LOCUS       NM_001145785            1425 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens myocyte enhancer factor 2B (MEF2B), transcript variant
            1, mRNA.
ACCESSION   NM_001145785
VERSION     NM_001145785.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1425)
  AUTHORS   Yu,C., Shen,Q., Holmes,A.B., Mo,T., Tosato,A., Soni,R.K.,
            Corinaldesi,C., Koul,S., Pasqualucci,L., Hussein,S., Forouhar,F.,
            Dalla-Favera,R. and Basso,K.
  TITLE     MEF2B C-terminal mutations enhance transcriptional activity and
            stability to drive B cell lymphomagenesis
  JOURNAL   Nat Commun 15 (1), 7195 (2024)
   PUBMED   39179580
  REMARK    GeneRIF: MEF2B C-terminal mutations enhance transcriptional
            activity and stability to drive B cell lymphomagenesis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1425)
  AUTHORS   Zia,A. and Rashid,S.
  TITLE     Systematic transition modeling analysis in the MEF2B-DNA binding
            interface due to Y69H and K4E variants
  JOURNAL   J Mol Graph Model 108, 108009 (2021)
   PUBMED   34418874
  REMARK    GeneRIF: Systematic transition modeling analysis in the MEF2B-DNA
            binding interface due to Y69H and K4E variants.
REFERENCE   3  (bases 1 to 1425)
  AUTHORS   Magistri,M., Happ,L.E., Ramdial,J., Lu,X., Stathias,V.,
            Kunkalla,K., Agarwal,N., Jiang,X., Schurer,S.C., Dubovy,S.R.,
            Chapman,J.R., Vega,F., Dave,S. and Lossos,I.S.
  TITLE     The Genetic Landscape of Ocular Adnexa MALT Lymphoma Reveals
            Frequent Aberrations in NFAT and MEF2B Signaling Pathways
  JOURNAL   Cancer Res Commun 1 (1), 1-16 (2021)
   PUBMED   35528192
  REMARK    GeneRIF: The Genetic Landscape of Ocular Adnexa MALT Lymphoma
            Reveals Frequent Aberrations in NFAT and MEF2B Signaling Pathways.
            Erratum:[Cancer Res Commun. 2023 Aug 29;3(8):1688. doi:
            10.1158/2767-9764.CRC-23-0371.. PMID: 37649813]
REFERENCE   4  (bases 1 to 1425)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 1425)
  AUTHORS   Dantas Machado,A.C., Cooper,B.H., Lei,X., Di Felice,R., Chen,L. and
            Rohs,R.
  TITLE     Landscape of DNA binding signatures of myocyte enhancer factor-2B
            reveals a unique interplay of base and shape readout
  JOURNAL   Nucleic Acids Res 48 (15), 8529-8544 (2020)
   PUBMED   32738045
  REMARK    GeneRIF: Landscape of DNA binding signatures of myocyte enhancer
            factor-2B reveals a unique interplay of base and shape readout.
REFERENCE   6  (bases 1 to 1425)
  AUTHORS   Katoh,Y., Molkentin,J.D., Dave,V., Olson,E.N. and Periasamy,M.
  TITLE     MEF2B is a component of a smooth muscle-specific complex that binds
            an A/T-rich element important for smooth muscle myosin heavy chain
            gene expression
  JOURNAL   J Biol Chem 273 (3), 1511-1518 (1998)
   PUBMED   9430690
REFERENCE   7  (bases 1 to 1425)
  AUTHORS   Hobson,G.M., Krahe,R., Garcia,E., Siciliano,M.J. and Funanage,V.L.
  TITLE     Regional chromosomal assignments for four members of the MADS
            domain transcription enhancer factor 2 (MEF2) gene family to human
            chromosomes 15q26, 19p12, 5q14, and 1q12-q23
  JOURNAL   Genomics 29 (3), 704-711 (1995)
   PUBMED   8575763
REFERENCE   8  (bases 1 to 1425)
  AUTHORS   Han,T.H. and Prywes,R.
  TITLE     Regulatory role of MEF2D in serum induction of the c-jun promoter
  JOURNAL   Mol Cell Biol 15 (6), 2907-2915 (1995)
   PUBMED   7760790
REFERENCE   9  (bases 1 to 1425)
  AUTHORS   Yu,Y.T., Breitbart,R.E., Smoot,L.B., Lee,Y., Mahdavi,V. and
            Nadal-Ginard,B.
  TITLE     Human myocyte-specific enhancer factor 2 comprises a group of
            tissue-restricted MADS box transcription factors
  JOURNAL   Genes Dev 6 (9), 1783-1798 (1992)
   PUBMED   1516833
REFERENCE   10 (bases 1 to 1425)
  AUTHORS   Pollock,R. and Treisman,R.
  TITLE     Human SRF-related proteins: DNA-binding properties and potential
            regulatory targets
  JOURNAL   Genes Dev 5 (12A), 2327-2341 (1991)
   PUBMED   1748287
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA488022.1, AC002126.1 and AI499707.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001145785.1.
            
            Summary: The product of this gene is a member of the MADS/MEF2
            family of DNA binding proteins. The protein is thought to regulate
            gene expression, including expression of the smooth muscle myosin
            heavy chain gene. This region undergoes considerable alternative
            splicing, with transcripts supporting two non-overlapping loci
            (GeneID 729991 and 100271849) as well as numerous read-through
            transcripts that span both loci (annotated as GeneID 4207). Several
            isoforms of this protein are expressed from either this locus or
            from some of the read-through transcripts annotated on GeneID 4207.
            [provided by RefSeq, Jan 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.91931.1,
                                           SRR1163657.336697.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000424583.7/ ENSP00000402154.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                DA488022.1         27-44
            19-59               AC002126.1         60940-60980         c
            60-142              AC002126.1         41417-41499         c
            143-346             AC002126.1         39961-40164         c
            347-481             AC002126.1         38433-38567         c
            482-629             AC002126.1         37771-37918         c
            630-763             AC002126.1         37477-37610         c
            764-857             AC002126.1         37290-37383         c
            858-969             AC002126.1         37008-37119         c
            970-1423            AC002126.1         36304-36757         c
            1424-1425           AI499707.1         22-23               c
FEATURES             Location/Qualifiers
     source          1..1425
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.11"
     gene            1..1425
                     /gene="MEF2B"
                     /gene_synonym="RSRFR2"
                     /note="myocyte enhancer factor 2B"
                     /db_xref="GeneID:100271849"
                     /db_xref="HGNC:HGNC:6995"
                     /db_xref="MIM:600661"
     exon            1..59
                     /gene="MEF2B"
                     /gene_synonym="RSRFR2"
                     /inference="alignment:Splign:2.1.0"
     exon            60..142
                     /gene="MEF2B"
                     /gene_synonym="RSRFR2"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..1195
                     /gene="MEF2B"
                     /gene_synonym="RSRFR2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     myocyte-specific enhancer factor 2B; MADS box
                     transcription enhancer factor 2, polypeptide B (myocyte
                     enhancer factor 2B); serum response factor-like protein 2"
                     /codon_start=1
                     /product="myocyte-specific enhancer factor 2B isoform 1"
                     /protein_id="NP_001139257.1"
                     /db_xref="CCDS:CCDS46024.1"
                     /db_xref="GeneID:100271849"
                     /db_xref="HGNC:HGNC:6995"
                     /db_xref="MIM:600661"
                     /translation="MGRKKIQISRILDQRNRQVTFTKRKFGLMKKAYELSVLCDCEIA
                     LIIFNSANRLFQYASTDMDRVLLKYTEYSEPHESRTNTDILETLKRRGIGLDGPELEP
                     DEGPEEPGEKFRRLAGEGGDPALPRPRLYPAAPAMPSPDVVYGALPPPGCDPSGLGEA
                     LPAQSRPSPFRPAAPKAGPPGLVHPLFSPSHLTSKTPPPLYLPTEGRRSDLPGGLAGP
                     RGGLNTSRSLYSGLQNPCSTATPGPPLGSFPFLPGGPPEYGLGDPPPPPGLLQPPTLA
                     PWQPSRGDGPPAVSSQPSGGRSLGEEGPPTRGASPPTPPVSIKSERLSPAPGGPGDFP
                     KTFPYPLLLARSLAEPLRPGPALRRLPLADGWPR"
     exon            143..346
                     /gene="MEF2B"
                     /gene_synonym="RSRFR2"
                     /inference="alignment:Splign:2.1.0"
     exon            347..481
                     /gene="MEF2B"
                     /gene_synonym="RSRFR2"
                     /inference="alignment:Splign:2.1.0"
     exon            482..629
                     /gene="MEF2B"
                     /gene_synonym="RSRFR2"
                     /inference="alignment:Splign:2.1.0"
     exon            630..763
                     /gene="MEF2B"
                     /gene_synonym="RSRFR2"
                     /inference="alignment:Splign:2.1.0"
     exon            764..857
                     /gene="MEF2B"
                     /gene_synonym="RSRFR2"
                     /inference="alignment:Splign:2.1.0"
     exon            858..969
                     /gene="MEF2B"
                     /gene_synonym="RSRFR2"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1425
                     /gene="MEF2B"
                     /gene_synonym="RSRFR2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1395..1400
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MEF2B"
                     /gene_synonym="RSRFR2"
                     /note="hexamer: AATAAA"
     polyA_site      1425
                     /gene="MEF2B"
                     /gene_synonym="RSRFR2"
                     /note="major polyA site"
ORIGIN      
        1 atcttcgtgc agccgccgcg ggtccgtgcg cccagcgtcc cagggcccag gccgagcaga
       61 caaagatcat tccactcagc ctgggacgat ggggaggaaa aaaatccaga tctcccgcat
      121 cctggaccaa aggaatcggc aggtgacgtt caccaagcgg aagttcgggc tgatgaagaa
      181 ggcctatgag ctgagcgtgc tctgtgactg tgagatagcc ctcatcatct tcaacagcgc
      241 caaccgcctc ttccagtatg ccagcacgga catggaccgt gtgctgctga agtacacaga
      301 gtacagcgag ccccacgaga gccgcaccaa cactgacatc ctcgagacgc tgaagcggag
      361 gggcattggc ctcgatgggc cagagctgga gccggatgaa gggcctgagg agccaggaga
      421 gaagtttcgg aggctggcag gcgaaggggg tgatccggcc ttgccccgac cccggctgta
      481 tcctgcagct cctgctatgc ccagcccaga tgtggtatac ggggccttac cgccaccagg
      541 ctgtgacccc agtgggcttg gggaagcact gcccgcccag agccgcccat ctcccttccg
      601 accagcagcc cccaaagccg ggcccccagg cctggtgcac cctctcttct caccaagcca
      661 cctcaccagc aagacaccac ccccactgta cctgccgacg gaagggcgga ggtcagacct
      721 gcctggtggc ctggctgggc cccgaggggg actaaacacc tccagaagcc tctacagtgg
      781 cctgcagaac ccctgctcca ctgcaactcc cggaccccca ctggggagct tccccttcct
      841 ccccggaggc cccccagaat atggcctggg agaccctcca ccgccccctg gcttgttgca
      901 gccccccacc ctggccccct ggcagccctc gaggggtgat gggccccccg ccgtgtcctc
      961 ccagcccagt gggggccgaa gcctgggcga ggagggtccc ccaacccgcg gcgcctcccc
     1021 gccgaccccc ccagtcagca tcaagtctga gcgcctctct ccggcccccg ggggccccgg
     1081 cgactttcct aagaccttcc cctatccctt gctcctcgcc cggtccctgg cagagcctct
     1141 gcggcctggg cccgccctgc gccggctgcc cttggccgac ggctggcccc ggtaggagat
     1201 cacccggtgg caccagccca gagcgctcgc caggtacggc gagggcacgt ggggacccca
     1261 cctccctcca ggcctcttca gagaagaccc aacagtgacg cccccctccg cggtgggggc
     1321 ttggaggtgg gcggctggac tcaatccacc ctggggggct cctttccttc ttcctatttg
     1381 tgtgtatatc cacaaataaa acgcgcgtgg cgtccgtgga ccaga
//
