LOCUS       NM_002397               7281 bp    mRNA    linear   PRI 16-DEC-2024
DEFINITION  Homo sapiens myocyte enhancer factor 2C (MEF2C), transcript variant
            1, mRNA.
ACCESSION   NM_002397
VERSION     NM_002397.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7281)
  AUTHORS   Ali,D., Laighneach,A., Corley,E., Patlola,S.R., Mahoney,R.,
            Holleran,L., McKernan,D.P., Kelly,J.P., Corvin,A.P., Hallahan,B.,
            McDonald,C., Donohoe,G. and Morris,D.W.
  TITLE     Direct targets of MEF2C are enriched for genes associated with
            schizophrenia and cognitive function and are involved in neuron
            development and mitochondrial function
  JOURNAL   PLoS Genet 20 (9), e1011093 (2024)
   PUBMED   39259737
  REMARK    GeneRIF: Direct targets of MEF2C are enriched for genes associated
            with schizophrenia and cognitive function and are involved in
            neuron development and mitochondrial function.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7281)
  AUTHORS   Menshawy,N.E., El-Ghonemy,M.S., Ebrahim,M.A., Fahmi,M.W., Saif,M.,
            Denewer,M. and El-Ashwah,S.
  TITLE     Aberrant ecotropic viral integration site-1 (EVI-1) and myocyte
            enhancer factor 2 C gene (MEF2C) in adult acute myeloid leukemia
            are associated with adverse t (9:22) & 11q23 rearrangements
  JOURNAL   Ann Hematol 103 (7), 2355-2364 (2024)
   PUBMED   38710877
  REMARK    GeneRIF: Aberrant ecotropic viral integration site-1 (EVI-1) and
            myocyte enhancer factor 2 C gene (MEF2C) in adult acute myeloid
            leukemia are associated with adverse t (9:22) & 11q23
            rearrangements.
REFERENCE   3  (bases 1 to 7281)
  AUTHORS   Le Meur,N., Holder-Espinasse,M., Jaillard,S., Goldenberg,A.,
            Joriot,S., Amati-Bonneau,P., Guichet,A., Barth,M., Charollais,A.,
            Journel,H., Auvin,S., Boucher,C., Kerckaert,J.P., David,V.,
            Manouvrier-Hanu,S., Saugier-Veber,P., Frebourg,T., Dubourg,C.,
            Andrieux,J. and Bonneau,D.
  TITLE     MEF2C haploinsufficiency caused by either microdeletion of the
            5q14.3 region or mutation is responsible for severe mental
            retardation with stereotypic movements, epilepsy and/or cerebral
            malformations
  JOURNAL   J Med Genet 47 (1), 22-29 (2010)
   PUBMED   19592390
  REMARK    GeneRIF: These results strongly suggest that haploinsufficiency of
            MEF2C is responsible for severe mental retardation with stereotypic
            movements, seizures and/or cerebral malformations.
REFERENCE   4  (bases 1 to 7281)
  AUTHORS   Zhu,B., Ramachandran,B. and Gulick,T.
  TITLE     Alternative pre-mRNA splicing governs expression of a conserved
            acidic transactivation domain in myocyte enhancer factor 2 factors
            of striated muscle and brain
  JOURNAL   J Biol Chem 280 (31), 28749-28760 (2005)
   PUBMED   15834131
  REMARK    GeneRIF: A conserved pattern of alternative splicing in vertebrate
            MEF2 (myocyte enhancer factor 2) genes generates an acidic
            activation domain in MEF2 proteins selectively in tissues where
            MEF2 target genes are highly expressed. (MEF2)
REFERENCE   5  (bases 1 to 7281)
  AUTHORS   Zhu,B. and Gulick,T.
  TITLE     Phosphorylation and alternative pre-mRNA splicing converge to
            regulate myocyte enhancer factor 2C activity
  JOURNAL   Mol Cell Biol 24 (18), 8264-8275 (2004)
   PUBMED   15340086
REFERENCE   6  (bases 1 to 7281)
  AUTHORS   Krainc,D., Haas,M., Ward,D.C., Lipton,S.A., Bruns,G. and Leifer,D.
  TITLE     Assignment of human myocyte-specific enhancer binding factor 2C
            (hMEF2C) to human chromosome 5q14 and evidence that MEF2C is
            evolutionarily conserved
  JOURNAL   Genomics 29 (3), 809-811 (1995)
   PUBMED   8575784
REFERENCE   7  (bases 1 to 7281)
  AUTHORS   Hobson,G.M., Krahe,R., Garcia,E., Siciliano,M.J. and Funanage,V.L.
  TITLE     Regional chromosomal assignments for four members of the MADS
            domain transcription enhancer factor 2 (MEF2) gene family to human
            chromosomes 15q26, 19p12, 5q14, and 1q12-q23
  JOURNAL   Genomics 29 (3), 704-711 (1995)
   PUBMED   8575763
REFERENCE   8  (bases 1 to 7281)
  AUTHORS   McDermott,J.C., Cardoso,M.C., Yu,Y.T., Andres,V., Leifer,D.,
            Krainc,D., Lipton,S.A. and Nadal-Ginard,B.
  TITLE     hMEF2C gene encodes skeletal muscle- and brain-specific
            transcription factors
  JOURNAL   Mol Cell Biol 13 (4), 2564-2577 (1993)
   PUBMED   8455629
REFERENCE   9  (bases 1 to 7281)
  AUTHORS   Leifer,D., Krainc,D., Yu,Y.T., McDermott,J., Breitbart,R.E.,
            Heng,J., Neve,R.L., Kosofsky,B., Nadal-Ginard,B. and Lipton,S.A.
  TITLE     MEF2C, a MADS/MEF2-family transcription factor expressed in a
            laminar distribution in cerebral cortex
  JOURNAL   Proc Natl Acad Sci U S A 90 (4), 1546-1550 (1993)
   PUBMED   7679508
REFERENCE   10 (bases 1 to 7281)
  AUTHORS   Cooley Coleman,J. and Skinner,S.A.
  TITLE     MEF2C-Related Disorder
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   39666846
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from L08895.1, AL833268.1 and
            AC008525.7.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_002397.4.
            
            Summary: This locus encodes a member of the MADS box transcription
            enhancer factor 2 (MEF2) family of proteins, which play a role in
            myogenesis. The encoded protein, MEF2 polypeptide C, has both
            trans-activating and DNA binding activities. This protein may play
            a role in maintaining the differentiated state of muscle cells.
            Mutations and deletions at this locus have been associated with
            severe cognitive disability, stereotypic movements, epilepsy, and
            cerebral malformation. Alternatively spliced transcript variants
            have been described. [provided by RefSeq, Jul 2010].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes isoform 1. Variants 1, 6, and 9-11 all
            encode the same isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.275782.1,
                                           SRR1660807.90557.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000504921.7/ ENSP00000421925.5
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3609              L08895.1           30-3638
            3610-3610           AL833268.1         3643-3643
            3611-4049           L08895.1           3639-4077
            4050-6093           AC008525.7         39622-41665         c
            6094-6157           AL833268.1         6128-6191
            6158-7281           AC008525.7         38434-39557         c
FEATURES             Location/Qualifiers
     source          1..7281
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q14.3"
     gene            1..7281
                     /gene="MEF2C"
                     /gene_synonym="C5DELq14.3; DEL5q14.3; NEDHSIL"
                     /note="myocyte enhancer factor 2C"
                     /db_xref="GeneID:4208"
                     /db_xref="HGNC:HGNC:6996"
                     /db_xref="MIM:600662"
     exon            1..230
                     /gene="MEF2C"
                     /gene_synonym="C5DELq14.3; DEL5q14.3; NEDHSIL"
                     /inference="alignment:Splign:2.1.0"
     exon            231..426
                     /gene="MEF2C"
                     /gene_synonym="C5DELq14.3; DEL5q14.3; NEDHSIL"
                     /inference="alignment:Splign:2.1.0"
     CDS             373..1794
                     /gene="MEF2C"
                     /gene_synonym="C5DELq14.3; DEL5q14.3; NEDHSIL"
                     /note="isoform 1 is encoded by transcript variant 1;
                     myocyte-specific enhancer factor 2C; MADS box
                     transcription enhancer factor 2, polypeptide C"
                     /codon_start=1
                     /product="myocyte-specific enhancer factor 2C isoform 1"
                     /protein_id="NP_002388.2"
                     /db_xref="CCDS:CCDS47245.1"
                     /db_xref="GeneID:4208"
                     /db_xref="HGNC:HGNC:6996"
                     /db_xref="MIM:600662"
                     /translation="MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIA
                     LIIFNSTNKLFQYASTDMDKVLLKYTEYNEPHESRTNSDIVETLRKKGLNGCDSPDPD
                     ADDSVGHSPESEDKYRKINEDIDLMISRQRLCAVPPPNFEMPVSIPVSSHNSLVYSNP
                     VSSLGNPNLLPLAHPSLQRNSMSPGVTHRPPSAGNTGGLMGGDLTSGAGTSAGNGYGN
                     PRNSPGLLVSPGNLNKNMQAKSPPPMNLGMNNRKPDLRVLIPPGSKNTMPSVSEDVDL
                     LLNQRINNSQSAQSLATPVVSVATPTLPGQGMGGYPSAISTTYGTEYSLSSADLSSLS
                     GFNTASALHLGSVTGWQQQHLHNMPPSALSQLGACTSTHLSQSSNLSLPSTQSLNIKS
                     EPVSPPRDRTTTPSRYPQHTRHEAGRSPVDSLSSCSSSYDGSDREDHRNEFHSPIGLT
                     RPSPDERESPSVKRMRLSEGWAT"
     exon            427..630
                     /gene="MEF2C"
                     /gene_synonym="C5DELq14.3; DEL5q14.3; NEDHSIL"
                     /inference="alignment:Splign:2.1.0"
     exon            631..774
                     /gene="MEF2C"
                     /gene_synonym="C5DELq14.3; DEL5q14.3; NEDHSIL"
                     /inference="alignment:Splign:2.1.0"
     exon            775..961
                     /gene="MEF2C"
                     /gene_synonym="C5DELq14.3; DEL5q14.3; NEDHSIL"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1009
                     /gene="MEF2C"
                     /gene_synonym="C5DELq14.3; DEL5q14.3; NEDHSIL"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1182
                     /gene="MEF2C"
                     /gene_synonym="C5DELq14.3; DEL5q14.3; NEDHSIL"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1206
                     /gene="MEF2C"
                     /gene_synonym="C5DELq14.3; DEL5q14.3; NEDHSIL"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1336
                     /gene="MEF2C"
                     /gene_synonym="C5DELq14.3; DEL5q14.3; NEDHSIL"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..1472
                     /gene="MEF2C"
                     /gene_synonym="C5DELq14.3; DEL5q14.3; NEDHSIL"
                     /inference="alignment:Splign:2.1.0"
     exon            1473..7281
                     /gene="MEF2C"
                     /gene_synonym="C5DELq14.3; DEL5q14.3; NEDHSIL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6132..6137
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MEF2C"
                     /gene_synonym="C5DELq14.3; DEL5q14.3; NEDHSIL"
                     /note="hexamer: AGTAAA"
     polyA_site      6157
                     /gene="MEF2C"
                     /gene_synonym="C5DELq14.3; DEL5q14.3; NEDHSIL"
                     /note="major polyA site"
     regulatory      7257..7262
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MEF2C"
                     /gene_synonym="C5DELq14.3; DEL5q14.3; NEDHSIL"
                     /note="hexamer: AATAAA"
     polyA_site      7281
                     /gene="MEF2C"
                     /gene_synonym="C5DELq14.3; DEL5q14.3; NEDHSIL"
ORIGIN      
        1 gcagtcacag acacttgagc acacgcgtac acccagacat cttcgggctg ctattggatt
       61 gactttgaag gttctgtgtg ggtcgccgtg gctgcatgtt tgaatcaggt ggagaagcac
      121 ttcaacgctg gacgaagtaa agattattgt tgttattttt tttttctctc tctctctctc
      181 ttaagaaagg aaaatatccc aaggactaat ctgatcgggt cttccttcat caggaacgaa
      241 tgcaggaatt tgggaactga gctgtgcaag tgctgaagaa ggagatttgt ttggaggaaa
      301 caggaaagag aaagaaaagg aaggaaaaaa tacataattt cagggacgag agagagaaga
      361 aaaacgggga ctatggggag aaaaaagatt cagattacga ggattatgga tgaacgtaac
      421 agacaggtga catttacaaa gaggaaattt gggttgatga agaaggctta tgagctgagc
      481 gtgctgtgtg actgtgagat tgcgctgatc atcttcaaca gcaccaacaa gctgttccag
      541 tatgccagca ccgacatgga caaagtgctt ctcaagtaca cggagtacaa cgagccgcat
      601 gagagccgga caaactcaga catcgtggag acgttgagaa agaagggcct taatggctgt
      661 gacagcccag accccgatgc ggacgattcc gtaggtcaca gccctgagtc tgaggacaag
      721 tacaggaaaa ttaacgaaga tattgatcta atgatcagca ggcaaagatt gtgtgctgtt
      781 ccacctccca acttcgagat gccagtctcc atcccagtgt ccagccacaa cagtttggtg
      841 tacagcaacc ctgtcagctc actgggaaac cccaacctat tgccactggc tcacccttct
      901 ctgcagagga atagtatgtc tcctggtgta acacatcgac ctccaagtgc aggtaacaca
      961 ggtggtctga tgggtggaga cctcacgtct ggtgcaggca ccagtgcagg gaacgggtat
     1021 ggcaatcccc gaaactcacc aggtctgctg gtctcacctg gtaacttgaa caagaatatg
     1081 caagcaaaat ctcctccccc aatgaattta ggaatgaata accgtaaacc agatctccga
     1141 gttcttattc caccaggcag caagaatacg atgccatcag tgtctgagga tgtcgacctg
     1201 cttttgaatc aaaggataaa taactcccag tcggctcagt cattggctac cccagtggtt
     1261 tccgtagcaa ctcctacttt accaggacaa ggaatgggag gatatccatc agccatttca
     1321 acaacatatg gtaccgagta ctctctgagt agtgcagacc tgtcatctct gtctgggttt
     1381 aacaccgcca gcgctcttca ccttggttca gtaactggct ggcaacagca acacctacat
     1441 aacatgccac catctgccct cagtcagttg ggagcttgca ctagcactca tttatctcag
     1501 agttcaaatc tctccctgcc ttctactcaa agcctcaaca tcaagtcaga acctgtttct
     1561 cctcctagag accgtaccac caccccttcg agatacccac aacacacgcg ccacgaggcg
     1621 gggagatctc ctgttgacag cttgagcagc tgtagcagtt cgtacgacgg gagcgaccga
     1681 gaggatcacc ggaacgaatt ccactccccc attggactca ccagaccttc gccggacgaa
     1741 agggaaagtc cctcagtcaa gcgcatgcga ctttctgaag gatgggcaac atgatcagat
     1801 tattacttac tagttttttt ttttttcttg cagtgtgtgt gtgtgctata ccttaatggg
     1861 gaaggggggt cgatatgcat tatatgtgcc gtgtgtggaa aaaaaaaaag tcaggtactc
     1921 tgttttgtaa aagtactttt aaattgcctc agtgatacag tataaagata aacagaaatg
     1981 ctgagataag cttagcactt gagttgtaca acagaacact tgtacaaaat agattttaag
     2041 gctaacttct tttcactgtt gtgctccttt gcaaaatgta tgttacaata gatagtgtca
     2101 tgttgcaggt tcaacgttat ttacatgtaa atagacaaaa ggaaacattt gccaaaagcg
     2161 gcagatcttt actgaaagag agagcagctg ttatgcaaca tatagaaaaa tgtatagatg
     2221 cttggacaga cccggtaatg ggtggccatt ggtaaatgtt aggaacacac caggtcacct
     2281 gacatcccaa gaatgctcac aaacctgcag gcatatcatt ggcgtatggc actcattaaa
     2341 aaggatcaga gaccattaaa agaggaccat acctattaaa aaaaaatgtg gagttggagg
     2401 gctaacatat ttaattaaat aaataaataa atctgggtct gcatctctta ttaaataaaa
     2461 atataaaaat atgtacatta cattttgctt attttcatat aaaaggtaag acagagtttg
     2521 caaagcattt gtggcttttt gtagtttact taagccaaaa tgtgtttttt tccccttgat
     2581 agcttcgcta atattttaaa cagtcctgta aaaaaccaaa aaggactttt tgtatagaaa
     2641 gcactaccct aagccatgaa gaactccatg ctttgctaac caagataact gttttctctt
     2701 tgtagaagtt ttgtttttga aatgtgtatt tctaattata taaaatatta agaatctttt
     2761 aaaaaaatct gtgaaattaa catgcttgtg tatagctttc taatatatat aatattatgg
     2821 taatagcaga agttttgtta tcttaatagc gggagggggg tatatttgtg cagttgcaca
     2881 tttgagtaac tattttcttt ctgttttctt ttactctgct tacattttat aagtttaagg
     2941 tcagctgtca aaaggataac ctgtggggtt agaacatatc acattgcaac accctaaatt
     3001 gtttttaata cattagcaat ctattgggtc aactgacatc cattgtatat actagtttct
     3061 ttcatgctat ttttattttg ttttttgcat ttttatcaaa tgcagggccc ctttctgatc
     3121 tcaccatttc accatgcatc ttggaattca gtaagtgcat atcctaactt gcccatattc
     3181 taaatcatct ggttggtttt cagcctagaa tttgatacgc tttttagaaa tatgcccaga
     3241 atagaaaagc tatgttgggg cacatgtcct gcaaatatgg ccctagaaac aagtgatatg
     3301 gaatttactt ggtgaataag ttataaattc ccacagaaga aaaatgtgaa agactgggtg
     3361 ctagacaaga aggaagcagg taaagggata gttgctttgt catccgtttt taattatttt
     3421 aactgaccct tgacaatctt gtcagcaata taggactgtt gaacaatccc ggtgtgtcag
     3481 gacccccaaa tgtcacttct gcataaagca tgtatgtcat ctattttttc ttcaataaag
     3541 agatttaata gccatttcaa gaaatcccat aaagaacctc tctatgtccc tttttttaat
     3601 ttaaaaaaaa tgactcttgt ctaatattcg tctataaggg attaattttc agacccttta
     3661 ataagtgagt gccataagaa agtcaatata tattgtttaa aagatatttc agtctaggaa
     3721 agattttcct tctcttggaa tgtgaagatc tgtcgattca tctccaatca tatgcattga
     3781 catacacagc aaagaagata taggcagtaa tatcaacact gctatatcat gtgtaggaca
     3841 tttcttatcc attttttctc ttttacttgc atagttgcta tgtgtttctc attgtaaaag
     3901 gctgccgctg ggtggcagaa gccaagagac cttattaact aggctatatt tttcttaact
     3961 tgatctgaaa tccacaatta gaccacaatg cacctttggt tgtatccata aaggatgcta
     4021 gcctgccttg tactaatgtt ttatatatta aaaaaaaaaa atctatcaac catttcatat
     4081 atatcccact actcaaggta tccatggaac atgaaagaat aacatttatg cagaggaaaa
     4141 acaaaaacat ccctgaaaat atacacactc atacacacac acgcacaggg gaataaaata
     4201 agaaaatcat tttcctcacc atagacttga tcccatcctt acaacccatc cttctaactt
     4261 gatgtgtata aaatatgcaa acatttcaca aatgttcttt gtcatttcaa aatactttag
     4321 tatatcaata tcagtagata ccagtgggtg ggaaagggtc attacatgaa aatatgaaga
     4381 aatagccata ttagtttttt aacctgcaat ttgcctcagc aacaaagaaa aagtgaattt
     4441 ttaatgctga agataaagta agctaaagta ccagcagaag ccttggctat ttatagcagt
     4501 tctgacaata gttttataag aacatgaaga gaacagaatc acttgaaaat ggatgccagt
     4561 catctcttgt tcccactact gaattcttat aaagtggtgg caagataggg aagggataat
     4621 ctgagaattt ttaaaagatg atttaatgag aagaagcaca attttgattt tgatgagtca
     4681 ctttctgtaa acaatcttgg tctatcttta cccttatacc ttatctgtaa tttaccattt
     4741 attgtatttg caaagctagt atggttttta atcacagtaa atcctttgta ttccagactt
     4801 tagggcagag ccctgaggga gtattatttt acataacccg tcctagagta acattttagg
     4861 caacattctt cattgcaagt aaaagatcca taagtggcat tttacacggc tgcgagtatt
     4921 gttatatcta atcctatttt aaaagatttt tggtaatatg aagcttgaat actggtaaca
     4981 gtgatgcaat atacgcaagc tgcacaacct gtatattgta tgcattgctg cgtggaggct
     5041 gtttatttca acctttttaa aaattgtgtt ttttagtaaa atggcttatt ttttcccaaa
     5101 ggtggaattt agcattttgt aatgatgaat ataaaaatac ctgtcatccc cagatcattt
     5161 aaaagttaac taaagtgaga atgaaaaaac aaaattccaa gacacttttt aaaagaatgt
     5221 ctgccctcac acacttttat ggatttgttt ttcttacata cccatctttt aacttagaga
     5281 tagcattttt tgccctcttt attttgttgt ttgtttctcc agagagtaaa cgctttgtag
     5341 ttctttcttt aaaaaacatt ttttttaaag aagaagaagc cacttgaacc ctcaataaag
     5401 gctgttgcct aagcatggca tacttcatct gttctcattt gtgccatctg ccgtgatgtc
     5461 gtcactttta tggcgttaat ttcctgccac tacagatctt ttgaagattg ctggaatact
     5521 ggtgtctgtt agaatgcttc agactacaga tgtaattaaa ggcttttctt aatatgtttt
     5581 aaccaaagat gtggagcaat ccaagccaca tatcttctac atcaaatttt tccattttgg
     5641 ttattttcat aatctggtat tgcattttgc cttccctgtt catacctcaa attgattcat
     5701 acctcagttt aattcagaga ggtcagttaa gtgacggatt ctgttgtggt ttgaatgcag
     5761 taccagtgtt ctcttcgagc aaagtagacc tgggtcactg taggcatagg acttggattg
     5821 cttcagatgg tttgctgtat catttttctt ctttttcttt tcctggggac ttgtttccat
     5881 taaatgagag taattaaaat cgcttgtaaa tgagggcata caagcatttg caacaaatat
     5941 tcaaatagag gctcacagcg gcataagctg gactttgtcg ccactagatg acaagatgtt
     6001 ataactaagt taaaccacat ctgtgtatct caagggactt aattcagctg tctgtagtga
     6061 ataaaagtgg gaaattttca aaagtttctc ctgctggaaa taaggtataa tttgtatttt
     6121 gcagacaatt cagtaaagtt actggctttc ttagtgatgc agtgtccgtg gtgcattttt
     6181 ttaaattaat gttttgctgt ttaaatttat tcaattttat tgtgtttttt aaaaagcagc
     6241 ttatgccaca agcacaaatg agctttctca gttttcaact caaaatatta tatgaaaaga
     6301 tggatatgtg tgtctgtgtg ggaggggtgt gaattggatg acggttctta gggtattaca
     6361 gaattcagcc agtggtggaa gtctaaggtt cttattgaat ggttcaactt ctttatcaaa
     6421 gaagttccat gaagatcttt gataacctgt ttaaatgtac agaatttttc aaaagccact
     6481 gtgaaaagca gtaccataag ttatttttta actaaaatct gtagaaagtg tttccaaaag
     6541 agttcctttt ttcttcttcg aagtaatttc taaaagttga aaacataggc ttataaatct
     6601 gaataaatta gtgaattcat acattttaga gactatcaaa tatatccatt attaacattc
     6661 aataataatc tctaaagggg aatgtcctta aaaagattga tagaaagatt aatttaaaaa
     6721 ctgaaaagga aaacaagaca ccaccagtta gccagctgga gaacttggac ttttgcatta
     6781 gtagtgatat ctgctccaaa aagaatgcag ttcgaggaaa tgttgcatgt ggcttcaaaa
     6841 tagcagtgct ttctgctttg ttctcttgta ttcattttca gcaaacatgt attaagcaat
     6901 tattatatgt aactcatgtg gtgattccag gatgaatgaa gttgtagccc tttctcttag
     6961 gaaacttata aactaatagg agataaaagg cattctcagg gaagtctaca aagtgctatg
     7021 agggagccac tttggccatc ctggggcaga gcagaccaga ggctcagagc atggacactt
     7081 cctcatccac ccagcagaag cctttcactt gattttgaag gtgggcagga ttgagaaagg
     7141 cccagaaggg gatgagttca aagctgtttg tgggcatgtg acccctgcag tcacatatgg
     7201 ccctagcttg tgtttcgttt agtgttctgc tatcattatc ctgataatat cctgataata
     7261 aaattatcct taataatttt a
//
