LOCUS       NM_001080497            6300 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens multiple EGF like domains 9 (MEGF9), mRNA.
ACCESSION   NM_001080497 XM_376905
VERSION     NM_001080497.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6300)
  AUTHORS   Jiang,L., Zhou,X., Xu,K., Hu,P., Bao,J., Li,J., Zhu,J. and Wu,L.
  TITLE     miR-7/EGFR/MEGF9 axis regulates cartilage degradation in
            osteoarthritis via PI3K/AKT/mTOR signaling pathway
  JOURNAL   Bioengineered 12 (1), 8622-8634 (2021)
   PUBMED   34629037
  REMARK    GeneRIF: miR-7/EGFR/MEGF9 axis regulates cartilage degradation in
            osteoarthritis via PI3K/AKT/mTOR signaling pathway.
REFERENCE   2  (bases 1 to 6300)
  AUTHORS   Feliciano,A., Castellvi,J., Artero-Castro,A., Leal,J.A.,
            Romagosa,C., Hernandez-Losa,J., Peg,V., Fabra,A., Vidal,F.,
            Kondoh,H., Ramon Y Cajal,S. and Lleonart,M.E.
  TITLE     miR-125b acts as a tumor suppressor in breast tumorigenesis via its
            novel direct targets ENPEP, CK2-alpha, CCNJ, and MEGF9
  JOURNAL   PLoS One 8 (10), e76247 (2013)
   PUBMED   24098452
  REMARK    GeneRIF: miR-125b acts as a tumor suppressor in breast
            tumorigenesis via its novel direct targets ENPEP, CK2-alpha, CCNJ,
            and MEGF9.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6300)
  AUTHORS   Barber,M.J., Mangravite,L.M., Hyde,C.L., Chasman,D.I., Smith,J.D.,
            McCarty,C.A., Li,X., Wilke,R.A., Rieder,M.J., Williams,P.T.,
            Ridker,P.M., Chatterjee,A., Rotter,J.I., Nickerson,D.A.,
            Stephens,M. and Krauss,R.M.
  TITLE     Genome-wide association of lipid-lowering response to statins in
            combined study populations
  JOURNAL   PLoS One 5 (3), e9763 (2010)
   PUBMED   20339536
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6300)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   5  (bases 1 to 6300)
  AUTHORS   Nakayama,M., Nakajima,D., Nagase,T., Nomura,N., Seki,N. and
            Ohara,O.
  TITLE     Identification of high-molecular-weight proteins with multiple
            EGF-like motifs by motif-trap screening
  JOURNAL   Genomics 51 (1), 27-34 (1998)
   PUBMED   9693030
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK295380.1, AB011542.1, BC016989.1, AJ420444.1, CK300579.1 and
            AL138836.15.
            
            On Nov 22, 2018 this sequence version replaced NM_001080497.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.14496.1,
                                           SRR1803617.96892.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373930.4/ ENSP00000363040.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1707              AK295380.1         18-1724
            1708-4962           AB011542.1         917-4171
            4963-5855           BC016989.1         538-1430
            5856-6184           AJ420444.1         507-835
            6185-6193           CK300579.1         18-26               c
            6194-6300           AL138836.15        31288-31394         c
FEATURES             Location/Qualifiers
     source          1..6300
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q33.2"
     gene            1..6300
                     /gene="MEGF9"
                     /gene_synonym="EGFL5"
                     /note="multiple EGF like domains 9"
                     /db_xref="GeneID:1955"
                     /db_xref="HGNC:HGNC:3234"
                     /db_xref="MIM:604268"
     exon            1..713
                     /gene="MEGF9"
                     /gene_synonym="EGFL5"
                     /inference="alignment:Splign:2.1.0"
     CDS             113..1921
                     /gene="MEGF9"
                     /gene_synonym="EGFL5"
                     /note="EGF-like-domain, multiple 5; multiple epidermal
                     growth factor-like domains protein 9; epidermal growth
                     factor-like protein 5"
                     /codon_start=1
                     /product="multiple epidermal growth factor-like domains
                     protein 9 precursor"
                     /protein_id="NP_001073966.2"
                     /db_xref="CCDS:CCDS48010.2"
                     /db_xref="GeneID:1955"
                     /db_xref="HGNC:HGNC:3234"
                     /db_xref="MIM:604268"
                     /translation="MNGGAERAMRSLPSLGGLALLCCAAAAAAAAVASAASAGNVTGG
                     GGAAGQVDASPGPGLRGEPSHPFPRATAPTAQAPRTGPPRATVHRPLAATSPAQSPET
                     TPLWATAGPSSTTFQAPLGPSPTTPPAAERTSTTSQAPTRPAPTTLSTTTGPAPTTPV
                     ATTVPAPTTPRTPTPDLPSSSNSSVLPTPPATEAPSSPPPEYVCNCSVVGSLNVNRCN
                     QTTGQCECRPGYQGLHCETCKEGFYLNYTSGLCQPCDCSPHGALSIPCNSSGKCQCKV
                     GVIGSICDRCQDGYYGFSKNGCLPCQCNNRSASCDALTGACLNCQENSKGNHCEECKE
                     GFYQSPDATKECLRCPCSAVTSTGSCSIKSSELEPECDQCKDGYIGPNCNKCENGYYN
                     FDSICRKCQCHGHVDPVKTPKICKPESGECINCLHNTTGFWCENCLEGYVHDLEGNCI
                     KKEVILPTPEGSTILVSNASLTTSVPTPVINSTFTPTTLQTIFSVSTSENSTSALADV
                     SWTQFNIIILTVIIIVVVLLMGFVGAVYMYREYQNRKLNAPFWTIELKEDNISFSSYH
                     DSIPNADVSGLLEDDGNEVAPNGQLTLTTPIHNYKA"
     exon            714..915
                     /gene="MEGF9"
                     /gene_synonym="EGFL5"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1055
                     /gene="MEGF9"
                     /gene_synonym="EGFL5"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1199
                     /gene="MEGF9"
                     /gene_synonym="EGFL5"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1469
                     /gene="MEGF9"
                     /gene_synonym="EGFL5"
                     /inference="alignment:Splign:2.1.0"
     exon            1470..6300
                     /gene="MEGF9"
                     /gene_synonym="EGFL5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6164..6169
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MEGF9"
                     /gene_synonym="EGFL5"
                     /note="hexamer: AATAAA"
     polyA_site      6184
                     /gene="MEGF9"
                     /gene_synonym="EGFL5"
                     /note="major polyA site"
     regulatory      6278..6283
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MEGF9"
                     /gene_synonym="EGFL5"
                     /note="hexamer: CATAAA"
     polyA_site      6300
                     /gene="MEGF9"
                     /gene_synonym="EGFL5"
ORIGIN      
        1 agagggaggt ggcgatggtg cgcccggtgg cggtggcggc ggcggttgcg gaggcttcct
       61 tggtcggatt gcaacgagga gaagatgact gaccaaccga ctggctgaat gaatgaatgg
      121 cggagccgag cgcgccatga ggagcctgcc gagcctgggc ggcctcgccc tgttgtgctg
      181 cgccgccgcc gccgccgccg ccgccgtcgc ctcagccgcc tcggcgggga atgtcaccgg
      241 tggcggcggg gccgcggggc aggtggacgc gtcgccgggc cccgggttgc ggggcgagcc
      301 cagccacccc ttccctaggg cgacggctcc cacggcccag gccccgagga ccgggccccc
      361 gcgcgccacc gtccaccgac ccctggctgc gacttctcca gcccagtccc cggagaccac
      421 ccctctttgg gcgactgctg gaccctcttc caccaccttt caggcgccgc tcggcccctc
      481 gccgaccacc cctccggcgg cggaacgcac ttcgaccacc tctcaggcgc cgaccagacc
      541 cgcgccgacc accctttcga cgaccactgg cccggcgccg accacccctg tagcgaccac
      601 cgtaccggcg cccacgactc cccggacccc gacccccgat ctccccagca gcagcaacag
      661 cagcgtcctc cccaccccac ctgccaccga ggccccctct tcgcctcctc cagagtatgt
      721 atgtaactgc tctgtggttg gaagcctgaa tgtgaatcgc tgcaaccaga ccacagggca
      781 gtgtgagtgt cggccaggtt atcaggggct tcactgtgaa acctgcaaag agggctttta
      841 cctaaattac acttctgggc tctgtcagcc atgtgactgt agtccacatg gagctctcag
      901 cataccgtgc aacagttctg ggaaatgcca gtgcaaagtg ggtgtcattg gctctatatg
      961 tgaccgatgc caagatggat attatggctt tagtaagaat ggctgcttgc cctgccaatg
     1021 caataatcgg tctgccagtt gcgatgccct cacaggtgct tgtttaaact gccaggaaaa
     1081 tagcaaagga aatcactgtg aagaatgtaa agaaggattt tatcagagtc ctgatgccac
     1141 taaagaatgt cttcgctgcc cttgttcagc agtgacatct acaggcagct gctctataaa
     1201 atcgagtgaa ttggaacctg aatgtgacca gtgtaaagat ggttacatag gcccgaactg
     1261 caataaatgt gaaaatggct attacaattt tgacagcatc tgtagaaagt gccaatgtca
     1321 cggccatgtg gacccagtta aaactccaaa gatttgtaag cccgagagtg gtgagtgcat
     1381 caactgcctc cataacacca ctgggttttg gtgtgagaac tgcctagaag gttatgttca
     1441 cgacctcgag ggaaattgca tcaagaaaga agttattctt ccaacacctg aaggttctac
     1501 cattttggtt tccaatgcct ctttgaccac atcagtgccc acccctgtta taaatagtac
     1561 ttttacccct acaaccctgc agactatctt ttcagtaagc acttctgaaa acagcacttc
     1621 agctttagct gatgtatcat ggacccaatt taacatcatc attttgacag tcatcatcat
     1681 tgttgtggtg ctgctaatgg gatttgtggg ggctgtatat atgtaccgcg agtaccaaaa
     1741 ccggaaactc aatgccccct tttggaccat cgagctgaaa gaagacaata tcagtttcag
     1801 cagctaccat gacagcattc ccaatgcaga tgtttcggga ttgttggaag atgatggcaa
     1861 tgaagtggct cccaatgggc agctgaccct gacgacgccc atacataact acaaagccta
     1921 aggagctaga actgttctga attgttaaac cacagtgctt gctaagacag agtcagcccc
     1981 tgggccagac aaagcctggc tagagtttgc tgagaaagca aaggcaaata gtgcatctga
     2041 aattttcagg tacaaatttg taatgcgctt agcctatcta ttgctcttag ttttcccatg
     2101 aagatctgaa gcgttcactg tcattaggac ttgaagtaaa gtatattttt gtaccaaacc
     2161 acatgggagt atggaaaggc tgaaccccat agtgcagccc aaaaccactt tgacctccag
     2221 atagactcct ggggaagcat tcaccaagcc agtggtaaca agatgatgaa tgtggagggg
     2281 gaaaagactg ctggaagact tcatctccat tcctgaaaca ttttttttaa aacagtgtca
     2341 gggattatat tcgttttact atacaaaagg acatcattga ggaaaagctt gtttctaggc
     2401 tgtatcacag taaataatct tgattgtttc tagaacaggg gtagaaaagt cccaagatct
     2461 tcagaagggc ttggtttttt cctcccagga ttcttgctca gtgatgagtt gaaagcacag
     2521 gataagcttc taagggagga aggcagcatt ggggagcagg aggctgatgg tcctcctcag
     2581 ggtctcagtg taaatgataa attgtctaaa aataaggaat attcctgcct ctagagaaat
     2641 aaggtgtaca tagttaatgt agcatatctg gtcgacgttg tatttgtatc tatttgtaaa
     2701 aaaaaaatca tgtcatattt tatcatctgg aatttatttg tacagcagtt aatggtgttg
     2761 taaaaagaaa aatatgggga ttgcttaaaa tactgtaaaa tagatggcaa tattgctaga
     2821 gctgggactc tggtgagcat ccgtcatttt tagtccttct tgaggacatt gctgaaattt
     2881 ataagaggtc gaatgtttct ttctttcctt tctcagtcta aaagtagagt tatatgctct
     2941 ttgacttact atgattcaag caatagattt tgaagtcagt aatcgttaag ctgggacata
     3001 ggatgcattc tccaaaaaca ttaatctaat tagacattag ccaccctata tattttacat
     3061 agattaatat aaaacatatc ctcattaaaa aatgtttttc ttgaatgtaa aagatagtct
     3121 tccaaaggat agaaatattt tagttccaag agaaaagcca tcatattact tgggatctgt
     3181 agttttcatg cctatgaaat atttataatc ctccctcacc ccaaataaaa aatctcctac
     3241 atgtgaacat agcctgtcac tcatttgcca tgaggtatgt gccatctccc tgcagtgcta
     3301 tagttctccc attgtcttcc tgtctggtta atgagcagct ttgtagatgg gtgtgtctag
     3361 ttagttcttg ctttttgatg gagttttttc ctagaggcca actactgttg ctctcgttta
     3421 ttatgatatt gacattttgg gttaagcaag gtgggtggga aaggtggtca gatgttaaat
     3481 ataacttatt aggaggaaca gtgaactgtg aagtggttag aaaaaaaata aaaacttctt
     3541 attagattag acctaggaaa ttcaagctga cccctttgcc taacttccct agagaaaaac
     3601 ctagaacttg gtcatccctt tataggagac ccctaagttg ttctcagggt ttggagatga
     3661 tgttctggag ggagtacaag caaataatct acttctggta atctgagggt gctttgcgta
     3721 tttggccatt gctcagaaga atagaggtta cattatatta cattatatga aaattattta
     3781 gtttttctat agccctttgt agtttgcaaa gcacttttcc atatgtgtgt cctctcttcc
     3841 acaccatagc cccctgagga agtaattgtt gtccccattt tatagatgaa aaggctgagg
     3901 cacagaggag ctaaatatct tgttcaaggc tatacaatgt gtgtgattat taggcttgga
     3961 atcagggcct ctaactctaa agcacatgtt ttttcaacta tatgcagaaa ttgcctagcc
     4021 atggacacaa gaaagctggg aggaagagtt ctacttgtgg atgtttttaa ttttttttaa
     4081 atatcaggag caatccaggg ccatacagct atgaagcact tagtgaaaag aacacaagaa
     4141 gatttactaa ctgaagttag tattagtgat tagaaaacaa aactgccagt ttgtgcttca
     4201 ttaaggtgaa ctcatctctc caagcaggaa gggaaaattt gctttcccta gcagttgctg
     4261 catatgtgtg tacagactgc acaattctaa gaaattgtgc aaaatggcat acctgtcttt
     4321 ctcccagata caccgccccc tgcccccccc aaaaaaggtc aggattaaag gtggtgagaa
     4381 gtgaacattt attaaacaga agttaaacca atagagagaa aggaggtttg ttggagtcta
     4441 agaggatttt gaccatgtag aaattccttg aaacagacct taaaaggtat tgaaaaattg
     4501 aatcacaaag aaagtttacc tttaaatact tgttaatggc tcctagatca tggttataat
     4561 ttttctcaat gggaaaaaaa gtcttaaaat ttgttttaaa taagatcctc taatgtctcg
     4621 agctttttga ttctggaaat aatttgcttt aaaatataaa tcaatcagaa agtgatctac
     4681 cactgaaatc attctaggaa actagcatgg gatgcactgc acaatgttct ttcctctaaa
     4741 ggcatgggcc ccataaactg tggcatctgg cagcaggatg ccatcagtcc tttagaaagc
     4801 ctaattttgg gccgggtgcg gtggctcacg cctgtaatcc cagcactttg ggaggccgag
     4861 gcgggtggat cacaaggtca ggagttcgag accagcctgg tcaacatggc gaaatcccgt
     4921 ctctactaaa aacacaaaaa ttagccgggt gtacgtgcct gtagtctcag ctacttggga
     4981 ggctgaggca ggagaatcac ttgaacctgg gaggcagagg ttacagtgag ccgagatggc
     5041 gccatttcac tccagcctgg gcgacagagc aagactctgt ctcaaaaaaa aggaagaaaa
     5101 agaaagccta atattgggag aatgtttgtg taaggattgg aaatctgttt atttttaaat
     5161 aagatagcac tgatgtgaat cttatttgga aattacagat actgccatta agcgatgctt
     5221 ttatcttcat taattcattt tggtaagcgc ctatgcattt ctgatggtta ggtgccctag
     5281 gtagtgttaa gtatgtccgt gtcctccctt actcccctct cgctccctct accctctatc
     5341 ccctagggtt cttttattaa tggaatttct ccagttatag agaaaaaaat gacatttgaa
     5401 aactaaagct catttatatt aatactaagg tcctgtgggc ctagtgcgtt actcttccca
     5461 gtgataccta gattttaaga gtagagaaca gaggaaacat gggatgagag gagagaggtt
     5521 ttttagacaa catttgtaga cacctcaaat tatatcactg ttctctagcg ccaatattcc
     5581 caggtaaatt gaccattaaa gcaatactca ctgacctact agtttatttt ggtcagctga
     5641 gtaccatcag gatatttaac cctttaagtg ctgttttggg agtagaaaac taaagcaaca
     5701 atacttcctc ttgacagctt tgattggaat ggggttatta gatcattcac cttggtccta
     5761 cactttttag gatgcttggt gaacataaca ccacttataa tgaacatccc tggttcctat
     5821 attttgggct atgtgggtag gaattgttac ttgttactgc agcagcagcc ctagaaagta
     5881 agcccagggc ttcagatcta agttagtcca aaagctaaat gatttaaagt caagttgtaa
     5941 tgctaggcat aagcactcta taatacatta aattataggc cgagcaatta gggaatgttt
     6001 ctgaaacatt aaacttgtat ttatgtcact aaaattctaa cacaaactta aaaaatgtgt
     6061 ctcatacata tgctgtacta ggcttcatca tgcatttcta aatttgtgta tgatttgaat
     6121 atatgaaaga atttatacaa gagtgttatt taaaattatt aaaaataaat gtatataatt
     6181 tgtacctatt gtagatttgt tgtttacttt tttgtgtggt cagagttgtt tcatgtcttc
     6241 aaatacatgc caaggatcat ttactttcag cccacttcat aaaaatcttt gaactcttca
//
