LOCUS       NM_001409               7443 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens multiple EGF like domains 6 (MEGF6), transcript
            variant 1, mRNA.
ACCESSION   NM_001409 XM_031401
VERSION     NM_001409.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7443)
  AUTHORS   Teerlink,C.C., Jurynec,M.J., Hernandez,R., Stevens,J., Hughes,D.C.,
            Brunker,C.P., Rowe,K., Grunwald,D.J., Facelli,J.C. and
            Cannon-Albright,L.A.
  TITLE     A role for the MEGF6 gene in predisposition to osteoporosis
  JOURNAL   Ann Hum Genet 85 (2), 58-72 (2021)
   PUBMED   33026655
  REMARK    GeneRIF: A role for the MEGF6 gene in predisposition to
            osteoporosis.
REFERENCE   2  (bases 1 to 7443)
  AUTHORS   Hu,H., Wang,M., Wang,H., Liu,Z., Guan,X., Yang,R., Huang,R.,
            Tang,Q., Zou,C., Wang,G., Gao,X. and Wang,X.
  TITLE     MEGF6 Promotes the Epithelial-to-Mesenchymal Transition via the
            TGFbeta/SMAD Signaling Pathway in Colorectal Cancer Metastasis
  JOURNAL   Cell Physiol Biochem 46 (5), 1895-1906 (2018)
   PUBMED   29719292
  REMARK    GeneRIF: MEGF6 accelerated Colorectal Cancer cell growth and
            inhibited apoptosis, and promoted Colorectal Cancer metastasis by
            inducing the Epithelial-to-Mesenchymal Transition.
REFERENCE   3  (bases 1 to 7443)
  AUTHORS   Kahle,J.J., Gulbahce,N., Shaw,C.A., Lim,J., Hill,D.E.,
            Barabasi,A.L. and Zoghbi,H.Y.
  TITLE     Comparison of an expanded ataxia interactome with patient medical
            records reveals a relationship between macular degeneration and
            ataxia
  JOURNAL   Hum Mol Genet 20 (3), 510-527 (2011)
   PUBMED   21078624
REFERENCE   4  (bases 1 to 7443)
  AUTHORS   Nakayama,M., Nakajima,D., Nagase,T., Nomura,N., Seki,N. and
            Ohara,O.
  TITLE     Identification of high-molecular-weight proteins with multiple
            EGF-like motifs by motif-trap screening
  JOURNAL   Genomics 51 (1), 27-34 (1998)
   PUBMED   9693030
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL513320.30, AB231860.1, AL512413.23, BU501408.1, AB011539.2 and
            BM984873.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001409.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB231860.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000356575.9/ ENSP00000348982.4
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                AL513320.30        109348-109360       c
            14-128              AB231860.1         1-115
            129-130             AL513320.30        109231-109232       c
            131-630             AB231860.1         118-617
            631-632             AL513320.30        77766-77767         c
            633-2522            AB231860.1         620-2509
            2523-2524           AL512413.23        55158-55159         c
            2525-2986           AB231860.1         2512-2973
            2987-2988           AL512413.23        53216-53217         c
            2989-3649           AB231860.1         2976-3636
            3650-4212           BU501408.1         85-647
            4213-4799           AB231860.1         4200-4786
            4800-5474           AB011539.2         3827-4501
            5475-6831           AL512413.23        41895-43251         c
            6832-7443           BM984873.1         21-632              c
FEATURES             Location/Qualifiers
     source          1..7443
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.32"
     gene            1..7443
                     /gene="MEGF6"
                     /gene_synonym="EGFL3"
                     /note="multiple EGF like domains 6"
                     /db_xref="GeneID:1953"
                     /db_xref="HGNC:HGNC:3232"
                     /db_xref="MIM:604266"
     exon            1..371
                     /gene="MEGF6"
                     /gene_synonym="EGFL3"
                     /inference="alignment:Splign:2.1.0"
     CDS             241..4866
                     /gene="MEGF6"
                     /gene_synonym="EGFL3"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; EGF-like-domain, multiple 3; multiple epidermal
                     growth factor-like domains protein 6; EGF-like protein 3;
                     multiple EGF-like domains protein 6; epidermal growth
                     factor-like protein 3"
                     /codon_start=1
                     /product="multiple epidermal growth factor-like domains
                     protein 6 isoform 1 precursor"
                     /protein_id="NP_001400.3"
                     /db_xref="CCDS:CCDS41237.1"
                     /db_xref="GeneID:1953"
                     /db_xref="HGNC:HGNC:3232"
                     /db_xref="MIM:604266"
                     /translation="MSFLEEARAAGRAVVLALVLLLLPAVPVGASVPPRPLLPLQPGM
                     PHVCAEQELTLVGRRQPCVQALSHTVPVWKAGCGWQAWCVGHERRTVYYMGYRQVYTT
                     EARTVLRCCRGWMQQPDEEGCLSAECSASLCFHGGRCVPGSAQPCHCPPGFQGPRCQY
                     DVDECRTHNGGCQHRCVNTPGSYLCECKPGFRLHTDSRTCLAINSCALGNGGCQHHCV
                     QLTITRHRCQCRPGFQLQEDGRHCVRRSPCANRNGSCMHRCQVVRGLARCECHVGYQL
                     AADGKACEDVDECAAGLAQCAHGCLNTQGSFKCVCHAGYELGADGRQCYRIEMEIVNS
                     CEANNGGCSHGCSHTSAGPLCTCPRGYELDTDQRTCIDVDDCADSPCCQQVCTNNPGG
                     YECGCYAGYRLSADGCGCEDVDECASSRGGCEHHCTNLAGSFQCSCEAGYRLHEDRRG
                     CSPLEEPMVDLDGELPFVRPLPHIAVLQDELPQLFQDDDVGADEEEAELRGEHTLTEK
                     FVCLDDSFGHDCSLTCDDCRNGGTCLLGLDGCDCPEGWTGLICNETCPPDTFGKNCSF
                     SCSCQNGGTCDSVTGACRCPPGVSGTNCEDGCPKGYYGKHCRKKCNCANRGRCHRLYG
                     ACLCDPGLYGRFCHLTCPPWAFGPGCSEECQCVQPHTQSCDKRDGSCSCKAGFRGERC
                     QAECELGYFGPGCWQACTCPVGVACDSVSGECGKRCPAGFQGEDCGQECPVGTFGVNC
                     SSSCSCGGAPCHGVTGQCRCPPGRTGEDCEADCPEGRWGLGCQEICPACQHAARCDPE
                     TGACLCLPGFVGSRCQDVCPAGWYGPSCQTRCSCANDGHCHPATGHCSCAPGWTGFSC
                     QRACDTGHWGPDCSHPCNCSAGHGSCDAISGLCLCEAGYVGPRCEQQCPQGHFGPGCE
                     QRCQCQHGAACDHVSGACTCPAGWRGTFCEHACPAGFFGLDCRSACNCTAGAACDAVN
                     GSCLCPAGRRGPRCAETCPAHTYGHNCSQACACFNGASCDPVHGQCHCAPGWMGPSCL
                     QACPAGLYGDNCRHSCLCQNGGTCDPVSGHCACPEGWAGLACEKECLPRDVRAGCRHS
                     GGCLNGGLCDPHTGRCLCPAGWTGDKCQSPCLRGWFGEACAQRCSCPPGAACHHVTGA
                     CRCPPGFTGSGCEQACPPGSFGEDCAQMCQCPGENPACHPATGTCSCAAGYHGPSCQQ
                     RCPPGRYGPGCEQLCGCLNGGSCDAATGACRCPTGFLGTDCNLTCPQGRFGPNCTHVC
                     GCGQGAACDPVTGTCLCPPGRAGVRCERGCPQNRFGVGCEHTCSCRNGGLCHASNGSC
                     SCGLGWTGRHCELACPPGRYGAACHLECSCHNNSTCEPATGTCRCGPGFYGQACEHPC
                     PPGFHGAGCQGLCWCQHGAPCDPISGRCLCPAGFHGHFCERGCEPGSFGEGCHQRCDC
                     DGGAPCDPVTGLCLCPPGRSGATCNLDCRRGQFGPSCTLHCDCGGGADCDPVSGQCHC
                     VDGYMGPTCREGGPLRLPENPSLAQGSAGTLPASSRPTSRSGGPARH"
     exon            372..506
                     /gene="MEGF6"
                     /gene_synonym="EGFL3"
                     /inference="alignment:Splign:2.1.0"
     exon            507..616
                     /gene="MEGF6"
                     /gene_synonym="EGFL3"
                     /inference="alignment:Splign:2.1.0"
     exon            617..721
                     /gene="MEGF6"
                     /gene_synonym="EGFL3"
                     /inference="alignment:Splign:2.1.0"
     exon            722..844
                     /gene="MEGF6"
                     /gene_synonym="EGFL3"
                     /inference="alignment:Splign:2.1.0"
     exon            845..970
                     /gene="MEGF6"
                     /gene_synonym="EGFL3"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1093
                     /gene="MEGF6"
                     /gene_synonym="EGFL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1216
                     /gene="MEGF6"
                     /gene_synonym="EGFL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1354
                     /gene="MEGF6"
                     /gene_synonym="EGFL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1355..1474
                     /gene="MEGF6"
                     /gene_synonym="EGFL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1475..1597
                     /gene="MEGF6"
                     /gene_synonym="EGFL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1598..1768
                     /gene="MEGF6"
                     /gene_synonym="EGFL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1769..1900
                     /gene="MEGF6"
                     /gene_synonym="EGFL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1901..2029
                     /gene="MEGF6"
                     /gene_synonym="EGFL3"
                     /inference="alignment:Splign:2.1.0"
     exon            2030..2158
                     /gene="MEGF6"
                     /gene_synonym="EGFL3"
                     /inference="alignment:Splign:2.1.0"
     exon            2159..2293
                     /gene="MEGF6"
                     /gene_synonym="EGFL3"
                     /inference="alignment:Splign:2.1.0"
     exon            2294..2428
                     /gene="MEGF6"
                     /gene_synonym="EGFL3"
                     /inference="alignment:Splign:2.1.0"
     exon            2429..2554
                     /gene="MEGF6"
                     /gene_synonym="EGFL3"
                     /inference="alignment:Splign:2.1.0"
     exon            2555..2686
                     /gene="MEGF6"
                     /gene_synonym="EGFL3"
                     /inference="alignment:Splign:2.1.0"
     exon            2687..2815
                     /gene="MEGF6"
                     /gene_synonym="EGFL3"
                     /inference="alignment:Splign:2.1.0"
     exon            2816..2947
                     /gene="MEGF6"
                     /gene_synonym="EGFL3"
                     /inference="alignment:Splign:2.1.0"
     exon            2948..3076
                     /gene="MEGF6"
                     /gene_synonym="EGFL3"
                     /inference="alignment:Splign:2.1.0"
     exon            3077..3205
                     /gene="MEGF6"
                     /gene_synonym="EGFL3"
                     /inference="alignment:Splign:2.1.0"
     exon            3206..3334
                     /gene="MEGF6"
                     /gene_synonym="EGFL3"
                     /inference="alignment:Splign:2.1.0"
     exon            3335..3463
                     /gene="MEGF6"
                     /gene_synonym="EGFL3"
                     /inference="alignment:Splign:2.1.0"
     exon            3464..3592
                     /gene="MEGF6"
                     /gene_synonym="EGFL3"
                     /inference="alignment:Splign:2.1.0"
     exon            3593..3721
                     /gene="MEGF6"
                     /gene_synonym="EGFL3"
                     /inference="alignment:Splign:2.1.0"
     exon            3722..3853
                     /gene="MEGF6"
                     /gene_synonym="EGFL3"
                     /inference="alignment:Splign:2.1.0"
     exon            3854..3982
                     /gene="MEGF6"
                     /gene_synonym="EGFL3"
                     /inference="alignment:Splign:2.1.0"
     exon            3983..4111
                     /gene="MEGF6"
                     /gene_synonym="EGFL3"
                     /inference="alignment:Splign:2.1.0"
     exon            4112..4240
                     /gene="MEGF6"
                     /gene_synonym="EGFL3"
                     /inference="alignment:Splign:2.1.0"
     exon            4241..4369
                     /gene="MEGF6"
                     /gene_synonym="EGFL3"
                     /inference="alignment:Splign:2.1.0"
     exon            4370..4498
                     /gene="MEGF6"
                     /gene_synonym="EGFL3"
                     /inference="alignment:Splign:2.1.0"
     exon            4499..4627
                     /gene="MEGF6"
                     /gene_synonym="EGFL3"
                     /inference="alignment:Splign:2.1.0"
     exon            4628..4756
                     /gene="MEGF6"
                     /gene_synonym="EGFL3"
                     /inference="alignment:Splign:2.1.0"
     exon            4757..4804
                     /gene="MEGF6"
                     /gene_synonym="EGFL3"
                     /inference="alignment:Splign:2.1.0"
     exon            4805..7443
                     /gene="MEGF6"
                     /gene_synonym="EGFL3"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      5474
                     /gene="MEGF6"
                     /gene_synonym="EGFL3"
                     /note="major polyA site"
     regulatory      7410..7415
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MEGF6"
                     /gene_synonym="EGFL3"
                     /note="hexamer: ATTAAA"
     regulatory      7422..7427
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MEGF6"
                     /gene_synonym="EGFL3"
                     /note="hexamer: ATTAAA"
     polyA_site      7431
                     /gene="MEGF6"
                     /gene_synonym="EGFL3"
                     /note="major polyA site"
     polyA_site      7443
                     /gene="MEGF6"
                     /gene_synonym="EGFL3"
ORIGIN      
        1 actgtgctca acgcgccggg gcgagttcct gcagggtgga cccggcgatc aggtctccgc
       61 ggtgccactt tgggcgcggg cgggaagccg ggacgctccg cacctgcagc gaccttgggc
      121 tccgcggagc gggcgcgggc acctgtggct gcgtcctatg gcgcacgtgg aggcggaggc
      181 tccggggagc cgccggggcc gcctgtgagc cggagagcgg aggaggcacc ggcgcgcacg
      241 atgtcgttcc ttgaagaggc gagggcagcg gggcgcgcgg tggtcctggc gttggtgctg
      301 ctgctgctcc ccgccgtgcc cgtgggcgcc agcgttccgc cgcggcccct gctcccgctg
      361 cagcccggca tgccccacgt gtgtgctgag caggagctga ccctggtggg ccgccgccag
      421 ccgtgcgtgc aggccttaag ccacacggtg ccggtgtgga aggccggctg tgggtggcag
      481 gcgtggtgcg tgggtcatga gcggagaacc gtctactaca tgggctacag gcaggtgtat
      541 accacggagg cccggaccgt gctcaggtgc tgccgagggt ggatgcagca gcccgacgag
      601 gagggctgcc tctcggctga atgcagcgcc agcctctgtt ttcacggtgg ccgttgtgtg
      661 ccaggctcag cccagccgtg tcactgtccc cccggcttcc agggaccccg ctgtcagtat
      721 gatgtggacg aatgccgaac ccacaacggt ggctgccagc accggtgcgt gaacacccca
      781 ggctcctacc tctgtgagtg caagcccggc ttccggctcc acactgacag caggacctgc
      841 ctggccatta actcctgcgc cctgggcaat ggcggctgcc agcaccactg tgtccagctc
      901 acaatcactc ggcatcgctg ccagtgccgg cccgggttcc agctccagga ggacggcagg
      961 cattgtgtcc gtagaagccc gtgtgccaac aggaacggca gctgcatgca caggtgccag
     1021 gtggtccggg gcctcgcccg ctgtgagtgc cacgtgggct atcagctagc agcggacggc
     1081 aaggcctgtg aagatgtgga cgaatgtgcc gcagggctgg cccagtgtgc ccatggctgc
     1141 ctcaacaccc aggggtcctt caagtgcgtg tgtcacgcgg gctatgagct gggcgccgat
     1201 ggccggcagt gctaccggat tgagatggaa atcgtgaaca gctgtgaggc caacaacggc
     1261 ggctgctccc atggctgcag ccacaccagt gctgggcccc tgtgcacatg tccccgcggc
     1321 tacgagctgg acacagatca gaggacctgc atcgatgtcg acgactgtgc agacagcccg
     1381 tgctgccagc aggtgtgcac caacaaccct ggcgggtacg agtgcggctg ctacgccggc
     1441 taccggctca gtgccgatgg ctgcggctgt gaggatgtgg atgagtgcgc ctccagccgt
     1501 ggcggctgcg agcaccactg caccaacctg gccggctcct tccagtgctc ctgcgaggcc
     1561 ggctaccggc tgcacgagga ccgtaggggc tgcagccccc tggaggagcc gatggtggac
     1621 ctggacggcg agctgccttt cgtgcggccc ctgccccaca ttgccgtgct ccaggacgag
     1681 ctgccgcaac tcttccagga tgacgacgtc ggggccgatg aggaagaggc agagttgcgg
     1741 ggcgaacaca cgctcacaga gaagtttgtc tgcctggatg actcctttgg ccatgactgc
     1801 agcttgacct gtgatgactg caggaacgga gggacctgcc tcctgggcct ggatggctgt
     1861 gattgccccg agggctggac tgggctcatc tgcaatgaga cttgtcctcc ggacaccttt
     1921 gggaagaact gcagcttctc ctgcagctgt cagaatggtg ggacctgcga ctctgtcacg
     1981 ggggcctgcc gctgcccccc gggtgtcagt ggaactaact gtgaggatgg ctgccccaag
     2041 ggctactatg gcaagcactg tcgcaagaaa tgcaactgtg ccaaccgggg ccggtgccac
     2101 cgcctctacg gggcctgcct ctgcgaccca gggctctacg gccgcttctg ccacctcacc
     2161 tgcccgccgt gggcctttgg gccgggctgc tcggaggagt gccagtgtgt gcagccccac
     2221 acgcagtcct gtgacaagag ggatggcagc tgctcctgca aggctggctt ccggggcgag
     2281 cgctgtcagg cagagtgtga gctgggctac tttgggccgg ggtgctggca ggcatgcacc
     2341 tgcccagtgg gcgtggcctg tgactccgtg agcggcgagt gtgggaagcg gtgtcctgct
     2401 ggcttccagg gagaggactg tggccaagag tgcccggtgg ggacgtttgg cgtgaactgc
     2461 tcgagctcct gctcctgtgg gggggccccc tgccacgggg tcacggggca gtgccggtgt
     2521 ccgccgggga ggactgggga agactgtgag gcagattgtc ccgagggccg ctgggggctg
     2581 ggctgccagg agatctgccc agcatgccag cacgctgccc gctgcgaccc tgagaccgga
     2641 gcctgcctgt gcctccctgg cttcgtcggc agccgctgcc aggacgtgtg cccagcaggc
     2701 tggtatggtc ccagctgcca gacaaggtgc tcttgtgcca atgatgggca ctgccaccca
     2761 gccaccggac actgcagctg tgcccccggg tggaccggct ttagctgcca gagagcctgt
     2821 gatactgggc actggggacc tgactgcagc cacccctgca actgcagcgc tggccacggg
     2881 agctgtgatg ccatcagcgg cctgtgtctg tgtgaggctg gctacgtggg cccgcggtgc
     2941 gagcagcagt gtccccaggg ccactttggg cccggctgtg agcagcggtg ccagtgtcag
     3001 catggagcag cctgtgacca cgtcagcggg gcctgcacct gcccggccgg ctggaggggc
     3061 accttctgcg agcatgcctg cccggccggc ttctttggat tggactgtcg cagtgcctgc
     3121 aactgcaccg ccggagctgc ctgtgatgcc gtgaatggct cctgcctctg ccccgctggc
     3181 cgccggggcc cccgctgtgc cgagacctgc ccagcccaca cctacgggca caattgcagc
     3241 caggcctgtg cctgctttaa cggggcctcc tgtgaccctg tccacgggca gtgccactgt
     3301 gcccctggct ggatggggcc ctcctgcctg caggcctgcc ctgccggcct gtacggcgac
     3361 aactgtcggc attcctgcct ctgccagaac ggagggacct gtgaccctgt ctcaggccac
     3421 tgtgcgtgcc cagagggctg ggccggcctg gcctgtgaga aggagtgcct cccccgggac
     3481 gtcagagctg gctgccggca cagcggcggt tgcctcaacg ggggcctgtg tgacccgcac
     3541 acgggccgct gcctctgccc agccggctgg actggggaca agtgtcagag cccctgcctg
     3601 cggggctggt ttggagaggc ctgtgcccag cgctgcagct gcccgcctgg cgctgcctgc
     3661 caccacgtca ctggggcctg ccgctgtccc cctggcttca ctggctccgg ctgcgagcag
     3721 gcctgcccac ccggcagctt tggggaggac tgtgcgcaga tgtgccagtg tcccggtgag
     3781 aacccggcct gccaccctgc caccgggacc tgctcatgtg ctgctggcta ccacggcccc
     3841 agctgccagc aacgatgtcc gcccgggcgg tatgggccag gctgtgaaca gctgtgtggg
     3901 tgtctcaacg ggggctcctg tgatgcggcc acgggggcct gccgctgccc cactgggttc
     3961 ctcgggacgg actgcaacct cacctgtccg cagggccgct tcggccccaa ctgcacccac
     4021 gtgtgtgggt gtgggcaggg ggcggcctgc gaccctgtga ccggcacctg cctctgcccc
     4081 ccggggagag ccggcgtccg ctgtgagcga ggctgccccc agaaccggtt tggcgtgggc
     4141 tgcgagcaca cctgctcctg cagaaatggg ggcctgtgcc acgccagcaa cggcagctgc
     4201 tcctgtggcc tgggctggac ggggcggcac tgcgagctgg cctgtccccc tgggcgctac
     4261 ggagccgcct gccatctgga gtgctcctgc cacaacaaca gcacgtgtga gcctgccacg
     4321 ggcacctgcc gctgcggccc cggcttctat ggccaggcct gcgagcaccc ctgtccccct
     4381 ggcttccacg gggctggctg ccaggggttg tgctggtgtc aacatggagc cccctgcgac
     4441 cccatcagtg gccgatgcct ctgccctgcc ggcttccacg gccacttctg tgagaggggg
     4501 tgtgagccag gttcatttgg agagggctgc caccagcgct gtgactgtga cgggggggca
     4561 ccctgtgacc ctgtcaccgg tctctgcctt tgcccaccag ggcgctcagg agccacctgt
     4621 aacctggatt gcagaagggg ccagtttggg cccagctgca ccctgcactg tgactgcggg
     4681 ggtggggctg actgcgaccc tgtcagtggg cagtgtcact gtgtggatgg ctacatgggg
     4741 cccacgtgcc gggaaggtgg gcccctccgg ctccccgaga acccgtcctt agcccagggc
     4801 tcagcgggca cactgcccgc ctccagcaga cccacatccc ggagcggtgg accagcgagg
     4861 cactagtaga ggcagtcccg tggagcccgc ctctccagtc ccagccagag gggaccctgg
     4921 cctttggtga ccactgagaa ggacacttca cgggcccaga gctcctggta ctgcccttcc
     4981 tttgagggcc gtggagggct gtggacagcc cagcaacctg tcgctcttgg aggctggtgt
     5041 ggccttgagg agggaagcct cgcatggccg ctggaagaga ggcgcctcct ggcctggctc
     5101 tgcagaaccc aggggcacgc tctgggcctg ggctgaggaa gtcccgctct ccccgcggct
     5161 ctgagttgga ctgaggacag gtgtgggcgc cagtgtgggt gcaggcgcag gtgcaggcac
     5221 agggccactg tcctccaggc aggctttttg gtgctaggcc ctgggactgg aagtcgccca
     5281 gcccgtattt atgtaaaggt atttatgggc cactgcacat gcccgctgca gccctgggat
     5341 cagctggaag ctgcctgtca tctcctgccc aatccccaga aaccctgatt caggtctgca
     5401 ggctcctgcg ggctcaccag gctgctggct ccggtaccat gtaaacctag gaaggtaaag
     5461 gagcaggcaa cctcctcgtg gcctgtgtgt ttgctgtgtt acgtggactc tgtgtgggct
     5521 cctccctggg gcccggccag cataacggtg cacccaggga cctcccagtg cacccggggc
     5581 cctttgcagg ggtgggggtg ccacacaagt gaagaagttg ggactcatct cagttcccag
     5641 tgctattgag gagaacgctg gggctgcatt cattaccgct gagacccaga gactggctgt
     5701 tcccagagaa tggcccaggg ggaggagggc tggtgtggag gggcaacctg gactgaggcc
     5761 gaactccctt gggctcaccc cacccacccc tacctgagca tcagcagtgg ggggagggca
     5821 gcatcgcagg ggcagggact ccctgggtga ggacagacca gccctcccga gcacctggca
     5881 ctcatgggct gaggctgact tctcctggaa gaagggccca gagtggaagg aagaggcaga
     5941 gggtagaggt ggtggctggg ggctcctctg cagagtgggg tggccaatgg agagggctgc
     6001 actcacaccg caacatagga ctctctctcc cttaagaagg cccccttagg gtctgggctg
     6061 ccgcccccat caccctaaaa ccagccaagg tagctgaggc cccagggcag acaatttcac
     6121 cagcaggagg aggaggagtc cagtgagctt ggttgctcac agacagcaag ggagctgtca
     6181 cagaggaagc tgatgaatgg accgctgtgg ggagacttta aagtagaaca gtgataaggg
     6241 agggcaggat ggtggggatg cagaagcagc agccagagag agacggactg gggtgcagac
     6301 ggagtgtgga aaacgcatac cttgaaatga agcatccagc agatggggtg agtggataca
     6361 gctcaggaga ttctcccagg aatagcaggg aggcgtaaag agagacaacg tacagagata
     6421 gatgaatgga aatgggtaag ggaggtgttc attcacatcc atctaactgc aaaatacaaa
     6481 agtaagaagt cattgacatg aagcaacgac gaccaagacg ttctcagatc taaaggtgaa
     6541 tgatctcagt cagcctggaa atgcacaagg tggaaaaata acataaaaaa gccataagac
     6601 cttgaagaac atcaatgtca aagataaatt ctaaagtccc agagaaaaaa gaatgggaat
     6661 caaattgacc tcagactata cgtgagaaac acggagagcc agaaaactgt gatgttccat
     6721 cctcagagtt tgaaggaaat atttgaaggc tgaattttac atccagctaa actatcaaag
     6781 gcatgcaaag tccatgttat tcttaggcct tcaaggcctc ggccattttt ctacagaaaa
     6841 gcctgatttt aaaatgctct tagagacgtt ctccagccag aagagaaaga agccaggagg
     6901 gtgctctgag atattcagtc accacagttc ccaaatggcc taggaattca gagagtcaga
     6961 atatcaccat tactccccaa tgggaacccc cgacagtctc agcatggtgt gagggtgtgg
     7021 acggggggcc tggcaggtac caatcactca tcccgctcag tgaagacaca gtgttcagct
     7081 acggaagcca taaggcaggc cgagcttctg cccatccgga ggaaatctca gctatccaac
     7141 ggcggtcagg agcagaggaa aataaagcag aataactaga aaacacgctc acagatccta
     7201 atgttaacgg ttacaaatga cgacggaaaa acaaactcct gaccatatat tatatagttt
     7261 caagcagcaa gaaggaggat attgaacatt ctcaacacac ataataaacg cttgagatga
     7321 tgatatgctc attaccctga tttgatcact agacatccca tgtatcaaaa catcactgtg
     7381 tatccgatga atatctacaa ttattgtcaa ttaaaaacat cattaaaaac agactagact
     7441 gca
//
