LOCUS       NM_025205              10858 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens mediator complex subunit 28 (MED28), mRNA.
ACCESSION   NM_025205 XR_017847
VERSION     NM_025205.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10858)
  AUTHORS   Huang,C.Y., Weng,Y.T., Hsieh,N.T., Li,P.C., Lee,T.Y., Li,C.I.,
            Liu,H.S. and Lee,M.F.
  TITLE     Bioactive Vitamin D Attenuates MED28-Mediated Cell Growth and
            Epithelial-Mesenchymal Transition in Human Colorectal Cancer Cells
  JOURNAL   Biomed Res Int 2022, 2268818 (2022)
   PUBMED   36072467
  REMARK    GeneRIF: Bioactive Vitamin D Attenuates MED28-Mediated Cell Growth
            and Epithelial-Mesenchymal Transition in Human Colorectal Cancer
            Cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10858)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 10858)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 10858)
  AUTHORS   Xiang,Z., Zhou,S., Liang,S., Zhang,G. and Tan,Y.
  TITLE     RCOR1 directly binds to MED28 and weakens its inducing effect on
            cancer stem cell-like activity of oral cavity squamous cell
            carcinoma cells
  JOURNAL   J Oral Pathol Med 49 (8), 741-750 (2020)
   PUBMED   32306431
  REMARK    GeneRIF: RCOR1 directly binds to MED28 and weakens its inducing
            effect on cancer stem cell-like activity of oral cavity squamous
            cell carcinoma cells.
REFERENCE   5  (bases 1 to 10858)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 10858)
  AUTHORS   Sato,S., Tomomori-Sato,C., Banks,C.A., Sorokina,I., Parmely,T.J.,
            Kong,S.E., Jin,J., Cai,Y., Lane,W.S., Brower,C.S., Conaway,R.C. and
            Conaway,J.W.
  TITLE     Identification of mammalian Mediator subunits with similarities to
            yeast Mediator subunits Srb5, Srb6, Med11, and Rox3
  JOURNAL   J Biol Chem 278 (17), 15123-15127 (2003)
   PUBMED   12584197
REFERENCE   7  (bases 1 to 10858)
  AUTHORS   Liu,C., Zhang,L., Shao,Z.M., Beatty,P., Sartippour,M., Lane,T.F.,
            Barsky,S.H., Livingston,E. and Nguyen,M.
  TITLE     Identification of a novel endothelial-derived gene EG-1
  JOURNAL   Biochem Biophys Res Commun 290 (1), 602-612 (2002)
   PUBMED   11779215
REFERENCE   8  (bases 1 to 10858)
  AUTHORS   Suzuki,H., Fukunishi,Y., Kagawa,I., Saito,R., Oda,H., Endo,T.,
            Kondo,S., Bono,H., Okazaki,Y. and Hayashizaki,Y.
  TITLE     Protein-protein interaction panel using mouse full-length cDNAs
  JOURNAL   Genome Res 11 (10), 1758-1765 (2001)
   PUBMED   11591653
REFERENCE   9  (bases 1 to 10858)
  AUTHORS   Mittler,G., Kremmer,E., Timmers,H.T. and Meisterernst,M.
  TITLE     Novel critical role of a human Mediator complex for basal RNA
            polymerase II transcription
  JOURNAL   EMBO Rep 2 (9), 808-813 (2001)
   PUBMED   11559591
REFERENCE   10 (bases 1 to 10858)
  AUTHORS   Rozovskaia,T., Rozenblatt-Rosen,O., Sedkov,Y., Burakov,D., Yano,T.,
            Nakamura,T., Petruck,S., Ben-Simchon,L., Croce,C.M., Mazo,A. and
            Canaani,E.
  TITLE     Self-association of the SET domains of human ALL-1 and of
            Drosophila TRITHORAX and ASH1 proteins
  JOURNAL   Oncogene 19 (3), 351-357 (2000)
   PUBMED   10656681
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF318059.1 and AC006160.9.
            
            On Nov 23, 2018 this sequence version replaced NM_025205.4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.104368.1,
                                           SRR1803613.277695.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000237380.12/ ENSP00000237380.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-787               AF318059.1         11-797
            788-10858           AC006160.9         73809-83879         c
FEATURES             Location/Qualifiers
     source          1..10858
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p15.32"
     gene            1..10858
                     /gene="MED28"
                     /gene_synonym="1500003D12Rik; EG1; magicin"
                     /note="mediator complex subunit 28"
                     /db_xref="GeneID:80306"
                     /db_xref="HGNC:HGNC:24628"
                     /db_xref="MIM:610311"
     exon            1..173
                     /gene="MED28"
                     /gene_synonym="1500003D12Rik; EG1; magicin"
                     /inference="alignment:Splign:2.1.0"
     CDS             15..551
                     /gene="MED28"
                     /gene_synonym="1500003D12Rik; EG1; magicin"
                     /note="endothelial-derived gene 1; endothelial-derived
                     protein 1; tumor angiogenesis marker EG-1; merlin and
                     Grb2-interacting cytoskeletal protein; mediator of RNA
                     polymerase II transcription, subunit 28 homolog"
                     /codon_start=1
                     /product="mediator of RNA polymerase II transcription
                     subunit 28"
                     /protein_id="NP_079481.2"
                     /db_xref="CCDS:CCDS33963.1"
                     /db_xref="GeneID:80306"
                     /db_xref="HGNC:HGNC:24628"
                     /db_xref="MIM:610311"
                     /translation="MAAPLGGMFSGQPPGPPQAPPGLPGQASLLQAAPGAPRPSSSTL
                     VDELESSFEACFASLVSQDYVNGTDQEEIRTGVDQCIQKFLDIARQTECFFLQKRLQL
                     SVQKPEQVIKEDVSELRNELQRKDALVQKHLTKLRHWQQVLEDINVQHKKPADIPQGS
                     LAYLEQASANIPAPLKPT"
     exon            174..240
                     /gene="MED28"
                     /gene_synonym="1500003D12Rik; EG1; magicin"
                     /inference="alignment:Splign:2.1.0"
     exon            241..353
                     /gene="MED28"
                     /gene_synonym="1500003D12Rik; EG1; magicin"
                     /inference="alignment:Splign:2.1.0"
     exon            354..10858
                     /gene="MED28"
                     /gene_synonym="1500003D12Rik; EG1; magicin"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2352..2357
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MED28"
                     /gene_synonym="1500003D12Rik; EG1; magicin"
                     /note="hexamer: ATTAAA"
     polyA_site      2381
                     /gene="MED28"
                     /gene_synonym="1500003D12Rik; EG1; magicin"
                     /note="major polyA site"
     regulatory      10824..10829
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MED28"
                     /gene_synonym="1500003D12Rik; EG1; magicin"
                     /note="hexamer: AATAAA"
     polyA_site      10858
                     /gene="MED28"
                     /gene_synonym="1500003D12Rik; EG1; magicin"
ORIGIN      
        1 gcgccattcc aaacatggcg gctccactag ggggtatgtt ttctgggcag ccacccggtc
       61 cccctcaggc cccgccgggc cttccgggcc aagcttcgct tcttcaggca gctccaggcg
      121 ctcctagacc ttccagcagt actttggtgg acgagttgga gtcatctttc gaggcttgct
      181 ttgcatctct ggtgagtcag gactatgtca atggcaccga tcaggaagaa attcgaaccg
      241 gtgttgatca gtgtatccag aagtttctgg atattgcaag acagacagaa tgttttttct
      301 tacaaaaaag attgcagtta tctgtccaga aaccagagca agttatcaaa gaggatgtgt
      361 cagaactaag gaatgaatta cagcggaaag atgcactagt ccagaagcac ttgacaaagc
      421 tgaggcattg gcagcaggtg ctggaggaca tcaacgtgca gcacaaaaag cccgccgaca
      481 tccctcaggg ctccttggcc tacctggagc aggcatctgc caacatccct gcacctctga
      541 agccaacgtg agcaaagggc agaggcagtt ggcctatgag tgggctgatg cgtgaggttg
      601 gccacacatt ccttcctgtg gacttgacat tttggaagaa ctctttgcca gataatgagt
      661 tcattttagt tttatgctcc cattgaaaaa ttttccacta tttttataag ctgttaattt
      721 cttgagtact ttataacatg tctgtagctt ggataaacca agtaagtatt ttttttttgt
      781 ctttagcaaa gtttagactg tgaatatgat gacacagatt cttttttatg gtggctttgc
      841 ttgttttaaa tttttgcatg acttttcatc tttttatgtg tgtttcctgt agtttgatcc
      901 gaaggaaaag agtatagtag cctgagaatc aggagatggg agttttagtc gtaggcctta
      961 tgataattac cccgcggtgg tgtgtagaaa agtatgtaaa tttgctctgt tttaagactt
     1021 tgaactacct caagaagagg aatctaatac aatatttgta atgtttccag agctctcaga
     1081 atgaggattt ttttgtaaat aggtcagaag acgatggaac tgtcctgggt tagtatagta
     1141 atcttacagt aggatcctta ggttgatgct gacttctgtt tggggtatgt ttatatttta
     1201 tgtggtgttt actttttttt tttgacatag aaggatatag tgggagcagt gatacgctaa
     1261 cattcattac attctgcagt aatgaatctg tttaatgggt cagtcactgt tttcagtagc
     1321 atgacagtgg ggtcataggt gagctgtgag gggctaaatc ttgctctgat tgtctctttc
     1381 tgttttgagt tttgtttgcg tgtatcattt ttgttctaca ttttgggagg ggaaacattt
     1441 tccgttaagg aaggttgttg ccagtggatt tgactccaag ggactagagt gtcgtggtgg
     1501 gggtggggag gggctgcagg gtgatcattg gctactgagc ctccacagag agcatgtggt
     1561 gccctgcctt tgggagggta ttttgctctc gttagttttg tgggcagcct cagattccct
     1621 gttgagttgc tgttaagaaa tggagatttc tggctctcat tgggtaaggt tttctgagtt
     1681 ttatatctta ttagatcaca tccctttacc cagaacaaat gcttcactgt cttctgattg
     1741 gcagtactcc tgtggctttg tgccttgact cattttgttg tcttcagcct tgaaggcccc
     1801 ttcccacatg gactgacatc cactcatgtg cctgatccct gaagcctccc agcacccatt
     1861 cagttgcatc cccagggcac aggactttga tctcttctgt tgccctcgct aggttctccc
     1921 tggtgggtta gtgctttgta tctgtctctc tgcccctcac taattctaca cccatgagaa
     1981 ttagacatta ttctccttaa atatataagg accatataat ctgtatcttt ttggtgtgtg
     2041 tatatggtat ctggcacatg gatctctgat taccagcctg acatcaacaa atcccctcag
     2101 ttacaacgta taggttaaac aaagctttta aaagctcatg tggtatgacc tcaaggttgc
     2161 taacctggtc actcatggta attagaaact ctgattggca gctttgtatt tcttgactaa
     2221 aaacctaaat aaactgatta ggttttaggc gttctttcaa agaggttctt gagaagattg
     2281 agaactatcc tatttggtgc ttagtgaaaa gattttgaat tactgtacgt accagttgtt
     2341 gccatttctt tattaaattc agaagttttt ttgccaaata acaatttttc aatcttctct
     2401 gtttgtagac atcttactgg gtgatgaata atcctctaag aaaccctctg agctgctaac
     2461 tttttcaggg agaaaatcac aagccatctt ctcaagttcc cctagaaacc tgtggaatgc
     2521 cctctgccaa gcactgctct ggtactgggg agtggagtat tatgtcttgg aagagactcc
     2581 tgctgtgatt gtccaggggt acgttctggt ctggcttggt gcttgacctt aggtctgccc
     2641 acaggcttca ggctttcaac tttgaaacaa acatctgtgc cacacacatt ttgtaaatga
     2701 tcccattcag tcttctagaa gccttataac agaatcaata ttgtttttcc cattttcaca
     2761 gatggataat aaatctgtaa aatagggata agactaggac ctattcccca ggattacttc
     2821 tgcagattaa aggagatgtt gaggccaggt gcagtggctc acgcctgtaa tcccagcact
     2881 ttggggggct gaggcaggag aatcgcttga acctgggagg cagaggttgt gatgagccaa
     2941 gatcgtgcca ttgcactcca tcctgggcta caagagtgaa actccgtctc aaaaaagaaa
     3001 aaggagatgt tgaatgggaa gtcagcaagg gtgctagaat gtagcaagta ttcttcaggt
     3061 gttagtgatt tctgttgttc gggaagagga gggttatgga ggaagagtat gggatttagg
     3121 tgggttaagt gatttgccca aagtcaagag gttagtcttt aacctttggc agaagcagga
     3181 tttgaagtga gttttcacac ccctcttccc tggtcagtgt gttgataaca gcccacccac
     3241 ctgtggttcc agggtgttct taagaagcca aggttgtctt gggtgtggta gctctttgaa
     3301 aggtagaaag ttccaccaag aaggcctttt ttcttgaata ctgcttagct tccttgtcag
     3361 gctccaagat gcagattgcc tgtgggctat ctctctccac agataaacct actcacatct
     3421 tcaggacagc cttttttttt tgagacagga gtcttgctct gttgcccagg ctgtagtgca
     3481 gtggcacaac ggggtcccac aggcaagtgc tggggaaagg cccacccagc catcaggtag
     3541 cctgtgtgtt ctacaaacag cagctggcag cactgtctcc tgccggacat tcctgccacc
     3601 cgacatcaaa gctggtgggt gaccttttca gccatttgac attcctccca gaagaacctc
     3661 tgcctcccag aggtttaagc agttctcctg cctcagcctc ccaagtagct gggctatttt
     3721 tttttttttt tttttgagat ggagtcttgc tctgtcgccc ggttagagtg cagtggtgca
     3781 atctcggctc actgcaacct ctgcctcccg ggttcaagta attttcctac gtcagcctcc
     3841 cgagtagctg tcaggtgcac accactacac ccagataatt ttgtattttt agtagagatg
     3901 gggtttcacc atgttggtca ggatggtctc aatctgacct cgtgatccgc ctgcctctgc
     3961 ctcccaaagg gctgggatta caggcatgag ccaccgcgcc cagccttaat ttttgtattt
     4021 ttaatggaga tggggttttg ccatgttggc caggctggtc ttgaactcct gacctcaagt
     4081 gatctgtccg cctcagcctc ccaaagtact gagattacag gcatgagcca ccgtgcccag
     4141 cccatcttca tcttctttac ttgaacttaa ttctttttca tgcatcttcc cttctttcct
     4201 cttttctcct ccacccaaat gtcttaactg ttaacattcc caggtgtttg gtcctgggcc
     4261 tctggaggtt gtgaaggagc actgctcagt cctcccttca agaaagcagc ttcaaggagt
     4321 tcaattacaa aagctcctgg cattggggac ctgccgccat gttcctgccc agggcatgct
     4381 ggtcctggct gtcaccaagc acagtggagg tcaggtgcta ggccatttct gcccgacaca
     4441 ggcctcctct aatgagcagt ctgaggccag gcacaggagg ctgaggcagg agaatcgctt
     4501 gaacccagga ggtggacgtt gcagtgagcc gagatcgagc cactgcactc cagcctgggt
     4561 gacagagtaa gacttcgtct caaaaaataa aaaataaaaa aatactgagc agtctgcttg
     4621 ggcgcttcca tcagcctggc catgacatct ttggagctgt cctgccctct tttgccccgg
     4681 tgttccttgg cccacctgtc agacctacat cataggctct tcctgtcttc tgtttcctct
     4741 cccctttctc taacataggt gtttctcctg agaaagaaaa aaaccacctg tccctgacat
     4801 tcagaagctg acaacactgt tcggtcatgc cattctcctg ttggacataa acagtctctg
     4861 aatgccaacc ccaaagttgc tctcaggcca tgataaaata aaccacttaa taattttgtc
     4921 taagcacgta caaagaaaat tcaaggtcag tttaccactc acaaaatacc aaacatcctt
     4981 ctgctggtta aaacgagtga cagctgccgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt
     5041 gtgtatgtgt atatgcgtat atatgtgtat gtatgtgtgt atatatatat gtgtgtgtgt
     5101 atatatatat atgcaattat acctttatcc ctactctagt ccaccttcct ataaataaga
     5161 tgtattgaga tgctcagtgc ccccattctg acagcatcca atcgagtgaa tcctcacttc
     5221 cttgaaatca cccaaccagg gccagaatcc taaaagaggt tctttgtgac accctctgtc
     5281 tgagaagtcc tatggttctc tgtgatgaat agacccaact tgttcaaata caggcatttc
     5341 tggtgggctt tggctgaagg cattcacacc ccccagtgaa tgtcttgcac ttctaattgt
     5401 gtctcggggc atgcctggtg gaggacctga ctgagacaat tgtgactgga tgtggtctga
     5461 gagcaggcag taggatgagg cttggggact ggctcactca ctgcccaact ggtagcaaaa
     5521 cccatctgga gcagcgtgtg aggtatggac actcactcac acgagggggt ggcccagttg
     5581 ctgaggattc caccagtggt accctgggaa aatatccctg tggaggggaa tgggaggagt
     5641 caaactgtgg aagataagag gagtactgca cacaaggaca gtagagtgtc tgttccctgc
     5701 agagggatag tgaggaactg atgaggtgac tgtgagtgcc cggggcctct gtcgttatct
     5761 tggaggatca ctttgaggtc aggagttcat gaccagcctg gccaacatgg tgaaaccctg
     5821 tctctactaa aaatacatta attagcatgg tggcgggtgc ctgtagtccc agctactcgg
     5881 gaggctgagg caggagaatc gcttgaaccc gggaggccga ggttgcagtg agctgagatg
     5941 gcgccactgc accccagctt gggtgacaga gcaagactcc gtctcaaaaa caaacacaca
     6001 gtactgcatc ctgggggtgg aggtgaggtg acggtagaga tcagtgctac ccttggaaat
     6061 ctgacagata cagtaagatg gtccctatca tagttccatt taatttgcca gcctcatctg
     6121 cagaatccag atggatcctg gagaaaaatt aaccaagtag cctcaatcac aaatgttggg
     6181 ttggatatta catcagtgtt agagcagtta agggctcagg tatgtggtgt gcagccattg
     6241 actgggtgaa tccattttta cctaccccaa ttacaaaaca gtttgctttc atgtggaaca
     6301 gatagtattc ctttcagttt tgctgcagga acatattaac tcttccaccc ctgtcataat
     6361 acagcctgaa gagatttacc attaaatact gtttttttct ctctcttaac ttaatcccga
     6421 attggataat ttctcttcat cttcactgtc acctctacgc catcactgtc atctctagac
     6481 cgctctgctg ttgagagatt gatggaatca ttatgcaaac taaaatagaa tgttttatct
     6541 atcaaattgt atttctttgt caatagtgtt agggcacagt aggttcattt actgctggta
     6601 agggtgtaaa ttgttagaaa ctttctgaat ggcagtttgg taataacaaa caaaaagctt
     6661 aagtttgtgt ccttaaatgc cttacttcaa tacccaaggc atatggcctc aataaaaaat
     6721 tatggaagca tgcaaagatt ttgttaacaa agatataatc attgcagggt agaatttaga
     6781 aatttaagac tgaaagatct tttcagtcac ctgcagcaag aaaggagtca aaacctatgt
     6841 acgatctcaa ctagtaaaat tttctccttg cccagggatc atgctgagtt taaggacaga
     6901 aatgcaaagt gcagcctggg aaagtgtttc aacacacaaa aatagaacca cctgtatgta
     6961 gtctttttga aagcacaaaa taaagagcag tcctacaggg ttcactgcta tgtcctgaat
     7021 gttgatgtcc cttccaaaat tcatatgttg gaacctaatg tcaatgtaat agtattaaga
     7081 ggtggggctt ttgggaagca atggagtcat gagggcttca ccctcatgag taggataagt
     7141 acccttacaa aagaggctca gggaggcgct cttgcctctt ccaccatgta aggacacgta
     7201 gcaggcaccc atttctgaag aatgggccct ccccagactc catatctgct ggtgccttga
     7261 tcttggactt agcctctagg actgtgagtg acatatttct attgtttata aattatccag
     7321 tataagtaag atattttgtt agagcagcct gaacgaacta agacactcta agcgggaaac
     7381 tcacaaaaaa tatttggtag tgaaaaacag tatggtgtgt taatgtatgg tgacaagtgt
     7441 ttgtttgcat ttaaaaatgc attggagcct cgttttgatt aggcagtaaa tttaccttta
     7501 atacgtaagt ttgacagtta tatgtaatca gctttttttt ttttaagatg gtgtgattga
     7561 ggttaatgtg aactgaactt tctatttcta agctgtcttc atctaatttt acctttctgt
     7621 ggaaaatcaa tacaagtcaa ccatttttat tgcccagtta ttcaaagttt tattcaaaga
     7681 gcaaagattt gacaatgcat agaattaaca ttggtttgtg ggccaccttc tgggccagca
     7741 ccaaagactg aaaaaatatt ttgcccccta aaagttgtta ttgagtcttg tcaaatcaca
     7801 ttgctctgtc agaaggtaag acaaatcagt gtggactgag agcaaggtca gcaccgtgaa
     7861 cagccattgc ggttccttta acccactggg aattcatgca gtgaagaagc aacacaccat
     7921 gaggcaaatg gctcaaaccc aaagaccaga ggttcagggg atatatatat atattttttt
     7981 aatctgtaga gatgggatct cactatcttg cccaggctgg tctcgaactc ttgggctcat
     8041 gctgtcctac ctcagacttc caagtagctg ggttttcttt gggctaatta tttttttgta
     8101 gagatggagg tctcgctgtg ttgcccaggc tggtctcaaa ttcctggcct caagctctcc
     8161 tcccatctca gcctcccaaa gtgttgggat tacaggcatg agccatgtgc ccagtctaga
     8221 agatctttga cttcaaagaa cagataatct agagaccttc acaagtgatc atgttggcac
     8281 tatggtcatt acactgagac ctataactgg gctaggattg gttatttaca gaaaaacctt
     8341 gtggtactta attccaattc atgttaattt atgttatctt gcttaatcct tgcaaagccc
     8401 ttttagaggt gggtgttatc ccatctataa tctgctgctt gtcttagacc aaggaagtga
     8461 aagtattcag tccaagcatg ctaccatcca tttctggtag gtttggtttg tttttagttg
     8521 gctttcctgt ttaactgtta tttgtcttcc tattgaggtt agatgtgcat tttggaattg
     8581 catcatttta catagaaaca gctttccagt ggagttgact agcatcctaa ggacaagtac
     8641 aaccactttt gaaatagatc atggaaatca caaagtctga tgttccacaa aatggagtat
     8701 gatgttatgg acactagaaa tacaaggtat gggtcattag taacgctaat aacattttcc
     8761 tatagatgac ttttaataac actggtttaa tgtcaatttt tttttttttt tttttttttt
     8821 tttttttttt tttttttttt ggagacaggg tctccctctg tcacccaggc tggttggaat
     8881 gcaggagttc gaacttggct cactgcaacc tctgcctcct aggttcaagt gatcctcccg
     8941 cctcagtccc ccaagtacct gggaccacag gcacacgcca ccatgcctgg ctaatttttg
     9001 tatattttgt agagatgggg tttcaccata ttggccaggc tggtctcaaa ttcctggact
     9061 caagcagtcc atctgcctca gcctcccaaa gtgatgggat tacaggcgtg agctgctgtg
     9121 cctggcagaa cagtatgaag tgttaacgcc aaaatttgtt ttagctatca tatataaatc
     9181 ataagcatat tatttggttg gttggtgtta gttcattcct tcaatcggat gatttaaaat
     9241 aaatgttttt caagtatcct ctgtgatgta tcccaaaggt tagcttagaa agaaaagtac
     9301 ttggtgaacc attcctggtg cggagagccc tgtttctgct ggacttcttt ggcttgggcc
     9361 gtttcaccat ctggggtcct aaaagcaaaa aaaggttttt ttatatggtt ttgaaaacta
     9421 tgcaagaagc agcttaatac ccaccatctt ttcagggaaa gataactgct tgtttactct
     9481 tcaaaaacac ccaaatggga ctggccaaca ttagtagtgg gaaacaaatt gtaaaggatg
     9541 gggctgggga gggagtacct aatcctcatt tggaaaacag aaggttcacc attgtttggt
     9601 tctccattgt tcctttgaga cttagtggtt gtagctctaa taatgcagga ttaaccaaac
     9661 ctacagatca agagactttg tttttatttt ttgtgacaga gtctccctct gtcacccagg
     9721 ctggagtgca gtggcatgat ctcggctcac tgcaacctcc agcctcctgc gttcaagcga
     9781 tcattgtgcc tcagcctccc ggggagctgg aattacaggc gcataccacc acacctggct
     9841 aatttttgta ttttttgtag agatgggttt caccatgttg cccaggctgg tctcgaactc
     9901 ctgaccttag gtgatccacc cacctccatc tcccaaagtg ctgggattac aggcgtgagc
     9961 caccaagccc ggcccgatta agagacttta gaattccaag gtgatagagt aaatcttgag
    10021 gaataatgtt agtaataata ctgaaactat attgaagatt tttgtgccaa gtcctgtgct
    10081 aagcacatcc tatggattaa ttcctttagt ctcacgtcag tctgatgaga taggtgctgt
    10141 attatcttaa ttttaaaggc aaggtatatg gagacctgga gaggtcaagt gacctgtcca
    10201 aggccacaga gctaagaatg aggaagactg taatttgaat tcagacctcc aggccagatg
    10261 gagtccacct tttgtataac ccatgctgaa gttttcaggt aagtgattca gtgtcccttg
    10321 tctaatcatc catgaaaaaa ggccttctgg aatttggtac caggtgctag aaagaatcct
    10381 acttcccctc ttatctacag ggaaatagaa taagggcccc tgtccccaac atcccccaaa
    10441 ccttgtggca gtttttgcat ctgtagactg gttgggtttg taggtccggc cacagctggg
    10501 gcttgggtcc aagctgggtg atgtagttat tggaggggca ttaatcctgg aactcagatc
    10561 gccactcaga aagttctttg cataggaggc gaggttcggc acgctgacca cgcggctggg
    10621 cacgtcctcc accttctttt tctgtttgta ttaatggaca ggttagtgca atgcaatgca
    10681 aaaaacaaaa taaagcatta ttgtaaaagc aaataatgct cacccaatca aaattgtatc
    10741 ggagaagaag caacaatttc atttatacac ttacatgcta ttttttaaag cacttttccc
    10801 tccaatcttc attttgtatt ataaataaat atgtatgttc acaacctctt aaccaaaa
//
