LOCUS       NM_004268               5087 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens mediator complex subunit 17 (MED17), mRNA.
ACCESSION   NM_004268
VERSION     NM_004268.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5087)
  AUTHORS   Rafiullah,R., Albalawi,A.M., Alaradi,S.R., Alluqmani,M.,
            Mushtaq,M., Wali,A. and Basit,S.
  TITLE     An expansion of phenotype: novel homozygous variant in the MED17
            identified in patients with progressive microcephaly and global
            developmental delay
  JOURNAL   J Neurogenet 36 (4), 108-114 (2022)
   PUBMED   36508181
  REMARK    GeneRIF: An expansion of phenotype: novel homozygous variant in the
            MED17 identified in patients with progressive microcephaly and
            global developmental delay.
REFERENCE   2  (bases 1 to 5087)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 5087)
  AUTHORS   Terabayashi,T. and Hashimoto,S.
  TITLE     Increased unfolded protein responses caused by MED17 mutations
  JOURNAL   Neurogenetics 22 (4), 353-357 (2021)
   PUBMED   34392449
  REMARK    GeneRIF: Increased unfolded protein responses caused by MED17
            mutations.
            Erratum:[Neurogenetics. 2022 Jan;23(1):75-76. doi:
            10.1007/s10048-021-00669-y.. PMID: 34515861]
REFERENCE   4  (bases 1 to 5087)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 5087)
  AUTHORS   Fattal-Valevski,A., Ben Sira,L., Lerman-Sagie,T., Strausberg,R.,
            Bloch-Mimouni,A., Edvardson,S., Kaufman,R., Chernuha,V., Schneebaum
            Sender,N., Heimer,G. and Ben Zeev,B.
  TITLE     Delineation of the phenotype of MED17-related disease in
            Caucasus-Jewish families
  JOURNAL   Eur J Paediatr Neurol 32, 40-45 (2021)
   PUBMED   33756211
  REMARK    GeneRIF: Delineation of the phenotype of MED17-related disease in
            Caucasus-Jewish families.
REFERENCE   6  (bases 1 to 5087)
  AUTHORS   Naar,A.M., Beaurang,P.A., Zhou,S., Abraham,S., Solomon,W. and
            Tjian,R.
  TITLE     Composite co-activator ARC mediates chromatin-directed
            transcriptional activation
  JOURNAL   Nature 398 (6730), 828-832 (1999)
   PUBMED   10235267
REFERENCE   7  (bases 1 to 5087)
  AUTHORS   Rachez,C., Lemon,B.D., Suldan,Z., Bromleigh,V., Gamble,M.,
            Naar,A.M., Erdjument-Bromage,H., Tempst,P. and Freedman,L.P.
  TITLE     Ligand-dependent transcription activation by nuclear receptors
            requires the DRIP complex
  JOURNAL   Nature 398 (6730), 824-828 (1999)
   PUBMED   10235266
REFERENCE   8  (bases 1 to 5087)
  AUTHORS   Ito,M., Yuan,C.X., Malik,S., Gu,W., Fondell,J.D., Yamamura,S.,
            Fu,Z.Y., Zhang,X., Qin,J. and Roeder,R.G.
  TITLE     Identity between TRAP and SMCC complexes indicates novel pathways
            for the function of nuclear receptors and diverse mammalian
            activators
  JOURNAL   Mol Cell 3 (3), 361-370 (1999)
   PUBMED   10198638
REFERENCE   9  (bases 1 to 5087)
  AUTHORS   Ryu,S., Zhou,S., Ladurner,A.G. and Tjian,R.
  TITLE     The transcriptional cofactor complex CRSP is required for activity
            of the enhancer-binding protein Sp1
  JOURNAL   Nature 397 (6718), 446-450 (1999)
   PUBMED   9989412
REFERENCE   10 (bases 1 to 5087)
  AUTHORS   Fondell,J.D., Ge,H. and Roeder,R.G.
  TITLE     Ligand induction of a transcriptionally active thyroid hormone
            receptor coactivator complex
  JOURNAL   Proc Natl Acad Sci U S A 93 (16), 8329-8333 (1996)
   PUBMED   8710870
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA506467.1, AK001674.1 and
            AP001894.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_004268.4.
            
            Summary: The activation of gene transcription is a multistep
            process that is triggered by factors that recognize transcriptional
            enhancer sites in DNA. These factors work with co-activators to
            direct transcriptional initiation by the RNA polymerase II
            apparatus. The protein encoded by this gene is a subunit of the
            CRSP (cofactor required for SP1 activation) complex, which, along
            with TFIID, is required for efficient activation by SP1. This
            protein is also a component of other multisubunit complexes e.g.
            thyroid hormone receptor-(TR-) associated proteins which interact
            with TR and facilitate TR function on DNA templates in conjunction
            with initiation factors and cofactors. [provided by RefSeq, Jul
            2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK001674.1, SRR1803617.196289.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000251871.9/ ENSP00000251871.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-568               DA506467.1         1-568
            569-2931            AK001674.1         569-2931
            2932-3454           AP001894.4         29454-29976
            3455-5087           AP001894.4         29977-31609
FEATURES             Location/Qualifiers
     source          1..5087
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q21"
     gene            1..5087
                     /gene="MED17"
                     /gene_synonym="CRSP6; CRSP77; DRIP80; SRB4; TRAP80"
                     /note="mediator complex subunit 17"
                     /db_xref="GeneID:9440"
                     /db_xref="HGNC:HGNC:2375"
                     /db_xref="MIM:603810"
     exon            1..482
                     /gene="MED17"
                     /gene_synonym="CRSP6; CRSP77; DRIP80; SRB4; TRAP80"
                     /inference="alignment:Splign:2.1.0"
     CDS             233..2188
                     /gene="MED17"
                     /gene_synonym="CRSP6; CRSP77; DRIP80; SRB4; TRAP80"
                     /note="cofactor required for Sp1 transcriptional
                     activation, subunit 6, 77kDa; epididymis secretory sperm
                     binding protein; ARC77; CRSP complex subunit 6;
                     transcriptional coactivator CRSP77; activator-recruited
                     cofactor 77 kDa component; vitamin D3 receptor-interacting
                     protein complex 80 kDa component; thyroid hormone
                     receptor-associated protein complex 80 kDa component"
                     /codon_start=1
                     /product="mediator of RNA polymerase II transcription
                     subunit 17"
                     /protein_id="NP_004259.3"
                     /db_xref="CCDS:CCDS8295.1"
                     /db_xref="GeneID:9440"
                     /db_xref="HGNC:HGNC:2375"
                     /db_xref="MIM:603810"
                     /translation="MSGVRAVRISIESACEKQVHEVGLDGTETYLPPLSMSQNLARLA
                     QRIDFSQGSGSEEEEAAGTEGDAQEWPGAGSSADQDDEEGVVKFQPSLWPWDSVRNNL
                     RSALTEMCVLYDVLSIVRDKKFMTLDPVSQDALPPKQNPQTLQLISKKKSLAGAAQIL
                     LKGAERLTKSVTENQENKLQRDFNSELLRLRQHWKLRKVGDKILGDLSYRSAGSLFPH
                     HGTFEVIKNTDLDLDKKIPEDYCPLDVQIPSDLEGSAYIKVSIQKQAPDIGDLGTVNL
                     FKRPLPKSKPGSPHWQTKLEAAQNVLLCKEIFAQLSREAVQIKSQVPHIVVKNQIISQ
                     PFPSLQLSISLCHSSNDKKSQKFATEKQCPEDHLYVLEHNLHLLIREFHKQTLSSIMM
                     PHPASAPFGHKRMRLSGPQAFDKNEINSLQSSEGLLEKIIKQAKHIFLRSRAAATIDS
                     LASRIEDPQIQAHWSNINDVYESSVKVLITSQGYEQICKSIQLQLNIGVEQIRVVHRD
                     GRVITLSYQEQELQDFLLSQMSQHQVHAVQQLAKVMGWQVLSFSNHVGLGPIESIGNA
                     SAITVASPSGDYAISVRNGPESGSKIMVQFPRNQCKDLPKSDVLQDNKWSHLRGPFKE
                     VQWNKMEGRNFVYKMELLMSALSPCLL"
     exon            483..649
                     /gene="MED17"
                     /gene_synonym="CRSP6; CRSP77; DRIP80; SRB4; TRAP80"
                     /inference="alignment:Splign:2.1.0"
     exon            650..869
                     /gene="MED17"
                     /gene_synonym="CRSP6; CRSP77; DRIP80; SRB4; TRAP80"
                     /inference="alignment:Splign:2.1.0"
     exon            870..1006
                     /gene="MED17"
                     /gene_synonym="CRSP6; CRSP77; DRIP80; SRB4; TRAP80"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1091
                     /gene="MED17"
                     /gene_synonym="CRSP6; CRSP77; DRIP80; SRB4; TRAP80"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1244
                     /gene="MED17"
                     /gene_synonym="CRSP6; CRSP77; DRIP80; SRB4; TRAP80"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1375
                     /gene="MED17"
                     /gene_synonym="CRSP6; CRSP77; DRIP80; SRB4; TRAP80"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1560
                     /gene="MED17"
                     /gene_synonym="CRSP6; CRSP77; DRIP80; SRB4; TRAP80"
                     /inference="alignment:Splign:2.1.0"
     exon            1561..1698
                     /gene="MED17"
                     /gene_synonym="CRSP6; CRSP77; DRIP80; SRB4; TRAP80"
                     /inference="alignment:Splign:2.1.0"
     exon            1699..1816
                     /gene="MED17"
                     /gene_synonym="CRSP6; CRSP77; DRIP80; SRB4; TRAP80"
                     /inference="alignment:Splign:2.1.0"
     exon            1817..1976
                     /gene="MED17"
                     /gene_synonym="CRSP6; CRSP77; DRIP80; SRB4; TRAP80"
                     /inference="alignment:Splign:2.1.0"
     exon            1977..5087
                     /gene="MED17"
                     /gene_synonym="CRSP6; CRSP77; DRIP80; SRB4; TRAP80"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2506..2511
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MED17"
                     /gene_synonym="CRSP6; CRSP77; DRIP80; SRB4; TRAP80"
                     /note="hexamer: AATAAA"
     polyA_site      2529
                     /gene="MED17"
                     /gene_synonym="CRSP6; CRSP77; DRIP80; SRB4; TRAP80"
                     /note="major polyA site"
     regulatory      3392..3397
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MED17"
                     /gene_synonym="CRSP6; CRSP77; DRIP80; SRB4; TRAP80"
                     /note="hexamer: AATAAA"
     polyA_site      3412
                     /gene="MED17"
                     /gene_synonym="CRSP6; CRSP77; DRIP80; SRB4; TRAP80"
     regulatory      3431..3436
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MED17"
                     /gene_synonym="CRSP6; CRSP77; DRIP80; SRB4; TRAP80"
                     /note="hexamer: AAGAAA"
     polyA_site      3462
                     /gene="MED17"
                     /gene_synonym="CRSP6; CRSP77; DRIP80; SRB4; TRAP80"
     regulatory      3520..3525
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MED17"
                     /gene_synonym="CRSP6; CRSP77; DRIP80; SRB4; TRAP80"
                     /note="hexamer: ATTAAA"
     polyA_site      3539
                     /gene="MED17"
                     /gene_synonym="CRSP6; CRSP77; DRIP80; SRB4; TRAP80"
     regulatory      4738..4743
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MED17"
                     /gene_synonym="CRSP6; CRSP77; DRIP80; SRB4; TRAP80"
                     /note="hexamer: AATAAA"
     polyA_site      4769
                     /gene="MED17"
                     /gene_synonym="CRSP6; CRSP77; DRIP80; SRB4; TRAP80"
     regulatory      5066..5071
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MED17"
                     /gene_synonym="CRSP6; CRSP77; DRIP80; SRB4; TRAP80"
                     /note="hexamer: AATAAA"
     polyA_site      5087
                     /gene="MED17"
                     /gene_synonym="CRSP6; CRSP77; DRIP80; SRB4; TRAP80"
ORIGIN      
        1 agttttgctc cgaaagactt accgaggagg gagcttgcgg tgcgttctgg gaaagttgct
       61 gggccagctc ctttgtttcc agtctgagcg ttgcgttcgg tttcccgagg gtcttctgag
      121 gcaccgcggc tgcgggcttc tgagttcccg gctctccgca gggaagcctc ctcttcgtac
      181 ctcgtttttt ggctcgtggg gggtcctccc accgctggcc gacgcagcca gcatgtccgg
      241 ggtgcgcgca gtgcggatca gcatcgaatc ggcctgcgag aagcaggtcc atgaggtggg
      301 cctggatggc accgagacgt acctgccccc gctgtccatg tcgcagaatc tggcgcgtct
      361 ggcccagcgg atagacttca gccagggttc gggctccgag gaggaggagg cggcggggac
      421 cgagggcgac gcgcaggagt ggccgggcgc cgggtccagc gcagaccagg acgacgagga
      481 aggagtggta aaatttcagc cttccctttg gccttgggac tcagtgagga acaatttgag
      541 aagtgccctg acagagatgt gtgttctcta tgatgttctc agtattgtta gggataaaaa
      601 atttatgact cttgatcctg tctctcagga tgcacttcct ccaaaacaga atcctcagac
      661 gttgcaattg atatctaaaa agaagtcact tgctggagca gcacaaatct tattgaaggg
      721 ggcagaaaga ctgactaaat cagttaccga aaaccaagaa aacaagctac aaagagactt
      781 caattctgag cttttgcgat tacggcaaca ctggaaactt cgaaaagttg gagataaaat
      841 tctcggagat ctgagctaca gaagtgcagg atctctcttt cctcatcatg gtacatttga
      901 agtaataaag aatacagatc tcgatctgga taaaaagata cctgaagatt actgtcctct
      961 tgatgtccaa attcctagtg atttagaggg gtctgcatat atcaaggttt caatacaaaa
     1021 acaggctcca gatataggtg acctcggcac agttaacctc ttcaaacgac ctttgcccaa
     1081 atccaaacca ggttccccac attggcagac aaaattagaa gcggcacaga atgttctctt
     1141 atgtaaagaa atttttgcac agctctctcg ggaagctgtt caaattaaat cacaagtccc
     1201 tcacattgtg gtgaaaaacc agattatctc tcagcccttt ccgagcttgc agttatctat
     1261 ttctttgtgc cattcctcaa atgataagaa atcccaaaaa tttgctactg agaagcaatg
     1321 tccggaggac cacctttatg tcctagagca taatttgcat ctactgatta gagagtttca
     1381 taaacagacc ttgagttcca tcatgatgcc tcatccagca agtgcacctt ttggccacaa
     1441 gagaatgaga ctttcgggtc ctcaagcttt tgataaaaat gaaattaatt cattacagtc
     1501 cagtgaaggg cttctggaaa aaataattaa acaagcaaag catatttttc taaggagtag
     1561 agctgctgca accattgaca gcttagcaag ccgaattgag gatcctcaga tacaggctca
     1621 ttggtcaaat atcaatgatg tttatgaatc tagtgtgaaa gttttaatca catcacaagg
     1681 ctatgaacaa atatgcaagt ccattcaact gcaattgaat attggagttg agcagattcg
     1741 agttgtacat agagatggaa gagtaattac actgtcttat caggagcagg agctacagga
     1801 ttttcttctg tctcagatgt cacagcacca ggtacatgca gttcagcaac tcgccaaggt
     1861 tatgggctgg caagtactga gcttcagtaa tcatgtggga cttggaccta tagagagcat
     1921 tggtaatgca tctgccatca cggtggcctc cccaagtggt gactatgcta tttcagttcg
     1981 taatggacct gaaagtggca gcaagattat ggttcagttt cctcgtaacc aatgtaaaga
     2041 ccttccaaaa agtgatgttt tacaagataa caaatggagt catcttcgtg ggccattcaa
     2101 agaagttcag tggaataaaa tggaaggtcg aaattttgtt tataaaatgg agctgcttat
     2161 gtctgcactt agcccttgtc tactatgatt ttttccagat gtttcctaaa gaagtttcca
     2221 gaaactttga cttgaaatgt ttgcagatca actataagca caaagaagag ataacttcca
     2281 aaagagtgct gtttttaaaa ataataatta ggaaatgttt atttagcact ttcaaacttt
     2341 tcactttata aatgacaagt gctttgaaat gcagaagttt atgtacagtt gtatatacag
     2401 tatgacaaga tgtaaaataa tatgtttttc atgcagttta aaatattact aacttaaggg
     2461 tttctatgtg ctttttaaaa tattccttct ttgatgttga catcaaataa agtatgtggt
     2521 ttaaaaaaat ctccaaatac ctttttttcc ccccaaatac tttctaaact tttttttttt
     2581 gagatggtat ctcactctgt agcccagtct ggagtgcagt ggtgtgatca tggttcactg
     2641 cagtcttgac ctcccaggct taggtgatcc ttctgtctca gccttccgag tagctgggac
     2701 cacaggcatg cacaaccacg cctggctaat ttttgtattt tttataaaga cagggttttt
     2761 ccatgttgcc caggctggtt tcgaactcgg ctcaagtgat ctacctgcct ctgcctccca
     2821 aagtgctagg attacaggcg tgagccacca tgcccagcct actctaaatt attgataacc
     2881 tcttcctcca gttgtctcct ttaagctttc ctgggtctaa cctacatagg taatttaaga
     2941 acatcctcag aaaggacagc tgaaggcaat aggaggcaga ttatctcttt agggcgtcct
     3001 caagtttttt tggtctgttc tcccacttga ttgacctcac cagttgagac acctagtgta
     3061 tggctcatgc ccagccttcc acctgggatt ctccagcctc cacccagcag ccctggattg
     3121 ctttctccaa ttaaggcctt tccatcagct ctctgctttt tcaaagcgaa aaaactaatg
     3181 gattagtggg ttatcttttc caaggaacag gtttgcactt cttggaaaaa gtgcctaaag
     3241 tgtgcccatt aatatgagga tagatttagg ctcataagcc ttttggtaac actgaaagta
     3301 gtatcatata ggcaagctct ccttataagt aaggctttca atttttaaaa cagacatcct
     3361 gctttaacaa tttgtaagat gactgtgcag taataaaagt cctttgtatt tctccaccgt
     3421 gttttcatta aagaaaaatg gagcttgtgg gccacgatag aacaactttg tgcttttttc
     3481 cccttctgat caagatcttg catctttcta tccatggaaa ttaaaataat tggtatgaat
     3541 ttgcagttat ttaaaaatct tgagtgcttc aaaaattatt gttgcctgca aaatttgcct
     3601 tggtcaatag gctaatctgc acaattccac tcacataagg agtcttttat gtgattttga
     3661 aggctcaggc tagaagagtg agtctgagac ttttgctgaa tgaccagttt ttgtttatat
     3721 aaacttctcc cattgcagat tgatactttg gtaaactaat aaaaatgaat tcctaaaatg
     3781 aaattttgaa aagatacaaa ataaaagccc catttatttg attataactt gattaaattg
     3841 catcaaatac tagaatttat agacagagtc tcactctgtt ccccaggctg gagtgcagca
     3901 gcactgtttt ggctcactgc aacctctgcc tcctgggttc aaatgactct catgcctcag
     3961 cctcccgagt aactgggatt acaggtgtgt gccaccacga ccgtctaatt tttgtaattt
     4021 tgataagagg gttttgccat cttggccagg ctggtcttga actcctggcc tcaattgatc
     4081 cgcccacctc ggcctcccaa agtgctagga ttacaggcat aagccacagt gcccagcccc
     4141 cccaaatata aacatttctg aatgctttat tttttatttc tctgcttgtc atgaatcagt
     4201 aacaaatcat ggaccaggac cacaccttga gtagaatggc tgagaataca tgtgcagata
     4261 ctaccgtctg ttcttttaaa ccccatctga gtagagtggg ataactgaag actttacgtt
     4321 cttcatgtct tactttccct gtttggtacg tcgctgtagt gagtagccag taccgaccta
     4381 aagaattgta gaaactaaag caaatgtgtg ggaaaatggt agcttagttg ctgtggtagc
     4441 aattcttatg ccttgtattt atttacattt tctagtttaa tgttttaacc tgaatttcct
     4501 ggagtttgaa ggatgtgcta tggaaacttg ggagacagtt tgaagaaaac caattagccc
     4561 ctcaacaagt attaacaggt tggcaaggag ctgtgtttga atcttggctc tgctactggc
     4621 ttgctgtatg aacttggcaa ggattctctg tgaacttgtt tccttatata taaatgaaga
     4681 tagaggtgcc tcctctacta acctcagtgg tgattgagaa gtttcagtaa cgttggtaat
     4741 aaatgttaaa ttctaaagta ctacataaat ataaagcatt aagcaagtgt gcttctaaga
     4801 gtcaagccaa ttagaaaaaa tggttgagac accagctgta tttattagga gaaagcattt
     4861 cagaatgtcc tgtattcata tttgtatgat gttttatata tggtgaagat attgagtgtt
     4921 tttcatcaga tttctttgct ggaacaccat caaatcaaag ggataacctg attatctcat
     4981 gttgatcagg aattgtaatt ggcccttaaa tgctgggatt acaggtatga gccaccatgc
     5041 ctggcctcct taggtattgc tgatgaataa aaacaggggc aactaca
//
