121 aatgtgtttt catgcccggc ctttgttcct ccataaatgt gtcctttagt ttcaaacaga
     3181 tctttatagt tcgtgcttca taagccaatt cttattatta tttttggggg actcttcttc
     3241 aaagagcttg ccaatgaaga tttaaagaca gagcaggagc ttcttccagg agttctgagc
     3301 cttggttgtg gacaaaacaa tcttaagttg ggcagctttc ctcaacacaa aaaaaagtta
     3361 ttaatggtca ttgaaccata actaggactt tatcagaaac tcaaagcttg ggggataaaa
     3421 aggagcaaga gaatactgta acaaacttcg tacagagttc ggtctattaa ttgtttcatg
     3481 ttagatattc tatgtgttta cctcaattga aaaaaaaaag aatgtttttg ctagtatcag
     3541 atctgctgtg gaattggtat tgtatgtcca tgaattcttc ttttctcagc acgtgttcct
     3601 cactagaaga aaatgctgtt acctttaagc tttgtcaaat ttacattaaa atacttgtat
     3661 gaggactgtg acgttatgtt aaaaaaaaaa aggtgttaag tcacaaaaag cggtaataaa
     3721 tatttcattt ttgatttttt gttaggcttt tgcgttttta atggttttag gacaagactg
     3781 cacaatgcca actctataca gtgttaaaag taggtttttc cccccagcag ttgagtatat
     3841 tttaaactca tcaataattt ttaaggtaat catctatagc ctttcaatgt ctatttgacc
     3901 tataagttcc accagcagaa aacttctaaa ggtacgaaac tatgtgtaca tgatgagcca
     3961 ggttgaaaga tccccttgaa catgctcaac ctccttttta gatgcatgac gttaaaaaat
     4021 atatactttc agataaagct tttcatgggc atcctctgcc agaataaagg acttttcagg
     4081 gttaatttta caacataaga aataatgtct gtgctcaaag gtaatttatc tgcctgtgtt
     4141 tttcctctgc ctgtcttact acaatattgt tggatatgta aatgaaaatt tacatatggg
     4201 tgttcataga taagtaaaca acttctatgg agtttgaaat tctgacttta aaagattact
     4261 taatcattaa tattttataa attatattgt ggtatatttt tatttcagac acatccatgt
     4321 gcagggatgc tagtgtgatg atttgataac taaacttaaa cttttttctg aaaacaaaac
     4381 aaaacaaaat ggacggtata atgccatttt caaaatttta tgcaacattc ctggaaatct
     4441 ataccattag cttattgata ctgcacaaac aatgtctgct aaagtgtgca aaaagggtga
     4501 ggcatgtccc ctcaattttc aaataaatat actatcctgg aattttttaa ctcttaaatt
     4561 ttgaatcttt gtttagaaag aataatgtca tatactttgg ctagatatgt gatgtcaacc
     4621 ggctaaggaa attattcatc atctctgcaa acttaaactt ggaagaaatc catagttatt
     4681 atttggggct cttccatctt tccatttcag acagcattta tggaggttct atataaatga
     4741 acgaggaaat acacttctat tgttttgtgt tatatttagt caggtagaat ttttacaaat
     4801 acatttcagt ttaagtgttg tgttgctgtt taaacataga aataatgctt ctgacacaaa
     4861 ctaacttaat agagaaattc agtgccactt gggaaagaga gatagcttcc ctctcatttt
     4921 tgctattcta ttttacatga agtctttttg taaattttaa atatttgcct atttttactt
     4981 taaatacttt tatgtaaact atgaaaattc cccattataa atcaactctc acatcaggtg
     5041 ggaaaaagaa cctttttttc tttccactca gtaaattctg aagggtttcc ttggcaattg
     5101 gctcgtgttt aggatgtgtt ttatgcaatt atcaagttat ctcattgaag tttagagacc
     5161 agagctctca actcttggtt ttaatgaata aagtcatctc atgcttagtt tattcgtcaa
     5221 acccacgtcc tatcatgtta actttaacct tcttaaatat ttggagatga atgataattg
     5281 taatatttgt ttgcattacc ttgctctccc ccacccccaa ccccatgata acacagagaa
     5341 gtgatagatt tgtccaattt ttataatgct ttttttacac caccccggaa ggcacttgct
     5401 cctatctcgg gtttactatt tagtgtaaag agttccgatt tgggtatatt taagaaagac
     5461 tcagctgtca aaagcaaaga aactgggaat ggtgttttga caaccatata gtgttaaagg
     5521 aaatactgta gtctgaataa aattgcttat gttctccaaa a
//
