LOCUS       NM_032849               2294 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens mesenteric estrogen dependent adipogenesis (MEDAG),
            mRNA.
ACCESSION   NM_032849
VERSION     NM_032849.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2294)
  AUTHORS   Yang,J. and Yu,P.
  TITLE     Identification of MEDAG as a Hub Candidate Gene in the Onset and
            Progression of Type 2 Diabetes Mellitus by Comprehensive
            Bioinformatics Analysis
  JOURNAL   Biomed Res Int 2021, 3947350 (2021)
   PUBMED   33728329
  REMARK    GeneRIF: Identification of MEDAG as a Hub Candidate Gene in the
            Onset and Progression of Type 2 Diabetes Mellitus by Comprehensive
            Bioinformatics Analysis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2294)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2294)
  AUTHORS   Wang,Y. and Tatakis,D.N.
  TITLE     Human gingiva transcriptome during wound healing
  JOURNAL   J Clin Periodontol 44 (4), 394-402 (2017)
   PUBMED   28005267
  REMARK    GeneRIF: MEDAG expression is significantly upregulated in human
            masticatory mucosa during wound healing
REFERENCE   4  (bases 1 to 2294)
  AUTHORS   Zhang,H., Chen,X. and Sairam,M.R.
  TITLE     Novel genes of visceral adiposity: identification of mouse and
            human mesenteric estrogen-dependent adipose (MEDA)-4 gene and its
            adipogenic function
  JOURNAL   Endocrinology 153 (6), 2665-2676 (2012)
   PUBMED   22510272
  REMARK    GeneRIF: study identifies Meda-4 as a novel adipogenic gene,
            capable of promoting differentiation of preadipocytes into
            adipocytes, increasing lipid content and glucose uptake in
            adipocytes; it might play an important role in adipose tissue
            expansion in normal and aberrant hormonal conditions and
            pathophysiological states
REFERENCE   5  (bases 1 to 2294)
  AUTHORS   Dunham,A., Matthews,L.H., Burton,J., Ashurst,J.L., Howe,K.L.,
            Ashcroft,K.J., Beare,D.M., Burford,D.C., Hunt,S.E.,
            Griffiths-Jones,S., Jones,M.C., Keenan,S.J., Oliver,K., Scott,C.E.,
            Ainscough,R., Almeida,J.P., Ambrose,K.D., Andrews,D.T.,
            Ashwell,R.I., Babbage,A.K., Bagguley,C.L., Bailey,J., Bannerjee,R.,
            Barlow,K.F., Bates,K., Beasley,H., Bird,C.P., Bray-Allen,S.,
            Brown,A.J., Brown,J.Y., Burrill,W., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M.E., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S.C., Cobley,V., Collins,J.E., Corby,N., Coville,G.J.,
            Deloukas,P., Dhami,P., Dunham,I., Dunn,M., Earthrowl,M.E.,
            Ellington,A.G., Faulkner,L., Frankish,A.G., Frankland,J.,
            French,L., Garner,P., Garnett,J., Gilbert,J.G., Gilson,C.J.,
            Ghori,J., Grafham,D.V., Gribble,S.M., Griffiths,C., Hall,R.E.,
            Hammond,S., Harley,J.L., Hart,E.A., Heath,P.D., Howden,P.J.,
            Huckle,E.J., Hunt,P.J., Hunt,A.R., Johnson,C., Johnson,D., Kay,M.,
            Kimberley,A.M., King,A., Laird,G.K., Langford,C.J., Lawlor,S.,
            Leongamornlert,D.A., Lloyd,D.M., Lloyd,C., Loveland,J.E.,
            Lovell,J., Martin,S., Mashreghi-Mohammadi,M., McLaren,S.J.,
            McMurray,A., Milne,S., Moore,M.J., Nickerson,T., Palmer,S.A.,
            Pearce,A.V., Peck,A.I., Pelan,S., Phillimore,B., Porter,K.M.,
            Rice,C.M., Searle,S., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Steward,C.A., Sycamore,N., Tester,J., Thomas,D.W.,
            Tracey,A., Tromans,A., Tubby,B., Wall,M., Wallis,J.M., West,A.P.,
            Whitehead,S.L., Willey,D.L., Wilming,L., Wray,P.W., Wright,M.W.,
            Young,L., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E., Beck,S.,
            Bentley,D.R., Rogers,J. and Ross,M.T.
  TITLE     The DNA sequence and analysis of human chromosome 13
  JOURNAL   Nature 428 (6982), 522-528 (2004)
   PUBMED   15057823
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL353680.8.
            
            On Nov 23, 2018 this sequence version replaced NM_032849.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC040165.1, AK055635.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000380482.9/ ENSP00000369849.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-523               AL353680.8         52350-52872
            524-633             AL353680.8         63482-63591
            634-746             AL353680.8         67093-67205
            747-1032            AL353680.8         67640-67925
            1033-2294           AL353680.8         70390-71651
FEATURES             Location/Qualifiers
     source          1..2294
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q12.3"
     gene            1..2294
                     /gene="MEDAG"
                     /gene_synonym="AWMS3; C13orf33; hAWMS3; MEDA-4; MEDA4"
                     /note="mesenteric estrogen dependent adipogenesis"
                     /db_xref="GeneID:84935"
                     /db_xref="HGNC:HGNC:25926"
     exon            1..523
                     /gene="MEDAG"
                     /gene_synonym="AWMS3; C13orf33; hAWMS3; MEDA-4; MEDA4"
                     /inference="alignment:Splign:2.1.0"
     CDS             246..1157
                     /gene="MEDAG"
                     /gene_synonym="AWMS3; C13orf33; hAWMS3; MEDA-4; MEDA4"
                     /note="activated in W/Wv mouse stomach 3 homolog;
                     mesenteric estrogen-dependent adipose 4"
                     /codon_start=1
                     /product="mesenteric estrogen-dependent adipogenesis
                     protein"
                     /protein_id="NP_116238.3"
                     /db_xref="CCDS:CCDS9338.1"
                     /db_xref="GeneID:84935"
                     /db_xref="HGNC:HGNC:25926"
                     /translation="MAGAACEPVARPSLTSISSGELRSLWTCDCELALLPLAQLLRLQ
                     PGAFQLSGDQLVVARPGEPAAARGGFNVFGDGLVRLDGQLYRLSSYIKRYVELTNYCD
                     YKDYRETILSKPMLFFINVQTKKDTSKERTYAFLVNTRHPKIRRQIEQGMDMVISSVI
                     GESYRLQFDFQEAVKNFFPPGNEVVNGENLSFAYEFKADALFDFFYWFGLSNSVVKVN
                     GKVLNLSSTSPEKKETIKLFLEKMSEPLIRRSSFSDRKFSVTSRGSIDDVFNCNLSPR
                     SSLTEPLLAELPFPSVLESEETPNQFI"
     exon            524..633
                     /gene="MEDAG"
                     /gene_synonym="AWMS3; C13orf33; hAWMS3; MEDA-4; MEDA4"
                     /inference="alignment:Splign:2.1.0"
     exon            634..746
                     /gene="MEDAG"
                     /gene_synonym="AWMS3; C13orf33; hAWMS3; MEDA-4; MEDA4"
                     /inference="alignment:Splign:2.1.0"
     exon            747..1032
                     /gene="MEDAG"
                     /gene_synonym="AWMS3; C13orf33; hAWMS3; MEDA-4; MEDA4"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..2294
                     /gene="MEDAG"
                     /gene_synonym="AWMS3; C13orf33; hAWMS3; MEDA-4; MEDA4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2237..2242
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MEDAG"
                     /gene_synonym="AWMS3; C13orf33; hAWMS3; MEDA-4; MEDA4"
                     /note="hexamer: ATTAAA"
     polyA_site      2260
                     /gene="MEDAG"
                     /gene_synonym="AWMS3; C13orf33; hAWMS3; MEDA-4; MEDA4"
                     /note="major polyA site"
     regulatory      2271..2276
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MEDAG"
                     /gene_synonym="AWMS3; C13orf33; hAWMS3; MEDA-4; MEDA4"
                     /note="hexamer: ATTAAA"
     polyA_site      2294
                     /gene="MEDAG"
                     /gene_synonym="AWMS3; C13orf33; hAWMS3; MEDA-4; MEDA4"
                     /note="major polyA site"
ORIGIN      
        1 gctttctccg cgcggtgcct gcagggctcc cagcgagtgg cagcttggga ggggccgccc
       61 gggcggtcag actggcacct gagcggccac cgcgtcccgg ccaggcgggc agaccgaccc
      121 cctcctcacc tcgcgcgcgg ctgacgcagg cagggcgccc ggcccctcct ggggaccatc
      181 aggtgccggc tgggggctgt aggcaccgga cggaagcagg cggtgtgagg accgacgacg
      241 cgggcatggc gggggcggcc tgcgagccgg tggccaggcc gagcctgacc tccatctcgt
      301 ctggggagct tcgcagcctg tggacctgcg actgcgagct ggccctgctg ccgctggctc
      361 agctgctgcg cctgcagccc ggtgccttcc agctgagcgg cgaccagctc gtggtggcca
      421 ggcccgggga gccggcggcg gcgcgggggg gcttcaacgt cttcggtgac ggcctcgtgc
      481 gcctcgacgg gcagctctac cgcctcagca gctacatcaa gaggtatgtg gaactgacca
      541 actactgtga ttataaagac tacagggaaa ctatattgag caaaccaatg ttgttcttta
      601 ttaatgtaca gaccaaaaaa gacacctcaa aagaaaggac gtacgcgttt cttgtaaaca
      661 cgaggcaccc caagataaga agacagatag agcaagggat ggacatggtc atctcctcag
      721 tgattggaga aagttaccgg cttcagtttg attttcaaga ggcagtgaag aatttcttcc
      781 ccccaggaaa tgaagtggtt aatggagaaa atttaagctt tgcatatgaa ttcaaagctg
      841 atgcattatt tgatttcttc tattggtttg ggctcagtaa ttccgttgta aaagtaaatg
      901 gaaaagttct gaatttgtca agtacaagtc cagaaaagaa ggagacgatt aagttatttc
      961 tggaaaaaat gagtgagcct ttaatccgaa ggagcagttt ctctgaccga aagttcagtg
     1021 taacttccag aggttcaata gatgatgttt ttaactgcaa tctgtcaccc agatcatctc
     1081 tgacagagcc tcttttggca gaattaccat ttccaagtgt tctggaatct gaagagacac
     1141 ccaaccaatt tatctgattg aactgaacat tgtagcagtt gctcccgcac tccaggcctg
     1201 tgctagacta taggctgggg ggagggtagg aggtgggagg cagatacttc cacctgcgtg
     1261 tcaatctccg gctcctccat ggcttctatg gaggactcct ctcttctgct tctgtggatg
     1321 tgatgccctg gcaggcccag ggcagctgat tcccctaaaa cttatgatta ccaggatgga
     1381 aaggccttgg tcccatggca ctgggtgggg ctgggggata ttctctactt tgaacacttc
     1441 tccaaagagg cagaagggcc acagagttct gccaccctga acatttttct cagttccctg
     1501 ggagtttttg tggcagcctt tgtgggagtg gtctgactgg ctgttgacct agcatgcttc
     1561 ataaatcagg gtttggccct ctgcttggag catccaaccc cttgaactca aacctgtcga
     1621 gcaaggggtt aagagttctg ttctcttgcc aacctggctg ggcaaaagcc tgtgccatct
     1681 ttcactggga ggcaaatatg tttttcatcc tgccatatga cacctatgag aaacgttcac
     1741 agtgaggagt agccaggttg ctaggacagt aaccctgcca cacactgcct gaaatcggaa
     1801 ctcccttggc ctccctctta actaagtgac ccatgtagaa ggaagccagg agatatggta
     1861 ccgaacaatg acaggggaag ggtattggac acggcagcgt cctccttatt gaaaacacat
     1921 tatgtcagtt gggaatttta aataagcttt tagcaaacct aacactaaaa gcaaaataga
     1981 agaaagctat accattacca taatacattt ttcatctcat ggctacaatg gaattcttga
     2041 aaaggaaaaa aaaatcctat ctacatataa aaacctgcat gaatgaatca ctacatatgc
     2101 ttataatgag gaagagttat gggtcctgag tgtaattttt tatcctttct taaaaagttt
     2161 ctgtattatg cattttgata acactactga tgatccttcc acttatattt gaaatgttat
     2221 gtaccacatt tgcacaatta aaacttttct tagcattcaa cctagaattg attaaattta
     2281 tgactgaggc ttca
//
