LOCUS       NM_001310124            2568 bp    mRNA    linear   PRI 07-DEC-2024
DEFINITION  Homo sapiens meiosis initiator (MEIOSIN), mRNA.
ACCESSION   NM_001310124
VERSION     NM_001310124.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2568)
  AUTHORS   Zhang,Q., Zhang,W., Wu,X., Ke,H., Qin,Y., Zhao,S. and Guo,T.
  TITLE     Homozygous missense variant in MEIOSIN causes premature ovarian
            insufficiency
  JOURNAL   Hum Reprod 38 (Suppl 2), ii47-ii56 (2023)
   PUBMED   37982418
  REMARK    GeneRIF: Homozygous missense variant in MEIOSIN causes premature
            ovarian insufficiency.
REFERENCE   2  (bases 1 to 2568)
  AUTHORS   Ishiguro,K.I., Matsuura,K., Tani,N., Takeda,N., Usuki,S.,
            Yamane,M., Sugimoto,M., Fujimura,S., Hosokawa,M., Chuma,S.,
            Ko,M.S.H., Araki,K. and Niwa,H.
  TITLE     MEIOSIN Directs the Switch from Mitosis to Meiosis in Mammalian
            Germ Cells
  JOURNAL   Dev Cell 52 (4), 429-445 (2020)
   PUBMED   32032549
REFERENCE   3  (bases 1 to 2568)
  AUTHORS   Gascoigne,D.K., Cheetham,S.W., Cattenoz,P.B., Clark,M.B.,
            Amaral,P.P., Taft,R.J., Wilhelm,D., Dinger,M.E. and Mattick,J.S.
  TITLE     Pinstripe: a suite of programs for integrating transcriptomic and
            proteomic datasets identifies novel proteins and improves
            differentiation of protein-coding and non-coding genes
  JOURNAL   Bioinformatics 28 (23), 3042-3050 (2012)
   PUBMED   23044541
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BI463439.1, BQ215245.1, DV080302.1 and AC074212.5.
            
            On Aug 6, 2019 this sequence version replaced NM_001310124.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1968968,
                              SAMEA2148093 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000457052.3/ ENSP00000402674.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-458               BI463439.1         200-657
            459-1000            BQ215245.1         83-624
            1001-1525           DV080302.1         1-525               c
            1526-1662           AC074212.5         22736-22872
            1663-1907           AC074212.5         22944-23188
            1908-1997           AC074212.5         24343-24432
            1998-2568           AC074212.5         24976-25546
FEATURES             Location/Qualifiers
     source          1..2568
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.32"
     gene            1..2568
                     /gene="MEIOSIN"
                     /gene_synonym="BHMG1; HMGDC"
                     /note="meiosis initiator"
                     /db_xref="GeneID:388553"
                     /db_xref="HGNC:HGNC:44318"
     exon            1..228
                     /gene="MEIOSIN"
                     /gene_synonym="BHMG1; HMGDC"
                     /inference="alignment:Splign:2.1.0"
     CDS             229..2145
                     /gene="MEIOSIN"
                     /gene_synonym="BHMG1; HMGDC"
                     /note="HMG domain containing; basic helix-loop-helix and
                     HMG box domain-containing protein 1; basic
                     helix-loop-helix and HMG box domain containing 1; basic
                     helix-loop-helix and HMG-box containing 1"
                     /codon_start=1
                     /product="meiosis initiator protein"
                     /protein_id="NP_001297053.1"
                     /db_xref="CCDS:CCDS82368.1"
                     /db_xref="GeneID:388553"
                     /db_xref="HGNC:HGNC:44318"
                     /translation="MFGSSRYLGSSEQPRANSLGPSDRTLVLCSLVEGEDKVNPSEPH
                     GLRMEEKWLLKGKLRNQRNQNKLLSPNKKQRKNHTSKLQELALLLPIALKTGTKKLTK
                     KEILVHVLQYIQYLQRNIDAAKALFKCHITTGEGGLAGLGQKPAWGPARRRRHSTPSS
                     SPSSQKSCLQGACQKPRKKKLTQASESQTRTPKPRRSLALNKPEKLVAPSPDQKGSGT
                     GGTTTPPRCPDSCGHPRPASSSPPGDRKGGQSQLTLLDLAEDTIHCDISSCWCQGSVQ
                     DDAPFPALLAQEDVARIHFLNKTQPHPRQKLVFYDSSEDVDKGSLDADPWLPAWTPEN
                     SPQGSPLFLGPPQIDVWSGTGHPSEILGLSPSLFSSPGKLLPDEILEDDMEYLTQAAF
                     FEEVCLDLESSPSAYTQEAPQEKDTASKAPKDPPESHSLHRSSVSLDHCYLSLSGNSK
                     APSSSSSSSSSSSSSEDSDSEPLWKQREDMQANPVGTPGSSEEDEDTTWTPTRLASPL
                     LAAEKKATKGQVARAPVKPKEKKKGPCPPQMKKKCVNGFIMFCRMNRKQYIRSCPGTA
                     STAATKELAQLWRVMTQQERRPYCTKARRFSRQHNRIVKQDGSSSEAEDWETPKPFYQ
                     LLAEKALPLPPHLQ"
     exon            229..299
                     /gene="MEIOSIN"
                     /gene_synonym="BHMG1; HMGDC"
                     /inference="alignment:Splign:2.1.0"
     exon            300..404
                     /gene="MEIOSIN"
                     /gene_synonym="BHMG1; HMGDC"
                     /inference="alignment:Splign:2.1.0"
     exon            405..534
                     /gene="MEIOSIN"
                     /gene_synonym="BHMG1; HMGDC"
                     /inference="alignment:Splign:2.1.0"
     exon            535..646
                     /gene="MEIOSIN"
                     /gene_synonym="BHMG1; HMGDC"
                     /inference="alignment:Splign:2.1.0"
     exon            647..784
                     /gene="MEIOSIN"
                     /gene_synonym="BHMG1; HMGDC"
                     /inference="alignment:Splign:2.1.0"
     exon            785..1030
                     /gene="MEIOSIN"
                     /gene_synonym="BHMG1; HMGDC"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1139
                     /gene="MEIOSIN"
                     /gene_synonym="BHMG1; HMGDC"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1240
                     /gene="MEIOSIN"
                     /gene_synonym="BHMG1; HMGDC"
                     /inference="alignment:Splign:2.1.0"
     exon            1241..1396
                     /gene="MEIOSIN"
                     /gene_synonym="BHMG1; HMGDC"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1473
                     /gene="MEIOSIN"
                     /gene_synonym="BHMG1; HMGDC"
                     /inference="alignment:Splign:2.1.0"
     exon            1474..1662
                     /gene="MEIOSIN"
                     /gene_synonym="BHMG1; HMGDC"
                     /inference="alignment:Splign:2.1.0"
     exon            1663..1907
                     /gene="MEIOSIN"
                     /gene_synonym="BHMG1; HMGDC"
                     /inference="alignment:Splign:2.1.0"
     exon            1908..1997
                     /gene="MEIOSIN"
                     /gene_synonym="BHMG1; HMGDC"
                     /inference="alignment:Splign:2.1.0"
     exon            1998..2568
                     /gene="MEIOSIN"
                     /gene_synonym="BHMG1; HMGDC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2532..2537
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MEIOSIN"
                     /gene_synonym="BHMG1; HMGDC"
                     /note="hexamer: AATAAA"
     regulatory      2537..2542
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MEIOSIN"
                     /gene_synonym="BHMG1; HMGDC"
                     /note="hexamer: AATAAA"
     polyA_site      2552
                     /gene="MEIOSIN"
                     /gene_synonym="BHMG1; HMGDC"
                     /note="major polyA site"
     polyA_site      2568
                     /gene="MEIOSIN"
                     /gene_synonym="BHMG1; HMGDC"
                     /note="major polyA site"
ORIGIN      
        1 actcttgctc tgctcctcac gcctcgcgca ggatcctcgc gccgggagga ttcgcaccca
       61 accccaagcc cggttgggaa cgtggtgtcc gagaccgtct gggatccccg cgcgcacggc
      121 cggcttcccg ggacccgcgc gagacgctgt ctgatcgggc tccctagagt ggggcccgga
      181 gaaaccagaa cggcgggggc agcctcacgc cattttgcac gccctgagat gtttggttcc
      241 agcagatact tgggttcctc tgaacagccc agagctaatt cactgggtcc cagtgacagg
      301 accttggttt tgtgctccct agtggaaggg gaagataagg tcaacccctc cgaaccacat
      361 ggactgagaa tggaggagaa atggttgctc aaaggaaaac tgaggaatca gaggaaccaa
      421 aacaagctcc tgtccccaaa caagaagcag aggaaaaacc acactagcaa gctgcaagag
      481 ttggcactgc tgctgcccat agccctgaag acggggacca agaagctcac aaagaaggag
      541 attctggtgc atgtcctgca gtacattcag tacctccaga gaaacatcga tgccgccaag
      601 gccttgttca aatgccacat caccactggg gaaggtggac ttgcggggct gggtcagaaa
      661 ccagcctggg gcccagccag gcggaggaga cactctaccc cctccagctc cccaagctct
      721 cagaagtcct gtctccaggg ggcgtgccag aagcctcgga agaagaagct gacccaggca
      781 tcagaaagcc agactcggac cccgaagcct cgccgctctc tggccctgaa caagcctgag
      841 aagctggtgg ccccatcccc agaccagaaa ggaagtggca caggggggac cactacccct
      901 ccaaggtgcc ctgactcctg cggtcacccg aggcctgcat catcctcacc tccaggtgac
      961 agaaaaggag gacagtccca gctgacgctg ttggatctgg ccgaggacac catccactgt
     1021 gacatctcaa gctgctggtg ccagggcagt gtccaggatg acgcaccttt ccctgcgctc
     1081 ctggctcagg aagatgtggc gaggatccat tttctcaaca agacccagcc ccatcccagg
     1141 cagaagctgg tgttctatga ttccagcgag gatgtggaca aagggtccct agacgctgac
     1201 ccttggctcc ctgcctggac cccagagaac agcccccaag ggagcccact gttcctgggg
     1261 cctccccaga ttgatgtctg gagtggaaca ggccacccaa gtgagatcct cgggctcagc
     1321 cctagccttt tcagctcccc agggaaactg ctgccagacg agatcttgga ggatgacatg
     1381 gagtacctga cccaagcggc tttctttgaa gaagtgtgct tagatctgga gtcttcacct
     1441 tcagcctaca cgcaggaggc tccacaggaa aaggacacag cctccaaggc ccccaaagac
     1501 cctcctgagt cccacagcct gcaccggtcc tcagtctcgc tggaccactg ctacctctcg
     1561 ctgagcggga acagcaaggc gccatccagc tccagctcca gctccagctc cagctccagc
     1621 tcggaggaca gcgactcgga gcccctgtgg aagcagcgag aggatatgca ggccaaccct
     1681 gtgggcacgc cgggctccag cgaagaggac gaagacacca catggacccc cacccggctg
     1741 gcctcacccc tgctggcagc tgagaaaaag gccacgaagg gccaagtagc cagggcccct
     1801 gtgaagccca aggagaagaa gaaaggcccc tgcccacccc agatgaagaa gaagtgtgtc
     1861 aacggcttca tcatgttctg caggatgaac cggaagcagt acatccgatc ctgccctgga
     1921 accgcttcca cagctgccac caaggagctg gcccagctgt ggcgggtgat gacccagcag
     1981 gagcggaggc catactgcac caaggctcgc aggttcagcc gccagcacaa ccgcatcgtg
     2041 aagcaggacg gctccagcag cgaggctgag gactgggaga cgccaaagcc cttctaccag
     2101 ctgctggccg agaaggcctt gccgctgccc ccgcacctcc agtgagaggg cggcccctcg
     2161 cctcgctccc ctcacccctc atggcaaccg cggctcttgc tggaagccag gacccatcga
     2221 tgaacttgtc cctcctgggc ctccagcccc tgagaatgca ggtcccatgg gactggggag
     2281 gggggcactg attagcccca accgctgggc acatttgcct ggagcaccag agtcacccac
     2341 agctgccttg attctccccc aggcttagga aggaaaccca aaatgaaatg cggggtgtcg
     2401 gaaggtgaag tttacccacc cctctcccct tcccttcccc accccagagc cactcggttg
     2461 caaccctgtt catgctcacc tcaccctact cctccctctc ctgttctatt tttagactat
     2521 ttattgtttt aaataaaata aagcaagtgg aacctttgtt accagcaa
//
