LOCUS       NM_001303622            1526 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens meiotic kinetochore factor (MEIKIN), mRNA.
ACCESSION   NM_001303622
VERSION     NM_001303622.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1526)
  AUTHORS   Kim,J., Ishiguro,K., Nambu,A., Akiyoshi,B., Yokobayashi,S.,
            Kagami,A., Ishiguro,T., Pendas,A.M., Takeda,N., Sakakibara,Y.,
            Kitajima,T.S., Tanno,Y., Sakuno,T. and Watanabe,Y.
  TITLE     Meikin is a conserved regulator of meiosis-I-specific kinetochore
            function
  JOURNAL   Nature 517 (7535), 466-471 (2015)
   PUBMED   25533956
  REMARK    Erratum:[Nature. 2018 Nov;563(7731):E23. doi:
            10.1038/s41586-018-0530-3.. PMID: 30275477]
REFERENCE   2  (bases 1 to 1526)
  AUTHORS   Luo,X.J., Diao,H.B., Wang,J.K., Zhang,H., Zhao,Z.M. and Su,B.
  TITLE     Association of haplotypes spanning PDZ-GEF2, LOC728637 and ACSL6
            with schizophrenia in Han Chinese
  JOURNAL   J Med Genet 45 (12), 818-826 (2008)
   PUBMED   18718982
  REMARK    GeneRIF: Single marker analysis indicated that SNP5 (rs1355095) in
            LOC728637 is associated with schizophrenia in Han Chinese.
REFERENCE   3  (bases 1 to 1526)
  AUTHORS   Harrington,J.J., Sherf,B., Rundlett,S., Jackson,P.D., Perry,R.,
            Cain,S., Leventhal,C., Thornton,M., Ramachandran,R.,
            Whittington,J., Lerner,L., Costanzo,D., McElligott,K., Boozer,S.,
            Mays,R., Smith,E., Veloso,N., Klika,A., Hess,J., Cothren,K., Lo,K.,
            Offenbacher,J., Danzig,J. and Ducar,M.
  TITLE     Creation of genome-wide protein expression libraries using random
            activation of gene expression
  JOURNAL   Nat Biotechnol 19 (5), 440-445 (2001)
   PUBMED   11329013
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB455285.1, AB987829.1 and BG181951.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001303622.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB987829.1, SRR5189667.275253.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148874, SAMEA2161674
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000442687.6/ ENSP00000488568.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-158               DB455285.1         36-193
            159-1280            AB987829.1         1-1122
            1281-1526           BG181951.1         160-405
FEATURES             Location/Qualifiers
     source          1..1526
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.1"
     gene            1..1526
                     /gene="MEIKIN"
                     /gene_synonym="SPO13"
                     /note="meiotic kinetochore factor"
                     /db_xref="GeneID:728637"
                     /db_xref="HGNC:HGNC:51253"
                     /db_xref="MIM:616232"
     exon            1..264
                     /gene="MEIKIN"
                     /gene_synonym="SPO13"
                     /inference="alignment:Splign:2.1.0"
     CDS             159..1280
                     /gene="MEIKIN"
                     /gene_synonym="SPO13"
                     /codon_start=1
                     /product="meiosis-specific kinetochore protein"
                     /protein_id="NP_001290551.1"
                     /db_xref="CCDS:CCDS75292.2"
                     /db_xref="GeneID:728637"
                     /db_xref="HGNC:HGNC:51253"
                     /db_xref="MIM:616232"
                     /translation="MWPLRVYTRKKREGQRLNLTPTPDLGSPAKAEAPPGSKRKGKVH
                     GLSKIAEKAERSRQGGSGSGPFSPRLGVTGEKSLQENRSSEDTQDEKIASLRESVTDD
                     LQVDSSSSNSELVSGLSLHHGMASSLLSYSVTDSYAEYKSFEESFPSPELFRKSDYLD
                     WECPNLEEHMQWKNSTLLDTSKAVAIEKAPQFSNVSAIFSTSSEDYQKCHRKTVMTVA
                     DQNVSPKAKCASNSESDNAACEILLAEKTCPSTPEKTKKKKTNSSTPGKKNRGLLTST
                     PSSETAGFVIDLSSVQKASFEELFPNVSNYVNSNEIVPVSSLQENSSNEFPANASEIC
                     CIIRTSPGTRQVKNKGVIVKKKKYSLPKDTPQDIIIKMA"
     exon            265..358
                     /gene="MEIKIN"
                     /gene_synonym="SPO13"
                     /inference="alignment:Splign:2.1.0"
     exon            359..446
                     /gene="MEIKIN"
                     /gene_synonym="SPO13"
                     /inference="alignment:Splign:2.1.0"
     exon            447..507
                     /gene="MEIKIN"
                     /gene_synonym="SPO13"
                     /inference="alignment:Splign:2.1.0"
     exon            508..636
                     /gene="MEIKIN"
                     /gene_synonym="SPO13"
                     /inference="alignment:Splign:2.1.0"
     exon            637..756
                     /gene="MEIKIN"
                     /gene_synonym="SPO13"
                     /inference="alignment:Splign:2.1.0"
     exon            757..796
                     /gene="MEIKIN"
                     /gene_synonym="SPO13"
                     /inference="alignment:Splign:2.1.0"
     exon            797..861
                     /gene="MEIKIN"
                     /gene_synonym="SPO13"
                     /inference="alignment:Splign:2.1.0"
     exon            862..932
                     /gene="MEIKIN"
                     /gene_synonym="SPO13"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1013
                     /gene="MEIKIN"
                     /gene_synonym="SPO13"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1133
                     /gene="MEIKIN"
                     /gene_synonym="SPO13"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1257
                     /gene="MEIKIN"
                     /gene_synonym="SPO13"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1526
                     /gene="MEIKIN"
                     /gene_synonym="SPO13"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1373..1378
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MEIKIN"
                     /gene_synonym="SPO13"
                     /note="hexamer: ATTAAA"
     regulatory      1380..1385
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MEIKIN"
                     /gene_synonym="SPO13"
                     /note="hexamer: ATTAAA"
     polyA_site      1394
                     /gene="MEIKIN"
                     /gene_synonym="SPO13"
                     /note="major polyA site"
     polyA_site      1398
                     /gene="MEIKIN"
                     /gene_synonym="SPO13"
     regulatory      1506..1511
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MEIKIN"
                     /gene_synonym="SPO13"
                     /note="hexamer: ATTAAA"
     polyA_site      1526
                     /gene="MEIKIN"
                     /gene_synonym="SPO13"
ORIGIN      
        1 agttctgggg cttttgcttt cgctcgatta gttgctgtga ggctgctccg cgggcctcgc
       61 ctggacgctg actccctgtg acttagccct gatcctcagg aaggcaggcc atcgagagtc
      121 cagaggcacc cgtggcctgg gggtagggtg ggatagcaat gtggccgcta cgggtctata
      181 cccgcaaaaa gcgggagggt cagaggctca atctcacccc gacgccagac ctaggctctc
      241 cagcgaaggc cgaggccccg ccaggttcga agagaaaagg caaagtgcac ggcttgtcga
      301 agattgcaga gaaagcagag cggagcaggc agggaggtag cggctctggg ccgttcagcc
      361 ctcgcttagg agttacagga gagaaaagcc tgcaagaaaa taggtctagt gaagacaccc
      421 aggatgagaa gattgcatcg ttgcgtgaat cagttactga tgacctccag gttgatagta
      481 gttcatcaaa tagtgaacta gtatcaggat taagtttgca ccatggtatg gccagttctc
      541 ttctgagcta ttcagtcaca gactcttatg cagaatacaa gagttttgaa gagagctttc
      601 catcacctga actgttcaga aaatcagatt atttagactg ggagtgtccc aacttggaag
      661 aacacatgca gtggaagaat tctactcttc tggataccag taaagcagta gcgatagaga
      721 aggcaccaca gttttcaaat gtctcagcaa ttttcagtac ctcttcagaa gactatcaga
      781 aatgccatag aaaaacagtg atgacagtag cagatcaaaa tgtttctcca aaagcaaagt
      841 gtgcttcaaa ttcagaatca gataatgcag cttgtgagat tttacttgct gagaaaactt
      901 gcccttcaac ccctgaaaaa acaaagaaaa aaaaaacaaa ttccagtact cctggtaaga
      961 aaaacagagg ccttttaaca agtactccat cttcagagac agctggtttt gtgattgatt
     1021 tgtcctcagt gcaaaaagca tcttttgaag aactatttcc aaatgtcagc aattatgtta
     1081 attcaaatga aattgttcct gtgtcaagtt tgcaggaaaa ttcttcaaat gagtttcctg
     1141 caaatgcatc agaaatatgt tgtattatta gaacatcacc aggaactaga caagtgaaaa
     1201 ataaaggtgt tattgtaaag aagaagaaat attctcttcc taaggatacc cctcaagata
     1261 tcataataaa aatggcatga aaaaacagct gtggctgaat tttcaccact ttgaagacag
     1321 gagtgtgaag tcaaagtcta taaagcagaa tgtctgcctg aaattatatg aaattaaaaa
     1381 ttaaaaattc tccagttatt tgtgatatat ctctatgttg aaattctact gaggttcttg
     1441 tcatttactt ttaatcagtt aagaaaaaaa attattccat atgcttctta aatatatgta
     1501 tttatattaa aagataaaga accaaa
//
