LOCUS       NP_001371957            1140 aa            linear   PRI 30-APR-2025
DEFINITION  multiple epidermal growth factor-like domains protein 11 isoform 1
            precursor [Homo sapiens].
ACCESSION   NP_001371957
VERSION     NP_001371957.1
DBSOURCE    REFSEQ: accession NM_001385028.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 1140)
  AUTHORS   Lee,J., Kim,J., Zinia,S.S., Park,J., Won,S. and Kim,W.J.
  TITLE     Prenatal phthalate exposure and cord blood DNA methylation
  JOURNAL   Sci Rep 13 (1), 7046 (2023)
   PUBMED   37120575
  REMARK    GeneRIF: Prenatal phthalate exposure and cord blood DNA
            methylation.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 1140)
  AUTHORS   Huang,C.P., Tsai,Y.F., Lin,Y.S., Liu,C.Y., Huang,T.T., Huang,C.C.,
            Chiu,J.H. and Tseng,L.M.
  TITLE     Overexpression of multiple epidermal growth factor like domains 11
            rescues anoikis survival through tumor cells-platelet interaction
            in triple negative breast Cancer cells
  JOURNAL   Life Sci 299, 120541 (2022)
   PUBMED   35398017
  REMARK    GeneRIF: Overexpression of multiple epidermal growth factor like
            domains 11 rescues anoikis survival through tumor cells-platelet
            interaction in triple negative breast Cancer cells.
REFERENCE   3  (residues 1 to 1140)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (residues 1 to 1140)
  AUTHORS   Yoshida,T., Kato,K., Yokoi,K., Oguri,M., Watanabe,S., Metoki,N.,
            Yoshida,H., Satoh,K., Aoyagi,Y., Nozawa,Y. and Yamada,Y.
  TITLE     Association of genetic variants with hemorrhagic stroke in Japanese
            individuals
  JOURNAL   Int J Mol Med 25 (4), 649-656 (2010)
   PUBMED   20198315
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (residues 1 to 1140)
  AUTHORS   Oguri,M., Kato,K., Yokoi,K., Yoshida,T., Watanabe,S., Metoki,N.,
            Yoshida,H., Satoh,K., Aoyagi,Y., Nozawa,Y. and Yamada,Y.
  TITLE     Assessment of a polymorphism of SDK1 with hypertension in Japanese
            Individuals
  JOURNAL   Am J Hypertens 23 (1), 70-77 (2010)
   PUBMED   19851296
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (residues 1 to 1140)
  AUTHORS   Suzuki,E. and Nakayama,M.
  TITLE     The mammalian Ced-1 ortholog MEGF10/KIAA1780 displays a novel
            adhesion pattern
  JOURNAL   Exp Cell Res 313 (11), 2451-2464 (2007)
   PUBMED   17498693
REFERENCE   7  (residues 1 to 1140)
  AUTHORS   Lim,J., Hao,T., Shaw,C., Patel,A.J., Szabo,G., Rual,J.F.,
            Fisk,C.J., Li,N., Smolyar,A., Hill,D.E., Barabasi,A.L., Vidal,M.
            and Zoghbi,H.Y.
  TITLE     A protein-protein interaction network for human inherited ataxias
            and disorders of Purkinje cell degeneration
  JOURNAL   Cell 125 (4), 801-814 (2006)
   PUBMED   16713569
REFERENCE   8  (residues 1 to 1140)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC087382.11, AC011847.9 and AC084854.11.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074969.832714.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1968189 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000395614.6/ ENSP00000378976.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1140
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q22.31"
     Protein         1..1140
                     /product="multiple epidermal growth factor-like domains
                     protein 11 isoform 1 precursor"
                     /note="multiple epidermal growth factor-like domains
                     protein 11; multiple EGF-like domains protein 11"
                     /calculated_mol_wt=119441
     sig_peptide     1..19
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=1996
     Region          25..94
                     /region_name="EMI"
                     /note="EMI domain; pfam07546"
                     /db_xref="CDD:462204"
     Region          275..320
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cl21504"
                     /db_xref="CDD:473889"
     Region          362..409
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cl21504"
                     /db_xref="CDD:473889"
     CDS             1..1140
                     /gene="MEGF11"
                     /coded_by="NM_001385028.1:155..3577"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS92027.1"
                     /db_xref="GeneID:84465"
                     /db_xref="HGNC:HGNC:29635"
                     /db_xref="MIM:612454"
ORIGIN      
        1 mvlsltglia fsflqatlal npedpnvcsh wesyavtvqe syahpfdqiy ytrctdilnw
       61 fkctrhrisy ktayrrglrt myrrrsqccp gyyesgdfci plcteecvhg rcvspdtchc
      121 epgwggpdcs sgcdsdhwgp hcsnrcqcqn galcnpitga cvcaagfrgw rceelcapgt
      181 hgkgcqlpcq crhgascdpr ageclcapgy tgvyceelcp pgshgahcel rcpcqnggtc
      241 hhitgecacp pgwtgavcaq pcppgtfgqn csqdcpchhg gqcdhvtgqc hctagymgdr
      301 cqeecpfgsf gfqcsqhcdc hnggqcsptt gacecepgyk gprcqerlcp eglhgpgctl
      361 pcpcdadnti schpvtgact cqpgwsghhc nescpvgyyg dgcqlpctcq ngadchsitg
      421 gctcapgfmg evcavscaag tygpncssic scnnggtcsp vdgsctckeg wqgldctlpc
      481 psgtwglncn esctcangaa cspidgscsc tpgwlgdtce lpcpdgtfgl ncsehcdcsh
      541 adgcdpvtgh ccclagwtgi rcdstcppgr wgpncsvscs cenggscspe dgscecapgf
      601 rgplcqricp pgfyghgcaq pcplcvhssr pchhisgice clpgfsgalc nqvcaggyfg
      661 qdcaqlcsca nngtcspidg scqcfpgwig kdcsqacppg fwgpacfhac schngascsa
      721 edgachctpg wtglfctqrc paaffgkdcg rvcqcqngas cdhisgkctc rtgftgqhce
      781 qrcapgtfgy gcqqlcecmn nstcdhvtgt cycspgfkgi rcdqaalmme elnpytkisp
      841 algaerhsvg avtgimlllf livvllglfa whrrrqkekg rdlaprvsyt pamrmtstdy
      901 slsdlsqsss hahcfsnssy halacggpat sqastldrns ptklsnksld rdtagwtpys
      961 yvnvldshfq isalearypp edfyielrhl srpaephspg acgmdrrqnt yimdkgfkdy
     1021 mkesvcssst cslnssenpy atikdppilt cklpessyve mkspvhmgsp ytdvpslsts
     1081 nkniyevept vsvvqegcgh nssyiqnayd lprnshipgh ydllpvrqsp angpsqdkqs
//
