LOCUS       NM_001256545            7606 bp    mRNA    linear   PRI 18-JUL-2024
DEFINITION  Homo sapiens multiple EGF like domains 10 (MEGF10), transcript
            variant 2, mRNA.
ACCESSION   NM_001256545
VERSION     NM_001256545.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7606)
  AUTHORS   Lin,Y.F., Wu,X.Y., Yang,L., Cheng,G.Q., Huang,Y. and Zhuang,D.Y.
  TITLE     [A family with early onset myopathy caused by MEGF10 gene defect
            and literature review]
  JOURNAL   Zhonghua Er Ke Za Zhi 61 (3), 261-265 (2023)
   PUBMED   36849355
  REMARK    GeneRIF: [A family with early onset myopathy caused by MEGF10 gene
            defect and literature review].
            Review article
REFERENCE   2  (bases 1 to 7606)
  AUTHORS   AlMuhaizea,M., Dabbagh,O., AlQudairy,H., AlHargan,A., Alotaibi,W.,
            Sami,R., AlOtaibi,R., Ali,M.M., AlHindi,H., Colak,D. and Kaya,N.
  TITLE     Phenotypic Variability of MEGF10 Variants Causing Congenital
            Myopathy: Report of Two Unrelated Patients from a Highly
            Consanguineous Population
  JOURNAL   Genes (Basel) 12 (11), 1783 (2021)
   PUBMED   34828389
  REMARK    GeneRIF: Phenotypic Variability of MEGF10 Variants Causing
            Congenital Myopathy: Report of Two Unrelated Patients from a Highly
            Consanguineous Population.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7606)
  AUTHORS   Yang,H., Cai,M.Y., Rong,H., Ma,L.R. and Xu,Y.L.
  TITLE     ZNF667-AS1, a positively regulating MEGF10, inhibits the
            progression of uveal melanoma by modulating cellular aggressiveness
  JOURNAL   J Biochem Mol Toxicol 35 (5), e22732 (2021)
   PUBMED   33512044
  REMARK    GeneRIF: ZNF667-AS1, a positively regulating MEGF10, inhibits the
            progression of uveal melanoma by modulating cellular
            aggressiveness.
REFERENCE   4  (bases 1 to 7606)
  AUTHORS   Saha,M., Rizzo,S.A., Ramanathan,M., Hightower,R.M.,
            Santostefano,K.E., Terada,N., Finkel,R.S., Berg,J.S., Chahin,N.,
            Pacak,C.A., Wagner,R.E., Alexander,M.S., Draper,I. and Kang,P.B.
  TITLE     Selective serotonin reuptake inhibitors ameliorate MEGF10 myopathy
  JOURNAL   Hum Mol Genet 28 (14), 2365-2377 (2019)
   PUBMED   31267131
REFERENCE   5  (bases 1 to 7606)
  AUTHORS   Logan,C.V., Lucke,B., Pottinger,C., Abdelhamed,Z.A., Parry,D.A.,
            Szymanska,K., Diggle,C.P., van Riesen,A., Morgan,J.E., Markham,G.,
            Ellis,I., Manzur,A.Y., Markham,A.F., Shires,M., Helliwell,T.,
            Scoto,M., Hubner,C., Bonthron,D.T., Taylor,G.R., Sheridan,E.,
            Muntoni,F., Carr,I.M., Schuelke,M. and Johnson,C.A.
  TITLE     Mutations in MEGF10, a regulator of satellite cell myogenesis,
            cause early onset myopathy, areflexia, respiratory distress and
            dysphagia (EMARDD)
  JOURNAL   Nat Genet 43 (12), 1189-1192 (2011)
   PUBMED   22101682
  REMARK    GeneRIF: Mutations in MEGF10, a regulator of satellite cell
            myogenesis, cause early onset myopathy, areflexia, respiratory
            distress and dysphagia (EMARDD)
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7606)
  AUTHORS   Singh,T.D., Park,S.Y., Bae,J.S., Yun,Y., Bae,Y.C., Park,R.W. and
            Kim,I.S.
  TITLE     MEGF10 functions as a receptor for the uptake of amyloid-beta
  JOURNAL   FEBS Lett 584 (18), 3936-3942 (2010)
   PUBMED   20828568
  REMARK    GeneRIF: MEGF10 is involved in the uptake of amyloid-beta peptide
            (Abeta42) in the brain.
REFERENCE   7  (bases 1 to 7606)
  AUTHORS   Chen,X., Wang,X., Chen,Q., Williamson,V., van den Oord,E.,
            Maher,B.S., O'Neill,F.A., Walsh,D. and Kendler,K.S.
  TITLE     MEGF10 association with schizophrenia
  JOURNAL   Biol Psychiatry 63 (5), 441-448 (2008)
   PUBMED   18179784
  REMARK    GeneRIF: In expression studies, MEGF10 had higher expression levels
            in the affected than the unaffected (p = .015). Schizophrenia
            patients with a 1/1 genotype at rs27388 had higher expressions than
            those patients with 1/2 and 2/2 genotypes (p = .0008).
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 7606)
  AUTHORS   Suzuki,E. and Nakayama,M.
  TITLE     MEGF10 is a mammalian ortholog of CED-1 that interacts with
            clathrin assembly protein complex 2 medium chain and induces large
            vacuole formation
  JOURNAL   Exp Cell Res 313 (17), 3729-3742 (2007)
   PUBMED   17643423
  REMARK    GeneRIF: An interaction between MEGF10 and clathrin assembly
            protein complex 2 medium chain (AP50), a component of
            clathrin-coated pits was identified.
REFERENCE   9  (bases 1 to 7606)
  AUTHORS   Suzuki,E. and Nakayama,M.
  TITLE     The mammalian Ced-1 ortholog MEGF10/KIAA1780 displays a novel
            adhesion pattern
  JOURNAL   Exp Cell Res 313 (11), 2451-2464 (2007)
   PUBMED   17498693
  REMARK    GeneRIF: Human MEGF10 is an ortholog of Ced1.
REFERENCE   10 (bases 1 to 7606)
  AUTHORS   Hamon,Y., Trompier,D., Ma,Z., Venegas,V., Pophillat,M.,
            Mignotte,V., Zhou,Z. and Chimini,G.
  TITLE     Cooperation between engulfment receptors: the case of ABCA1 and
            MEGF10
  JOURNAL   PLoS One 1 (1), e120 (2006)
   PUBMED   17205124
  REMARK    GeneRIF: in a system of forced expression by transfection, MEGF10
            function can be modulated by the ATP binding cassette transporter
            ABCA1, ortholog to CED-7
            Publication Status: Online-Only
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA240513.1, AC008402.6,
            AC008682.6, DA738723.1 and AC010424.9.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001256545.1.
            
            Summary: This gene encodes a member of the multiple epidermal
            growth factor-like domains protein family. The encoded protein
            plays a role in cell adhesion, motility and proliferation, and is a
            critical mediator of apoptotic cell phagocytosis as well as
            amyloid-beta peptide uptake in the brain. Expression of this gene
            may be associated with schizophrenia, and mutations in this gene
            are a cause of early-onset myopathy, areflexia, respiratory
            distress, and dysphagia (EMARDD) as well as congenital myopathy
            with minicores. Alternatively spliced transcript variants have been
            observed for this gene. [provided by RefSeq, Apr 2012].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CR749437.1, SRR1660805.16218.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000503335.7/ ENSP00000423354.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                DA240513.1         33-67
            36-261              AC008402.6         3059-3284           c
            262-395             AC008682.6         170326-170459       c
            396-497             AC008682.6         162529-162630       c
            498-598             AC008682.6         161120-161220       c
            599-691             AC008682.6         131748-131840       c
            692-938             AC008682.6         104972-105218       c
            939-1059            AC008682.6         102954-103074       c
            1060-1196           AC008682.6         99068-99204         c
            1197-1409           AC008682.6         91149-91361         c
            1410-1584           AC008682.6         83938-84112         c
            1585-1705           AC008682.6         82510-82630         c
            1706-1869           AC008682.6         81543-81706         c
            1870-1906           AC008682.6         79044-79080         c
            1907-2067           DA738723.1         214-374
            2068-2119           AC008682.6         68241-68292         c
            2120-2254           AC008682.6         66929-67063         c
            2255-2383           AC008682.6         66261-66389         c
            2384-2512           AC008682.6         63183-63311         c
            2513-2641           AC008682.6         60883-61011         c
            2642-2770           AC008682.6         58624-58752         c
            2771-3007           AC010424.9         14375-14611
            3008-3135           AC010424.9         16475-16602
            3136-3259           AC010424.9         18017-18140
            3260-3304           AC010424.9         23484-23528
            3305-3511           AC010424.9         24319-24525
            3512-7606           AC010424.9         26046-30140
FEATURES             Location/Qualifiers
     source          1..7606
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q23.2"
     gene            1..7606
                     /gene="MEGF10"
                     /gene_synonym="CMYO10A; CMYO10B; CMYP10A; CMYP10B; EMARDD;
                     SR-F3"
                     /note="multiple EGF like domains 10"
                     /db_xref="GeneID:84466"
                     /db_xref="HGNC:HGNC:29634"
                     /db_xref="MIM:612453"
     exon            1..261
                     /gene="MEGF10"
                     /gene_synonym="CMYO10A; CMYO10B; CMYP10A; CMYP10B; EMARDD;
                     SR-F3"
                     /inference="alignment:Splign:2.1.0"
     exon            262..395
                     /gene="MEGF10"
                     /gene_synonym="CMYO10A; CMYO10B; CMYP10A; CMYP10B; EMARDD;
                     SR-F3"
                     /inference="alignment:Splign:2.1.0"
     CDS             280..3702
                     /gene="MEGF10"
                     /gene_synonym="CMYO10A; CMYO10B; CMYP10A; CMYP10B; EMARDD;
                     SR-F3"
                     /note="isoform a precursor is encoded by transcript
                     variant 2; multiple epidermal growth factor-like domains
                     protein 10"
                     /codon_start=1
                     /product="multiple epidermal growth factor-like domains
                     protein 10 isoform a precursor"
                     /protein_id="NP_001243474.1"
                     /db_xref="CCDS:CCDS4142.1"
                     /db_xref="GeneID:84466"
                     /db_xref="HGNC:HGNC:29634"
                     /db_xref="MIM:612453"
                     /translation="MVISLNSCLSFICLLLCHWIGTASPLNLEDPNVCSHWESYSVTV
                     QESYPHPFDQIYYTSCTDILNWFKCTRHRVSYRTAYRHGEKTMYRRKSQCCPGFYESG
                     EMCVPHCADKCVHGRCIAPNTCQCEPGWGGTNCSSACDGDHWGPHCTSRCQCKNGALC
                     NPITGACHCAAGFRGWRCEDRCEQGTYGNDCHQRCQCQNGATCDHVTGECRCPPGYTG
                     AFCEDLCPPGKHGPQCEQRCPCQNGGVCHHVTGECSCPSGWMGTVCGQPCPEGRFGKN
                     CSQECQCHNGGTCDAATGQCHCSPGYTGERCQDECPVGTYGVLCAETCQCVNGGKCYH
                     VSGACLCEAGFAGERCEARLCPEGLYGIKCDKRCPCHLENTHSCHPMSGECACKPGWS
                     GLYCNETCSPGFYGEACQQICSCQNGADCDSVTGKCTCAPGFKGIDCSTPCPLGTYGI
                     NCSSRCGCKNDAVCSPVDGSCTCKAGWHGVDCSIRCPSGTWGFGCNLTCQCLNGGACN
                     TLDGTCTCAPGWRGEKCELPCQDGTYGLNCAERCDCSHADGCHPTTGHCRCLPGWSGV
                     HCDSVCAEGRWGPNCSLPCYCKNGASCSPDDGICECAPGFRGTTCQRICSPGFYGHRC
                     SQTCPQCVHSSGPCHHITGLCDCLPGFTGALCNEVCPSGRFGKNCAGICTCTNNGTCN
                     PIDRSCQCYPGWIGSDCSQPCPPAHWGPNCIHTCNCHNGAFCSAYDGECKCTPGWTGL
                     YCTQRCPLGFYGKDCALICQCQNGADCDHISGQCTCRTGFMGRHCEQKCPSGTYGYGC
                     RQICDCLNNSTCDHITGTCYCSPGWKGARCDQAGVIIVGNLNSLSRTSTALPADSYQI
                     GAIAGIIILVLVVLFLLALFIIYRHKQKGKESSMPAVTYTPAMRVVNADYTISGTLPH
                     SNGGNANSHYFTNPSYHTLTQCATSPHVNNRDRMTVTKSKNNQLFVNLKNVNPGKRGP
                     VGDCTGTLPADWKHGGYLNELGAFGLDRSYMGKSLKDLGKNSEYNSSNCSLSSSENPY
                     ATIKDPPVLIPKSSECGYVEMKSPARRDSPYAEINNSTSANRNVYEVEPTVSVVQGVF
                     SNNGRLSQDPYDLPKNSHIPCHYDLLPVRDSSSSPKQEDSGGSSSNSSSSSE"
     exon            396..497
                     /gene="MEGF10"
                     /gene_synonym="CMYO10A; CMYO10B; CMYP10A; CMYP10B; EMARDD;
                     SR-F3"
                     /inference="alignment:Splign:2.1.0"
     exon            498..598
                     /gene="MEGF10"
                     /gene_synonym="CMYO10A; CMYO10B; CMYP10A; CMYP10B; EMARDD;
                     SR-F3"
                     /inference="alignment:Splign:2.1.0"
     exon            599..691
                     /gene="MEGF10"
                     /gene_synonym="CMYO10A; CMYO10B; CMYP10A; CMYP10B; EMARDD;
                     SR-F3"
                     /inference="alignment:Splign:2.1.0"
     exon            692..938
                     /gene="MEGF10"
                     /gene_synonym="CMYO10A; CMYO10B; CMYP10A; CMYP10B; EMARDD;
                     SR-F3"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1059
                     /gene="MEGF10"
                     /gene_synonym="CMYO10A; CMYO10B; CMYP10A; CMYP10B; EMARDD;
                     SR-F3"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1196
                     /gene="MEGF10"
                     /gene_synonym="CMYO10A; CMYO10B; CMYP10A; CMYP10B; EMARDD;
                     SR-F3"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1409
                     /gene="MEGF10"
                     /gene_synonym="CMYO10A; CMYO10B; CMYP10A; CMYP10B; EMARDD;
                     SR-F3"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..1584
                     /gene="MEGF10"
                     /gene_synonym="CMYO10A; CMYO10B; CMYP10A; CMYP10B; EMARDD;
                     SR-F3"
                     /inference="alignment:Splign:2.1.0"
     exon            1585..1705
                     /gene="MEGF10"
                     /gene_synonym="CMYO10A; CMYO10B; CMYP10A; CMYP10B; EMARDD;
                     SR-F3"
                     /inference="alignment:Splign:2.1.0"
     exon            1706..1869
                     /gene="MEGF10"
                     /gene_synonym="CMYO10A; CMYO10B; CMYP10A; CMYP10B; EMARDD;
                     SR-F3"
                     /inference="alignment:Splign:2.1.0"
     exon            1870..1972
                     /gene="MEGF10"
                     /gene_synonym="CMYO10A; CMYO10B; CMYP10A; CMYP10B; EMARDD;
                     SR-F3"
                     /inference="alignment:Splign:2.1.0"
     exon            1973..2119
                     /gene="MEGF10"
                     /gene_synonym="CMYO10A; CMYO10B; CMYP10A; CMYP10B; EMARDD;
                     SR-F3"
                     /inference="alignment:Splign:2.1.0"
     exon            2120..2254
                     /gene="MEGF10"
                     /gene_synonym="CMYO10A; CMYO10B; CMYP10A; CMYP10B; EMARDD;
                     SR-F3"
                     /inference="alignment:Splign:2.1.0"
     exon            2255..2383
                     /gene="MEGF10"
                     /gene_synonym="CMYO10A; CMYO10B; CMYP10A; CMYP10B; EMARDD;
                     SR-F3"
                     /inference="alignment:Splign:2.1.0"
     exon            2384..2512
                     /gene="MEGF10"
                     /gene_synonym="CMYO10A; CMYO10B; CMYP10A; CMYP10B; EMARDD;
                     SR-F3"
                     /inference="alignment:Splign:2.1.0"
     exon            2513..2641
                     /gene="MEGF10"
                     /gene_synonym="CMYO10A; CMYO10B; CMYP10A; CMYP10B; EMARDD;
                     SR-F3"
                     /inference="alignment:Splign:2.1.0"
     exon            2642..2770
                     /gene="MEGF10"
                     /gene_synonym="CMYO10A; CMYO10B; CMYP10A; CMYP10B; EMARDD;
                     SR-F3"
                     /inference="alignment:Splign:2.1.0"
     exon            2771..3007
                     /gene="MEGF10"
                     /gene_synonym="CMYO10A; CMYO10B; CMYP10A; CMYP10B; EMARDD;
                     SR-F3"
                     /inference="alignment:Splign:2.1.0"
     exon            3008..3135
                     /gene="MEGF10"
                     /gene_synonym="CMYO10A; CMYO10B; CMYP10A; CMYP10B; EMARDD;
                     SR-F3"
                     /inference="alignment:Splign:2.1.0"
     exon            3136..3259
                     /gene="MEGF10"
                     /gene_synonym="CMYO10A; CMYO10B; CMYP10A; CMYP10B; EMARDD;
                     SR-F3"
                     /inference="alignment:Splign:2.1.0"
     exon            3260..3304
                     /gene="MEGF10"
                     /gene_synonym="CMYO10A; CMYO10B; CMYP10A; CMYP10B; EMARDD;
                     SR-F3"
                     /inference="alignment:Splign:2.1.0"
     exon            3305..3511
                     /gene="MEGF10"
                     /gene_synonym="CMYO10A; CMYO10B; CMYP10A; CMYP10B; EMARDD;
                     SR-F3"
                     /inference="alignment:Splign:2.1.0"
     exon            3512..7606
                     /gene="MEGF10"
                     /gene_synonym="CMYO10A; CMYO10B; CMYP10A; CMYP10B; EMARDD;
                     SR-F3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7586..7591
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MEGF10"
                     /gene_synonym="CMYO10A; CMYO10B; CMYP10A; CMYP10B; EMARDD;
                     SR-F3"
                     /note="hexamer: AATAAA"
     polyA_site      7606
                     /gene="MEGF10"
                     /gene_synonym="CMYO10A; CMYO10B; CMYP10A; CMYP10B; EMARDD;
                     SR-F3"
                     /note="major polyA site"
ORIGIN      
        1 agacagagaa aaccttgttc aagtttgcag caagtacttt cccggtgcgc aaaactgggc
       61 gactgggaac gcgttgagac gttcctcttt cccgcttctc cacctttacg cctgaaagaa
      121 gactcccaaa gattgctttc ttctgggacg ctgcttggac gctaaccgcg ttgattggaa
      181 cagattttgt gtcttggctg gctttgggtg aagaccgggg agaaaaggtt gcgctgcgat
      241 tctcaagatc tctggacctg ggttgttctt cagaaaaaaa tggttatttc tttgaactca
      301 tgcctgagct ttatttgttt attgttatgc cactggattg ggacagcatc acctctgaat
      361 cttgaagacc ctaatgtgtg tagccactgg gaaagctact cagtgactgt gcaagagtca
      421 tacccacatc cctttgatca aatttactac acgagctgca ctgacattct aaactggttt
      481 aaatgcacgc ggcacagagt cagctatcgg acagcctatc gacatgggga gaagactatg
      541 tataggcgca agtctcagtg ttgtcctgga ttttatgaaa gcggggaaat gtgtgtcccc
      601 cactgtgctg ataaatgtgt ccatggtcgc tgtattgctc caaacacctg tcagtgtgag
      661 cctggctggg gagggaccaa ctgctccagt gcctgcgatg gtgatcactg gggtccccac
      721 tgcaccagcc ggtgccagtg caaaaatggg gctctgtgca accccatcac cggggcttgc
      781 cactgtgctg cgggcttccg gggctggcgc tgcgaggacc gctgtgagca gggcacctat
      841 ggtaacgact gtcatcagag atgccagtgc cagaatggag ccacctgcga ccacgtcacg
      901 ggggaatgcc gctgcccacc aggatacacc ggagccttct gtgaggatct ttgtcctcct
      961 ggtaaacatg gtccacagtg tgagcagaga tgcccttgtc aaaatggagg agtgtgtcat
     1021 cacgtcactg gagaatgctc ttgcccttct ggctggatgg gcacagtgtg tggtcagcct
     1081 tgccccgagg gtcgctttgg aaagaactgt tcccaagaat gccagtgcca taatggaggg
     1141 acgtgtgatg ctgccacagg ccaatgtcat tgcagtccag gatacacagg ggaacggtgc
     1201 caggatgagt gtcctgttgg gacctatggc gttctctgtg ctgagacctg ccagtgtgtc
     1261 aacggaggga agtgttacca cgtgagcggc gcatgcctct gtgaagcagg ctttgctggc
     1321 gagcgctgcg aagcacgcct gtgtcctgag gggctctacg gcatcaaatg tgacaaacgg
     1381 tgtccctgcc acctggaaaa cactcatagc tgtcacccca tgtctggaga gtgtgcctgc
     1441 aagccgggct ggtcaggact ctactgtaat gagacatgtt ctcctggatt ctacggggaa
     1501 gcttgccagc agatctgcag ctgccaaaat ggggcagact gtgacagtgt gactggaaag
     1561 tgcacctgtg ccccaggatt caaaggaatt gactgctcta ccccatgccc tctgggaacc
     1621 tatgggataa actgttcctc tcgctgtggc tgtaaaaatg atgcagtctg ctctcctgtg
     1681 gacgggtctt gtacttgcaa ggcaggctgg cacggggtgg actgctccat cagatgtccc
     1741 agtggcacat ggggctttgg ctgtaactta acatgccagt gcctcaacgg gggagcctgc
     1801 aacaccctgg acgggacctg cacgtgtgca cctggatggc gcggggagaa atgcgaactt
     1861 ccctgccagg atggcacgta cgggctgaac tgtgctgagc gctgcgactg cagccacgca
     1921 gatggctgcc accctaccac gggccattgc cgctgcctcc ccggatggtc aggtgtccac
     1981 tgtgacagcg tgtgtgctga gggacgctgg ggccccaact gctccctgcc ctgctactgt
     2041 aaaaatgggg cttcatgctc ccctgatgat ggcatctgcg agtgtgcacc aggcttccga
     2101 ggcaccactt gtcagaggat ctgctcccct ggtttttatg ggcatcgctg cagccagaca
     2161 tgcccacagt gcgttcacag cagcgggccc tgccaccaca tcaccggcct gtgtgactgc
     2221 ttgcctggct tcacaggcgc cctctgcaat gaagtgtgtc ccagtggcag atttgggaaa
     2281 aactgtgcag gaatttgtac ctgcaccaac aacggaacct gtaaccccat tgacagatct
     2341 tgtcagtgtt accccggttg gattggcagt gactgctctc aaccatgtcc acctgcccac
     2401 tggggcccaa actgcatcca cacgtgcaac tgccataatg gagctttctg cagcgcctac
     2461 gatggggaat gtaaatgcac tcctggctgg acagggctct actgcactca gagatgtcct
     2521 ctagggtttt atggaaaaga ttgtgcactg atatgccaat gtcaaaacgg agctgactgc
     2581 gaccacattt ctgggcagtg tacttgccgc actggattca tgggacggca ctgtgagcag
     2641 aagtgccctt caggaacata tggctatggc tgtcgccaga tatgtgattg tctgaacaac
     2701 tccacctgcg accacatcac tgggacctgt tactgcagcc ccggatggaa gggagcgaga
     2761 tgtgatcaag ctggtgttat catagttgga aatctgaaca gcttaagccg aaccagtact
     2821 gctctccctg ctgattccta ccagatcggg gccattgcag gcatcatcat tcttgtccta
     2881 gttgttctct tcctactggc attgttcatt atttatagac acaagcagaa gggaaaggaa
     2941 tcaagcatgc cagcagttac ctacacccct gctatgaggg tcgtcaatgc agattatacc
     3001 atttcaggaa cccttcctca cagcaatggt ggaaacgcta atagccacta cttcaccaat
     3061 cccagttacc acacgctcac ccagtgtgcc acatcccctc acgtcaacaa cagggacagg
     3121 atgactgtca cgaagtcaaa aaacaatcaa ctgtttgtga atcttaaaaa tgtgaaccct
     3181 gggaagagag gccctgtggg ggactgcact gggacattgc cggctgactg gaaacatggc
     3241 ggctacctca acgagctcgg tgcttttgga cttgacagaa gctatatggg aaaatcctta
     3301 aaagacctgg gaaagaattc tgaatataat tcaagtaact gctccctaag cagttctgag
     3361 aacccatatg ccactattaa agacccacct gtacttatcc cgaaaagctc agagtgtggt
     3421 tatgtggaga tgaaatcgcc ggcacgaaga gattccccat atgcagagat caataactca
     3481 acttcagcca acaggaatgt ctatgaagtt gaacctacag tgagtgttgt ccaaggagta
     3541 ttcagcaata atgggcgtct ctcccaggat ccatatgacc tcccaaagaa cagtcacatc
     3601 ccttgtcatt atgacctgct gccagtccga gacagttcat cctcccctaa gcaagaggac
     3661 agtggtggta gcagcagcaa cagcagcagc agcagtgaat gacaccaaag gaccgcttgg
     3721 tagccactgg aaccctttcc agaactgctg tttggttctt ctccatcctc aattttgcca
     3781 ctttcatgtg aatgttagtc aattcggtgg gcaatttttg gacatgaacc agaaagctga
     3841 aagctgaggc tgacacggac tgtaggtgct ttttgttcag gtggattcga aggagttaga
     3901 gatgtgattt cccattgctg ttagttttag aactataccc gtgaagcatg acttattgta
     3961 agatgttggc tgaaagcatg aacttgcaga actccctcgg agacgcaggt tgcagtggac
     4021 attgggattg ttgcttgaaa aattaaaatt tgaatatttt ctctctcatt tgcatcatac
     4081 agctctacct aggattgtac agtttaccat aaaatttact tcatgaaagt gggaatcact
     4141 gaacatgtag aagacaagga acatattgtt aactcctgat tcttaacttt attcaactgg
     4201 actcagaatt gtagggataa tatgaatgca ggaggaaaca ttctgtcagg cggtatgact
     4261 ggacagactt tgaatatact ctaaaagtgg acagaaaatt tacgaaaatc ttagattttg
     4321 tttagaatga gaaaatatac aattagaatt attttagaaa tagtaggaag tattgcagaa
     4381 gtcaatacac aaatgtgcca ggcagaggtg gttttctctg tttgactctc aaccaacttc
     4441 agatctatga cattattctg atcactggct ccatcataca tattcaccac ttgagattca
     4501 taacatatca atagttattt cataaatata gaaatgaaat aattttattt ttgacagact
     4561 ggatggaatg agtgtgtaat gattgataaa ggttgtaaat tttaaatgca agatgacgct
     4621 tacgttctgt aaaccattag taatacatgc tgtaatatag aattagtgga acattttgat
     4681 taatctttcc ctagaagtga ctgaaatatt tttgtgcata tttgagaaag ggaactttcc
     4741 ttttattaat tgtcaattta gagaaactat gcttaagctg gtcttttgca ttgctaatgt
     4801 gacatgtacc caacttttca ttaatttgta tttccatttt taaattgcat attctatgtt
     4861 ttgtagtgtt tggattgtta atgaaaaaat attatatgtt cgttattcct tgtattattg
     4921 ccacttatct tttgcttgat aaaaatgcgt tgttcttttt tcttttggag ggacaagatg
     4981 aaaatatata atttgaattg attaaaattg gtcgttacta aaatagtata gtaaccacaa
     5041 gtgattggct tataaatgaa gtagaaatgc tttttaatat tccaaaatag agttcctttt
     5101 gatctgttgg tgctgagcct tggttaaacc agggagaagg ggagcagaaa ggaaacgttg
     5161 ttactgatga gtaccacaga ctcatcttaa aaaaaactct cattatggtg atcatagaat
     5221 tgaccatcca aactgggaca ctcttgagag taaatggagg gcattattaa taattatctt
     5281 gtaatgaact taaatctgga ctgttccagg caaaccagac ttatcttgca atatgagaat
     5341 gctgacacaa tgcaggaaag ccagtttccc ttttgttgat ctacttgacc aagcaaaggg
     5401 gctgaaaaac tgaataagga aacaacttta taagagaaac agtggtcttc aatcttttaa
     5461 agacatgaaa tcctatatgg cattctgtct cagtgagtca gttaacaaat acgtatgtgc
     5521 aacccttctg ctagtagtgc acataagtga ttatccctgc caggtatcga gttggaatat
     5581 ccagttattt catgtcacac atcggcacgt atgatggtgg tttggtcaga tggataatac
     5641 agcagacaca cttagaacac tcactgcact ggtggctgtt cattttgagg aactccaaag
     5701 tcaattcaag gaaataagga atgacctgga acaggcctta gaaacaattg atttattcca
     5761 atagttaacc actggctggc tcccaactct aggtgatagg catctaattg agacatgtgt
     5821 gagtcaatag ccatcggggt cctttttggt gagaagaaat aagacatttt ctccctttta
     5881 aagatcatct cttcagagct gcatggtaaa tttgaatttc cccattgttc tctagagcta
     5941 ggtcaaaaaa acaactgttt cttttcttat tccactatta ataaattgaa agcttgctgt
     6001 acaaaggcaa cagcaactta aaaaagaaaa tctggacaat agatgtggac tccaaggggc
     6061 cactgccatc ccttcctgtg tgctcttttt gacaagtaaa tcactccagt tagctgatgt
     6121 cctgaaatga catttgtacc tgaggcaatt cttattagag cttactcagg acttttcaaa
     6181 catcaggaca cacatagcaa tttggatgtt gtaaaactac gtgttacatt tggagaggtc
     6241 ttgttgagaa ggcaaaattt tctaaatatt ttgatatcaa tttgggtaaa gaaaggaata
     6301 cttttgttag aatgagaatt aaagagaaaa caaaagaatc ttggcaaaat tttccctctg
     6361 aaattacaaa ctttaggaac ttttccagat gtatcgaatt taatttgaca ttgatgtcac
     6421 tcttcatacc aagtgaatct attctcatga actttgaacc catgttaatt ttggacccta
     6481 taactaattt cctttctgta tcccatggtg gtcaaagcag taaaggagtt tagagatact
     6541 tagcaaatgc cattcatata gtattgttag ccaaactatt attccttcct tagaagttga
     6601 tgtatcagaa aatttataag ttatttgtat ttatatataa gtacatcaga acttgcccac
     6661 atgataactc atgtttgctt taataaggaa aatatgttat ttgaggttaa ttatatgata
     6721 gtgaggaaca ttttacaatt atttacagtg tttgacatta attgctgtcc tatgatacag
     6781 tagtaatgtt aacagagagt ttaatatgtt tagcattatc tttatggaat ttatattcac
     6841 caatttcagg aaaaccaacc atagaacttt ataataggac agttataacc tgactgaacc
     6901 aaatccatca gcataatgac tgtgtgttct gagaaatgca aacaacttta tgaaagtgtg
     6961 gtcatcttga cccccaaaga gccacagtag ctgtcaatta ttgagatttt taaatggtaa
     7021 atattgcaaa agttaaacaa gggtaccaca atatcattta taattgatgt caatattagt
     7081 agtccacttt atgcttaaaa taaaatcata aaaaatcaag ttttaaggtt atatttttta
     7141 aaataatgaa ttttctatct ctaggcaaca tgtctttatt attcaagctg aatgtttaag
     7201 agagattttg gtcttaaagg cttcacatca tgaaagtgta catgcatatg caagtgtgaa
     7261 ttacgtggta tggatgtttg cttgtttatt aactaaagat gtacagcaaa ctgcccgttt
     7321 agagtcctgt taatattgat gtcctaacac tgggtctgct tatgctagtt cagtatttgg
     7381 tctaggcttc attttgatat gactgaattg caatctatat ttttaaaaag aaaaatcaaa
     7441 atacattagg gtttacttgg ttgtggcaaa caaacaaaaa atgctttcag tgttgaaata
     7501 tctctatttt ccaaagatga taaactttca tcgttcttag cctacattgt catttatatc
     7561 accaaatgag tttatagatt aatgcaataa actttctaat aaaaaa
//
