LOCUS       NM_002398               4566 bp    mRNA    linear   PRI 17-JUN-2024
DEFINITION  Homo sapiens Meis homeobox 1 (MEIS1), mRNA.
ACCESSION   NM_002398
VERSION     NM_002398.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4566)
  AUTHORS   Javanshir,E., Ebrahimi,Z.J., Mirzohreh,S.T., Ghaffari,S.,
            Banisefid,E., Alamdari,N.M. and Roshanravan,N.
  TITLE     Disparity of gene expression in coronary artery disease: insights
            from MEIS1, HIRA, and Myocardin
  JOURNAL   Mol Biol Rep 51 (1), 712 (2024)
   PUBMED   38824221
  REMARK    GeneRIF: Disparity of gene expression in coronary artery disease:
            insights from MEIS1, HIRA, and Myocardin.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4566)
  AUTHORS   Xiang,P., Yang,X., Escano,L., Dhillon,I., Schneider,E.,
            Clemans-Gibbon,J., Wei,W., Wong,J., Wang,S.X., Tam,D., Deng,Y.,
            Yung,E., Morin,G.B., Hoodless,P.A., Hirst,M., Karsan,A.,
            Kuchenbauer,F., Humphries,R.K. and Rouhi,A.
  TITLE     Elucidating the importance and regulation of key enhancers for
            human MEIS1 expression
  JOURNAL   Leukemia 36 (8), 1980-1989 (2022)
   PUBMED   35624144
  REMARK    GeneRIF: Elucidating the importance and regulation of key enhancers
            for human MEIS1 expression.
REFERENCE   3  (bases 1 to 4566)
  AUTHORS   Le Nabec,A., Blotas,C., Briset,A., Collobert,M., Ferec,C. and
            Moisan,S.
  TITLE     3D Chromatin Organization Involving MEIS1 Factor in the
            cis-Regulatory Landscape of GJB2
  JOURNAL   Int J Mol Sci 23 (13), 6964 (2022)
   PUBMED   35805969
  REMARK    GeneRIF: 3D Chromatin Organization Involving MEIS1 Factor in the
            cis-Regulatory Landscape of GJB2.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4566)
  AUTHORS   Li,Y., Gan,Y., Liu,J., Li,J., Zhou,Z., Tian,R., Sun,R., Liu,J.,
            Xiao,Q., Li,Y., Lu,P., Peng,Y., Peng,Y., Shu,G. and Yin,G.
  TITLE     Downregulation of MEIS1 mediated by ELFN1-AS1/EZH2/DNMT3a axis
            promotes tumorigenesis and oxaliplatin resistance in colorectal
            cancer
  JOURNAL   Signal Transduct Target Ther 7 (1), 87 (2022)
   PUBMED   35351858
  REMARK    GeneRIF: Downregulation of MEIS1 mediated by ELFN1-AS1/EZH2/DNMT3a
            axis promotes tumorigenesis and oxaliplatin resistance in
            colorectal cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4566)
  AUTHORS   Choi,J.H., Jang,T.Y., Jeon,S.E., Kim,J.H., Lee,C.J., Yun,H.J.,
            Jung,J.Y., Park,S.Y. and Nam,J.S.
  TITLE     The Small-Molecule Wnt Inhibitor ICG-001 Efficiently Inhibits
            Colorectal Cancer Stemness and Metastasis by Suppressing MEIS1
            Expression
  JOURNAL   Int J Mol Sci 22 (24), 13413 (2021)
   PUBMED   34948208
  REMARK    GeneRIF: The Small-Molecule Wnt Inhibitor ICG-001 Efficiently
            Inhibits Colorectal Cancer Stemness and Metastasis by Suppressing
            MEIS1 Expression.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4566)
  AUTHORS   Knoepfler,P.S., Calvo,K.R., Chen,H., Antonarakis,S.E. and
            Kamps,M.P.
  TITLE     Meis1 and pKnox1 bind DNA cooperatively with Pbx1 utilizing an
            interaction surface disrupted in oncoprotein E2a-Pbx1
  JOURNAL   Proc Natl Acad Sci U S A 94 (26), 14553-14558 (1997)
   PUBMED   9405651
REFERENCE   7  (bases 1 to 4566)
  AUTHORS   Shen,W.F., Montgomery,J.C., Rozenfeld,S., Moskow,J.J.,
            Lawrence,H.J., Buchberg,A.M. and Largman,C.
  TITLE     AbdB-like Hox proteins stabilize DNA binding by the Meis1
            homeodomain proteins
  JOURNAL   Mol Cell Biol 17 (11), 6448-6458 (1997)
   PUBMED   9343407
REFERENCE   8  (bases 1 to 4566)
  AUTHORS   Smith,J.E. Jr., Bollekens,J.A., Inghirami,G. and Takeshita,K.
  TITLE     Cloning and mapping of the MEIS1 gene, the human homolog of a
            murine leukemogenic gene
  JOURNAL   Genomics 43 (1), 99-103 (1997)
   PUBMED   9226379
REFERENCE   9  (bases 1 to 4566)
  AUTHORS   Steelman,S., Moskow,J.J., Muzynski,K., North,C., Druck,T.,
            Montgomery,J.C., Huebner,K., Daar,I.O. and Buchberg,A.M.
  TITLE     Identification of a conserved family of Meis1-related homeobox
            genes
  JOURNAL   Genome Res 7 (2), 142-156 (1997)
   PUBMED   9049632
REFERENCE   10 (bases 1 to 4566)
  AUTHORS   Moskow,J.J., Bullrich,F., Huebner,K., Daar,I.O. and Buchberg,A.M.
  TITLE     Meis1, a PBX1-related homeobox gene involved in myeloid leukemia in
            BXH-2 mice
  JOURNAL   Mol Cell Biol 15 (10), 5434-5443 (1995)
   PUBMED   7565694
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC092669.2, BC043503.1,
            AL832770.1, AI203963.1, U85707.1, CB854199.1 and AC007392.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_002398.2.
            
            Summary: Homeobox genes, of which the most well-characterized
            category is represented by the HOX genes, play a crucial role in
            normal development. In addition, several homeoproteins are involved
            in neoplasia. This gene encodes a homeobox protein belonging to the
            TALE ('three amino acid loop extension') family of
            homeodomain-containing proteins. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.241017.1,
                                           SRR1660809.75844.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000272369.14/ ENSP00000272369.8
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-275               AC092669.2         60535-60809         c
            276-442             BC043503.1         1-167
            443-619             AL832770.1         182-358
            620-659             AI203963.1         9-48
            660-1942            BC043503.1         380-1662
            1943-3178           U85707.1           1276-2511
            3179-3456           CB854199.1         18-295              c
            3457-4566           AC007392.4         155114-156223       c
FEATURES             Location/Qualifiers
     source          1..4566
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p14"
     gene            1..4566
                     /gene="MEIS1"
                     /note="Meis homeobox 1"
                     /db_xref="GeneID:4211"
                     /db_xref="HGNC:HGNC:7000"
                     /db_xref="MIM:601739"
     exon            1..744
                     /gene="MEIS1"
                     /inference="alignment:Splign:2.1.0"
     CDS             733..1905
                     /gene="MEIS1"
                     /note="WUGSC:H_NH0444B04.1; leukemogenic homolog protein;
                     Meis1, myeloid ecotropic viral integration site 1 homolog"
                     /codon_start=1
                     /product="homeobox protein Meis1"
                     /protein_id="NP_002389.1"
                     /db_xref="CCDS:CCDS46309.1"
                     /db_xref="GeneID:4211"
                     /db_xref="HGNC:HGNC:7000"
                     /db_xref="MIM:601739"
                     /translation="MAQRYDDLPHYGGMDGVGIPSTMYGDPHAARSMQPVHHLNHGPP
                     LHSHQYPHTAHTNAMAPSMGSSVNDALKRDKDAIYGHPLFPLLALIFEKCELATCTPR
                     EPGVAGGDVCSSESFNEDIAVFAKQIRAEKPLFSSNPELDNLMIQAIQVLRFHLLELE
                     KVHELCDNFCHRYISCLKGKMPIDLVIDDREGGSKSDSEDITRSANLTDQPSWNRDHD
                     DTASTRSGGTPGPSSGGHTSHSGDNSSEQGDGLDNSVASPSTGDDDDPDKDKKRHKKR
                     GIFPKVATNIMRAWLFQHLTHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPM
                     IDQSNRAVSQGTPYNPDGQPMGGFVMDGQQHMGIRAPGPMSGMGMNMGMEGQWHYM"
     exon            745..971
                     /gene="MEIS1"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1113
                     /gene="MEIS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1164
                     /gene="MEIS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1215
                     /gene="MEIS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..1362
                     /gene="MEIS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1474
                     /gene="MEIS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1475..1620
                     /gene="MEIS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1621..1697
                     /gene="MEIS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1698..1756
                     /gene="MEIS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1757..1846
                     /gene="MEIS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1847..1942
                     /gene="MEIS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1943..4566
                     /gene="MEIS1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3121..3126
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MEIS1"
                     /note="hexamer: AATAAA"
     polyA_site      3151
                     /gene="MEIS1"
                     /note="major polyA site"
     regulatory      3432..3437
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MEIS1"
                     /note="hexamer: AATAAA"
     polyA_site      3456
                     /gene="MEIS1"
     regulatory      4547..4552
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MEIS1"
                     /note="hexamer: AATAAA"
     polyA_site      4566
                     /gene="MEIS1"
ORIGIN      
        1 attctggtcg gaatccacct ctccgcctgt gcaacacaca ctttacacac gcacggggac
       61 tgcaagcggg cagcatcgat cgtggctcct ttaagacaaa ctcagacaga catttttttt
      121 aaccctcctt ctctaatctc cttccagtgc agcacttgca aagagggaga gagagggaga
      181 gaaagaaaga gagagagaga agagagaaac tgattaggaa ttaggactga ttcaagggaa
      241 gcgagcgcta gggctttgtg catttgaata ttaacatttg aggtgttctg accagaagaa
      301 gacagagcgg atgatcattc attcaccacg ttgacaacct cgcctgtgat tgacagctgg
      361 agtggcagaa agccatgaga tttggtagtt gggtctgagg ggcgctcttt tttttccttt
      421 tctttctttc tttctttttt tttttttaaa ctgatttttg ggggagagaa gatctgcttt
      481 tttttgcccc cgctgctgtc ttggaaacgg agcgctttta tgctcagtga ctcgggcgct
      541 ttgcttcagg tcccgtagac cgaagatctg ggaccagtag ctcacgttgc tggagacgtt
      601 aagggatttt tcgtcgtgct tttttttttt tttttttttt tttccggggg agtttgaata
      661 tttgtttctt ttcacactgg ccttaaagag gatatattag aagttgaagt aggaagggag
      721 ccagagaggc cgatggcgca aaggtacgac gatctacccc attacggggg catggatgga
      781 gtaggcatcc cctccacgat gtatggggac ccgcatgcag ccaggtccat gcagccggtc
      841 caccacctga accacgggcc tcctctgcac tcgcatcagt acccgcacac agctcatacc
      901 aacgccatgg cccccagcat gggctcctct gtcaatgacg ctttaaagag agataaagat
      961 gccatttatg gacaccccct cttccctctc ttagcactga tttttgagaa atgtgaatta
     1021 gctacttgta ccccccgcga gccgggggtg gcgggcgggg acgtctgctc gtcagagtca
     1081 ttcaatgaag atatagccgt gttcgccaaa cagattcgcg cagaaaaacc tctattttct
     1141 tctaatccag aactggataa cttgatgatt caagccatac aagtattaag gtttcatcta
     1201 ttggaattag agaaggtaca cgaattatgt gacaatttct gccaccggta tattagctgt
     1261 ttgaaaggga aaatgcctat cgatttggtg atagacgata gagaaggagg atcaaaatca
     1321 gacagtgaag atataacaag atcagcaaat ctaactgacc agccctcttg gaacagagat
     1381 catgatgaca cggcatctac tcgttcagga ggaaccccag gcccttccag cggtggccac
     1441 acgtcacaca gtggggacaa cagcagtgag caaggtgatg gcttggacaa cagtgtagct
     1501 tcccccagca caggtgacga tgatgaccct gataaggaca aaaagcgtca caaaaagcgt
     1561 ggcatctttc ccaaagtagc cacaaatatc atgagggcgt ggctgttcca gcatctaaca
     1621 cacccttacc cttctgaaga acagaaaaag cagttggcac aagacacggg actcaccatc
     1681 cttcaagtga acaattggtt tattaatgcc cggagaagaa tagtgcagcc catgatagac
     1741 cagtccaacc gagcagtaag tcaaggaaca ccttataatc ctgatggaca gcccatggga
     1801 ggtttcgtaa tggacggtca gcaacatatg ggaattagag caccaggacc tatgagtgga
     1861 atgggcatga atatgggcat ggaggggcag tggcactaca tgtaaccttc atctagttaa
     1921 ccaatcgcaa agcaaggggg aaggctgcaa agtatgccag gggagtatgt agcccggggt
     1981 ggtccaatgg gtgtgagtat gggacagcca agttataccc aaccccagat gcccccccat
     2041 cctgctcagc tgcgtcatgg gccccccatg catacgtaca ttcctggaca ccctcaccac
     2101 ccaacagtga tgatgcatgg aggaccgccc caccctggaa tgccaatgtc agcatcaagc
     2161 cccacagttc ttaatacagg agacccaaca atgagtggac aagtcatgga cattcatgct
     2221 cagtagctta agggaatatg cattgtctgc aatggtgact gatttcaaat catgtttttt
     2281 ctgcaatgac tgtggagttc cattcttggc atctactctg gaccaaggag catccctaat
     2341 tcttcatagg gacctttaaa aagcaggaaa taccaactga agtcaatttg ggggacatgc
     2401 taaataacta tataagacat taagagaaca aagagtgaaa tattgtaaat gctattatac
     2461 tgttatccat attacgttgt ttcttataga ttttttaaaa aaaatgtgaa atttttccac
     2521 actatgtgtg ttgtttccat agctcttcac ttcctccaga agcctcctta cattaaaaag
     2581 ccttacagtt atcctgcaag ggacaggaag gtctgatttg caggattttt agagcattaa
     2641 aataactatc aggcagaaga atctttcttc tcgcctagga tttcagccat gcgcgcgctc
     2701 tctctctttc tctctctttt cctctctctc cctctttcta gcctggggct tgaatttgca
     2761 tgtctaattc atttactcac catatttgaa ttggcctgaa cagatgtaaa tcgggaagga
     2821 tgggaaaaac tgcagtcatc aacaatgatt aatcagctgt tgcaggcagt gtcttaagga
     2881 gactggtagg aggaggcatg gaaaccaaaa ggccgtgtgt ttagaagcct aattgtcaca
     2941 tcaagcatca ttgtccccat gcaacaacca ccaccttata catcacttcc tgttttaagc
     3001 agctctaaaa catagactga agatttattt ttaatatgtt gactttattt ctgagcaaag
     3061 catcggtcat gtgtgtattt tttcatagtc ccaccttgga gcatttatgt agacattgta
     3121 aataaatttt gtgcaaaaag gactggaaaa atgaactgta ttattgcaat ttttttttgt
     3181 aaaagtagca gtttggtatg agttggcatg catacaagat ttactaagtg ggataagcta
     3241 attatacttt ttgttgtgga taaacaaatg cttgttgata gcctttttct atcaagaaac
     3301 caaggagcta attattaata acaatcattg cacactgagt cttagcgttt ctgatggaaa
     3361 cagtttggat tgtataataa cgccaagccc agttgtagtc gtttgagtgc agtaatgaaa
     3421 tctgaatcta aaataaaaac aagattattt ttgtcatgct gactccactg cttgaaaaat
     3481 ttgtttactg ccccccagat ttttaaagat taatacagta aatataaaaa ttaattttgg
     3541 ctccctaagc catatatgta tttgacaatt ttaaccgcaa agtaagttgt ttaataataa
     3601 ccactgattt ctttaagctg acttaatgaa ctcctaatat cagcaaattt gaggcctaaa
     3661 ggcactaaac taactctaga ctcagaatta catccaacag aattactcat ctaatatcag
     3721 tgaaattatt cttgcacata aaggcaaacc taagtacaaa gttaagtctt ttactaaagg
     3781 atgttaccta ggatgagcag tatatgttta ttaggaaatt aactacatga attgaagaga
     3841 ccagacttca aaatctaatt tttataaata tgctctatgt tctcattgga taaaactggt
     3901 tattaaccaa ttttccagaa cagctgtaca agatttctgc atggcagccg gctaaatggt
     3961 agaaaataat atgtttaagc tggaatagct tataatttta tttaaataaa attgctgcta
     4021 taaaaagtgc ttcccaaagc taaggaaaat atacaaatat tttaattaag gcaaattcgt
     4081 tttaaaaaat aagcctttca gtagtgattg ctttgtaaac aaaggatggg tcggaggaga
     4141 gagagcctta aactcaagtc tgacattcag gcccaagtca ccctataaac cggcccttag
     4201 caattctatt ttctattcga aaagagaaac cagctgtggg ttggctttac taggtgatgt
     4261 gtgattgact gactcacctg ctggagtagc aatgcattct caccttttgc tgatggggcc
     4321 ttgtttctaa acacgtggat gcgcagagag caaggctcag cctactgcag ccatctctgg
     4381 cagcgcttct acccctcccc agcccataga tgggattgtt taaatctccc ttgttgacct
     4441 agtggcaatt cttcctctac ctaaatagtc gatgtgagtg aaatcattct cttttgatag
     4501 gtggttgcta gcagttaaca accatttatt tactttaaca attaataata aactttataa
     4561 actgtc
//
