LOCUS       NM_001145080            4610 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens meiosis specific with coiled-coil domain (MEIOC),
            mRNA.
ACCESSION   NM_001145080
VERSION     NM_001145080.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4610)
  AUTHORS   Abby,E., Tourpin,S., Ribeiro,J., Daniel,K., Messiaen,S., Moison,D.,
            Guerquin,J., Gaillard,J.C., Armengaud,J., Langa,F., Toth,A.,
            Martini,E. and Livera,G.
  TITLE     Implementation of meiosis prophase I programme requires a conserved
            retinoid-independent stabilizer of meiotic transcripts
  JOURNAL   Nat Commun 7, 10324 (2016)
   PUBMED   26742488
  REMARK    GeneRIF: Meioc is expressed in germ cells during meiotic prophase
            I. MEIOC prevents meiotic transcript degradation and interacts with
            an RNA helicase that binds numerous meiotic mRNAs.
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB460166.1, DV080633.1, AC091152.18, BC041481.2 and AA205120.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001145080.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.72258.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000409122.7/ ENSP00000386452.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-387               DB460166.1         78-464
            388-635             DV080633.1         180-427
            636-1897            AC091152.18        117516-118777
            1898-3047           BC041481.2         1-1150
            3048-4330           AC091152.18        125354-126636
            4331-4608           AA205120.1         12-289              c
            4609-4610           AC091152.18        126915-126916
FEATURES             Location/Qualifiers
     source          1..4610
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.31"
     gene            1..4610
                     /gene="MEIOC"
                     /gene_synonym="C17orf104"
                     /note="meiosis specific with coiled-coil domain"
                     /db_xref="GeneID:284071"
                     /db_xref="HGNC:HGNC:26670"
                     /db_xref="MIM:616934"
     exon            1..215
                     /gene="MEIOC"
                     /gene_synonym="C17orf104"
                     /inference="alignment:Splign:2.1.0"
     CDS             147..3005
                     /gene="MEIOC"
                     /gene_synonym="C17orf104"
                     /note="meiosis-specific with coiled-coil domain protein"
                     /codon_start=1
                     /product="meiosis-specific coiled-coil domain-containing
                     protein MEIOC"
                     /protein_id="NP_001138552.2"
                     /db_xref="CCDS:CCDS45703.2"
                     /db_xref="GeneID:284071"
                     /db_xref="HGNC:HGNC:26670"
                     /db_xref="MIM:616934"
                     /translation="MEVRRGDTCPRPHPSGLREEGLEPKVAFPGGANRCWNLGADAGS
                     RLTDVFGSVMLTGSASFYDCYTSQSEDNVDLRQTYTPFSSTEYSSSVDSSLFCAPWST
                     YGDDIKQPSNSQISIKNRIQTERNDYGSETDLYGLVSNILEEQDKSQPYFAEGTCSSN
                     LKSVWPMNTSRFADHHDLLTETKRPIDTVISQQAFYSDESVSAMEKQYLRNSNLTPQQ
                     KIDELHHGFTGLDLEEQWMYPSRSDHSNCHNIQTNDTAKTTFQEYPLIKNCFTPQTGL
                     SDIMKESGVDIYHYGRDRICTKGLEAPLQQKRAEMFLSQFNRYNENVDYCRYPEYVHP
                     NKAKLNKCSNFSVQDSKKLANGTPETPTVEADTYTKLFQVKPANQKKMEETIPDQQNF
                     TFPKTTPHLTEKQFAKEAVFTADFGLTSEYGLKPHTACPANDFANVTEKQQFAKPDPP
                     HSEYFKSVNLLSNSATSSGGINLNRPTWMNVQTKNNTPIPYRNQGNLMKLNSHLSAAS
                     KGSNHSSDFPQLSSTNLTPNSNLFQKYCQENPSAFSSFDFSYSGAERIQSVNHIEGLT
                     KPGEENLFKLVTDKKIKQPNGFCDNYSAQKYGIIENVNKHNFQAKPQSGHYDPEEGPK
                     HLDGLSQNTYQDLLESQGHSNSHRTRGGDNSRVNRTQVSCFSNNYMMGDLRHNQCFQQ
                     LGSNGFPLRSTHPFGHSVVPLLDSYDLLSYDDLSHLYPYFNMMYGDNSFSGLMPTFGF
                     QRPIKTRSGPASELHIRLEECCEQWRALEKERKKTELALAKNYPGKKVSSTNNTPVPR
                     LTSNPSRVDRLIVDELRELARVVTLLGKMERLRSSLLHASISTALDRHLESIHIVQSR
                     RKDEIVNASNRQRQGVPRCQDDRDVFALASAIKEMCVATRKTRTALWCALQMTLPKTA
                     STADVVKPLQDTVNCEDKVHESINSSNPMNQRGETNKH"
     exon            216..350
                     /gene="MEIOC"
                     /gene_synonym="C17orf104"
                     /inference="alignment:Splign:2.1.0"
     exon            351..505
                     /gene="MEIOC"
                     /gene_synonym="C17orf104"
                     /inference="alignment:Splign:2.1.0"
     exon            506..610
                     /gene="MEIOC"
                     /gene_synonym="C17orf104"
                     /inference="alignment:Splign:2.1.0"
     exon            611..2468
                     /gene="MEIOC"
                     /gene_synonym="C17orf104"
                     /inference="alignment:Splign:2.1.0"
     exon            2469..2603
                     /gene="MEIOC"
                     /gene_synonym="C17orf104"
                     /inference="alignment:Splign:2.1.0"
     exon            2604..2784
                     /gene="MEIOC"
                     /gene_synonym="C17orf104"
                     /inference="alignment:Splign:2.1.0"
     exon            2785..4610
                     /gene="MEIOC"
                     /gene_synonym="C17orf104"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4588..4593
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MEIOC"
                     /gene_synonym="C17orf104"
                     /note="hexamer: AATAAA"
     polyA_site      4603
                     /gene="MEIOC"
                     /gene_synonym="C17orf104"
     polyA_site      4610
                     /gene="MEIOC"
                     /gene_synonym="C17orf104"
                     /note="major polyA site"
ORIGIN      
        1 acactggctc caggcagcgc ccgggcggcg gaggcggctg cggagacggc ggggtgcggg
       61 ctgagggagc cgggcctgga cgcccccccc atcacccccg taccccagga gctgtgccta
      121 gtccaggaga ggctgggggg cgccccatgg aggtgagacg cggagacacc tgcccgcgcc
      181 ctcacccctc aggcctgagg gaggaaggac ttgagcccaa agtcgcgttc cccggaggtg
      241 cgaatcgctg ttggaacctc ggcgccgacg ccggcagcag gttaaccgac gtcttcggca
      301 gcgtgatgtt gactggctcc gcttccttct acgattgcta cacatcgcag agtgaagaca
      361 atgtagacct aaggcagacc tatactccat tttcttcaac agaatattca agttctgtag
      421 attcttcact tttctgtgca ccatggtcta cttatggaga tgacattaaa caaccttcta
      481 attctcagat cagtataaag aacaggattc aaacagaaag aaatgactat ggcagtgaaa
      541 cagacttata tggacttgtg tctaacattt tggaagaaca agataagtca cagccatatt
      601 ttgctgaagg gacctgctcc tccaatttaa agtcagtttg gccaatgaac acaagcagat
      661 ttgcagatca ccatgacctc ttaacagaaa ccaaaaggcc aatagataca gtcatctctc
      721 agcaagcttt ttatagtgat gaatctgtgt cagcaatgga aaagcaatac ctgcgtaaca
      781 gtaatctcac accacaacaa aaaatagatg aacttcatca tggatttact ggtttagatc
      841 ttgaagaaca atggatgtac ccctcacgaa gtgatcattc taactgtcac aatattcaga
      901 caaatgatac agctaagaca acattccaag aatatccact tatcaaaaac tgttttacac
      961 cccaaactgg tctgtctgat atcatgaaag aatcaggagt tgatatctac cattatggaa
     1021 gagacagaat atgtactaaa ggtcttgaag caccactaca gcaaaaaagg gcagagatgt
     1081 ttctttctca atttaataga tacaatgaaa atgtagatta ttgtagatac ccagagtatg
     1141 ttcatcctaa taaggctaag cttaataaat gttcaaattt tagtgtccaa gatagcaaaa
     1201 aattagccaa tggcacacct gaaacaccaa ctgtagaagc agacacctac acaaagttat
     1261 ttcaggttaa gccagcgaat cagaaaaaaa tggaggagac aatccctgat cagcagaatt
     1321 tcacatttcc aaaaactacg ccacatctga cagagaaaca gtttgcaaag gaagcagtat
     1381 tcactgctga ttttggctta acatcagaat atggactaaa acctcacaca gcttgtcccg
     1441 ctaatgattt tgctaacgtc acagaaaagc aacagtttgc taaacctgat cccccacatt
     1501 ctgagtattt taaatcagtg aatttattat caaactcagc aacatcttca ggaggtatca
     1561 atttaaacag accaacttgg atgaatgttc aaacaaaaaa taacactcct attccttatc
     1621 gaaatcaagg taacttgatg aaattaaata gtcatttaag tgcagcttca aaaggttcta
     1681 accattcttc agatttcccc caactatcat ccacaaactt aaccccaaat agcaatttat
     1741 ttcagaaata ttgccaagaa aacccttcag cattttctag ttttgatttt agttacagtg
     1801 gtgcagaaag aatccaatct gtcaatcaca tagaaggact aacaaagcct ggagaagaaa
     1861 atctcttcaa attggttacg gataaaaaaa taaagcagcc aaatggattt tgtgataact
     1921 attcagctca gaagtatggg ataattgaaa atgtaaacaa acataatttt caagccaagc
     1981 cccagagtgg acattatgat cctgaggaag gtccaaagca tttagatggc ttatcacaaa
     2041 atacatacca agatctactg gagtcacagg gtcattctaa tagccacaga acgagaggtg
     2101 gagacaatag ccgtgtgaat cgcacacaag tgtcatgctt ttctaataat tatatgatgg
     2161 gagatttaag gcataatcag tgttttcaac aacttggttc aaatgggttt cccctaagat
     2221 ccacccaccc atttggccat tcagttgttc cactgttgga ttcctatgac ttactttctt
     2281 atgatgactt aagccatttg tacccttatt ttaatatgat gtatggtgat aattcttttt
     2341 ctggtctcat gccaactttt ggatttcaaa gaccaattaa aacccgtagt ggaccagcca
     2401 gtgaacttca tattcgtcta gaagagtgct gtgaacaatg gagagcatta gaaaaagaga
     2461 gaaaaaagac tgaattagcc cttgccaaga attatcctgg aaaaaaagta tccagtacta
     2521 acaacactcc agttccaagg ctgacttcca acccatctag agttgatcgc ttaattgtgg
     2581 atgaacttcg agaactagcc agagttgtga ctttactagg caaaatggaa cgtcttcgga
     2641 gttctcttct tcatgccagt atctctactg ctcttgatag acacttggag tctattcaca
     2701 ttgtacagtc acgtagaaag gatgaaattg ttaatgcttc caatcggcaa aggcaaggag
     2761 ttcctagatg ccaagatgac agagatgttt ttgcccttgc ttctgcaatt aaagagatgt
     2821 gtgtggctac tcggaaaaca cgcactgccc tgtggtgtgc actgcagatg accttgccaa
     2881 aaacagccag tacagctgat gtggtaaagc ctttacaaga tacagtaaac tgtgaagata
     2941 aagtccatga aagcataaat agtagcaatc caatgaacca gagaggtgaa acaaacaaac
     3001 attaaggaaa tgccagcaga aagaagaata aaaagctgat aaatatacca agacatgcta
     3061 aaaatgtttt aatgaacttg tcaaactttc agtatgtttt ctttcagatt taaagttaat
     3121 accagtacct taatgaagtc taacttctat ttaaaaatct tctatttgaa gtgaatccga
     3181 tatagtttta agtaaacgca aaggtacagt tgactactca gagttctgag tagtcagata
     3241 acaagtttaa gtaaattaaa tatttcctaa cagctaaaat gtgcttaaac tcattctgcc
     3301 atgcaggtaa atgcaaatgt gaaattcttc taggagataa atttcattta ggtttgtctt
     3361 agttaagtat aattccaaat aatgaatcta agtgactgta acccaattac ggctacagcc
     3421 tagtaaccaa gacaagtttt gattgtgata tcaaagtgtt ttccttacaa aactggataa
     3481 tacctgggaa acaaaggaaa atacggataa acccaatatt catgtacaaa cttaatattt
     3541 aaaatactat actaccatat ttataaattt ggaatcttaa tgcctaggta tatggaggga
     3601 aatgcatctg attctcctaa attaatgata aaagtgtcag tgtaaaaacc atgcaagtta
     3661 ctgaatataa aacctattca gatcatttgt gtatattctt taaattttaa ttatattatc
     3721 aattgttaaa tgtttccaat tttaaagtta tttaaattga atcacaaaac attcccttta
     3781 tctggatctt ttagacttga tgcacagtaa ctgaaataat gactactgtt ttaataccct
     3841 tagtttgctg ccttttatga gggtgtcacg aagttctaaa atgtattttt ttaaaggtta
     3901 atctctaact agtttagctt gcaattggtt agtgtatatt ttgtgtagtt gtgttcatta
     3961 gtttgcttct aagttctaaa atgtattttt taaaggttaa tctctaacta gtttagcttg
     4021 caattggtta gcctatattt tgcgtagttg tgttcattag tttgcttctg tattttttta
     4081 aaactattga aagcttaact ttttctgttt ctcatcactt agtatctttg tatagaactt
     4141 gagtaattta ttcgttaata tgaaatgttg gtattatgtg actcagaaga tcttgggttt
     4201 taacatttct agcatgagtt aaactataat gtactgatga aatttaattg aaatatcctt
     4261 gactagaaac actgatgttt taaatgttag tgtttttctt agttttagaa attctggtat
     4321 taaaaaaaaa aagagtgtaa tcataccaca taaattttct ttagatgatg tgcagaagaa
     4381 actgattgag aatgcaagag taactgtagg gagaaacatt ttgatcactg atatgcctta
     4441 gaactaccca aatgaattac attgagggta gtcaaataaa atagatcatc tcaccacagt
     4501 cactgcatag aaagtggtta agtttaacat aagacatgtt ggatgttata aaaacaaata
     4561 ctgtactgaa tttagtctca ggaaaaaaat aaattacttt gttgaaaaca
//
