LOCUS       NM_001385028            6212 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens multiple EGF like domains 11 (MEGF11), transcript
            variant 1, mRNA.
ACCESSION   NM_001385028
VERSION     NM_001385028.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6212)
  AUTHORS   Lee,J., Kim,J., Zinia,S.S., Park,J., Won,S. and Kim,W.J.
  TITLE     Prenatal phthalate exposure and cord blood DNA methylation
  JOURNAL   Sci Rep 13 (1), 7046 (2023)
   PUBMED   37120575
  REMARK    GeneRIF: Prenatal phthalate exposure and cord blood DNA
            methylation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6212)
  AUTHORS   Huang,C.P., Tsai,Y.F., Lin,Y.S., Liu,C.Y., Huang,T.T., Huang,C.C.,
            Chiu,J.H. and Tseng,L.M.
  TITLE     Overexpression of multiple epidermal growth factor like domains 11
            rescues anoikis survival through tumor cells-platelet interaction
            in triple negative breast Cancer cells
  JOURNAL   Life Sci 299, 120541 (2022)
   PUBMED   35398017
  REMARK    GeneRIF: Overexpression of multiple epidermal growth factor like
            domains 11 rescues anoikis survival through tumor cells-platelet
            interaction in triple negative breast Cancer cells.
REFERENCE   3  (bases 1 to 6212)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 6212)
  AUTHORS   Yoshida,T., Kato,K., Yokoi,K., Oguri,M., Watanabe,S., Metoki,N.,
            Yoshida,H., Satoh,K., Aoyagi,Y., Nozawa,Y. and Yamada,Y.
  TITLE     Association of genetic variants with hemorrhagic stroke in Japanese
            individuals
  JOURNAL   Int J Mol Med 25 (4), 649-656 (2010)
   PUBMED   20198315
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 6212)
  AUTHORS   Oguri,M., Kato,K., Yokoi,K., Yoshida,T., Watanabe,S., Metoki,N.,
            Yoshida,H., Satoh,K., Aoyagi,Y., Nozawa,Y. and Yamada,Y.
  TITLE     Assessment of a polymorphism of SDK1 with hypertension in Japanese
            Individuals
  JOURNAL   Am J Hypertens 23 (1), 70-77 (2010)
   PUBMED   19851296
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 6212)
  AUTHORS   Suzuki,E. and Nakayama,M.
  TITLE     The mammalian Ced-1 ortholog MEGF10/KIAA1780 displays a novel
            adhesion pattern
  JOURNAL   Exp Cell Res 313 (11), 2451-2464 (2007)
   PUBMED   17498693
REFERENCE   7  (bases 1 to 6212)
  AUTHORS   Lim,J., Hao,T., Shaw,C., Patel,A.J., Szabo,G., Rual,J.F.,
            Fisk,C.J., Li,N., Smolyar,A., Hill,D.E., Barabasi,A.L., Vidal,M.
            and Zoghbi,H.Y.
  TITLE     A protein-protein interaction network for human inherited ataxias
            and disorders of Purkinje cell degeneration
  JOURNAL   Cell 125 (4), 801-814 (2006)
   PUBMED   16713569
REFERENCE   8  (bases 1 to 6212)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC087382.11, AC011847.9 and AC084854.11.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074969.832714.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1968189 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000395614.6/ ENSP00000378976.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-146               AC087382.11        31069-31214
            147-252             AC087382.11        156408-156513
            253-354             AC087382.11        160819-160920
            355-455             AC087382.11        165633-165733
            456-548             AC087382.11        190325-190417
            549-795             AC011847.9         102264-102510
            796-916             AC011847.9         103854-103974
            917-1053            AC011847.9         114063-114199
            1054-1266           AC011847.9         119632-119844
            1267-1441           AC011847.9         127031-127205
            1442-1562           AC011847.9         153809-153929
            1563-1726           AC011847.9         154869-155032
            1727-1829           AC011847.9         156225-156327
            1830-1976           AC011847.9         161783-161929
            1977-2111           AC011847.9         162280-162414
            2112-2240           AC011847.9         166658-166786
            2241-2369           AC011847.9         167796-167924
            2370-2498           AC011847.9         168476-168604
            2499-2627           AC011847.9         169154-169282
            2628-2864           AC011847.9         170779-171015
            2865-2983           AC011847.9         172552-172670
            2984-3050           AC011847.9         174946-175012
            3051-3152           AC011847.9         175617-175718
            3153-3209           AC084854.11        143104-143160       c
            3210-3416           AC084854.11        135747-135953       c
            3417-6212           AC084854.11        132318-135113       c
FEATURES             Location/Qualifiers
     source          1..6212
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q22.31"
     gene            1..6212
                     /gene="MEGF11"
                     /note="multiple EGF like domains 11"
                     /db_xref="GeneID:84465"
                     /db_xref="HGNC:HGNC:29635"
                     /db_xref="MIM:612454"
     exon            1..146
                     /gene="MEGF11"
                     /inference="alignment:Splign:2.1.0"
     exon            147..252
                     /gene="MEGF11"
                     /inference="alignment:Splign:2.1.0"
     CDS             155..3577
                     /gene="MEGF11"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; multiple epidermal growth factor-like domains
                     protein 11; multiple EGF-like domains protein 11"
                     /codon_start=1
                     /product="multiple epidermal growth factor-like domains
                     protein 11 isoform 1 precursor"
                     /protein_id="NP_001371957.1"
                     /db_xref="CCDS:CCDS92027.1"
                     /db_xref="GeneID:84465"
                     /db_xref="HGNC:HGNC:29635"
                     /db_xref="MIM:612454"
                     /translation="MVLSLTGLIAFSFLQATLALNPEDPNVCSHWESYAVTVQESYAH
                     PFDQIYYTRCTDILNWFKCTRHRISYKTAYRRGLRTMYRRRSQCCPGYYESGDFCIPL
                     CTEECVHGRCVSPDTCHCEPGWGGPDCSSGCDSDHWGPHCSNRCQCQNGALCNPITGA
                     CVCAAGFRGWRCEELCAPGTHGKGCQLPCQCRHGASCDPRAGECLCAPGYTGVYCEEL
                     CPPGSHGAHCELRCPCQNGGTCHHITGECACPPGWTGAVCAQPCPPGTFGQNCSQDCP
                     CHHGGQCDHVTGQCHCTAGYMGDRCQEECPFGSFGFQCSQHCDCHNGGQCSPTTGACE
                     CEPGYKGPRCQERLCPEGLHGPGCTLPCPCDADNTISCHPVTGACTCQPGWSGHHCNE
                     SCPVGYYGDGCQLPCTCQNGADCHSITGGCTCAPGFMGEVCAVSCAAGTYGPNCSSIC
                     SCNNGGTCSPVDGSCTCKEGWQGLDCTLPCPSGTWGLNCNESCTCANGAACSPIDGSC
                     SCTPGWLGDTCELPCPDGTFGLNCSEHCDCSHADGCDPVTGHCCCLAGWTGIRCDSTC
                     PPGRWGPNCSVSCSCENGGSCSPEDGSCECAPGFRGPLCQRICPPGFYGHGCAQPCPL
                     CVHSSRPCHHISGICECLPGFSGALCNQVCAGGYFGQDCAQLCSCANNGTCSPIDGSC
                     QCFPGWIGKDCSQACPPGFWGPACFHACSCHNGASCSAEDGACHCTPGWTGLFCTQRC
                     PAAFFGKDCGRVCQCQNGASCDHISGKCTCRTGFTGQHCEQRCAPGTFGYGCQQLCEC
                     MNNSTCDHVTGTCYCSPGFKGIRCDQAALMMEELNPYTKISPALGAERHSVGAVTGIM
                     LLLFLIVVLLGLFAWHRRRQKEKGRDLAPRVSYTPAMRMTSTDYSLSDLSQSSSHAHC
                     FSNSSYHALACGGPATSQASTLDRNSPTKLSNKSLDRDTAGWTPYSYVNVLDSHFQIS
                     ALEARYPPEDFYIELRHLSRPAEPHSPGACGMDRRQNTYIMDKGFKDYMKESVCSSST
                     CSLNSSENPYATIKDPPILTCKLPESSYVEMKSPVHMGSPYTDVPSLSTSNKNIYEVE
                     PTVSVVQEGCGHNSSYIQNAYDLPRNSHIPGHYDLLPVRQSPANGPSQDKQS"
     exon            253..354
                     /gene="MEGF11"
                     /inference="alignment:Splign:2.1.0"
     exon            355..455
                     /gene="MEGF11"
                     /inference="alignment:Splign:2.1.0"
     exon            456..548
                     /gene="MEGF11"
                     /inference="alignment:Splign:2.1.0"
     exon            549..795
                     /gene="MEGF11"
                     /inference="alignment:Splign:2.1.0"
     exon            796..916
                     /gene="MEGF11"
                     /inference="alignment:Splign:2.1.0"
     exon            917..1053
                     /gene="MEGF11"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1266
                     /gene="MEGF11"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1441
                     /gene="MEGF11"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..1562
                     /gene="MEGF11"
                     /inference="alignment:Splign:2.1.0"
     exon            1563..1726
                     /gene="MEGF11"
                     /inference="alignment:Splign:2.1.0"
     exon            1727..1829
                     /gene="MEGF11"
                     /inference="alignment:Splign:2.1.0"
     exon            1830..1976
                     /gene="MEGF11"
                     /inference="alignment:Splign:2.1.0"
     exon            1977..2111
                     /gene="MEGF11"
                     /inference="alignment:Splign:2.1.0"
     exon            2112..2240
                     /gene="MEGF11"
                     /inference="alignment:Splign:2.1.0"
     exon            2241..2369
                     /gene="MEGF11"
                     /inference="alignment:Splign:2.1.0"
     exon            2370..2498
                     /gene="MEGF11"
                     /inference="alignment:Splign:2.1.0"
     exon            2499..2627
                     /gene="MEGF11"
                     /inference="alignment:Splign:2.1.0"
     exon            2628..2864
                     /gene="MEGF11"
                     /inference="alignment:Splign:2.1.0"
     exon            2865..2983
                     /gene="MEGF11"
                     /inference="alignment:Splign:2.1.0"
     exon            2984..3050
                     /gene="MEGF11"
                     /inference="alignment:Splign:2.1.0"
     exon            3051..3152
                     /gene="MEGF11"
                     /inference="alignment:Splign:2.1.0"
     exon            3153..3209
                     /gene="MEGF11"
                     /inference="alignment:Splign:2.1.0"
     exon            3210..3416
                     /gene="MEGF11"
                     /inference="alignment:Splign:2.1.0"
     exon            3417..6212
                     /gene="MEGF11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6194..6199
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MEGF11"
                     /note="hexamer: AACAAA"
     polyA_site      6212
                     /gene="MEGF11"
                     /note="major polyA site"
ORIGIN      
        1 agtcgctccc ggtgcccgct gcccgccgcc cggctcccgg ctgctcgcgg ccccctgctc
       61 ctgcctggcg ctctggccag gctcgggctc cggaggacag gaccgcgcga ctggccggcc
      121 gatccctggg ccggccgcgg gagcagggcc cgggatggtg ctctccctga cggggctcat
      181 tgccttctcc ttcctgcaag ccacccttgc cctgaacccc gaggacccca acgtgtgcag
      241 ccactgggag agctatgctg tgactgtcca ggaatcgtat gcacacccct tcgatcagat
      301 ctattacaca cgatgcacag acatcctcaa ctggttcaag tgcaccaggc accggatcag
      361 ttataagacg gcgtatcgga gaggcctccg gaccatgtac cggcggaggt cccagtgctg
      421 ccctggctac tatgagagcg gagacttctg catacccctg tgtacggagg agtgtgtgca
      481 cggccgctgc gtttccccgg acacctgcca ctgcgagcct ggctggggag ggcccgactg
      541 ctccagcggc tgcgacagcg accactgggg gccccactgc agcaaccggt gccagtgcca
      601 gaacggcgcc ctgtgtaacc ccatcacagg cgcctgcgtg tgcgccgccg gcttccgtgg
      661 atggcgctgc gaggagctct gcgcacctgg cacccacggc aagggatgcc agctgccgtg
      721 ccagtgccga cacggtgcca gctgcgaccc ccgcgccggc gagtgcctct gcgcacctgg
      781 ctacaccggc gtctactgcg aggagctgtg ccctcctggg agccatggag ctcactgtga
      841 gctgcgctgc ccctgtcaga atgggggcac ctgccaccac atcactggcg agtgtgcctg
      901 ccccccaggc tggacgggag cagtgtgtgc ccagccctgc ccaccaggga catttggcca
      961 gaactgcagc caggattgtc cttgccacca tggagggcag tgtgaccacg tgactggaca
     1021 gtgccactgt acagctggat acatggggga caggtgccaa gaggagtgcc ccttcgggtc
     1081 cttcggcttc cagtgctcac agcactgtga ctgccacaat ggggggcagt gttcacccac
     1141 cacgggtgcc tgcgagtgtg agcctggcta caagggccca cgctgccagg agcgactgtg
     1201 cccggagggc ctgcatggcc caggctgcac cctgccctgc ccctgtgacg ctgacaacac
     1261 catcagctgc cacccagtaa ctggagcttg tacctgccag ccaggctggt ctggtcacca
     1321 ctgcaatgaa tcctgccctg ttggctacta tggcgatggc tgccagctgc cttgcacctg
     1381 tcagaatggc gccgactgcc acagcatcac tgggggctgc acttgtgctc cgggcttcat
     1441 gggagaggtc tgtgccgttt cctgtgcagc agggacctat ggccccaact gctcgtccat
     1501 ctgtagctgt aacaatggtg gcacctgctc cccagtagat ggctcctgta cctgcaagga
     1561 agggtggcag ggcctggact gcaccctgcc atgtcccagt gggacgtggg gcctgaactg
     1621 caacgagagc tgcacctgtg ccaatggggc agcctgcagc cccatagacg gctcctgctc
     1681 ctgcactcct ggctggctgg gagacacctg tgagctgcct tgcccggatg gcacatttgg
     1741 gctgaactgc agtgaacact gtgactgcag ccatgctgat ggatgtgacc ccgtcacagg
     1801 ccactgctgc tgcctggccg gatggacagg catccgctgt gacagcacgt gtccacctgg
     1861 ccgctggggc cccaactgct ctgtctcctg cagctgtgag aatggaggct cctgctcccc
     1921 agaggatggg agctgcgagt gtgcccctgg cttccgagga cccttatgcc agagaatctg
     1981 cccccctggg ttctatggcc acggctgcgc ccagccatgc cccctctgcg tgcacagcag
     2041 caggccctgc caccacatca gcggcatctg tgagtgcctc ccaggattct ctggagctct
     2101 ctgcaaccaa gtgtgtgctg gaggatactt tgggcaggac tgtgcccagc tctgctcctg
     2161 tgccaacaac gggacctgca gccctatcga tggctcctgc cagtgctttc ctggatggat
     2221 tggcaaggac tgctcacagg cttgcccacc cgggttctgg ggccccgcct gcttccacgc
     2281 atgcagctgc cacaacgggg cgagctgcag cgccgaggac ggggcctgcc actgcacccc
     2341 tggctggact ggactcttct gcacacagcg ctgcccagca gcattttttg ggaaggactg
     2401 tgggcgcgta tgccagtgtc agaatggcgc cagctgtgac cacatcagtg gcaagtgcac
     2461 ctgccgcaca ggcttcaccg ggcaacactg tgagcagaga tgtgccccag gaacctttgg
     2521 ctatgggtgt cagcagctat gtgagtgcat gaacaactcc acctgtgacc atgtcaccgg
     2581 cacctgttac tgcagccctg gcttcaaagg aatcaggtgt gaccaagctg ccctcatgat
     2641 ggaggagctg aatccctaca ccaagatcag cccagcactg ggtgcagagc ggcactcggt
     2701 gggtgctgtc acaggcatca tgctcctgtt attcctcatt gtggtgctgc tgggcctatt
     2761 tgcctggcat cggcggcggc agaaagagaa gggccgagac ctggctcccc gtgtctccta
     2821 cacacctgcc atgaggatga ccagcaccga ctactccctc tcagatttgt ctcaaagtag
     2881 cagccatgcc cactgctttt ccaattccag ctaccacgca ctggcatgtg gggggcctgc
     2941 caccagccag gccagcactc tggacaggaa cagccccacc aagctcagta acaagtccct
     3001 tgacagagac acagcaggct ggacccccta cagctatgtg aacgtgttag actcccattt
     3061 ccagatcagt gccctggagg ccaggtaccc gcccgaggac ttctacattg aacttagaca
     3121 cctcagccgc cccgctgagc cacactcacc aggtgcttgt ggaatggata gacgtcagaa
     3181 cacatacatt atggacaaag gcttcaaaga ttacatgaaa gaatccgtgt gcagttctag
     3241 tacttgttcc ttgaatagca gtgaaaaccc ttacgccaca attaaggacc cacccatcct
     3301 cacctgcaag cttccagaaa gcagctatgt agaaatgaag tcgcctgtgc acatggggtc
     3361 tccgtacaca gatgtgccat ccttgtcgac atctaataaa aatatatatg aagttgagcc
     3421 cacagtcagt gtggtccaag aaggttgcgg tcataactcc agctatatcc agaatgcata
     3481 cgacctacct aggaacagcc atattcctgg tcattatgac ctcctcccag taagacagag
     3541 ccctgccaat gggccgtccc aggacaagca atcttaagag ggataagctt ctctcttgca
     3601 gtgtgctcta ctgaatattc tgactctgaa agaagacagt cccttgactt gaagtaatgg
     3661 tacagactgg ctccagctgc atgttagtta ttacgttcac ctggaactaa agaagagcgt
     3721 ccaggtggga ctgggataat tgttcaagga attgtgttct caaaggcaaa tcctatcacc
     3781 cactcagccc caaatgccct ggattatatg atttttaaaa cattttaaga tacagctact
     3841 catcaacatc agctaaatat agctgatata tatatatata tttatctgaa acgtgatatt
     3901 ttaaaaacat gtaggtttaa caaaccttcc taggacaaaa aggagactgg ggagggaaga
     3961 ggattacttt aaagcacctg aaacgtatat gtacttttgg ttgctgttac catcaacatc
     4021 tgttttatta ccgaagacaa ttagtacaca gacatgaact gttcttaaac agaacagtct
     4081 taaaatgtct gtacatatct gtctggtcca tcaaattaca acagccaaga ttacagaatc
     4141 tatatagtct aatgctgaca acttctattt taaaaaacaa gactttactt tcttctgccc
     4201 cctaagtgat aggtttaaac acacagagac acacacacac gtttccaaag tgcagcagtg
     4261 tctctttcag tctacaataa gattcctagg gcagctttat caaattttgc caattcaaag
     4321 ttcaaggaca ttacaagtta gtcctggctt tgtcatatct acttagtcca tccgacacct
     4381 gaatcattcc atgtaaaaca gagctctaag atgatccttt aagcaagcag tcatagactg
     4441 gtcgggatta agtaaaagac ggctagttgg cctcctcatt ttatttggtc agcatccctt
     4501 gactcaagag tacttgcttt caagttcttc ataaatcttg agattgacgt agtatgaaac
     4561 ctaaaagtat acaggaaatt ggacaaatgt ggatacagca agtttacact gcttaaagta
     4621 cattatgctt tttaatggaa ctaaatgatc aaaaaaagaa tggactgtaa ccagttgctg
     4681 taacgtgatg taaaaacgtt actgtaaaca gcatgaggat atgaagtcct tccaccttct
     4741 atcttaaaac tactacttac tgagctagcc caatatgcat tacaatgagc taatgctcca
     4801 gatcccagta ttcagatgtg tctatacctt ccactatgaa cacagataaa ctgaggctca
     4861 gataagtcca aatgaaatga aatcaactcc caagccctaa agagaacctt ctcacaagaa
     4921 ttaaaaacaa aaagggcaaa cctaggaagc taacggctac tcctgtacca ctctattcac
     4981 tggtacagtc cagccagtaa aaaacacttc caaaaagata cacagaagag gaactaaatg
     5041 actgcgaagc tggaatactg ctacaggaag tatgagagtt ctgaaaccct tgatagaaac
     5101 tggaagcctg ccatggaaca caatactttg ggcaataatc agaaaaagca aaaaaataaa
     5161 taaatgagta catctcccct tcccacatca ctcaaggcat aagcagattt tactgttaga
     5221 ggaaaatatg taatacttac atgaatgttg catgtgtgca tgggagcaac tgagtagcaa
     5281 tagtaaattt actttccaaa aaagccttat taaaatataa atattagaaa attactttgg
     5341 agacccaagt aaatatttct catacatatg tagaaagaaa tataggtaag cagcttacct
     5401 cagtatttca gggcagcaag tgtttgtgaa gcaaggatga gcagcatgaa gatgtcagat
     5461 cagcaaggag aaacttcaac tcaatcccag gttttctctt cttcccttat cctgcatgta
     5521 caataactgc tgcctggcaa actgcaaaca agcagcatca ctcaagtttg aagtttcgcc
     5581 gcttttgtca actatcctct gggcaaaggt attcagcaag aggtggaatg gctagacact
     5641 gaatcaagag atttcagtgt tactctggtc aagttagtcg ccctctctgg gctccctttt
     5701 ttcctatgca taaaaagggg agaagcagag agtgggaaga cagctctact aacccttcag
     5761 ctctagcagt ccatgacttt ttaaggaaat gtaatacaag tcaaaccagg caatacagag
     5821 gagaagggaa aggcagaggg tgtgattatg gtgacaatag ctgccttccc ctatcgaaca
     5881 gttatcagta aaagacattt caatcttaca aagcaactgt tagaaacttc tgtctaacac
     5941 catcacaaat aggttcatgg tcagcctaaa catgtatact gtgcatttta tgggtgactt
     6001 tgaaagatct gttcaattat ttttcagaaa ctaaattttc aaaaaattaa tatgtgtaca
     6061 attaaaatga atgaaagaaa aaccattatt gtacagaggt attaatgaga ctatgaaacg
     6121 gcaatacttt tttaaatcac agatttgtaa tatatgttca ctgtgcagag ggattgtacc
     6181 ttgtacaaaa taaaacaaat ttctcaaact aa
//
