LOCUS       NM_014815               3480 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens mediator complex subunit 24 (MED24), transcript
            variant 1, mRNA.
ACCESSION   NM_014815
VERSION     NM_014815.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3480)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 3480)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 3480)
  AUTHORS   Zavbi,M., Korosec,P., Flezar,M., Skrgat Kristan,S., Marc Malovrh,M.
            and Rijavec,M.
  TITLE     Polymorphisms and haplotypes of the chromosome locus 17q12-17q21.1
            contribute to adult asthma susceptibility in Slovenian patients
  JOURNAL   Hum Immunol 77 (6), 527-534 (2016)
   PUBMED   27163155
  REMARK    GeneRIF: this study shows that haplotypes consisting of single
            nucleotide polymorphisms harboring PSMD3, CSF3 and MED24 genes are
            associated with asthma in Slovenian patients
REFERENCE   4  (bases 1 to 3480)
  AUTHORS   Basel-Vanagaite,L., Smirin-Yosef,P., Essakow,J.L., Tzur,S.,
            Lagovsky,I., Maya,I., Pasmanik-Chor,M., Yeheskel,A., Konen,O.,
            Orenstein,N., Weisz Hubshman,M., Drasinover,V., Magal,N., Peretz
            Amit,G., Zalzstein,Y., Zeharia,A., Shohat,M., Straussberg,R.,
            Monte,D., Salmon-Divon,M. and Behar,D.M.
  TITLE     Homozygous MED25 mutation implicated in eye-intellectual disability
            syndrome
  JOURNAL   Hum Genet 134 (6), 577-587 (2015)
   PUBMED   25792360
REFERENCE   5  (bases 1 to 3480)
  AUTHORS   Sato,S., Tomomori-Sato,C., Parmely,T.J., Florens,L., Zybailov,B.,
            Swanson,S.K., Banks,C.A., Jin,J., Cai,Y., Washburn,M.P.,
            Conaway,J.W. and Conaway,R.C.
  TITLE     A set of consensus mammalian mediator subunits identified by
            multidimensional protein identification technology
  JOURNAL   Mol Cell 14 (5), 685-691 (2004)
   PUBMED   15175163
REFERENCE   6  (bases 1 to 3480)
  AUTHORS   Ito,M., Yuan,C.X., Malik,S., Gu,W., Fondell,J.D., Yamamura,S.,
            Fu,Z.Y., Zhang,X., Qin,J. and Roeder,R.G.
  TITLE     Identity between TRAP and SMCC complexes indicates novel pathways
            for the function of nuclear receptors and diverse mammalian
            activators
  JOURNAL   Mol Cell 3 (3), 361-370 (1999)
   PUBMED   10198638
REFERENCE   7  (bases 1 to 3480)
  AUTHORS   Gu,W., Malik,S., Ito,M., Yuan,C.X., Fondell,J.D., Zhang,X.,
            Martinez,E., Qin,J. and Roeder,R.G.
  TITLE     A novel human SRB/MED-containing cofactor complex, SMCC, involved
            in transcription regulation
  JOURNAL   Mol Cell 3 (1), 97-108 (1999)
   PUBMED   10024883
  REMARK    Erratum:[Mol Cell 1999 Apr;3(4):following 541]
REFERENCE   8  (bases 1 to 3480)
  AUTHORS   Yuan,C.X., Ito,M., Fondell,J.D., Fu,Z.Y. and Roeder,R.G.
  TITLE     The TRAP220 component of a thyroid hormone receptor- associated
            protein (TRAP) coactivator complex interacts directly with nuclear
            receptors in a ligand-dependent fashion
  JOURNAL   Proc Natl Acad Sci U S A 95 (14), 7939-7944 (1998)
   PUBMED   9653119
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1998 Nov 24;95(24):14584]
REFERENCE   9  (bases 1 to 3480)
  AUTHORS   Rachez,C., Suldan,Z., Ward,J., Chang,C.P., Burakov,D.,
            Erdjument-Bromage,H., Tempst,P. and Freedman,L.P.
  TITLE     A novel protein complex that interacts with the vitamin D3 receptor
            in a ligand-dependent manner and enhances VDR transactivation in a
            cell-free system
  JOURNAL   Genes Dev 12 (12), 1787-1800 (1998)
   PUBMED   9637681
REFERENCE   10 (bases 1 to 3480)
  AUTHORS   Fondell,J.D., Ge,H. and Roeder,R.G.
  TITLE     Ligand induction of a transcriptionally active thyroid hormone
            receptor coactivator complex
  JOURNAL   Proc Natl Acad Sci U S A 93 (16), 8329-8333 (1996)
   PUBMED   8710870
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB144359.1, D50920.1,
            AF277379.1 and BC011375.1.
            
            On Nov 22, 2018 this sequence version replaced NM_014815.3.
            
            Summary: This gene encodes a component of the mediator complex
            (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional
            coactivator complex thought to be required for the expression of
            almost all genes. The mediator complex is recruited by
            transcriptional activators or nuclear receptors to induce gene
            expression, possibly by interacting with RNA polymerase II and
            promoting the formation of a transcriptional pre-initiation
            complex. Multiple transcript variants encoding different isoforms
            have been found for this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: Transcript Variant: This variant (1) represents
            the longest transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D50920.1, SRR11853562.14859.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000394128.7/ ENSP00000377686.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                DB144359.1         231-242
            13-142              D50920.1           1-130
            143-1748            AF277379.1         58-1663
            1749-3406           D50920.1           1737-3394
            3407-3480           BC011375.1         3597-3670
FEATURES             Location/Qualifiers
     source          1..3480
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.1"
     gene            1..3480
                     /gene="MED24"
                     /gene_synonym="ARC100; CRSP100; CRSP4; DRIP100; MED5;
                     THRAP4; TRAP100"
                     /note="mediator complex subunit 24"
                     /db_xref="GeneID:9862"
                     /db_xref="HGNC:HGNC:22963"
                     /db_xref="MIM:607000"
     exon            1..48
                     /gene="MED24"
                     /gene_synonym="ARC100; CRSP100; CRSP4; DRIP100; MED5;
                     THRAP4; TRAP100"
                     /inference="alignment:Splign:2.1.0"
     exon            49..215
                     /gene="MED24"
                     /gene_synonym="ARC100; CRSP100; CRSP4; DRIP100; MED5;
                     THRAP4; TRAP100"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..3055
                     /gene="MED24"
                     /gene_synonym="ARC100; CRSP100; CRSP4; DRIP100; MED5;
                     THRAP4; TRAP100"
                     /note="isoform 1 is encoded by transcript variant 1;
                     cofactor required for Sp1 transcriptional activation,
                     subunit 4, 100kDa; thyroid hormone receptor-associated
                     protein complex 100 kDa component; vitamin D3
                     receptor-interacting protein complex component DRIP100;
                     activator-recruited cofactor 100 kDa component; mediator
                     of RNA polymerase II transcription, subunit 24 homolog;
                     mediator of RNA polymerase II transcription subunit 24;
                     CRSP complex subunit 4; thyroid hormone
                     receptor-associated protein 4; cofactor required for Sp1
                     transcriptional activation subunit 4; vitamin D3
                     receptor-interacting protein complex 100 kDa component"
                     /codon_start=1
                     /product="mediator of RNA polymerase II transcription
                     subunit 24 isoform 1"
                     /protein_id="NP_055630.2"
                     /db_xref="CCDS:CCDS11359.1"
                     /db_xref="GeneID:9862"
                     /db_xref="HGNC:HGNC:22963"
                     /db_xref="MIM:607000"
                     /translation="MKVVNLKQAILQAWKERWSDYQWAINMKKFFPKGATWDILNLAD
                     ALLEQAMIGPSPNPLILSYLKYAISSQMVSYSSVLTAISKFDDFSRDLCVQALLDIMD
                     MFCDRLSCHGKAEECIGLCRALLSALHWLLRCTAASAERLREGLEAGTPAAGEKQLAM
                     CLQRLEKTLSSTKNRALLHIAKLEEASSWTAIEHSLLKLGEILANLSNPQLRSQAEQC
                     GTLIRSIPTMLSVHAEQMHKTGFPTVHAVILLEGTMNLTGETQSLVEQLTMVKRMQHI
                     PTPLFVLEIWKACFVGLIESPEGTEELKWTAFTFLKIPQVLVKLKKYSHGDKDFTEDV
                     NCAFEFLLKLTPLLDKADQRCNCDCTNFLLQECGKQGLLSEASVNNLMAKRKADREHA
                     PQQKSGENANIQPNIQLILRAEPTVTNILKTMDADHSKSPEGLLGVLGHMLSGKSLDL
                     LLAAAAATGKLKSFARKFINLNEFTTYGSEESTKPASVRALLFDISFLMLCHVAQTYG
                     SEVILSESRTGAEVPFFETWMQTCMPEEGKILNPDHPCFRPDSTKVESLVALLNNSSE
                     MKLVQMKWHEACLSISAAILEILNAWENGVLAFESIQKITDNIKGKVCSLAVCAVAWL
                     VAHVRMLGLDEREKSLQMIRQLAGPLFSENTLQFYNERVVIMNSILERMCADVLQQTA
                     TQIKFPSTGVDTMPYWNLLPPKRPIKEVLTDIFAKVLEKGWVDSRSIHIFDTLLHMGG
                     VYWFCNNLIKELLKETRKEHTLRAVELLYSIFCLDMQQVTLVLLGHILPGLLTDSSKW
                     HSLMDPPGTALAKLAVWCALSSYSSHKGQASTRQKKRHREDIEDYISLFPLDDVQPSK
                     LMRLLSSNEDDANILSSPTDRSMSSSLSASQLHTVNMRDPLNRVLANLFLLISSILGS
                     RTAGPHTQFVQWFMEECVDCLEQGGRGSVLQFMPFTTVSELVKVSAMSSPKVVLAITD
                     LSLPLGRQVAAKAIAAL"
     exon            216..298
                     /gene="MED24"
                     /gene_synonym="ARC100; CRSP100; CRSP4; DRIP100; MED5;
                     THRAP4; TRAP100"
                     /inference="alignment:Splign:2.1.0"
     exon            299..337
                     /gene="MED24"
                     /gene_synonym="ARC100; CRSP100; CRSP4; DRIP100; MED5;
                     THRAP4; TRAP100"
                     /inference="alignment:Splign:2.1.0"
     exon            338..411
                     /gene="MED24"
                     /gene_synonym="ARC100; CRSP100; CRSP4; DRIP100; MED5;
                     THRAP4; TRAP100"
                     /inference="alignment:Splign:2.1.0"
     exon            412..644
                     /gene="MED24"
                     /gene_synonym="ARC100; CRSP100; CRSP4; DRIP100; MED5;
                     THRAP4; TRAP100"
                     /inference="alignment:Splign:2.1.0"
     exon            645..756
                     /gene="MED24"
                     /gene_synonym="ARC100; CRSP100; CRSP4; DRIP100; MED5;
                     THRAP4; TRAP100"
                     /inference="alignment:Splign:2.1.0"
     exon            757..907
                     /gene="MED24"
                     /gene_synonym="ARC100; CRSP100; CRSP4; DRIP100; MED5;
                     THRAP4; TRAP100"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1021
                     /gene="MED24"
                     /gene_synonym="ARC100; CRSP100; CRSP4; DRIP100; MED5;
                     THRAP4; TRAP100"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1069
                     /gene="MED24"
                     /gene_synonym="ARC100; CRSP100; CRSP4; DRIP100; MED5;
                     THRAP4; TRAP100"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1152
                     /gene="MED24"
                     /gene_synonym="ARC100; CRSP100; CRSP4; DRIP100; MED5;
                     THRAP4; TRAP100"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1239
                     /gene="MED24"
                     /gene_synonym="ARC100; CRSP100; CRSP4; DRIP100; MED5;
                     THRAP4; TRAP100"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..1351
                     /gene="MED24"
                     /gene_synonym="ARC100; CRSP100; CRSP4; DRIP100; MED5;
                     THRAP4; TRAP100"
                     /inference="alignment:Splign:2.1.0"
     exon            1352..1494
                     /gene="MED24"
                     /gene_synonym="ARC100; CRSP100; CRSP4; DRIP100; MED5;
                     THRAP4; TRAP100"
                     /inference="alignment:Splign:2.1.0"
     exon            1495..1532
                     /gene="MED24"
                     /gene_synonym="ARC100; CRSP100; CRSP4; DRIP100; MED5;
                     THRAP4; TRAP100"
                     /inference="alignment:Splign:2.1.0"
     exon            1533..1615
                     /gene="MED24"
                     /gene_synonym="ARC100; CRSP100; CRSP4; DRIP100; MED5;
                     THRAP4; TRAP100"
                     /inference="alignment:Splign:2.1.0"
     exon            1616..1794
                     /gene="MED24"
                     /gene_synonym="ARC100; CRSP100; CRSP4; DRIP100; MED5;
                     THRAP4; TRAP100"
                     /inference="alignment:Splign:2.1.0"
     exon            1795..1894
                     /gene="MED24"
                     /gene_synonym="ARC100; CRSP100; CRSP4; DRIP100; MED5;
                     THRAP4; TRAP100"
                     /inference="alignment:Splign:2.1.0"
     exon            1895..2070
                     /gene="MED24"
                     /gene_synonym="ARC100; CRSP100; CRSP4; DRIP100; MED5;
                     THRAP4; TRAP100"
                     /inference="alignment:Splign:2.1.0"
     exon            2071..2335
                     /gene="MED24"
                     /gene_synonym="ARC100; CRSP100; CRSP4; DRIP100; MED5;
                     THRAP4; TRAP100"
                     /inference="alignment:Splign:2.1.0"
     exon            2336..2517
                     /gene="MED24"
                     /gene_synonym="ARC100; CRSP100; CRSP4; DRIP100; MED5;
                     THRAP4; TRAP100"
                     /inference="alignment:Splign:2.1.0"
     exon            2518..2608
                     /gene="MED24"
                     /gene_synonym="ARC100; CRSP100; CRSP4; DRIP100; MED5;
                     THRAP4; TRAP100"
                     /inference="alignment:Splign:2.1.0"
     exon            2609..2708
                     /gene="MED24"
                     /gene_synonym="ARC100; CRSP100; CRSP4; DRIP100; MED5;
                     THRAP4; TRAP100"
                     /inference="alignment:Splign:2.1.0"
     exon            2709..2789
                     /gene="MED24"
                     /gene_synonym="ARC100; CRSP100; CRSP4; DRIP100; MED5;
                     THRAP4; TRAP100"
                     /inference="alignment:Splign:2.1.0"
     exon            2790..2938
                     /gene="MED24"
                     /gene_synonym="ARC100; CRSP100; CRSP4; DRIP100; MED5;
                     THRAP4; TRAP100"
                     /inference="alignment:Splign:2.1.0"
     exon            2939..3480
                     /gene="MED24"
                     /gene_synonym="ARC100; CRSP100; CRSP4; DRIP100; MED5;
                     THRAP4; TRAP100"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3459..3464
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MED24"
                     /gene_synonym="ARC100; CRSP100; CRSP4; DRIP100; MED5;
                     THRAP4; TRAP100"
                     /note="hexamer: AATAAA"
     polyA_site      3480
                     /gene="MED24"
                     /gene_synonym="ARC100; CRSP100; CRSP4; DRIP100; MED5;
                     THRAP4; TRAP100"
                     /note="major polyA site"
ORIGIN      
        1 gacaagtgcc aaaatggcga tgcctaccac ctagaactgg attgtgcgct ggccgccacc
       61 gctgccacct gctcagagtg aaataatgaa ggtggtcaac ctgaagcaag ccattttgca
      121 agcctggaag gagcgctgga gtgactacca atgggcaatc aacatgaaga aattctttcc
      181 taaaggagcc acctgggata ttctcaacct ggcagatgcg ttactagagc aggccatgat
      241 tggaccatcc cccaatcctc tcatcttgtc ctacctgaag tatgccatta gttcccagat
      301 ggtgtcctac tcttctgtcc tcacagccat cagtaagttt gatgactttt ctcgggacct
      361 gtgtgtccag gcattgctgg acatcatgga catgttttgt gaccgtctga gctgtcacgg
      421 caaagcagag gaatgcatcg gactgtgccg agcccttctt agcgccctcc actggctgct
      481 gcgctgcacg gcagcctctg cagagcggct gcgggagggg ctggaggccg gcactccagc
      541 cgctggggag aagcagcttg ccatgtgcct tcagcgcctg gagaaaaccc tcagcagcac
      601 caagaaccgg gccctgctgc acatcgccaa actagaggag gcctcttctt ggactgccat
      661 cgagcattct ctcttgaaac ttggagagat cctggccaat ctcagcaacc cgcagctccg
      721 gagtcaggcc gagcagtgtg gcaccctcat taggagcatc cccacgatgc tgtctgtgca
      781 tgcggagcag atgcacaaga ccggcttccc cactgtccac gccgtgatcc tgctcgaggg
      841 caccatgaac ctgacaggcg agacgcagtc cctggtggag cagctgacga tggtgaagcg
      901 catgcagcat atccccaccc cactttttgt cctggagatc tggaaagctt gcttcgtggg
      961 gctcattgag tctcccgagg gtacggagga gctcaagtgg acagctttca ctttcctcaa
     1021 gattccacag gttttggtga agttgaagaa gtactctcat ggagacaagg acttcactga
     1081 ggatgtcaac tgtgcttttg agttcctgct gaagctcacc cccttgttgg acaaagctga
     1141 ccagcgctgc aactgtgact gtacaaactt cctgctccaa gaatgtggca agcaggggct
     1201 tctgtctgag gccagcgtca acaaccttat ggctaagcgc aaagcggacc gagagcacgc
     1261 accccagcag aaatcgggag agaatgccaa catccagccc aacatccagc tgatcctccg
     1321 ggcggagccc actgtcacaa acatcctcaa gacgatggat gcagaccact ctaagtcacc
     1381 ggagggactg ctgggagtcc tgggccacat gctgtccggg aagagtctgg acttgctgct
     1441 ggctgccgcc gccgccactg gaaagctgaa atccttcgcc cggaaattca tcaatttgaa
     1501 tgaattcaca acctatggca gcgaagaaag caccaaaccg gcctccgtcc gggccctgct
     1561 gtttgacatc tccttcctca tgctgtgcca tgtggcccag acctatggtt cagaggtgat
     1621 tctgtccgag tcgcgcacag gagctgaggt gcccttcttc gagacctgga tgcagacctg
     1681 catgcctgag gagggcaaga tcctgaaccc tgaccacccc tgcttccgcc ccgactccac
     1741 caaagtggag tccctggtgg ccctgctcaa caactcctcg gagatgaagc tagtgcagat
     1801 gaagtggcat gaggcctgtc tcagcatctc agccgccatc ttggaaatcc tcaatgcctg
     1861 ggagaatggg gtcctggcct tcgagtccat ccagaaaatc actgataaca tcaaagggaa
     1921 ggtatgcagt ctggcggtgt gtgctgtggc ttggcttgtg gcccacgtcc ggatgctggg
     1981 gctggatgag cgtgagaagt cgctgcagat gatccgccag ctggcagggc cactgtttag
     2041 tgagaacacc ctgcagttct acaatgagag ggtggtgatc atgaactcga tcctggagcg
     2101 catgtgtgcc gacgtgctgc agcagacagc cacgcagatc aagtttccct ccaccggggt
     2161 ggacacaatg ccctactgga acctgctgcc ccccaagcgg cccatcaaag aggtgctgac
     2221 ggacattttt gccaaggtgc tggagaaggg ctgggtggac agccgctcca tccacatctt
     2281 tgacaccctg ctgcacatgg gcggcgtcta ctggttctgc aacaacctga ttaaggagct
     2341 gctgaaggag acgcggaagg agcacacgct gcgggcagtg gagctgctct actccatctt
     2401 ctgcctggac atgcagcaag tgaccctggt cctgctgggc cacatcctac ctggcctgct
     2461 cactgactcc tccaagtggc acagcctcat ggaccccccg ggcactgctc ttgccaagct
     2521 ggccgtgtgg tgtgccctca gttcctactc ctcccacaag ggacaggcgt ccacccgcca
     2581 gaagaagaga caccgcgaag acattgagga ttatatcagc ctcttccccc tggacgatgt
     2641 gcagccttcg aagttgatgc gactgctgag ctctaatgag gacgatgcca acatcctttc
     2701 gagccccaca gaccgatcca tgagcagctc cctctcagcc tctcagctcc acacggtcaa
     2761 catgcgggac cctctgaacc gagtcctggc caacctgttc ctgctcatct cctccatcct
     2821 ggggtctcgc accgctggcc cccacaccca gttcgtgcag tggttcatgg aggagtgtgt
     2881 ggactgcctg gagcagggtg gccgtggcag cgtcctgcag ttcatgccct tcaccaccgt
     2941 gtcggaactg gtgaaggtgt cagccatgtc cagccccaag gtggttctgg ccatcacgga
     3001 cctcagcctg cccctgggcc gccaggtggc tgctaaagcc attgctgcac tctgaggggc
     3061 ttggcatggc cgcagtgggg gctggggact ggcgcagccc caggcgcctc caagggaagc
     3121 agtgaggaaa gatgaggcat cgtgcctcac atccgctcca catggtgcaa gagcctctag
     3181 cggcttccag ttccccgctc ctgactcctg acctccagga tgtctcccgg tttcttcttt
     3241 caaaatttcc tctccatctg ctggcacctg aggagagtga gcagcctgga ccacaagccc
     3301 agtggtcacc cctgtgtgcg cccgccccag cccaggagta gtcttacctc tgaggaactt
     3361 tctagatgca aagtgtgtat gtgtgtgtgt gtgtgtgtgt gtgtgtgttt gtgtgtattt
     3421 tgtaatatgt gagggaaatc taccttcgtt catgtataaa taaagctcct cgtggctccc
//
