LOCUS       NM_001163560            1867 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens meiosis specific with OB-fold (MEIOB), transcript
            variant 1, mRNA.
ACCESSION   NM_001163560
VERSION     NM_001163560.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1867)
  AUTHORS   Xu,Y., Chen,Z., Wu,P., Qu,W., Shi,H., Cheng,M., Xu,Y., Jin,T.,
            Liu,C., Li,Y. and Luo,M.
  TITLE     Nuclear localization of human MEIOB requires its NLS in the OB
            domain and interaction with SPATA22
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 55 (1), 154-161 (2022)
   PUBMED   36331299
  REMARK    GeneRIF: Nuclear localization of human MEIOB requires its NLS in
            the OB domain and interaction with SPATA22.
REFERENCE   2  (bases 1 to 1867)
  AUTHORS   Wang,Y., Liu,L., Tan,C., Meng,G., Meng,L., Nie,H., Du,J., Lu,G.X.,
            Lin,G., He,W.B. and Tan,Y.Q.
  TITLE     Novel MEIOB variants cause primary ovarian insufficiency and
            non-obstructive azoospermia
  JOURNAL   Front Genet 13, 936264 (2022)
   PUBMED   35991565
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1867)
  AUTHORS   Wu,Y., Li,Y., Murtaza,G., Zhou,J., Jiao,Y., Gong,C., Hu,C., Han,Q.,
            Zhang,H., Zhang,Y., Shi,B., Ma,H., Jiang,X. and Shi,Q.
  TITLE     Whole-exome sequencing of consanguineous families with infertile
            men and women identifies homologous mutations in SPATA22 and MEIOB
  JOURNAL   Hum Reprod 36 (10), 2793-2804 (2021)
   PUBMED   34392356
  REMARK    GeneRIF: Whole-exome sequencing of consanguineous families with
            infertile men and women identifies homologous mutations in SPATA22
            and MEIOB.
REFERENCE   4  (bases 1 to 1867)
  AUTHORS   Ribeiro,J., Dupaigne,P., Petrillo,C., Ducrot,C., Duquenne,C.,
            Veaute,X., Saintome,C., Busso,D., Guerois,R., Martini,E. and
            Livera,G.
  TITLE     The meiosis-specific MEIOB-SPATA22 complex cooperates with RPA to
            form a compacted mixed MEIOB/SPATA22/RPA/ssDNA complex
  JOURNAL   DNA Repair (Amst) 102, 103097 (2021)
   PUBMED   33812231
  REMARK    GeneRIF: The meiosis-specific MEIOB-SPATA22 complex cooperates with
            RPA to form a compacted mixed MEIOB/SPATA22/RPA/ssDNA complex.
REFERENCE   5  (bases 1 to 1867)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 1867)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   7  (bases 1 to 1867)
  AUTHORS   Xu,Y., Greenberg,R.A., Schonbrunn,E. and Wang,P.J.
  TITLE     Meiosis-specific proteins MEIOB and SPATA22 cooperatively associate
            with the single-stranded DNA-binding replication protein A complex
            and DNA double-strand breaks
  JOURNAL   Biol Reprod 96 (5), 1096-1104 (2017)
   PUBMED   28453612
REFERENCE   8  (bases 1 to 1867)
  AUTHORS   Luo,M., Yang,F., Leu,N.A., Landaiche,J., Handel,M.A., Benavente,R.,
            La Salle,S. and Wang,P.J.
  TITLE     MEIOB exhibits single-stranded DNA-binding and exonuclease
            activities and is essential for meiotic recombination
  JOURNAL   Nat Commun 4, 2788 (2013)
   PUBMED   24240703
  REMARK    GeneRIF: MEIOB interacts with RPA and SPATA22.
REFERENCE   9  (bases 1 to 1867)
  AUTHORS   Souquet,B., Abby,E., Herve,R., Finsterbusch,F., Tourpin,S., Le
            Bouffant,R., Duquenne,C., Messiaen,S., Martini,E.,
            Bernardino-Sgherri,J., Toth,A., Habert,R. and Livera,G.
  TITLE     MEIOB targets single-strand DNA and is necessary for meiotic
            recombination
  JOURNAL   PLoS Genet 9 (9), e1003784 (2013)
   PUBMED   24068956
  REMARK    GeneRIF: we propose that RPA and this new single-strand DNA binding
            protein MEIOB, are essential to ensure the proper stabilization of
            recombinases which is required for successful homology search and
            meiotic recombination.
REFERENCE   10 (bases 1 to 1867)
  AUTHORS   Daniels,R.J., Peden,J.F., Lloyd,C., Horsley,S.W., Clark,K.,
            Tufarelli,C., Kearney,L., Buckle,V.J., Doggett,N.A., Flint,J. and
            Higgs,D.R.
  TITLE     Sequence, structure and pathology of the fully annotated terminal 2
            Mb of the short arm of human chromosome 16
  JOURNAL   Hum Mol Genet 10 (4), 339-352 (2001)
   PUBMED   11157797
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL499628.1 and AL031722.20.
            
            On Jun 2, 2019 this sequence version replaced NM_001163560.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR3218372.90426.1,
                                           SRR9304718.161046.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968968,
                                           SAMEA1970526 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000325962.9/ ENSP00000314484.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-172               AL499628.1         22753-22924         c
            173-250             AL499628.1         18867-18944         c
            251-308             AL499628.1         16538-16595         c
            309-440             AL499628.1         12745-12876         c
            441-513             AL499628.1         11163-11235         c
            514-709             AL499628.1         8495-8690           c
            710-810             AL499628.1         4860-4960           c
            811-863             AL499628.1         3979-4031           c
            864-959             AL499628.1         3799-3894           c
            960-1061            AL031722.20        37333-37434         c
            1062-1215           AL031722.20        34291-34444         c
            1216-1399           AL031722.20        31726-31909         c
            1400-1486           AL031722.20        30255-30341         c
            1487-1867           AL031722.20        26457-26837         c
FEATURES             Location/Qualifiers
     source          1..1867
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..1867
                     /gene="MEIOB"
                     /gene_synonym="C16orf73; gs129; POF23; SPGF22"
                     /note="meiosis specific with OB-fold"
                     /db_xref="GeneID:254528"
                     /db_xref="HGNC:HGNC:28569"
                     /db_xref="MIM:617670"
     exon            1..172
                     /gene="MEIOB"
                     /gene_synonym="C16orf73; gs129; POF23; SPGF22"
                     /inference="alignment:Splign:2.1.0"
     exon            173..250
                     /gene="MEIOB"
                     /gene_synonym="C16orf73; gs129; POF23; SPGF22"
                     /inference="alignment:Splign:2.1.0"
     CDS             182..1597
                     /gene="MEIOB"
                     /gene_synonym="C16orf73; gs129; POF23; SPGF22"
                     /note="isoform 1 is encoded by transcript variant 1;
                     meiosis-specific with OB domain-containing protein;
                     meiosis specific with OB domains"
                     /codon_start=1
                     /product="meiosis-specific with OB domain-containing
                     protein isoform 1"
                     /protein_id="NP_001157032.1"
                     /db_xref="CCDS:CCDS53983.1"
                     /db_xref="GeneID:254528"
                     /db_xref="HGNC:HGNC:28569"
                     /db_xref="MIM:617670"
                     /translation="MANSFAARIFTTLSDLQTNMANLKVIGIVIGKTDVKGFPDRKNI
                     GSERYTFSFTIRDSPAHFVNAASWGNEDYIKSLSDSFRVGDCVIIENPLIQRKEIERE
                     EKFSPATPSNCKLLLSENHSTVKVCSSYEVDTKLLSLIHLPVKESHDYYSLGDIVANG
                     HSLNGRIINVLAAVKSVGEPKYFTTSDRRKGQRCEVRLYDETESSFAMTCWDNESILL
                     AQSWMPRETVIFASDVRINFDKFRNCMTATVISKTIITTNPDIPEANILLNFIRENKE
                     TNVLDDEIDSYFKESINLSTIVDVYTVEQLKGKALKNEGKADPSYGILYAYISTLNID
                     DETTKVVRNRCSSCGYIVNEASNMCTTCNKNSLDFKSVFLSFHVLIDLTDHTGTLHSC
                     SLTGSVAEETLGCTVHEFLAMTDEQKTALKWQFLLERSKIYLKFVLSHRARSGLKISV
                     LSCKLADPTEASRNLSGQKHV"
     exon            251..308
                     /gene="MEIOB"
                     /gene_synonym="C16orf73; gs129; POF23; SPGF22"
                     /inference="alignment:Splign:2.1.0"
     exon            309..440
                     /gene="MEIOB"
                     /gene_synonym="C16orf73; gs129; POF23; SPGF22"
                     /inference="alignment:Splign:2.1.0"
     exon            441..513
                     /gene="MEIOB"
                     /gene_synonym="C16orf73; gs129; POF23; SPGF22"
                     /inference="alignment:Splign:2.1.0"
     exon            514..709
                     /gene="MEIOB"
                     /gene_synonym="C16orf73; gs129; POF23; SPGF22"
                     /inference="alignment:Splign:2.1.0"
     exon            710..810
                     /gene="MEIOB"
                     /gene_synonym="C16orf73; gs129; POF23; SPGF22"
                     /inference="alignment:Splign:2.1.0"
     exon            811..863
                     /gene="MEIOB"
                     /gene_synonym="C16orf73; gs129; POF23; SPGF22"
                     /inference="alignment:Splign:2.1.0"
     exon            864..959
                     /gene="MEIOB"
                     /gene_synonym="C16orf73; gs129; POF23; SPGF22"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1061
                     /gene="MEIOB"
                     /gene_synonym="C16orf73; gs129; POF23; SPGF22"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1215
                     /gene="MEIOB"
                     /gene_synonym="C16orf73; gs129; POF23; SPGF22"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..1399
                     /gene="MEIOB"
                     /gene_synonym="C16orf73; gs129; POF23; SPGF22"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..1486
                     /gene="MEIOB"
                     /gene_synonym="C16orf73; gs129; POF23; SPGF22"
                     /inference="alignment:Splign:2.1.0"
     exon            1487..1867
                     /gene="MEIOB"
                     /gene_synonym="C16orf73; gs129; POF23; SPGF22"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1846..1851
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MEIOB"
                     /gene_synonym="C16orf73; gs129; POF23; SPGF22"
                     /note="hexamer: AATAAA"
     polyA_site      1867
                     /gene="MEIOB"
                     /gene_synonym="C16orf73; gs129; POF23; SPGF22"
                     /note="major polyA site"
ORIGIN      
        1 ggggcctcgc gctaacggtc gcgcggccgt cgcacctgca cgaggctgtg gcccgagcgt
       61 cctgtggaga agccgcgaag cgcgggcgac ccgggggtcg ggcgggccag gtccgcgagg
      121 ccgcggcggc agctgtgcag gcccggggag cagccggccg ggcgagcctc ggattaaaaa
      181 aatggcaaac tcctttgcag cgaggatttt cactaccctt tcagatctgc agacaaatat
      241 ggctaatctg aaagttatcg gtatagttat tgggaaaaca gatgtcaaag gctttccaga
      301 cagaaaaaat attggatcag aaaggtacac tttcagcttc accattcggg attcaccagc
      361 acattttgta aatgcagctt cctggggcaa tgaagattac atcaagtctc tttctgacag
      421 ctttagggtt ggtgactgtg tgataattga aaatcctctg atccaaagaa aggaaataga
      481 aagagaagaa aaattcagcc ctgcaactcc tagcaactgt aaactgttgc tcagtgagaa
      541 tcactcaaca gtaaaagttt gttccagtta tgaagtggac acaaagttac tttctttgat
      601 acatttacct gttaaagagt ctcatgatta ttattcactg ggtgacattg ttgcaaatgg
      661 acacagtctt aatgggagga ttattaacgt gcttgcagct gtgaaatcgg ttggagagcc
      721 aaaatacttt acaacttcag accggagaaa aggccagagg tgtgaagtta gactctatga
      781 tgaaacagag tcgtcttttg cgatgacatg ttgggataat gaatccattc tacttgcaca
      841 gagctggatg ccacgagaaa cagtaatatt tgcctcagat gtaagaataa attttgacaa
      901 atttcggaac tgcatgacag caactgtaat ctcaaaaacc attattacaa ctaatccaga
      961 tataccagaa gctaacattc tgctgaattt tatacgagaa aataaagaaa cgaatgttct
     1021 ggatgatgaa attgacagtt atttcaaaga atccataaat ttaagtacaa tagttgatgt
     1081 ctacacagtt gaacaattaa agggaaaagc tttgaagaat gaaggaaaag ctgatccttc
     1141 ctatggcatc ctttatgcct acatttccac actcaacatt gatgatgaaa ctacaaaagt
     1201 agttcgaaat agatgttcca gctgtggtta tattgtaaat gaagcatcta acatgtgcac
     1261 aacttgcaac aaaaactcct tggactttaa atctgtcttt ctcagtttcc atgtgctgat
     1321 tgatctgact gatcacacag gcacccttca ttcctgtagt ctcacaggaa gtgttgctga
     1381 ggagactttg ggctgcacgg tacatgagtt tcttgcaatg acagatgaac agaaaacagc
     1441 attaaagtgg caatttctct tggaaagaag caaaatttat ttaaaattcg ttctatcaca
     1501 cagagcaagg agtggattga aaattagtgt actctcgtgc aagcttgcag atcctactga
     1561 ggcaagcaga aacttgtctg gacaaaaaca tgtttaaaac ggtctatcat tttgaactct
     1621 ggaaaagtat aagagtttta actcccttta aaatggaata ttaatttgaa aattatgggg
     1681 aaaattgcat tttgtttaca tgtggtgaac atgtttctag aaattgttat ggtggaggtg
     1741 gtctgggtga gtctgaaggc ctctctcatc tgacctccct tcttagaagg cctcctactg
     1801 tctttgcctt gtctcctccc aagttggaaa atgtttacat gaattaataa acagatttaa
     1861 tcttcta
//
