LOCUS       NM_001364329            7470 bp    mRNA    linear   PRI 16-DEC-2024
DEFINITION  Homo sapiens myocyte enhancer factor 2C (MEF2C), transcript variant
            9, mRNA.
ACCESSION   NM_001364329 XM_006714619
VERSION     NM_001364329.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7470)
  AUTHORS   Ali,D., Laighneach,A., Corley,E., Patlola,S.R., Mahoney,R.,
            Holleran,L., McKernan,D.P., Kelly,J.P., Corvin,A.P., Hallahan,B.,
            McDonald,C., Donohoe,G. and Morris,D.W.
  TITLE     Direct targets of MEF2C are enriched for genes associated with
            schizophrenia and cognitive function and are involved in neuron
            development and mitochondrial function
  JOURNAL   PLoS Genet 20 (9), e1011093 (2024)
   PUBMED   39259737
  REMARK    GeneRIF: Direct targets of MEF2C are enriched for genes associated
            with schizophrenia and cognitive function and are involved in
            neuron development and mitochondrial function.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7470)
  AUTHORS   Menshawy,N.E., El-Ghonemy,M.S., Ebrahim,M.A., Fahmi,M.W., Saif,M.,
            Denewer,M. and El-Ashwah,S.
  TITLE     Aberrant ecotropic viral integration site-1 (EVI-1) and myocyte
            enhancer factor 2 C gene (MEF2C) in adult acute myeloid leukemia
            are associated with adverse t (9:22) & 11q23 rearrangements
  JOURNAL   Ann Hematol 103 (7), 2355-2364 (2024)
   PUBMED   38710877
  REMARK    GeneRIF: Aberrant ecotropic viral integration site-1 (EVI-1) and
            myocyte enhancer factor 2 C gene (MEF2C) in adult acute myeloid
            leukemia are associated with adverse t (9:22) & 11q23
            rearrangements.
REFERENCE   3  (bases 1 to 7470)
  AUTHORS   Le Meur,N., Holder-Espinasse,M., Jaillard,S., Goldenberg,A.,
            Joriot,S., Amati-Bonneau,P., Guichet,A., Barth,M., Charollais,A.,
            Journel,H., Auvin,S., Boucher,C., Kerckaert,J.P., David,V.,
            Manouvrier-Hanu,S., Saugier-Veber,P., Frebourg,T., Dubourg,C.,
            Andrieux,J. and Bonneau,D.
  TITLE     MEF2C haploinsufficiency caused by either microdeletion of the
            5q14.3 region or mutation is responsible for severe mental
            retardation with stereotypic movements, epilepsy and/or cerebral
            malformations
  JOURNAL   J Med Genet 47 (1), 22-29 (2010)
   PUBMED   19592390
  REMARK    GeneRIF: These results strongly suggest that haploinsufficiency of
            MEF2C is responsible for severe mental retardation with stereotypic
            movements, seizures and/or cerebral malformations.
REFERENCE   4  (bases 1 to 7470)
  AUTHORS   Zhu,B., Ramachandran,B. and Gulick,T.
  TITLE     Alternative pre-mRNA splicing governs expression of a conserved
            acidic transactivation domain in myocyte enhancer factor 2 factors
            of striated muscle and brain
  JOURNAL   J Biol Chem 280 (31), 28749-28760 (2005)
   PUBMED   15834131
  REMARK    GeneRIF: A conserved pattern of alternative splicing in vertebrate
            MEF2 (myocyte enhancer factor 2) genes generates an acidic
            activation domain in MEF2 proteins selectively in tissues where
            MEF2 target genes are highly expressed. (MEF2)
REFERENCE   5  (bases 1 to 7470)
  AUTHORS   Zhu,B. and Gulick,T.
  TITLE     Phosphorylation and alternative pre-mRNA splicing converge to
            regulate myocyte enhancer factor 2C activity
  JOURNAL   Mol Cell Biol 24 (18), 8264-8275 (2004)
   PUBMED   15340086
REFERENCE   6  (bases 1 to 7470)
  AUTHORS   Krainc,D., Haas,M., Ward,D.C., Lipton,S.A., Bruns,G. and Leifer,D.
  TITLE     Assignment of human myocyte-specific enhancer binding factor 2C
            (hMEF2C) to human chromosome 5q14 and evidence that MEF2C is
            evolutionarily conserved
  JOURNAL   Genomics 29 (3), 809-811 (1995)
   PUBMED   8575784
REFERENCE   7  (bases 1 to 7470)
  AUTHORS   Hobson,G.M., Krahe,R., Garcia,E., Siciliano,M.J. and Funanage,V.L.
  TITLE     Regional chromosomal assignments for four members of the MADS
            domain transcription enhancer factor 2 (MEF2) gene family to human
            chromosomes 15q26, 19p12, 5q14, and 1q12-q23
  JOURNAL   Genomics 29 (3), 704-711 (1995)
   PUBMED   8575763
REFERENCE   8  (bases 1 to 7470)
  AUTHORS   McDermott,J.C., Cardoso,M.C., Yu,Y.T., Andres,V., Leifer,D.,
            Krainc,D., Lipton,S.A. and Nadal-Ginard,B.
  TITLE     hMEF2C gene encodes skeletal muscle- and brain-specific
            transcription factors
  JOURNAL   Mol Cell Biol 13 (4), 2564-2577 (1993)
   PUBMED   8455629
REFERENCE   9  (bases 1 to 7470)
  AUTHORS   Leifer,D., Krainc,D., Yu,Y.T., McDermott,J., Breitbart,R.E.,
            Heng,J., Neve,R.L., Kosofsky,B., Nadal-Ginard,B. and Lipton,S.A.
  TITLE     MEF2C, a MADS/MEF2-family transcription factor expressed in a
            laminar distribution in cerebral cortex
  JOURNAL   Proc Natl Acad Sci U S A 90 (4), 1546-1550 (1993)
   PUBMED   7679508
REFERENCE   10 (bases 1 to 7470)
  AUTHORS   Cooley Coleman,J. and Skinner,S.A.
  TITLE     MEF2C-Related Disorder
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   39666846
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC008835.6 and AC008525.7.
            
            On Jun 2, 2019 this sequence version replaced NM_001364329.1.
            
            Summary: This locus encodes a member of the MADS box transcription
            enhancer factor 2 (MEF2) family of proteins, which play a role in
            myogenesis. The encoded protein, MEF2 polypeptide C, has both
            trans-activating and DNA binding activities. This protein may play
            a role in maintaining the differentiated state of muscle cells.
            Mutations and deletions at this locus have been associated with
            severe cognitive disability, stereotypic movements, epilepsy, and
            cerebral malformation. Alternatively spliced transcript variants
            have been described. [provided by RefSeq, Jul 2010].
            
            Transcript Variant: This variant (9), as well as variants 1, 6, 10,
            and 11, encodes isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.111749.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-325               AC008835.6         96822-97146         c
            326-422             AC008835.6         95273-95369         c
            423-615             AC008835.6         31506-31698         c
            616-819             AC008835.6         12369-12572         c
            820-963             AC008525.7         82502-82645         c
            964-1150            AC008525.7         73174-73360         c
            1151-1198           AC008525.7         70387-70434         c
            1199-1371           AC008525.7         53046-53218         c
            1372-1395           AC008525.7         51528-51551         c
            1396-1525           AC008525.7         50535-50664         c
            1526-1661           AC008525.7         49810-49945         c
            1662-7470           AC008525.7         38434-44242         c
FEATURES             Location/Qualifiers
     source          1..7470
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q14.3"
     gene            1..7470
                     /gene="MEF2C"
                     /gene_synonym="C5DELq14.3; DEL5q14.3; NEDHSIL"
                     /note="myocyte enhancer factor 2C"
                     /db_xref="GeneID:4208"
                     /db_xref="HGNC:HGNC:6996"
                     /db_xref="MIM:600662"
     exon            1..325
                     /gene="MEF2C"
                     /gene_synonym="C5DELq14.3; DEL5q14.3; NEDHSIL"
                     /inference="alignment:Splign:2.1.0"
     exon            326..422
                     /gene="MEF2C"
                     /gene_synonym="C5DELq14.3; DEL5q14.3; NEDHSIL"
                     /inference="alignment:Splign:2.1.0"
     exon            423..615
                     /gene="MEF2C"
                     /gene_synonym="C5DELq14.3; DEL5q14.3; NEDHSIL"
                     /inference="alignment:Splign:2.1.0"
     CDS             562..1983
                     /gene="MEF2C"
                     /gene_synonym="C5DELq14.3; DEL5q14.3; NEDHSIL"
                     /note="isoform 1 is encoded by transcript variant 9;
                     myocyte-specific enhancer factor 2C; MADS box
                     transcription enhancer factor 2, polypeptide C"
                     /codon_start=1
                     /product="myocyte-specific enhancer factor 2C isoform 1"
                     /protein_id="NP_001351258.1"
                     /db_xref="CCDS:CCDS47245.1"
                     /db_xref="GeneID:4208"
                     /db_xref="HGNC:HGNC:6996"
                     /db_xref="MIM:600662"
                     /translation="MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIA
                     LIIFNSTNKLFQYASTDMDKVLLKYTEYNEPHESRTNSDIVETLRKKGLNGCDSPDPD
                     ADDSVGHSPESEDKYRKINEDIDLMISRQRLCAVPPPNFEMPVSIPVSSHNSLVYSNP
                     VSSLGNPNLLPLAHPSLQRNSMSPGVTHRPPSAGNTGGLMGGDLTSGAGTSAGNGYGN
                     PRNSPGLLVSPGNLNKNMQAKSPPPMNLGMNNRKPDLRVLIPPGSKNTMPSVSEDVDL
                     LLNQRINNSQSAQSLATPVVSVATPTLPGQGMGGYPSAISTTYGTEYSLSSADLSSLS
                     GFNTASALHLGSVTGWQQQHLHNMPPSALSQLGACTSTHLSQSSNLSLPSTQSLNIKS
                     EPVSPPRDRTTTPSRYPQHTRHEAGRSPVDSLSSCSSSYDGSDREDHRNEFHSPIGLT
                     RPSPDERESPSVKRMRLSEGWAT"
     exon            616..819
                     /gene="MEF2C"
                     /gene_synonym="C5DELq14.3; DEL5q14.3; NEDHSIL"
                     /inference="alignment:Splign:2.1.0"
     exon            820..963
                     /gene="MEF2C"
                     /gene_synonym="C5DELq14.3; DEL5q14.3; NEDHSIL"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1150
                     /gene="MEF2C"
                     /gene_synonym="C5DELq14.3; DEL5q14.3; NEDHSIL"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1198
                     /gene="MEF2C"
                     /gene_synonym="C5DELq14.3; DEL5q14.3; NEDHSIL"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1371
                     /gene="MEF2C"
                     /gene_synonym="C5DELq14.3; DEL5q14.3; NEDHSIL"
                     /inference="alignment:Splign:2.1.0"
     exon            1372..1395
                     /gene="MEF2C"
                     /gene_synonym="C5DELq14.3; DEL5q14.3; NEDHSIL"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..1525
                     /gene="MEF2C"
                     /gene_synonym="C5DELq14.3; DEL5q14.3; NEDHSIL"
                     /inference="alignment:Splign:2.1.0"
     exon            1526..1661
                     /gene="MEF2C"
                     /gene_synonym="C5DELq14.3; DEL5q14.3; NEDHSIL"
                     /inference="alignment:Splign:2.1.0"
     exon            1662..7470
                     /gene="MEF2C"
                     /gene_synonym="C5DELq14.3; DEL5q14.3; NEDHSIL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6321..6326
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MEF2C"
                     /gene_synonym="C5DELq14.3; DEL5q14.3; NEDHSIL"
                     /note="hexamer: AGTAAA"
     polyA_site      6346
                     /gene="MEF2C"
                     /gene_synonym="C5DELq14.3; DEL5q14.3; NEDHSIL"
                     /note="major polyA site"
     regulatory      7446..7451
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MEF2C"
                     /gene_synonym="C5DELq14.3; DEL5q14.3; NEDHSIL"
                     /note="hexamer: AATAAA"
     polyA_site      7470
                     /gene="MEF2C"
                     /gene_synonym="C5DELq14.3; DEL5q14.3; NEDHSIL"
ORIGIN      
        1 agagacgggc agagagaaga gtatataggt gatgagagca gtgttggagg ggaggatcgg
       61 caataattgg atggcgttgc agctgttgcg cctctgctga acgcccagcc agagcggatt
      121 cacttttcac acaaatcaac cggagggatt gttgctgcct gcaatcaata actcagcgga
      181 gtgagttgct caaactagag gcgtccctcg tctgggtctt tgagggccgt ccggattgag
      241 tcccagcgct ctgctttcca aacaaagaag tgggcaccaa aacgcaggac gagattttta
      301 atccccactt ccaccacaac cccgggtgcc aaagaagagt tgcaaactgt gaagtaactt
      361 ctatgaagag atgaagtaaa gaacggaagg caaatgattg tggcagtaaa gaagtgtatg
      421 tggaacgaat gcaggaattt gggaactgag ctgtgcaagt gctgaagaag gagatttgtt
      481 tggaggaaac aggaaagaga aagaaaagga aggaaaaaat acataatttc agggacgaga
      541 gagagaagaa aaacggggac tatggggaga aaaaagattc agattacgag gattatggat
      601 gaacgtaaca gacaggtgac atttacaaag aggaaatttg ggttgatgaa gaaggcttat
      661 gagctgagcg tgctgtgtga ctgtgagatt gcgctgatca tcttcaacag caccaacaag
      721 ctgttccagt atgccagcac cgacatggac aaagtgcttc tcaagtacac ggagtacaac
      781 gagccgcatg agagccggac aaactcagac atcgtggaga cgttgagaaa gaagggcctt
      841 aatggctgtg acagcccaga ccccgatgcg gacgattccg taggtcacag ccctgagtct
      901 gaggacaagt acaggaaaat taacgaagat attgatctaa tgatcagcag gcaaagattg
      961 tgtgctgttc cacctcccaa cttcgagatg ccagtctcca tcccagtgtc cagccacaac
     1021 agtttggtgt acagcaaccc tgtcagctca ctgggaaacc ccaacctatt gccactggct
     1081 cacccttctc tgcagaggaa tagtatgtct cctggtgtaa cacatcgacc tccaagtgca
     1141 ggtaacacag gtggtctgat gggtggagac ctcacgtctg gtgcaggcac cagtgcaggg
     1201 aacgggtatg gcaatccccg aaactcacca ggtctgctgg tctcacctgg taacttgaac
     1261 aagaatatgc aagcaaaatc tcctccccca atgaatttag gaatgaataa ccgtaaacca
     1321 gatctccgag ttcttattcc accaggcagc aagaatacga tgccatcagt gtctgaggat
     1381 gtcgacctgc ttttgaatca aaggataaat aactcccagt cggctcagtc attggctacc
     1441 ccagtggttt ccgtagcaac tcctacttta ccaggacaag gaatgggagg atatccatca
     1501 gccatttcaa caacatatgg taccgagtac tctctgagta gtgcagacct gtcatctctg
     1561 tctgggttta acaccgccag cgctcttcac cttggttcag taactggctg gcaacagcaa
     1621 cacctacata acatgccacc atctgccctc agtcagttgg gagcttgcac tagcactcat
     1681 ttatctcaga gttcaaatct ctccctgcct tctactcaaa gcctcaacat caagtcagaa
     1741 cctgtttctc ctcctagaga ccgtaccacc accccttcga gatacccaca acacacgcgc
     1801 cacgaggcgg ggagatctcc tgttgacagc ttgagcagct gtagcagttc gtacgacggg
     1861 agcgaccgag aggatcaccg gaacgaattc cactccccca ttggactcac cagaccttcg
     1921 ccggacgaaa gggaaagtcc ctcagtcaag cgcatgcgac tttctgaagg atgggcaaca
     1981 tgatcagatt attacttact agtttttttt tttttcttgc agtgtgtgtg tgtgctatac
     2041 cttaatgggg aaggggggtc gatatgcatt atatgtgccg tgtgtggaaa aaaaaaaagt
     2101 caggtactct gttttgtaaa agtactttta aattgcctca gtgatacagt ataaagataa
     2161 acagaaatgc tgagataagc ttagcacttg agttgtacaa cagaacactt gtacaaaata
     2221 gattttaagg ctaacttctt ttcactgttg tgctcctttg caaaatgtat gttacaatag
     2281 atagtgtcat gttgcaggtt caacgttatt tacatgtaaa tagacaaaag gaaacatttg
     2341 ccaaaagcgg cagatcttta ctgaaagaga gagcagctgt tatgcaacat atagaaaaat
     2401 gtatagatgc ttggacagac ccggtaatgg gtggccattg gtaaatgtta ggaacacacc
     2461 aggtcacctg acatcccaag aatgctcaca aacctgcagg catatcattg gcgtatggca
     2521 ctcattaaaa aggatcagag accattaaaa gaggaccata cctattaaaa aaaaatgtgg
     2581 agttggaggg ctaacatatt taattaaata aataaataaa tctgggtctg catctcttat
     2641 taaataaaaa tataaaaata tgtacattac attttgctta ttttcatata aaaggtaaga
     2701 cagagtttgc aaagcatttg tggctttttg tagtttactt aagccaaaat gtgttttttt
     2761 ccccttgata gcttcgctaa tattttaaac agtcctgtaa aaaaccaaaa aggacttttt
     2821 gtatagaaag cactacccta agccatgaag aactccatgc tttgctaacc aagataactg
     2881 ttttctcttt gtagaagttt tgtttttgaa atgtgtattt ctaattatat aaaatattaa
     2941 gaatctttta aaaaaatctg tgaaattaac atgcttgtgt atagctttct aatatatata
     3001 atattatggt aatagcagaa gttttgttat cttaatagcg ggaggggggt atatttgtgc
     3061 agttgcacat ttgagtaact attttctttc tgttttcttt tactctgctt acattttata
     3121 agtttaaggt cagctgtcaa aaggataacc tgtggggtta gaacatatca cattgcaaca
     3181 ccctaaattg tttttaatac attagcaatc tattgggtca actgacatcc attgtatata
     3241 ctagtttctt tcatgctatt tttattttgt tttttgcatt tttatcaaat gcagggcccc
     3301 tttctgatct caccatttca ccatgcatct tggaattcag taagtgcata tcctaacttg
     3361 cccatattct aaatcatctg gttggttttc agcctagaat ttgatacgct ttttagaaat
     3421 atgcccagaa tagaaaagct atgttggggc acatgtcctg caaatatggc cctagaaaca
     3481 agtgatatgg aatttacttg gtgaataagt tataaattcc cacagaagaa aaatgtgaaa
     3541 gactgggtgc tagacaagaa ggaagcaggt aaagggatag ttgctttgtc atccgttttt
     3601 aattatttta actgaccctt gacaatcttg tcagcaatat aggactgttg aacaatcccg
     3661 gtgtgtcagg acccccaaat gtcacttctg cataaagcat gtatgtcatc tattttttct
     3721 tcaataaaga gatttaatag ccatttcaag aaatcccata aagaacctct ctatgtccct
     3781 ttttttaatt taaaaaaaat gactcttgtc taatattcgt ctataaggga ttaattttca
     3841 gaccctttaa taagtgagtg ccataagaaa gtcaatatat attgtttaaa agatatttca
     3901 gtctaggaaa gattttcctt ctcttggaat gtgaagatct gtcgattcat ctccaatcat
     3961 atgcattgac atacacagca aagaagatat aggcagtaat atcaacactg ctatatcatg
     4021 tgtaggacat ttcttatcca ttttttctct tttacttgca tagttgctat gtgtttctca
     4081 ttgtaaaagg ctgccgctgg gtggcagaag ccaagagacc ttattaacta ggctatattt
     4141 ttcttaactt gatctgaaat ccacaattag accacaatgc acctttggtt gtatccataa
     4201 aggatgctag cctgccttgt actaatgttt tatatattaa aaaaaaaaaa tctatcaacc
     4261 atttcatata tatcccacta ctcaaggtat ccatggaaca tgaaagaata acatttatgc
     4321 agaggaaaaa caaaaacatc cctgaaaata tacacactca tacacacaca cgcacagggg
     4381 aataaaataa gaaaatcatt ttcctcacca tagacttgat cccatcctta caacccatcc
     4441 ttctaacttg atgtgtataa aatatgcaaa catttcacaa atgttctttg tcatttcaaa
     4501 atactttagt atatcaatat cagtagatac cagtgggtgg gaaagggtca ttacatgaaa
     4561 atatgaagaa atagccatat tagtttttta acctgcaatt tgcctcagca acaaagaaaa
     4621 agtgaatttt taatgctgaa gataaagtaa gctaaagtac cagcagaagc cttggctatt
     4681 tatagcagtt ctgacaatag ttttataaga acatgaagag aacagaatca cttgaaaatg
     4741 gatgccagtc atctcttgtt cccactactg aattcttata aagtggtggc aagataggga
     4801 agggataatc tgagaatttt taaaagatga tttaatgaga agaagcacaa ttttgatttt
     4861 gatgagtcac tttctgtaaa caatcttggt ctatctttac ccttatacct tatctgtaat
     4921 ttaccattta ttgtatttgc aaagctagta tggtttttaa tcacagtaaa tcctttgtat
     4981 tccagacttt agggcagagc cctgagggag tattatttta cataacccgt cctagagtaa
     5041 cattttaggc aacattcttc attgcaagta aaagatccat aagtggcatt ttacacggct
     5101 gcgagtattg ttatatctaa tcctatttta aaagattttt ggtaatatga agcttgaata
     5161 ctggtaacag tgatgcaata tacgcaagct gcacaacctg tatattgtat gcattgctgc
     5221 gtggaggctg tttatttcaa cctttttaaa aattgtgttt tttagtaaaa tggcttattt
     5281 tttcccaaag gtggaattta gcattttgta atgatgaata taaaaatacc tgtcatcccc
     5341 agatcattta aaagttaact aaagtgagaa tgaaaaaaca aaattccaag acacttttta
     5401 aaagaatgtc tgccctcaca cacttttatg gatttgtttt tcttacatac ccatctttta
     5461 acttagagat agcatttttt gccctcttta ttttgttgtt tgtttctcca gagagtaaac
     5521 gctttgtagt tctttcttta aaaaacattt tttttaaaga agaagaagcc acttgaaccc
     5581 tcaataaagg ctgttgccta agcatggcat acttcatctg ttctcatttg tgccatctgc
     5641 cgtgatgtcg tcacttttat ggcgttaatt tcctgccact acagatcttt tgaagattgc
     5701 tggaatactg gtgtctgtta gaatgcttca gactacagat gtaattaaag gcttttctta
     5761 atatgtttta accaaagatg tggagcaatc caagccacat atcttctaca tcaaattttt
     5821 ccattttggt tattttcata atctggtatt gcattttgcc ttccctgttc atacctcaaa
     5881 ttgattcata cctcagttta attcagagag gtcagttaag tgacggattc tgttgtggtt
     5941 tgaatgcagt accagtgttc tcttcgagca aagtagacct gggtcactgt aggcatagga
     6001 cttggattgc ttcagatggt ttgctgtatc atttttcttc tttttctttt cctggggact
     6061 tgtttccatt aaatgagagt aattaaaatc gcttgtaaat gagggcatac aagcatttgc
     6121 aacaaatatt caaatagagg ctcacagcgg cataagctgg actttgtcgc cactagatga
     6181 caagatgtta taactaagtt aaaccacatc tgtgtatctc aagggactta attcagctgt
     6241 ctgtagtgaa taaaagtggg aaattttcaa aagtttctcc tgctggaaat aaggtataat
     6301 ttgtattttg cagacaattc agtaaagtta ctggctttct tagtgatgca gtgtccgtgg
     6361 tgcatttttt taaattaatg ttttgctgtt taaatttatt caattttatt gtgtttttta
     6421 aaaagcagct tatgccacaa gcacaaatga gctttctcag ttttcaactc aaaatattat
     6481 atgaaaagat ggatatgtgt gtctgtgtgg gaggggtgtg aattggatga cggttcttag
     6541 ggtattacag aattcagcca gtggtggaag tctaaggttc ttattgaatg gttcaacttc
     6601 tttatcaaag aagttccatg aagatctttg ataacctgtt taaatgtaca gaatttttca
     6661 aaagccactg tgaaaagcag taccataagt tattttttaa ctaaaatctg tagaaagtgt
     6721 ttccaaaaga gttccttttt tcttcttcga agtaatttct aaaagttgaa aacataggct
     6781 tataaatctg aataaattag tgaattcata cattttagag actatcaaat atatccatta
     6841 ttaacattca ataataatct ctaaagggga atgtccttaa aaagattgat agaaagatta
     6901 atttaaaaac tgaaaaggaa aacaagacac caccagttag ccagctggag aacttggact
     6961 tttgcattag tagtgatatc tgctccaaaa agaatgcagt tcgaggaaat gttgcatgtg
     7021 gcttcaaaat agcagtgctt tctgctttgt tctcttgtat tcattttcag caaacatgta
     7081 ttaagcaatt attatatgta actcatgtgg tgattccagg atgaatgaag ttgtagccct
     7141 ttctcttagg aaacttataa actaatagga gataaaaggc attctcaggg aagtctacaa
     7201 agtgctatga gggagccact ttggccatcc tggggcagag cagaccagag gctcagagca
     7261 tggacacttc ctcatccacc cagcagaagc ctttcacttg attttgaagg tgggcaggat
     7321 tgagaaaggc ccagaagggg atgagttcaa agctgtttgt gggcatgtga cccctgcagt
     7381 cacatatggc cctagcttgt gtttcgttta gtgttctgct atcattatcc tgataatatc
     7441 ctgataataa aattatcctt aataatttta
//
