LOCUS       NP_002389                390 aa            linear   PRI 17-JUN-2024
DEFINITION  homeobox protein Meis1 [Homo sapiens].
ACCESSION   NP_002389
VERSION     NP_002389.1
DBSOURCE    REFSEQ: accession NM_002398.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 390)
  AUTHORS   Javanshir,E., Ebrahimi,Z.J., Mirzohreh,S.T., Ghaffari,S.,
            Banisefid,E., Alamdari,N.M. and Roshanravan,N.
  TITLE     Disparity of gene expression in coronary artery disease: insights
            from MEIS1, HIRA, and Myocardin
  JOURNAL   Mol Biol Rep 51 (1), 712 (2024)
   PUBMED   38824221
  REMARK    GeneRIF: Disparity of gene expression in coronary artery disease:
            insights from MEIS1, HIRA, and Myocardin.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 390)
  AUTHORS   Xiang,P., Yang,X., Escano,L., Dhillon,I., Schneider,E.,
            Clemans-Gibbon,J., Wei,W., Wong,J., Wang,S.X., Tam,D., Deng,Y.,
            Yung,E., Morin,G.B., Hoodless,P.A., Hirst,M., Karsan,A.,
            Kuchenbauer,F., Humphries,R.K. and Rouhi,A.
  TITLE     Elucidating the importance and regulation of key enhancers for
            human MEIS1 expression
  JOURNAL   Leukemia 36 (8), 1980-1989 (2022)
   PUBMED   35624144
  REMARK    GeneRIF: Elucidating the importance and regulation of key enhancers
            for human MEIS1 expression.
REFERENCE   3  (residues 1 to 390)
  AUTHORS   Le Nabec,A., Blotas,C., Briset,A., Collobert,M., Ferec,C. and
            Moisan,S.
  TITLE     3D Chromatin Organization Involving MEIS1 Factor in the
            cis-Regulatory Landscape of GJB2
  JOURNAL   Int J Mol Sci 23 (13), 6964 (2022)
   PUBMED   35805969
  REMARK    GeneRIF: 3D Chromatin Organization Involving MEIS1 Factor in the
            cis-Regulatory Landscape of GJB2.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 390)
  AUTHORS   Li,Y., Gan,Y., Liu,J., Li,J., Zhou,Z., Tian,R., Sun,R., Liu,J.,
            Xiao,Q., Li,Y., Lu,P., Peng,Y., Peng,Y., Shu,G. and Yin,G.
  TITLE     Downregulation of MEIS1 mediated by ELFN1-AS1/EZH2/DNMT3a axis
            promotes tumorigenesis and oxaliplatin resistance in colorectal
            cancer
  JOURNAL   Signal Transduct Target Ther 7 (1), 87 (2022)
   PUBMED   35351858
  REMARK    GeneRIF: Downregulation of MEIS1 mediated by ELFN1-AS1/EZH2/DNMT3a
            axis promotes tumorigenesis and oxaliplatin resistance in
            colorectal cancer.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 390)
  AUTHORS   Choi,J.H., Jang,T.Y., Jeon,S.E., Kim,J.H., Lee,C.J., Yun,H.J.,
            Jung,J.Y., Park,S.Y. and Nam,J.S.
  TITLE     The Small-Molecule Wnt Inhibitor ICG-001 Efficiently Inhibits
            Colorectal Cancer Stemness and Metastasis by Suppressing MEIS1
            Expression
  JOURNAL   Int J Mol Sci 22 (24), 13413 (2021)
   PUBMED   34948208
  REMARK    GeneRIF: The Small-Molecule Wnt Inhibitor ICG-001 Efficiently
            Inhibits Colorectal Cancer Stemness and Metastasis by Suppressing
            MEIS1 Expression.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 390)
  AUTHORS   Knoepfler,P.S., Calvo,K.R., Chen,H., Antonarakis,S.E. and
            Kamps,M.P.
  TITLE     Meis1 and pKnox1 bind DNA cooperatively with Pbx1 utilizing an
            interaction surface disrupted in oncoprotein E2a-Pbx1
  JOURNAL   Proc Natl Acad Sci U S A 94 (26), 14553-14558 (1997)
   PUBMED   9405651
REFERENCE   7  (residues 1 to 390)
  AUTHORS   Shen,W.F., Montgomery,J.C., Rozenfeld,S., Moskow,J.J.,
            Lawrence,H.J., Buchberg,A.M. and Largman,C.
  TITLE     AbdB-like Hox proteins stabilize DNA binding by the Meis1
            homeodomain proteins
  JOURNAL   Mol Cell Biol 17 (11), 6448-6458 (1997)
   PUBMED   9343407
REFERENCE   8  (residues 1 to 390)
  AUTHORS   Smith,J.E. Jr., Bollekens,J.A., Inghirami,G. and Takeshita,K.
  TITLE     Cloning and mapping of the MEIS1 gene, the human homolog of a
            murine leukemogenic gene
  JOURNAL   Genomics 43 (1), 99-103 (1997)
   PUBMED   9226379
REFERENCE   9  (residues 1 to 390)
  AUTHORS   Steelman,S., Moskow,J.J., Muzynski,K., North,C., Druck,T.,
            Montgomery,J.C., Huebner,K., Daar,I.O. and Buchberg,A.M.
  TITLE     Identification of a conserved family of Meis1-related homeobox
            genes
  JOURNAL   Genome Res 7 (2), 142-156 (1997)
   PUBMED   9049632
REFERENCE   10 (residues 1 to 390)
  AUTHORS   Moskow,J.J., Bullrich,F., Huebner,K., Daar,I.O. and Buchberg,A.M.
  TITLE     Meis1, a PBX1-related homeobox gene involved in myeloid leukemia in
            BXH-2 mice
  JOURNAL   Mol Cell Biol 15 (10), 5434-5443 (1995)
   PUBMED   7565694
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC092669.2, BC043503.1,
            AL832770.1, AI203963.1, U85707.1, CB854199.1 and AC007392.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: Homeobox genes, of which the most well-characterized
            category is represented by the HOX genes, play a crucial role in
            normal development. In addition, several homeoproteins are involved
            in neoplasia. This gene encodes a homeobox protein belonging to the
            TALE ('three amino acid loop extension') family of
            homeodomain-containing proteins. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.241017.1,
                                           SRR1660809.75844.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000272369.14/ ENSP00000272369.8
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..390
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p14"
     Protein         1..390
                     /product="homeobox protein Meis1"
                     /note="WUGSC:H_NH0444B04.1; leukemogenic homolog protein;
                     Meis1, myeloid ecotropic viral integration site 1 homolog"
                     /calculated_mol_wt=42885
     Region          108..192
                     /region_name="Meis_PKNOX_N"
                     /note="N-terminal of Homeobox Meis and PKNOX1; pfam16493"
                     /db_xref="CDD:465140"
     Region          190..279
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O00470.1)"
     Site            order(278,321,324..325,328)
                     /site_type="other"
                     /note="specific DNA base contacts [nucleotide binding]"
                     /db_xref="CDD:238039"
     Region          291..329
                     /region_name="Homeobox_KN"
                     /note="Homeobox KN domain; pfam05920"
                     /db_xref="CDD:428673"
     Region          299..329
                     /region_name="Interaction with DNA.
                     /evidence=ECO:0000305|PubMed:26550823,
                     ECO:0000305|PubMed:28473536"
                     /note="propagated from UniProtKB/Swiss-Prot (O00470.1)"
     Region          335..390
                     /region_name="Required for transcriptional activation.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (O00470.1)"
     CDS             1..390
                     /gene="MEIS1"
                     /coded_by="NM_002398.3:733..1905"
                     /db_xref="CCDS:CCDS46309.1"
                     /db_xref="GeneID:4211"
                     /db_xref="HGNC:HGNC:7000"
                     /db_xref="MIM:601739"
ORIGIN      
        1 maqryddlph yggmdgvgip stmygdphaa rsmqpvhhln hgpplhshqy phtahtnama
       61 psmgssvnda lkrdkdaiyg hplfpllali fekcelatct prepgvaggd vcssesfned
      121 iavfakqira ekplfssnpe ldnlmiqaiq vlrfhllele kvhelcdnfc hryisclkgk
      181 mpidlviddr eggsksdsed itrsanltdq pswnrdhddt astrsggtpg pssgghtshs
      241 gdnsseqgdg ldnsvaspst gddddpdkdk krhkkrgifp kvatnimraw lfqhlthpyp
      301 seeqkkqlaq dtgltilqvn nwfinarrri vqpmidqsnr avsqgtpynp dgqpmggfvm
      361 dgqqhmgira pgpmsgmgmn mgmegqwhym
//
