LOCUS       NM_001080836             682 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens meiosis/spermiogenesis associated 1 (MEIG1), mRNA.
ACCESSION   NM_001080836 XM_927975 XM_939073
VERSION     NM_001080836.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 682)
  AUTHORS   Gupta,N., Sarkar,S., Mehta,P., Sankhwar,S.N. and Rajender,S.
  TITLE     Polymorphisms in the HSF2, LRRC6, MEIG1 and PTIP genes correlate
            with sperm motility in idiopathic infertility
  JOURNAL   Andrologia 54 (9), e14517 (2022)
   PUBMED   35768906
  REMARK    GeneRIF: Polymorphisms in the HSF2, LRRC6, MEIG1 and PTIP genes
            correlate with sperm motility in idiopathic infertility.
REFERENCE   2  (bases 1 to 682)
  AUTHORS   Khan,N., Pelletier,D., McAlear,T.S., Croteau,N., Veyron,S.,
            Bayne,A.N., Black,C., Ichikawa,M., Khalifa,A.A.Z., Chaaban,S.,
            Kurinov,I., Brouhard,G., Bechstedt,S., Bui,K.H. and Trempe,J.F.
  TITLE     Crystal structure of human PACRG in complex with MEIG1 reveals
            roles in axoneme formation and tubulin binding
  JOURNAL   Structure 29 (6), 572-586 (2021)
   PUBMED   33529594
  REMARK    GeneRIF: Crystal structure of human PACRG in complex with MEIG1
            reveals roles in axoneme formation and tubulin binding.
REFERENCE   3  (bases 1 to 682)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 682)
  AUTHORS   Teves,M.E., Jha,K.N., Song,J., Nagarkatti-Gude,D.R., Herr,J.C.,
            Foster,J.A., Strauss,J.F. 3rd and Zhang,Z.
  TITLE     Germ cell-specific disruption of the Meig1 gene causes impaired
            spermiogenesis in mice
  JOURNAL   Andrology 1 (1), 37-46 (2013)
   PUBMED   23258628
REFERENCE   5  (bases 1 to 682)
  AUTHORS   Zhang,Z., Shen,X., Gude,D.R., Wilkinson,B.M., Justice,M.J.,
            Flickinger,C.J., Herr,J.C., Eddy,E.M. and Strauss,J.F. 3rd.
  TITLE     MEIG1 is essential for spermiogenesis in mice
  JOURNAL   Proc Natl Acad Sci U S A 106 (40), 17055-17060 (2009)
   PUBMED   19805151
REFERENCE   6  (bases 1 to 682)
  AUTHORS   Harrington,J.J., Sherf,B., Rundlett,S., Jackson,P.D., Perry,R.,
            Cain,S., Leventhal,C., Thornton,M., Ramachandran,R.,
            Whittington,J., Lerner,L., Costanzo,D., McElligott,K., Boozer,S.,
            Mays,R., Smith,E., Veloso,N., Klika,A., Hess,J., Cothren,K., Lo,K.,
            Offenbacher,J., Danzig,J. and Ducar,M.
  TITLE     Creation of genome-wide protein expression libraries using random
            activation of gene expression
  JOURNAL   Nat Biotechnol 19 (5), 440-445 (2001)
   PUBMED   11329013
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL360083.27, AI694434.1, AA971146.1 and BG189536.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001080836.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: HY044233.1, HY038331.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2144333
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000407572.6/ ENSP00000384334.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-51                AL360083.27        59760-59810
            52-170              AI694434.1         340-458             c
            171-224             AA971146.1         292-345             c
            225-676             BG189536.1         58-509
            677-682             AL360083.27        73224-73229
FEATURES             Location/Qualifiers
     source          1..682
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p13"
     gene            1..682
                     /gene="MEIG1"
                     /gene_synonym="bA2K17.3; SPATA39"
                     /note="meiosis/spermiogenesis associated 1"
                     /db_xref="GeneID:644890"
                     /db_xref="HGNC:HGNC:23429"
                     /db_xref="MIM:614174"
     exon            1..170
                     /gene="MEIG1"
                     /gene_synonym="bA2K17.3; SPATA39"
                     /inference="alignment:Splign:2.1.0"
     exon            171..337
                     /gene="MEIG1"
                     /gene_synonym="bA2K17.3; SPATA39"
                     /inference="alignment:Splign:2.1.0"
     CDS             200..466
                     /gene="MEIG1"
                     /gene_synonym="bA2K17.3; SPATA39"
                     /note="spermatogenesis associated 39; meiosis expressed
                     gene 1 homolog"
                     /codon_start=1
                     /product="meiosis expressed gene 1 protein homolog"
                     /protein_id="NP_001074305.1"
                     /db_xref="CCDS:CCDS31151.1"
                     /db_xref="GeneID:644890"
                     /db_xref="HGNC:HGNC:23429"
                     /db_xref="MIM:614174"
                     /translation="MASSDVKPKSVSHAKKWSEEIENLYRFQQAGYRDETEYRQVKQV
                     SMVDRWPETGYVKKLQRRDNTFYYYNKQRECDDKEVHKVKIYAY"
     exon            338..682
                     /gene="MEIG1"
                     /gene_synonym="bA2K17.3; SPATA39"
                     /inference="alignment:Splign:2.1.0"
     regulatory      492..497
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MEIG1"
                     /gene_synonym="bA2K17.3; SPATA39"
                     /note="hexamer: ATTATA"
     polyA_site      513
                     /gene="MEIG1"
                     /gene_synonym="bA2K17.3; SPATA39"
                     /note="major polyA site"
     regulatory      656..661
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MEIG1"
                     /gene_synonym="bA2K17.3; SPATA39"
                     /note="hexamer: ATTAAA"
     polyA_site      682
                     /gene="MEIG1"
                     /gene_synonym="bA2K17.3; SPATA39"
                     /note="major polyA site"
ORIGIN      
        1 actaagagac gcgagggtcg cgaagggcac aacacttggc ctctcgctgg ccctgctcgc
       61 ggatcccgag tagagaacgc aagcacccac gcccgcctgc aagctcccgg gcgcccccgg
      121 cctctcctgc tcggcggaac gaggataacc cagtagagcc ggacccaggg atattattga
      181 taataaggcc tctgtaacca tggctagttc tgacgtaaaa ccaaaatcag taagtcatgc
      241 caaaaaatgg tcagaagaga tagaaaatct gtacagattt caacaagcag gatatcggga
      301 tgaaaccgaa tatagacaag tgaaacaagt ttctatggta gatcgttggc cggagacagg
      361 atatgtgaag aaacttcaga gaagggacaa tacgttctat tactacaaca aacagaggga
      421 atgtgatgac aaagaagtcc acaaagtgaa aatttatgct tactagcctg tcttctttgt
      481 attacttgtc aattatattt taagtattca tcatttcctt ctacatcatg tgtttgtcat
      541 ttgatgaaat aattcaagat gcagtctgca gtttaatgtt ttgtgaaaca caaaagccat
      601 gagaattggt atctgctaat caccttgtcc tgttctaaga actggctgca gatgcattaa
      661 agttgtactt tcttggtcct gc
//
